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| 1 | Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring显示文摘树鼯有一种靠近的关系到首领并且在生物医学的研究比啮齿类动物有许多优点。然而,基因操作方法的缺乏妨碍了这个动物的更宽的使用。Spermatogonial 干细胞(SSC ) 成功地在文化被扩展了允许复杂基因在老鼠和老鼠编辑。这里,没有干细胞性质的损失,我们为树鼯 SSC 的长期的扩大描述一个文化系统。在我们的学习,胸腺房间抗原 1 被用来充实树鼯 SSC。定序 RNA 分析表明表明小径的 Wnt/-catenin 在无差别的 SSC 是活跃的,但是是在 SSC 区别的开始之上的 downregulated。树鼯的暴露到 recombinant Wnt3a 蛋白质的主要 SSC 在文化的起始的段落期间提高了 SSC 的幸存。当 feeder 被发现为树鼯 SSC 增长必要,树鼯 Sertoli 房间,然而并非老鼠使用胚胎的成纤维细胞,导致柔韧的房间扩大和长期的文化。扩展的树鼯 SSC 是有提高的绿色的 transfected 荧光灯表示 lentiviral 向量的蛋白质(EGFP ) 。在进消毒的成年的男树鼯睾丸的移植以后,标注 EGFP 的 SSC 能恢复精子发生并且成功地产生转基因的后代。而且,这些 SSC 对 CRISPR/Cas9-mediated 基因修正合适。在有编辑的基因的联合的树鼯 SSC 接近膨胀的一个文化系统的发展用树鼯为精确染色体操作铺平道路。 | Chao-Hui Li Lan-Zhen Yan Wen-Zan Ban Qiu TH Yong Wu Lin Wang Rui Bi Shuang Ji Yu-Hua Ma Wen-Hui Nie Long-Bao Lv Yong-Gang Yao Xu-Dong Zhao Ping Zheng | 2017 | Cell Research2017，27，2： | 22 |
| 2 | Detrital zircon U-Pb geochronology of stromatolitic carbonates from the greenstone belts of Dharwar Craton and Cuddapah basin of Peninsular India显示文摘Oldest rocks are sparsely distributed within the Dharwar Craton and little is known about their involvement in the sedimentary sequences which are present in the Archean greenstone successions and the Proterozoic Cuddapah basin.Stromatolitic carbonates are well preserved in the Neoarchean greenstone belts of Dharwar Craton and Cuddapah Basin of Peninsular India displaying varied morphological and geochemical characteristics.In this study,we report results from U-Pb geochronology and trace element composition of the detrital zircons from stromatolitic carbonates present within the Dharwar Craton and Cuddapah basin to understand the provenance and time of accretion and deposition.The UPb ages of the detrital zircons from the Bhimasamudra and Marikanve stromatolites of the Chitradurga greenstone belt of Dharwar Craton display ages of 3426±26 Ma to 2650±38 Ma whereas the Sandur stromatolites gave an age of 3508±29 Ma to 2926±36 Ma suggesting Paleo-to Neoarchean provenance.The U-Pb detrital zircons of the Tadpatri stromatolites gave an age of 2761±31 Ma to1672±38 Ma suggesting Neoarchean to Mesoproterozoic provenance.The Rare Earth Element(REE)patterns of the studied detrital zircons from Archean Dharwar Craton and Proterozoic Cuddapah basin display depletion in light rare earth elements(LREE)and enrichment in heavy rare earth elements(HREE)with pronounced positive Ce and negative Eu anomalies,typical of magmatic zircons.The trace element composition and their relationship collectively indicate a mixed granitoid and mafic source for both the Dharwar and Cuddapah stromatolites.The 3508±29 Ma age of the detrital zircons support the existence of 3.5 Ga crust in the Western Dharwar Craton.The overall detrital zircon ages(3.5-2.7 Ga)obtained from the stromatolitic carbonates of Archean greenstone belts and Proterozoic Cuddapah basin(2.7-1.6 Ga)collectively reflect on^800-900 Ma duration for the Precambrian stromatolite deposition in the Dharwar Craton. | Arubam C.Khelen C.Manikyamba Li Tang M.Santosh K.S.V.Subramanyam Th Dhanakumar Singh | 2020 | Geoscience Frontiers2020，11，1： | 2 |
| 3 | Deoxynivalenol accumulation and detoxification in cereals and its potential role in wheat-Fusarium graminearum interactions显示文摘Deoxynivalenol(DON)is a prominent mycotoxin showing significant accumulation in cereal plants during infection by the phytopathogen Fusarium graminearum.It is a virulence factor that is important in the spread of F.graminearum within cereal heads,and it causes serious yield losses and significant contamination of cereal grains.In recent decades,genetic and genomic studies have facilitated the characterization of the molecular pathways of DON biosynthesis in F.graminearum and the environmental factors that influence DON accumulation.In addition,diverse scab resistance traits related to the repression of DON accumulation in plants have been identified,and experimental studies of wheat–pathogen interactions have contributed to understanding detoxification mechanisms in host plants.The present review illustrates and summarizes the molecular networks of DON mycotoxin production in F.graminearum and the methods of DON detoxification in plants based on the current literature,which provides molecular targets for crop improvement programs.This review also comprehensively discusses recent advances and challenges related to genetic engineering-mediated cultivar improvements to strengthen scab resistance.Furthermore,ongoing advancements in genetic engineering will enable the application of these molecular targets to develop more scab-resistant wheat cultivars with DON detoxification traits. | Kun Luo Jiao Guo Dejia He Guangwei Li Thérèse Ouellet | 2023 | aBIOTECH2023，4，2： | 2 |
| 4 | Ultraharmonic myocardial contrast imaging: in vivo experimental and clinical data from a novel technique显示文摘 | Kuersten B Murthy TH Li P | 2001 | J Am Soc Echocardiogr2001，14，9： | 2 |
| 5 | High-Dose Misoprostol as an Alternative Therapy after Failed Medical Abortion显示文摘 | Li YT GQ Hou TH Chen | 2008 | Taiwan J Obstet Gynecol2008，47，4： | 1 |
| 6 | Novel fuzzy feedback linearization strategy for control via differential geometry approach 显示文摘 | Li TH Huang C J Chen CC | 2010 | ISA Transactions2010，3，49： | 1 |
| 7 | Smoking and depressive symp- toms in Chinese elderly in Hong Kong 显示文摘 | Lam TH Li ZB He SY | 2004 | Acta Psychiatr Scartd2004，110，3： | 1 |
| 8 | Activation of the renin-angiotensin system within podocytes in diabetes 显示文摘 | Yoo TH Li J J Kim JJ | 2007 | Kidney Int2007，71，10： | 1 |
| 9 | Amyloid-beta protein dimers isolated dir-ectly from Alzheimer's brains impair syn- aptic plasticity and memory显示文摘 | Shankar GM Li S Mehta TH | 2008 | Nat Med2008，14，8： | 1 |
| 10 | IVF results in de novo DNA methylation and histonc metylation at an Igf2-H19 imprinting epigenetic switch 显示文摘 | Li T Vu TH Ulaner GA Littman E Ling JQ Chen HL | 2005 | Mol Hum Reprod2005，11，9： | 1 |
| 11 | Differential effects of concomitant use of vitamins C and E on trophoblast apoptosis and autophagy between normoxia and hypoxia-reoxygenation显示文摘 | Hung TH Chen SF Li Mj | 2010 | PloS One2010，5，12： | 1 |
| 12 | Anti - tumor effect of pEgr- IFNgamma gene - radiotherapy in B16 melanoma -bearing mice显示文摘 | Wu CM Li XY Huang TH | 2004 | World J Gastroenterol2004，10，20： | 1 |
| 13 | SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in mice显示文摘 | Li Y Chert L Chan TH | 2013 | Gastroenterology2013，144，1： | 1 |
| 14 | Smoking and tuberculosis among the elderly in Hong Kong 显示文摘 | Leung CC Li T Lam TH | 2004 | Am J Respir Crit Care Med2004，170，9： | 1 |
| 15 | Melamine toxicity and the kidney显示文摘 | Hau AK Kwan TH Li PK | 2009 | J Am Soc Nephrol2009，20，2： | 1 |
| 16 | Electrical,morphological,and ultra structural remodeling and reverse remodeling in a canine model of chronic atrial fibrillation显示文摘 | EVERETT TH LI H MANGRUM JM | 2000 | Circulation2000，102，12： | 1 |
| 17 | Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor显示文摘 | Vu TH Chuyen NV Li T | 2003 | Cancer Res2003，63，8： | 1 |
| 18 | Surface chemistry of carbon-templated mesoporous aluminas显示文摘 | Onfroy T Li W C Schüth F | 2009 | Physical Chemistry Chemical Physics2009，11，19： | 1 |
| 19 | A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo显示文摘 | Shih AY Li P Murphy TH | 2005 | J Neurosci2005，25，10： | 1 |
| 20 | Activation of the renin-angiotensin system within podocytes in diabetes显示文摘 | Yoo TH Li J J Kim JJ | 2007 | Kidney Int2007，71，10： | 1 |
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