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| 1 | Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas显示文摘In gliomas, the canonical Wingless/Int(WNT)/b-catenin pathway is increased while peroxisome proliferator-activated receptor gamma(PPAR-c) is downregulated.The two systems act in an opposite manner. This review focuses on the interplay between WNT/b-catenin signaling and PPAR-c and their metabolic implications as potential therapeutic target in gliomas. Activation of the WNT/bcatenin pathway stimulates the transcription of genes involved in proliferation, invasion, nucleotide synthesis,tumor growth, and angiogenesis. Activation of PPAR-c agonists inhibits various signaling pathways such as the JAK/STAT, WNT/b-catenin, and PI3 K/Akt pathways,which reduces tumor growth, cell proliferation, cell invasiveness, and angiogenesis. Nonsteroidal anti-inflammatory drugs, curcumin, antipsychotic drugs, adiponectin,and sulforaphane downregulate the WNT/b-catenin pathway through the upregulation of PPAR-c and thus appear to provide an interesting therapeutic approach for gliomas.Temozolomide(TMZ) is an antiangiogenic agent. The downstream action of this opposite interplay may explain the TMZ-resistance often reported in gliomas. | AlexANDre Vallée Yves Lecarpentier Rémy Guillevin Jean-Noёl Vallée | 2018 | Neuroscience Bulletin2018，34，3： | 7 |
| 2 | Maintenance of Remission Among Patients With Crohn’s Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped显示文摘 | Edouard Louis Jean–Yves Mary Gwenola Vernier–Massouille Jean–Charles Grimaud Yoram Bouhnik David Laharie Jean–Louis Dupas Hélène Pillant Laurence Picon Michel Veyrac Mathurin Flamant Guillaume Savoye Raymond Jian Martine DeVos Rapha?l Porcher Gilles Paint | 2012 | Gastroenterology2012，，1： | 4 |
| 3 | Splenic and portal venous obstruction in chronic pancreatitis显示文摘 | Pr. Pierre Bernades André Baetz Philippe Lévy Jacques Belghiti Yves Menu Fran?ois Fékété | 1992 | Digestive Diseases and Sciences1992，，3： | 2 |
| 4 | Effect of Ischemia–Reperfusion on Bile Canalicular F-Actin Microfilaments in Hepatocytes of Human Liver Allograft显示文摘 | Liliane Benko?l Frank Dodero Jean Hardwigsen Pierre Campan Danielle Botta-Fridlund Dominique Lombardo Yves Patrice Le Treut Albert Chamlian | 2001 | Digestive Diseases and Sciences2001，，8： | 2 |
| 5 | Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3′-UTR sequence arising from a single exon显示文摘 | Laurence Bernard Christine Leroux Hélène Hayes Mathieu Gautier Yves Chilliard Patrice Martin | 2001 | Gene2001，，1： | 2 |
| 6 | Quantitative element mapping of Mg alloys by laser ablation ICP-MS and EPMA显示文摘 | Christopher L Yves M Patrik S | 2005 | Applied Surface Science2005，252，1： | 1 |
| 7 | Early postnatal food intake alters myofiber maturation in pig skeletal muscle1显示文摘 | LOUIS L PATRICK E YVES M B | 2003 | The Journal of Nutrition2003，133，1： | 1 |
| 8 | Verifying remote dataintegrity inpeer-to-peer data storage:a comprehensivesurvey ofprotocols显示文摘 | NOUHA O JEAN L YVES R | 2011 | Peer-to-Peer Networking and Applications2011，5，3： | 1 |
| 9 | Clarifying Business Models : Origins, Present, and Future of the Con-cept 显示文摘 | Osterwalder A Yves Pigneur and Chirstopher L Tucci | 2005 | Communications of the Information Systems2005，15，5： | 1 |
| 10 | A new cold-induced alfalfa gene is associated with enhanced hardening at subzero temperature显示文摘 | MONROY A F YVES C SERGE L | 1993 | Plant Physid1993，102，： | 1 |
| 11 | The PLAGL1 gene is down-regulated in human extraskeletal myxoid chondrosarcoma tumors显示文摘 | Hugo P Yves L | 2005 | Cancer Letters2005，227，： | 1 |
| 12 | Recombinant mouse OB protein:evidence for a peripheral signal linking adiposity and central neural networks显示文摘 | Arthur L C Francoise J S Yves G | 1995 | Science1995，269，： | 1 |
| 13 | Immuno- capture-RT-PCR assay for detection and molecular epidemiolo- gy studies of rabbit haemorrhagic disease and European brown hare syndrome viruses显示文摘 | GHISLAINE L G FRANCOISE Z YVES P | 2001 | J Virol Methods2001，97，12： | 1 |
| 14 | -Cycloaddition s of enantiomerically pure oxazoline-N-oxides:A short stereoselective synthesis of (+)-carbovir显示文摘 | THIERRY B YVES L | 1995 | Tetrahydron Letters1995，36，31： | 1 |
| 15 | Rheological Pro- perties of Hyperbranched Polymer/Poly (ethylene tereph- thalate) Reactive Blends显示文摘 | Seung B K Yannick A Yves L | 2003 | Polymer Engineering and Sci- ence2003，43，2： | 1 |
| 16 | Patient participation:current knowledge and applicability to patient safety 显示文摘 | Yves L Hugo S Lucian LL | 2010 | Mayo Clin Proe2010，85，1： | 1 |
| 17 | Safety, Feasibility, and Short-Term Outcomes of Single Port Access Colorectal Surgery: A Single Institutional Case-Matched Study显示文摘 | Sébastien Gaujoux Léon Maggiori Frédéric Bretagnol Marianne Ferron Yves Panis | 2012 | Journal of Gastrointestinal Surgery2012，，3： | 1 |
| 18 | Strategic Agility A Leadership Agenda for Accelerating Business Model Renewal 显示文摘 | Embedding Yves L Doz Mikko Kosonen | 2009 | Long Range Planning2009，43，： | 1 |
| 19 | Influence of the adhesive thickness and steel plate thickness on the behavior of strengthened concrete beams 显示文摘 | Alex L Tchao A Yves D | 2000 | Journal of Adhesion Science and Technology2000，14，13： | 1 |
| 20 | Long‐term survival after hepatic and pulmonary resection of colorectal cancer metastases显示文摘 | Isabelle Sourrouille Pierre Mordant Léon Maggiori Safi Dokmak Guy Lesèche Yves Panis Jacques Belghiti Yves Castier | 2013 | J Surg Oncol2013，，4： | 1 |
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