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| 1 | Esophageal cancer:Epidemiology,risk factors and screening显示文摘More than 600,000 people are diagnosed with esophageal cancer(EC)every year globally,and the five-year survival rate of EC is less than 20%.Two common histological subtypes of EC,esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC),have great geographical variations in incidence rates.About half of the world’s EC was diagnosed in China and a majority of which belong to ESCC.Globally,the overall incidence rate of EC is decreasing.In some high-risk Asian regions,such as China,the incidence rate of ESCC has generally declined,potentially due to economic growth and improvement of diet habits.In some European high-income countries and the United States,the decline is mainly attributed to the decrease in smoking and drinking.The risk factors of EC are not well understood,and the importance of environmental and genetic factors in the pathogenesis is also unclear.The incidence and mortality of advanced EC can be reduced through early diagnosis and screening.White light endoscopy is still the gold standard in the current screening technology.This article reviews the epidemiology,risk factors,and screening strategies of EC in recent years to help researchers determine the most effective management strategies to reduce the risk of EC. | Jiang Li Jianguo Xu Yadi Zheng Ya Gao Siyi He He Li Kaiyong Zou Ni Li Jinhui Tian Wanqing Chen Jie He | 2021 | Chinese Journal of Cancer Research2021，33，5： | 12 |
| 2 | The chromosome-level reference genome assembly for Panax notoginseng and insights into ginsenoside biosynthesis显示文摘Panax notoginseng,a perennial herb of the genus Panax in the family Araliaceae,has played an important role in clinical treatment in China for thousands of years because of its extensive pharmacological effects.Here,we report a high-quality reference genome of P.notoginseng,with a genome size up to 2.66 Gb and a contig N50 of 1.12 Mb,produced with third-generation PacBio sequencing technology.This is the first chromosome-level genome assembly for the genus Panax.Through genome evolution analysis,we explored phylogenetic and whole-genome duplication events and examined their impact on saponin biosynthesis.We performed a detailed transcriptional analysis of P.notoginseng and explored genelevel mechanisms that regulate the formation of characteristic tubercles.Next,we studied the biosynthesis and regulation of saponins at temporal and spatial levels.We combined multi-omics data to identify genes that encode key enzymes in the P.notoginseng terpenoid biosynthetic pathway.Finally,we identified five glycosyltransferase genes whose products catalyzed the formation of different ginsenosides in P.notoginseng.The genetic information obtained in this study provides a resource for further exploration of the growth characteristics,cultivation,breeding,and saponin biosynthesis of P.notoginseng. | Zhouqian Jiang Lichan Tu Weifei Yang Yifeng Zhang Tianyuan Hu Baowei Ma Yun Lu Xiuming Cui Jie Gao Xiaoyi Wu Yuru Tong Jiawei Zhou Yadi Song Yuan Liu Nan Liu Luqi Huang Wei Gao | 2021 | Plant Communications2021，2，1： | 11 |
| 3 | Dosimetric evaluation of VMAT radiation therapy technique for breast cancer after conservative surgery based on three different types of multileaf collimators显示文摘Objective Radiotherapy combined with conservative surgery plays an important role in the treatment of early-stage breast cancer. Volumetric modulated arc therapy(VMAT) has been introduced into clinical practice. The purpose of this study was to investigate the dosimetric effects of different multileaf collimators(MLC) on VMAT radiotherapy plans for treating breast cancer.Methods Fifteen breast cancer patients who were treated using a conventional technique in our department were selected to participate in this retrospective analysis. VMAT plans based on three types of Elekta MLCs [Beam Modulator(BM) with 4-mm leaf width, Agility with 5-mm leaf width and MLCi2 with 10-mm leaf width] were independently generated for each patient. Plan comparisons were performed based on dose-volume histogram(DVH) analysis including dosimetric parameters such as the homogeneity index(HI), conformity index(CI), Dmax, Dmin, and Dmean for the planning treatment volume(PTV), in addition to dose-volume parameters for the organs at risk(OARs). The delivery efficiency of the three types of MLCs was compared in terms of the beam delivery time and the monitor units(MUs) per fraction for each plan. Results Both target uniformity and conformity were improved in plans for Agility and BM MLC compared with the plan using MLCi2. The mean HI decreased from 1.14 for MLCi2 to 1.13 for BM and 1.10 for Agility, while the mean CI increased from 0.68 for MLCi2 to 0.73 for BM and 0.75 for Agility. Furthermore, at both low and high dose levels, smaller volumes of ipsilateral lung, heart, contralateral lung, and breast were irradiated with Agility MLC than with the other two types of MLCs. The delivery time with Agility MLC was reduced by 10.8% and 32.1%, respectively, compared with that for MLCi2 and BM.Conclusion Our results indicate that the Agility MLC exhibits a dosimetric advantage and a significant improvement in delivery efficiency for the treatment of breast cancer using VMAT. | Fuli Zhang Weidong Xu Huayong Jiang Yadi Wang Junmao Gao Qingzhi Liu | 2018 | Oncology and Translational Medicine2018，4，5： | 4 |
| 4 | Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates显示文摘Emerging SARS-CoV-2 variants and the gradually decreasing neutralizing antibodies over time post vaccination have led to an increase in incidents of breakthrough infection across the world.To investigate the potential protective effect of the recombinant protein subunit COVID-19 vaccine targeting receptor-binding domain(RBD)(PS-RBD)and whole inactivated virus particle vaccine(IV)against the variant strains,in this study,rhesus macaques were immunized with PS-RBD or IV vaccine,followed by a Beta variant(B.1.351)challenge.Although neutralizing activity against the Beta variant was reduced compared with that against the prototype,the decreased viral load in both upper and lower respiratory tracts,milder pathological changes,and downregulated inflammatory cytokine levels in lung tissues after challenge demonstrated that PS-RBD and IV still provided effective protection against the Beta variant in the macaque model.Furthermore,PS-RBD-induced macaque sera possessed general binding and neutralizing activity to Alpha,Beta,Delta,and Omicron variants in our study,though the neutralizing antibody(NAb)titers declined by varying degrees,demonstrating potential protection of PS-RBD against current circulating variants of concern(VOCs).Interestingly,although the IV vaccine-induced extremely low neutralizing antibody titers against the Beta variant,it still showed reduction for viral load and significantly alleviated pathological change.Other correlates of vaccine-induced protection(CoP)like antibody-dependent cellular cytotoxicity(ADCC)and immune memory were both confirmed to be existing in IV vaccinated group and possibly be involved in the protective mechanism. | Qian He Qunying Mao Xiaozhong Peng Zhanlong He Shuaiyao Lu Jialu Zhang Fan Gao Lianlian Bian Chaoqiang An Wenhai Yu Fengmei Yang Yanan Zhou Yun Yang Yanyan Li Yadi Yuan Xujia Yan Jinghuan Yang Xing Wu Weijin Huang Changgui Li Junzhi Wang Zhenglun Liang Miao Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 5 | Comparison of the effects of two typesof multileaf collimators on tumor control probabilityin radiotherapy for breast cancer after conservativesurgery based on the EUD model显示文摘Objective To compute and compare the tumor control probability(TCP) of volumetric modulated arc therapy(VMAT) for breast cancer after conservative surgery based on two types of multileaf collimator(MLC) through a retrospective planning study.Methods For a group of 9 patients diagnosed with left breast cancer,VMAT plan based on Agility MLC and beam modulator(BM) MLC were designed.The prescription dose was 50 Gy covering at least 95% of the planning target volume,2 Gy per fraction.TCPs were calculated according to dose-volume histogram(DVH) analysis.Results The TCP of the BM VMAT plan was slightly higher than that of the Agility VMAT plan(94.61% vs 94.23%) but was inferior with respect to delivery efficiency;the delivery time was reduced for Agility VMAT plan by 35% compared to BM VMAT plan.Conclusion For breast cancer radiation therapy after conservative surgery,BM VMAT plans provide slightly higher TCP while the delivery of Agility VMAT plans is significantly faster than the BM VMAT plans. | Fuli Zhang Yadi Wang Weidong Xu Huayong Jiang Junmao Gao Qingzhi Liu Na Lu Diandian Chen Bo Yao Jun Hou Heliang He Jianping Chen | 2017 | Oncology and Translational Medicine2017，3，2： | 2 |
| 6 | Preoperative Diagnosis of Solitary Fibrous Tumor of the Kidney with Percutaneous Fine Needle Biopsy and Management with Laparoscopic Partial Nephrectomy: One Case Report and Literatures Review显示文摘Introduction Solitary fibrous tumor (SFT) of the kidney is a rare spindle cell neo-plasm and all reported SFTs of the kidney were diagnosed throughpathological examination | Liaoyuan Li Yadi He Xin Gao Ming Yang Haibin Zhang Yuanyuan Xu Wenfeng Xu | 2008 | Chinese Journal of Clinical Oncology2008，5，6： | 2 |
| 7 | The protective effect of icariin on glucocorticoid-damaged BMECs explored by microfluidic organ chip显示文摘Osteonecrosis of the femoral head(ONFH)is a devastating musculoskeletal disease characterized by the impaired circulation of bone.The purpose of this study was to explore the underlying mechanisms of the protective effect of icariin on the glucocorticoid-induced injury of bone microvascular endothelial cells(BMECs).Normal BMECs were extracted from the femoral heads by enzymatic isolation and magneticactivated cell sorting methods.Dexamethasone and icariin were used to intervene BMECs in microfluidic organ chips,and phalloidin staining was conducted to observe the cell morphology and viability.Then next-generation transcriptome sequencing and real-time quantitative reverse transcription-polymerase chain reaction(q RT-PCR)were performed to identify the differentially expressed genes(DEGs)in different groups.Through the microfluidic organ chip,it can be observed that after dexamethasone intervention,the filamentous structure in cell fibers disappeared and the cell morphology changed from spindle to round until death.Icariin could relieve these changes and showed a protective effect on glucocorticoiddamaged BMECs.In addition,201 DEGs were detected between the icariin protection group and the dexamethasone group,which were significantly enriched in 17 signaling pathways.8 of the top ten selected hub genes(IL6,PTGS2,VEGFA,etc.)were confirmed by q RT-PCR.Transcription factors(TFs)-gene network showed 63 connections between 18 TFs and 12 DEGs.For instance,GATA2 could regulate 5 DEGs.The associations between 92 mi RNA and 12 DEGs were visualized in a mi RNA-gene network.The hub mi RNA,has-mir-335–5 p was predicted to interact with 8 DEGs(PTGS2,VEGFA,etc.).Microfluidic organ chips could provide excellent morphological results for cell experiments,by which it could be observed that icariin showed a protective effect on the glucocorticoid-induced injury of BMECs.Beside,these DEGs,possible regulatory TF(GATA2,FOXC1,etc.)and mi RNA(has-mir-335–5 p)might be dysregulated in the initiation of ONFH and have prospective importance in ONFH diagnosis and therapy. | Tengqi Li Qingyu Zhang Fuqiang Gao Yadi Liu Wei Sun Yiyang Dong | 2022 | Chinese Chemical Letters2022，33，6： | 1 |
| 8 | Metabolic engineering of Yarrowia lipolytica for scutellarin production显示文摘Scutellarin related drugs have superior therapeutic effects on cerebrovascular and cardiovascular diseases.Here,an optimal biosynthetic pathway for scutellarin was constructed in Yarrowia lipolytica platform due to its excellent metabolic potential.By integrating multi-copies of core genes from different species,the production of scutellarin was increased from 15.11 mg/L to 94.79 mg/L and the ratio of scutellarin to the main by-product was improved about 110-fold in flask condition.Finally,the production of scutellarin was improved 23-fold and reached to 346 mg/L in fed-batch bioreactor,which was the highest reported titer for de novo production of scutellarin in microbes.Our results represent a solid basis for further production of natural products on unconventional yeasts and have a potential of industrial implementation. | Yina Wang Xiaonan Liu Bihuan Chen Wei Liu Zhaokuan Guo Xiangyu Liu Xiaoxi Zhu Jiayu Liu Jin Zhang Jing Li Lei Zhang Yadi Gao Guanghui Zhang Yan Wang MIqbal Choudhary Shengchao Yang Huifeng Jiang | 2022 | Synthetic and Systems Biotechnology2022，7，3： | 1 |
| 9 | CT-guided implantation of radioactive 125 I seed in advanced non-small-cell lung cancer after failure of first-line chemotherapy显示文摘 | Tao Zhang Mingjian Lu Sheng Peng Weidong Zhang Guang Yang Zhenyin Liu Sristi Singh Yadi Yang Fujun Zhang Fei Gao | 2014 | Journal of Cancer Research and Clinical Oncology2014，，8： | 1 |
| 10 | A dosimetric evaluation of flattening filter-free volumetric modulated arc therapy for postoperative treatment of cervical cancer显示文摘Objective The aim of the study was to compare flattening filter-free(FFF) beams and conventional flattening filter(FF) beams in volumetric modulated arc therapy(VMAT) for cervical cancer after surgery, through a retrospective planning study.Methods VMAT plans of FFF beams and normal FF beams were designed for a cohort of 15 patients. The prescribed dose was 45 Gy to 1.8 Gy per fraction, and at least 95% of the planning target volume received this dose. Doses were computed with a commercially available treatment planning system using a Monte Carlo(MC) algorithm. Plans were compared according to dose-volume histogram analysis in terms of planning target volume homogeneity and conformity indices(HI and CI), as well as organs at risk(OAR) dose and volume parameters. Results FFF-VMAT was similar to FF-VMAT in terms of CI, but inferior to FF-VMAT considering HI. No statistically differences were observed between FFF-VMAT and FF-VMAT in following organ at risks including pelvic bone marrow, small bowel, bladder, rectum, and normal tissue(NT)..Conclusion For patients with cervical cancer after hysterectomy, the FFF beam achieved target and OAR dose distribution similar to that of the FF beam. Reduction of beam-on time in cervical cancer is beneficial. | Fuli Zhang Huayong Jiang Weidong Xu Yadi Wang Junmao Gao Qingzhi Liu Ping Wang Na Lu Diandian Chen Bo Yao Jun Hou Heliang He Jianping Chen | 2016 | Oncology and Translational Medicine2016，2，4： | 1 |
| 11 | Hydrogen peroxide overload increases adriamycin-induced apoptosis ofSaOS2FM, a manganese superoxide dismutase-overexpressing human osteosarcoma cellline显示文摘 | Yadi Wang Masahiro Kuroda Xian-Shu Gao Jun-Ichi Asaumi Kohichi Shibuya Shoji Kawasaki Shiro Akaki Daret St. Clair Yoshio Hiraki Susumu Kanazawa | 2005 | International Journal of Oncology2005，，5： | 1 |
| 12 | Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)显示文摘A lasting imbalance between fatty acid synthesis and consumption leads to non-alcoholic fatty liver disease(NAFLD),coupled with hepatitis and insulin resistance.Yet the details of the underlying mechanisms are not fully understood.Here,we unraveled that the expression of the transcription factor Zbtb18 is markedly decreased in the livers of both patients and murine models of NAFLD.Hepatic Zbtb18 knockout promoted NAFLD features like impaired energy expenditure and fatty acid oxidation(FAO),and induced insulin resistance.Conversely,hepatic Zbtb18 overexpression alleviated hepato-steatosis,insulin resistance,and hyperglycemia in mice fed on a high-fat diet(HFD)or in diabetic mice.Notably,in vitro and in vivo mechanistic studies revealed that Zbtb18 transcriptional activation of Farnesoid X receptor(FXR)mediated FAO and Clathrin Heavy Chain(CLTC)protein hinders NLRP3 inflammasome activity.This key mechanism by which hepatocyte’s Zbtb18 expression alleviates NAFLD and consequent liver fibrosis was further verified by FXR’s deletion and forced expression in mice and cultured mouse primary hepatocytes(MPHs).Moreover,CLTC deletion significantly abrogated the hepatic Zbtb18 overexpression-driven inhibition of NLRP3 inflammasome activity in macrophages.Altogether,Zbtb18 transcriptionally activates the FXR-mediated FAO and CLTC expression,which inhibits NLRP3 inflammasome’s activity alleviating inflammatory stress and insulin resistance,representing an attractive remedy for hepatic steatosis and fibrosis. | Lei Zhang Jiabing Chen Xiaoying Yang Chuangpeng Shen Jiawen Huang Dong Zhang Naihua Liu Chaonan Liu Yadi Zhong Yingjian Chen Kaijia Tang Jingyi Guo Tianqi Cui Siwei Duan Jiayu Li Shangyi Huang Huafeng Pan Huabing Zhang Xiaoqiang Tang Yongsheng Chang Yong Gao | 2024 | Signal Transduction and Targeted Therapy2024，9，2： | 0 |
| 13 | Photooligomerization Determines Photosensitivity and Photoreactivity of Plant Cryptochromes显示文摘Plant and non-plant species possess cryptochrome(CRY)photoreceptors to mediate blue light regulation of development or the circadian clock.The blue light-dependent homooligomerization of Arabidopsis CRY2 is a known early photoreaction necessary for its functions,but the photobiochemistry and function of light-dependent homooligomerization and heterooligomerization of cryptochromes,collectively referred to as CRY photooligomerization,have not been well established.Here,we show that photooligomerization is an evolutionarily conserved photoreaction characteristic of CRY photoreceptors in plants and some non-plant species.Our analyses of the kinetics of the forward and reverse reactions of photooligomerization of Arabidopsis CRY1 and CRY2 provide a previously unrecognized mechanism underlying the different photosensitivity and photoreactivity of these two closely related photoreceptors.We found that photooligomerization is necessary but not sufficient for the functions of CRY2,implying that CRY photooligomerization is presumably accompanied by additional function-empowering conformational changes.We further demonstrated that the CRY2-CRY1 heterooligomerization plays roles in regulating functions of Arabidopsis CRYs in vivo.Taken together,these results suggest that photooligomerization is an evolutionarily conserved mechanism determining the photosensitivity and photoreactivity of plant CRYs. | Qing Liu Tiantian Su Wenjin He Huibo Ren Siyuan Liu Yadi Chen Lin Gao Xiaohua Hu Haoyue Lu Shijiang Cao Ying Huang Xu Wang Qin Wang Chentao Lin | 2020 | Molecular Plant2020，13，3： | 0 |
| 14 | Dosimetric comparison of different multileaf collimators in volumetric modulated arc therapy for malignant pleural mesothelioma显示文摘Objective The aiom of the study was to compare the impacts of two types of multileaf collimators(MLC) [standard MLC with a width of 10 mm(s MLC) and micro-MLC with a width of 5 mm(m MLC)] on volumetric modulated arc therapy(VMAT) planning for malignant pleural mesothelioma. Methods VMAT for ten patients with inoperable malignant pleural mesotheliomas was retrospectively planned with the s MLC and m MLC. Histogram-based dose-volume parameters of the planning target volume(PTV) [conformity index(CI) and homogeneous index(HI)] and organs-at-risk were compared for VMAT plans with s MLC(s MLC-VMAT) and m MLC(m MLC-VMAT). Results The m MLC-VMAT plans were more efficient(average delivery time: 2.67±1.49 min) than the s MLC-VMAT plans(average delivery time: 4.21 ± 2.03 min; P < 0.05). Moreover, compared to the s MLC plans, the m MLC plans demonstrated advantages in the dose coverage of the PTV(CI 0.75 ± 0.08 vs 0.73 ± 0.09; HI 1.09 ± 0.02 vs 1.10 ± 0.02), although the difference was not statistically significant(P > 0.05). In addition, significant dose sparing in the fraction of the ipsilateral lung volume receiving > 20 Gy(V20; 54.72 ± 27.08 vs 58.52 ± 29.30) and > 30 Gy(V30; 42.74 ± 27.86 vs 46.86 ± 31.49) radiation, respectively, was observed for the m MLC plans(P < 0.05). Conclusion Comparing s MLC-VMAT and m MLC-VMAT not only demonstrated the higher efficiency and better optimal target coverage of m MLC-VMAT, but also considerably improved the dose sparing of the ipsilateral lung in the VMAT plans for malignant pleural mesothelioma. | Fuli Zhang Huayong Jiang Weidong Xu Yadi Wang Junmao Gao Qingzhi Liu Na Lu Diandian Chen Bo Yao Jun Hou Jianping Chen | 2015 | Oncology and Translational Medicine2015，1，4： | 0 |
| 15 | MDKB-Bot:A Practical Framework for Multi-Domain Task-Oriented Dialogue System显示文摘One of the major challenges to build a task-oriented dialogue system is that dialogue state transition frequently happens between multiple domains such as booking hotels or restaurants.Recently,the encoder-decoder model based on the end-to-end neural network has become an attractive approach to meet this challenge.However,it usually requires a sufficiently large amount of training data and it is not flexible to handle dialogue state transition.This paper addresses these problems by proposing a simple but practical framework called Multi-Domain KB-BOT(MDKB-BOT),which leverages both neural networks and rule-based strategy in natural language understanding(NLU)and dialogue management(DM).Experiments on the data set of the Chinese Human-Computer Dialogue Technology Evaluation Campaign show that MDKB-BOT achieves competitive performance on several evaluation metrics,including task completion rate and user satisfaction. | Yadi Lao Weijie Liu Sheng Gao Si Li | 2019 | Data Intelligence2019，1，2： | 0 |
| 16 | Dosimetric analysis of tomotherapy-based intensity-modulated radiotherapy with and without bone marrow sparing for the treatment of cervical cancer显示文摘Objective The aim of the study was to compare tomotherapy-based bone marrow-sparing intensity-modulated radiotherapy(BMS-IMRT) with intensity-modulated radiotherapy(IMRT) without entering the pelvic bone marrow as a planning constraint in the treatment of cervical cancer after hysterectomy. Methods BMS-IMRT and IMRT plans were designed for a cohort of nine patients. The prescribed dose was 45 Gy in 1.8 Gy daily fractions, and 95% of the planned target volume received this dose. The doses were computed using a commercially available treatment planning system with the convolution/superposition algorithm. Plans were compared according to dose-volume histogram analysis in terms of planning target volume homogeneity and conformity indices(HI and CI) as well as organ at risk dose and volume parameters. Results BMS-IMRT had advantages over IMRT in terms of CI, but was equivalent to the latter in HI. V5, V10, V20, V30, and V40 of pelvic bone marrow in BMS-IMRT decreased by 0.06%, 17.33%, 22.19%, 13.85%, and 16.46%, respectively, compared with IMRT. Except for V30 of the small bowel and V30 and V40 of the bladder, no statistically significant differences were found between BMS-IMRT and IMRT in the small bowel, bladder, and rectum. Conclusion For cervical cancer patients receiving tomotherapy-based radiotherapy after hysterectomy, BMS-IMRT reduced pelvic bone marrow volume receiving low-dose radiation, and it may be conducive to preventing acute hematologic toxicity. | Fuli Zhang Weidong Xu Huayong Jiang Yadi Wang Junmao Gao Qingzhi Liu Na Lu Diandian Chen Bo Yao Jianping Chen Heliang He | 2015 | Oncology and Translational Medicine2015，1，3： | 0 |
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