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| 1 | Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens显示文摘The study of pathophysiological mecha nisms in huma n liver disease has bee n constrained by the in ability to expa nd primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. We and others have previously shown that mouse mature hepatocytes can be con verted to liver progenitor-like cells in vitro with defined chemical factors. Here we describe a protocol achieving efficient conversion of human primary hepatocytes into liver progenitor-like cells (HepLPCs) through delivery of developmentally relevant cues, including NAD +-dependent deacetylase SIRT1 signaling. These HepLPCs could be expanded sign ifica ntly duri ng in vitro passage. The expa nded cells can readily be con verted back into metabolically functional hepatocytes in vitro and upon tran splantati on in vivo. Under three-dime nsional culture conditions, differentiated cells gen erated from HepLPCs regai ned the ability to support infect io n or reactivatio n of hepatitis B virus (HBV). Our work dem on strates the utility of the con versi on betwee n hepatocyte and liver proge nitor-like cells for studying HBV biology and an tiviral therapies. These fin dings will facilitate the study of liver diseases and regenerative medicine. | Gong-Bo Fu Wei-Jian Huang Min Zeng Xu Zhou Hong-Ping Wu Chang-Cheng Liu Han Wu Jun Weng Hong-Dan Zhang Yong-Chao Cai Charles Ashton Min Ding Dan Tang Bao-Hua Zhang Yi Gao Wei-Feng Yu Bo Zhai Zhi-Ying He Hong-Yang Wang He-Xin Yan | 2019 | Cell Research2019，29，1： | 18 |
| 2 | Electroacupuncture at He-Mu points reduces P2X_4 receptor expression in visceral hypersensitivity显示文摘Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) was reported to improve visceral hypersensitivity in rats.Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome.Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment.Simultaneously,P2X 4 receptor immunoreactivity significantly increased in the colon and spinal cord.Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity,and significantly decreased P2X 4 receptor immunoreactivity in the colon and spinal cord.These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X 4 receptor immunoreactivity in the colon and spinal cord. | Xinxin Guo Jifei Chen Yuan Lu Luyi Wu Zhijun Weng Ling Yang Yuhu Xin Xianming Lin Yi Liang Jianqiao Fang | 2013 | Neural Regeneration Research2013，8，22： | 9 |
| 3 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 4 | Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference显示文摘Mesenchymal stem cells(MSCs)are multipotent stem cells and capable of differentiating into multiple cell types including osteoblastic,chondrogenic and adipogenic lineages.We previously identified BMP9 as one of the most potent BMPs that induce osteoblastic differentiation of MSCs although exact molecular mechanism through which BMP9 regulates osteogenic differentiation remains to be fully understood.Here,we seek to develop a recombinant adenovirus system to optimally silence mouse BMP9 and then characterize the important role of BMP9 in osteogenic differentiation of MSCs.Using two different siRNA bioinformatic prediction programs,we design five siRNAs targeting mouse BMP9(or simB9),which are expressed under the control of the converging H1 and U6 promoters in recombinant adenovirus vectors.We demonstrate that two of the five siRNAs,simB9-4 and simB9-7,exhibit the highest efficiency on silencing exogenous mouse BMP9 in MSCs.Furthermore,simB9-4 and simB9-7 act synergistically in inhibiting BMP9-induced expression of osteogenic markers,matrix mineralization and ectopic bone formation from MSCs.Thus,our findings demonstrate the important role of BMP9 in osteogenic differentiation of MSCs.The characterized simB9 siRNAs may be used as an important tool to investigate the molecular mechanism behind BMP9 osteogenic signaling.Our results also indicate that recombinant adenovirus-mediated expression of siRNAs is efficient and sustained,and thus may be used as an effective delivery vehicle of siRNA therapeutics. | Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C.Haydon Michael J.Lee Russell R.Reid Jennifer Moriatis Wolf Qiong Shi Hue H.Luu Tong-Chuan He Yaguang Weng | 2018 | Genes & Diseases2018，5，2： | 8 |
| 5 | Clinical observation of gastric bypass in treatment of type 2 diabetes显示文摘 | PU Yong-dong LI Jing-quan CAO Zhi-yu WANG Li HU Xiao DONG Li-guo LI Yue-min ZHAO Hua-zhou QIN Rong YANG Bo HE Jiao-miao WU You-jun WANG Yi LU Gang ZHANG Bo WANG Yue LIU Wei-ping WENG Jian-feng | 2012 | Chinese Medical Journal2012，，11： | 8 |
| 6 | Effects of Shuanghuanglian oral liquids on patients with COVID-19:a randomized,open-label,parallel-controlled,multicenter clinical trial显示文摘We conducted a randomized,open-label,parallel-controlled,multicenter trial on the use of Shuanghuanglian(SHL),a traditional Chinese patent medicine,in treating cases of COVID-19.A total of 176 patients received SHL by three doses(56 in low dose,61 in middle dose,and 59 in high dose)in addition to standard care.The control group was composed of 59 patients who received standard therapy alone.Treatment with SHL was not associated with a difference from standard care in the time to disease recovery.Patients with 14-day SHL treatment had significantly higher rate in negative conversion of SARS-CoV-2 in nucleic acid swab tests than the patients from the control group(93.4%vs.73.9%,P=0.006).Analysis of chest computed tomography images showed that treatment with high-dose SHL significantly promoted absorption of inflammatory focus of pneumonia,which was evaluated by density reduction of inflammatory focus from baseline,at day 7(mean difference(95%CI),−46.39(−86.83 to−5.94)HU;P=0.025)and day 14(mean difference(95%CI),−74.21(−133.35 to−15.08)HU;P=0.014).No serious adverse events occurred in the SHL groups.This study illustrated that SHL in combination with standard care was safe and partially effective for the treatment of COVID-19. | Li Ni Zheng Wen Xiaowen Hu Wei Tang Haisheng Wang Ling Zhou Lujin Wu Hong Wang Chang Xu Xizhen Xu Zhichao Xiao Zongzhe Li Chene Li Yujian Liu Jialin Duan Chen Chen Dan Li Runhua Zhang Jinliang Li Yongxiang Yi Wei Huang Yanyan Chen Jianping Zhao Jianping Zuo Jianping Weng Hualiang Jiang Dao Wen Wang | 2021 | Frontiers of Medicine2021，15，5： | 7 |
| 7 | Comparable efficacy of 100 mg aspirin twice daily and rivaroxaban for venous thromboembolism prophylaxis following primary total hip arthroplasty:a randomized controlled trial显示文摘Background:Aspirin has demonstrated safety and efficacy for venous thromboembolism(VTE)prophylaxis following total hip arthroplasty(THA);however,inconsistent dose regimens have been reported in the literature.This study aimed to evaluate and compare the safety and efficacy of 100 mg aspirin twice daily with rivaroxaban in VTE prophylaxis following THA.Methods:Patients undergoing elective unilateral primary THA between January 2019 and January 2020 were prospectively enrolled in the study and randomly allocated to receive 5 weeks of VTE prophylaxis with either oral enteric-coated aspirin(100 mg twice daily)or rivaroxaban(10 mg once daily).Medication safety and efficacy were comprehensively evaluated through symptomatic VTE incidence,deep vein thrombosis(DVT)on Doppler ultrasonography,total blood loss(TBL),laboratory bloodwork,Harris hip score(HHS),post-operative recovery,and the incidence of other complications.Results:We included 70 patients in this study;34 and 36 were allocated to receive aspirin and rivaroxaban prophylaxis,respectively.No cases of symptomatic VTE occurred in this study.The DVT rate on Doppler ultrasonography in the aspirin group was not significantly different from that in the rivaroxaban group(8.8%vs.8.3%,χ^(2)=0.01,P=0.91),confirming the non-inferiority of aspirin for DVT prophylaxis(χ^(2)=2.29,P=0.01).The calculated TBL in the aspirin group(944.9 mL[658.5-1137.8 mL])was similar to that in the rivaroxaban group(978.3 mL[747.4-1740.6mL])(χ^(2)=1.55,P=0.12).However,there were no significant inter-group differences in HHS at post-operative day(POD)30(Aspirin:81.0[78.8-83.0],Rivaroxaban:81.0[79.3-83.0],χ^(2)=0.43,P=0.67)and POD 90(Aspirin:90.0[89.0-92.0],Rivaroxaban:91.5[88.3-92.8],χ^(2)=0.77,P=0.44),the incidence of bleeding events(2.9%vs.8.3%,χ^(2)=0.96,P=0.33),or gastrointestinal complications(2.9%vs.5.6%,χ^(2)=1.13,P=0.29).Conclusion:In terms of safety and efficacy,the prophylactic use of 100 mg aspirin twice daily was not statistically different from that of rivaroxaban in preventing VTE and reducing the risk of blood loss following elective primary THA.This supports the use of aspirin chemoprophylaxis following THA as a less expensive and more widely available option for future THAs.Trial Registration:Chictr.org,ChiCTR18000202894;http://gffzz62a03ee25e6f4a77hcw96b6f6fv5x6cxq.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=33284. | Yi Ren Shi-Liang Cao Zeng Li Tim Luo Bin Feng Xi-Sheng Weng | 2021 | Chinese Medical Journal2021，，2： | 6 |
| 8 | Directly accessing octave-spanning dissipative Kerr soliton frequency combs in an AlN microresonator显示文摘Self-referenced dissipative Kerr solitons (DKSs) based on optical microresonators offer prominent characteristics allowing for various applications from precision measurement to astronomical spectrometer calibration. To date,direct octave-spanning DKS generation has been achieved only in ultrahigh-Q silicon nitride microresonators under optimized laser tuning speed or bi-directional tuning. Here we propose a simple method to easily access the octave-spanning DKS in an aluminum nitride (AlN) microresonator. In the design,two modes that belong to different families but with the same polarization are nearly degenerate and act as a pump and an auxiliary resonance,respectively. The presence of the auxiliary resonance can balance the thermal dragging effect,crucially simplifying the DKS generation with a single pump and leading to an enhanced soliton access window. We experimentally demonstrate the long-lived DKS operation with a record single-soliton step (10.4 GHz or83 pm) and an octave-spanning bandwidth (1100–2300 nm) through adiabatic pump tuning. Our scheme also allows for direct creation of the DKS state with high probability and without elaborate wavelength or power schemes being required to stabilize the soliton behavior. | HAIZHONG WENG JIA LIU ADNAN ALI AFRIDI JING LI JIANGNAN DAI XIANG MA YI ZHANG QIAOYIN LU JOHN F.DONEGAN WEIHUA GUO | 2021 | Photonics Research2021，9，7： | 6 |
| 9 | Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity显示文摘血大脑障碍(BBB ) 是在 endothelial 房间和星形细胞之间形成的一条紧密的边界,它在循环把大脑与大多数病原体以及神经毒素分开并且保护。然而,详细说明了涉及 BBB 的形成的分子的播放器完全不被知道。牙质矩阵蛋白质 1 (DMP1 )-proteoglycan (PG ) 被知道涉及骨头和牙质的矿化作用,也与未知功能包括大脑在软纸巾被表示。在现在的学习,我们报导 DMP1-PG 在大脑星形细胞被表示并且在 BBB 充实单位。DMP1 的唯一的 glycosylation 地点在在鼠标的蛋白质的 N 终端域是 serine89 (S89 ) 。有 DMP1 的变异的老鼠削尖把 S89 改变到 glycine (S89G ) 的变化,它蛋白质的完全根除的 glycosylation,表明的严重 BBB 混乱。DMP1 变异的鼠标的另一个品种,缺乏 DMP1 的 C 终端域,表明了正常 BBB 功能。S89G-DMP1 星形细胞的极性被破坏,房间房间粘附被松开。通过一组分析,我们发现 DMP1 glycosylation 极其在 vitro 并且在 vivo 为星形细胞成熟被要求。S89G-DMP1 变异的星形细胞没能表示 aquaporin 4 并且减少了 laminin 和 ZO1 表示,它导致了 BBB 的混乱。有趣地,在 nestin 倡导者驾驶的老鼠大脑的野类型的 DMP1-PG 的 overexpression 在野类型层次以外提高了 laminin 和 ZO1 表示并且能有效地抵抗的静脉内的导致甘露糖醇的 BBB 可逆的洞。一起拿,我们的学习不仅揭示了一个新奇元素,即, DMP1-PG,调整了 BBB 形成,而且把新功能分到 DMP1-PG。 | Bo Jing Chunxue Zhang Xianjun Liu Liqiang Zhou Jiping Liu Yinan Yao Juehua Yu Yuteng Weng Min Pan Jie Liu Zuolin Wang Yao Sun Yi Eve Sun | 2018 | Protein & Cell2018，9，3： | 5 |
| 10 | Updates in version 2020 of CSCO guidelines for colorectal cancer from version 2019显示文摘According to the latest data released by the National Cancer Center,colorectal cancer(CRC)had the third highest incidence and the fifth highest mortality of all malignancies,with 388,000 new cases and 187,000 cancer deaths in China(1).The Chinese Society of Clinical Oncology(CSCO)originally published the English version of 2018 guideline concerning CRC and updated them in2019(2,3).According to the latest progress,clinical guidelines have been updated.Here,we present the main updates of the 2020 version compared to 2019 version. | Shanshan Weng Ying Yuan Xicheng Wang Gong Chen Yi Wang Weiqi Sheng Xinxiang Li Aiping Zhou Zhen Zhang Guichao Li Sanjun Cai Ruihua Xu Jin Li Suzhan Zhang | 2020 | Chinese Journal of Cancer Research2020，32，3： | 4 |
| 11 | The first power generation test of hot dry rock resources exploration and production demonstration project in the Gonghe Basin,Qinghai Province,China显示文摘Hot dry rock(HDR)is a kind of clean energy with significant potential.Since the 1970s,the United States,Japan,France,Australia,and other countries have attempted to conduct several HDR development research projects to extract thermal energy by breaking through key technologies.However,up to now,the development of HDR is still in the research,development,and demonstration stage.An HDR exploration borehole(with 236℃ at a depth of 3705 m)was drilled into Triassic granite in the Gonghe Basin in northwest China in 2017.Subsequently,China Geological Survey(CGS)launched the HDR resources exploration and production demonstration project in 2019.After three years of efforts,a sequence of significant technological breakthroughs have been made,including the genetic model of deep heat sources,directional drilling and well completion in high-temperature hard rock,large-scale reservoir stimulation,reservoir characterization,and productivity evaluation,reservoir connectivity and flow circulation,efficient thermoelectric conversion,monitoring,and geological risk assessment,etc.Then the whole-process technological system for HDR exploration and production has been preliminarily established accordingly.The first power generation test was completed in November 2021.The results of this project will provide scientific support for HDR development and utilization in the future. | Er-yong Zhang Dong-guang Wen Gui-ling Wang Wei-de Yan Wen-shi Wang Cheng-ming Ye Xu-feng Li Huang Wang Xian-chun Tang Wei Weng Kuan Li Chong-yuan Zhang Ming-xing Liang Hong-bao Luo Han-yue Hu Wei Zhang Sen-qi Zhang Xian-peng Jin Hai-dong Wu Lin-you Zhang Qing-da Feng Jing-yu Xie Dan Wang Yun-chao He Yue-wei Wang Zu-bin Chen Zheng-pu Cheng Wei-feng Luo Yi Yang Hao Zhang En-lai Zha Yu-lie Gong Yu Zheng Chang-sheng Jiang Sheng-sheng Zhang Xue Niu Hui Zhang Li-sha Hu Gui-lin Zhu Wen-hao Xu Zhao-xuan Niu Li Yang | 2022 | China Geology2022，5，3： | 4 |
| 12 | Capsid protein from red-spotted grouper nervous necrosis virus induces incomplete autophagy by inactivating the HSP90ab1-AKT-MTOR pathway显示文摘As a highly important fish virus,nervous necrosis virus(NNV)has caused severe economic losses to the aquaculture industry worldwide.Autophagy,an evolutionarily conserved intracellular degradation process,is involved in the pathogenesis of several viruses.Although NNV can induce autophagy to facilitate infection in grouper fish spleen cells,how it initiates and mediates autophagy pathways during the initial stage of infection is still unclear.Here,we found that red-spotted grouper NNV(RGNNV)induced autophagosome formation in two fish cell lines at 1.5 and 3 h post infection,indicating that autophagy is activated upon entry of RGNNV.Moreover,autophagic detection showed that RGNNV entry induced incomplete autophagy by impairing the fusion of autophagosomes with lysosomes.Further investigation revealed that binding of the RGNNV capsid protein(CP)to the Lateolabrax japonicus heat shock protein HSP90ab1(LjHSP90ab1),a cell surface receptor of RGNNV,contributed to RGNNV invasion-induced autophagy.Finally,we found that CP blocked the interaction of L.japonicus protein kinase B(AKT)with LjHSP90ab1 by competitively binding the NM domain of LjHSP90ab1 to inhibit the AKT-mechanistic target of the rapamycin(MTOR)pathway.This study provides novel insight into the relationship between NNV receptors and autophagy,which may help clarify the pathogenesis of NNV. | Wan-Wan Zhang Peng Jia Xiao-Bing Lu Xiao-Qi Chen Jue-Hua Weng Kun-Tong Jia Mei-Sheng Yi | 2022 | Zoological Research2022，43，1： | 3 |
| 13 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
| 14 | Oscillations during partial oxidation of methane to synthesis gas over Ru/Al_2O_3 catalyst显示文摘Oscillations in temperatures of catalyst bed as well as concentrations of gas phase species at the exit of reactor were observed during the partial oxidation of methane to synthesis gas over Ru/Al2O3 in the temperature range of 600 to 850 ℃.XRD,H2-TPR and in situ Raman techniques was used to characterize the catalyst.Two types of ruthenium species,i.e.the ruthenium species weakly interacted with Al2O3 and that strongly interacted with the support,were identified by H2-TPR experiment.These species are responsible for two types of oscillation profiles observed during the reaction.The oscillations were the result of these ruthenium species switching cyclically between the oxidized state and the reduced state under the reaction condition.These cyclic transformations,in turn,were the result of temperature variations caused by the varying levels of the strongly exothermic CH4 combustion and the highly endothermic CH4 reforming(with H2O and CO2) reactions(or the less exothermic direct partial oxidation of methane to CO and H2),which were favored by the oxidized and the metallic sites,respectively.The major pathway of synthesis gas formation over the catalyst was via the combustion-reforming mechanism. | Meiliu Wang Weizheng Weng Haozhuan Zheng Xiaodong Yi Chuanjing Huang Huilin Wan | 2009 | Journal of Natural Gas Chemistry2009，18，3： | 3 |
| 15 | Novel D-galactosamine-induced cynomolgus monkey model of acute liver failure显示文摘AIM To establish a simplified, reproducible D-galactosamineinduced cynomolgus monkey model of acute liver failure having an appropriate treatment window. METHODS Sixteen cynomolgus monkeys were randomly dividedinto four groups(A, B, C and D) after intracranial pressure(ICP) sensor implantation. D-galactosamine at 0.3, 0.25, 0.20 + 0.05(24 h interval), and 0.20 g/kg body weight, respectively, was injected via the small saphenous vein. Vital signs, ICP, biochemical indices, and inflammatory factors were recorded at 0, 12, 24, 36, 48, 72, 96, and 120 h after D-galactosamine administration. Progression of clinical manifestations, survival times, and results of H&E staining, TUNEL, and Masson staining were recorded. RESULTS Cynomolgus monkeys developed different degrees of debilitation, loss of appetite, and jaundice after D-galactosamine administration. Survival times of groups A, B, and C were 56 ± 8.7 h, 95 ± 5.5 h, and 99 ± 2.2 h, respectively, and in group D all monkeys survived the 144-h observation period except for one, which died at 136 h. Blood levels of ALT, AST, CK, LDH, TBi L, Cr, BUN, and ammonia, prothrombin time, ICP, endotoxin, and inflammatory markers [(tumor necrosis factor(TNF)-α, interleukin(IL)-1β, and IL-6)] significantly increased compared with baseline values in different groups(P < 0.05). Pathological results showed obvious liver cell necrosis that was positively correlated with the dose of D-galactosamine.CONCLUSION We successfully established a simplified, reproducible D-galactosamine-induced cynomolgus monkey model of acute liver failure, and the single or divided dosage of 0.25 g/kg is optimal for creating this model. | Lei Feng Lei Cai Guo-Lin He Jun Weng Yang Li Ming-Xin Pan Ze-Sheng Jiang Qing Peng Yi Gao | 2017 | World Journal of Gastroenterology2017，23，42： | 3 |
| 16 | Adult metaplastic hutch diverticulum with robotic-assisted diverticulectomy and reconstruction:A case report显示文摘BACKGROUND Hutch diverticulum arises from the compromised muscular development at the ureteral orifice.It is a congenital disease and extremely rare in adult,only accounting for about 3%occurrence worldwide.It can be either symptomatic or asymptomatic,and relies on image tools for diagnosis and preoperative planning.Indications for surgery are dependent on the complications from the diverticulum.Metaplasia is about 10%among those with hutch diverticulum,and it still has chances turning into malignancy,especially urothelial cell carcinoma.CASE SUMMARY A 27-year-old man was presented with frequently recurrent urinary tract infection for one year,and had suffered from intermittent right flank pain for 3 mo.No past medical histories were recorded before.No obvious abnormalities on laboratory data and urine examination were found.Under ultrasound,right hydronephrosis was seen and an anatomical abnormality was observed on intravenous pyelography.Further computed tomography urogram showed one diverticulum seated at superolateral side of right ureteral orifice.Cystoscopy was done and biopsy results showed focal metaplasia.After discussing with him,roboticassisted diverticulectomy with reconstruction was performed.Right hydronephrosis was greatly improved after surgery.He has completed his 1.5-year follow-ups,and no malignancies were seen from urine cytology and image of intravenous pyelography.CONCLUSION Robotic-assisted diverticulectomy and reconstruction to hutch diverticulum is a safe and efficient operation,providing several advantages over open and laparoscopic ones. | Che H Yang Yi S Lin Yen C Ou Wei C Weng Li H Huang Chin H Lu Chao Y Hsu Min C Tung | 2020 | World Journal of Clinical Cases2020，8，20： | 2 |
| 17 | Synthesis and Antioxidant Properties of Novel Silybin Analogues显示文摘八新奇 silybin 类似物(7a-h ) 被综合并且他们包括清除的能力的抗氧化剂性质 DPPH 自由基上的超级氧化物阴离子自由基和禁止的效果被决定。几合成混合物显示出可比较的抗氧化的效果到橡黄素的。 | Jing Xu GONG Lin Jia WENG Feng WANG Yu Bin FENG Chang Xin ZHOU Hai Bo LI Yi Hang WU Xiao Jiang HAO Xiu Mei WU Hua BAI Joachim STOECKIGT Yu ZHAO | 2006 | Chinese Chemical Letters2006，17，4： | 2 |
| 18 | CSCO guidelines for colorectal cancer version 2023:Updates and insights显示文摘Colorectal cancer(CRC)is the second most common cancer and the most common type of gastrointestinal cancer with rapidly increasing incidence and mortality in China(1,2).Since the first edition of the Chinese Society of Clinical Oncology(CSCO)guideline was published in2017,the guideline has been updated annually according to the latest results of clinical research at home and abroad,the accessibility of drugs and the opinions of CSCO experts(3-7). | Mi Mi Shanshan Weng Ziheng Xu Hanguang Hu Yi Wang Ying Yuan | 2023 | Chinese Journal of Cancer Research2023，35，3： | 2 |
| 19 | Involvement of the crebellum in sequential finger movement learning:Evidence from functional magnetic resonance imaging显示文摘Whether the cerebellum is involved in volun-tary motor learning or motor performance is the subject of a new debate. Using functional magnetic resonance imaging (fMRI), we examined cerebellar activation in eight volun-teers before and after an extended period of training. Activa-tion volume on both sides of cerebellum after learning was significantly reduced compared to that before learning even under the same motor frequency. Remarkably, while motor frequency for the training sequence was significantly higher than the control sequence after 41 d of learning, activation in the cerebellum for both sequences, with respect to activation loci and volumes, was very similar. These results suggest that the cerebellum was involved in motor learning but not motor performance. Changes of cerebellar activation from training thus appear to be associated with learning but not with im-provement on task performance. | ZHU Yihong DI Haibo YUAN Yi REN Jin'ge YU Wei ZHANG Zhaoqi GAO Jiahong WENG Xuchu CHEN Yizhang | 2005 | Chinese Science Bulletin2005，50，17： | 2 |
| 20 | Application of single balloon enteroscopy-assisted therapeutic endoscopic retrograde cholangiopancreatography in patients after bilioenteric Roux-en-Y anastomosis: Experience of multi-disciplinary collaboration显示文摘BACKGROUND Bilioenteric Roux-en-Y anastomosis is one of the most complicated approaches for reconstructing the gastrointestinal tract, and endoscopic retrograde cholangiopancreatography (ERCP) is technically challenging in patients after bilioenteric Roux-en-Y anastomosis. The optimal endoscopic strategies for such cases remain unknown. AIM To explore the feasibility and effectiveness of single balloon enteroscopy-assisted (SBE-assisted) therapeutic ERCP in patients after bilioenteric Roux-en-Y anastomosis based on multi-disciplinary collaboration between endoscopists and surgeons as well as report the experience from China. METHODS This is a single center retrospective study. All of the SBE-assisted therapeutic ERCP procedures were performed by the collaboration between endoscopists and surgeons. The operation time, success rate, and complication rate were calculated. RESULTS Forty-six patients received a total of 64 SBE-assisted therapeutic ERCP procedures, with successful scope intubation in 60 (93.8%) cases and successful diagnosis in 59 (92.2%). All successfully diagnosed cases received successful therapy. None of the cases had perforation or bleeding during or after operation, and no post-ERCP pancreatitis occurred. CONCLUSION Based on multi-disciplinary collaboration, SBE-assisted therapeutic ERCP in patients after bilioenteric Roux-en-Y anastomosis is relatively safe and effective and has a high success rate. | Wen-Guang Wu Lu-Cui Qin Xiao-Ling Song Ming-Ning Zhao Wen-Jie Zhang Jun Gu Hao Weng Ying-Bin Liu Yi Zhang Chun-Ying Qu Lei-Ming Xu Xue-Feng Wang | 2019 | World Journal of Gastroenterology2019，25，36： | 2 |
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