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| 1 | Validation of the Rockall scoring system for outcomes from non-variceal upper gastrointestinal bleeding in a Canadian setting显示文摘AIM: To validate the Rockall scoring system for predicting outcomes of rebleeding, and the need for a surgical procedure and death. METHODS: We used data extracted from the Registry of Upper Gastrointestinal Bleeding and Endoscopy including information of 1869 patients with non-variceal upper gastrointestinal bleeding treated in Canadian hospitals. Risk scores were calculated and used to classify patients based on outcomes. For each outcome, we used χ2 goodness-of-fit tests to assess the degree of calibration, and built receiver operating characteristic curves and calculated the area under the curve (AUC) to evaluate the discriminative ability of the scoring system. RESULTS: For rebleeding, the χ2 goodness-of-fit test indicated an acceptable fit for the model [χ2 (8) = 12.83, P = 0.12]. For surgical procedures [χ2 (8) = 5.3, P = 0.73] and death [χ2 (8) = 3.78, P = 0.88], the tests showed solid correspondence between observed proportions and predicted probabilities. The AUC was 0.59 (95% CI: 0.55-0.62) for the outcome of rebleeding and 0.60 (95% CI: 0.54-0.67) for surgical procedures, representing apoor discriminative ability of the scoring system. For the outcome of death, the AUC was 0.73 (95% CI: 0.69-0.78), indicating an acceptable discriminative ability. CONCLUSION: The Rockall scoring system provides an acceptable tool to predict death, but performs poorly for endpoints of rebleeding and surgical procedures. | Robert A Enns Yves M Gagnon Alan N Barkun David Armstrong Jamie C Gregor Richard N Fedorak RUGBE Investigators Group | 2006 | World Journal of Gastroenterology2006，12，48： | 14 |
| 2 | Rationale for the potential use of mesenchymal stromal cells in liver transplantation显示文摘Mesenchymal stromal cells(MSCs) are multipotent and self-renewing cells that reside essentially in the bone marrow as a non-hematopoietic cell population, but may also be isolated from the connective tissues of most organs. MSCs represent a heterogeneous population of adult, fibroblast-like cells characterized by their ability to differentiate into tissues of mesodermal lineages including adipocytes, chondrocytes and osteocytes. For several years now, MSCs have been evaluated for their in vivo and in vitro immunomodulatory and ‘tissue reconstruction' properties, which could make them interesting in various clinical settings, and particularly in organ transplantation. This paper aims to review current knowledge on the properties of MSCs and their use in pre-clinical and clinical studies in solid organ transplantation, and particularly in the field of liver transplantation. The first available clinical data seem to show that MSCs are safe to use, at least in the medium-term, but more time is needed to evaluate the potential adverse effects of long-term use. Many issues must be resolved on the correct use of MSCs. Intensive in vitro and pre-clinical research are the keys to a better understanding of the way that MSCs act, and to eventually lead to clinical success. | Morgan Vandermeulen Céline Grégoire Alexandra Briquet Chantal Lechanteur Yves Beguin Olivier Detry | 2014 | World Journal of Gastroenterology2014，20，44： | 2 |
| 3 | Laparoscopic subtotal colectomy for acute or severe colitis complicating inflammatory bowel disease: A case-matched study in 88 patients显示文摘 | Cécile Marceau Arnaud Alves Mehdi Ouaissi Yoram Bouhnik Patrice Valleur Yves Panis | 2007 | Surgery2007，，5： | 2 |
| 4 | Progressive necrosis after hepatectomy and the pathophysiology of liver failure after massive resection显示文摘 | Yves Panis David M McMullan Jean C Emond | 1997 | Surgery1997，，2： | 2 |
| 5 | Autosomal dominant polycystic kidney disease显示文摘 | Vicente E Torres Peter C Harris Yves Pirson | 2007 | The Lancet2007，，9569： | 2 |
| 6 | A new cold-induced alfalfa gene is associated with enhanced hardening at subzero temperature显示文摘 | MONROY A F YVES C SERGE L | 1993 | Plant Physid1993，102，： | 1 |
| 7 | Artificial aeration to increase pollutant removal efficiency of constructed wetlands in cold climate显示文摘 | CLAUDIANE O P FLORENT C YVES C | 2006 | Ecological Engineering2006，27，3： | 1 |
| 8 | Emulsions stabilized with solid nanoparticles: Pickering emulsions 显示文摘 | YVES C MARIE - ALEXANDRINE B | 2013 | Colloids and Surfaces A: Physicochemical Engineering Aspects2013，439，： | 1 |
| 9 | Tricuspid valve replacement: an analysis of 25 years of experience at a single center显示文摘 | Michel Carrier Yves Hébert Michel Pellerin Denis Bouchard Louis P Perrault Raymond Cartier Arsène Basmajian Pierre Pagé Nancy C Poirier | 2003 | The Annals of Thoracic Surgery2003，，1： | 1 |
| 10 | Recombinant mouse OB protein:evidence for a peripheral signal linking adiposity and central neural networks显示文摘 | Arthur L C Francoise J S Yves G | 1995 | Science1995，269，： | 1 |
| 11 | Photosynthetic bradyrhizobia are natural endophytes of the African wild rice Oryza breviliguulata 显示文摘 | CLEMENCE C ERIC G YVES P | 2000 | Appl Environ Microbiol2000，，2： | 1 |
| 12 | PIS path modeling显示文摘 | MICHEL T VINCENZO E V YVES - MARIE C | 2005 | Computational Statistics & Data Analysis2005，48，1： | 1 |
| 13 | Multi scale modeling of grouted sand behavior显示文摘 | Pierre Yves H Ching S C Christophe D | | 0，，： | 1 |
| 14 | 显示文摘 | Yves C Joris V D K Frits C R S | 2002 | Discrete Applied Mathematics2002，123，： | 1 |
| 15 | Quantitative Genetic Bases of Anthocyanin Variation in Grape (Vitis vinifera L. ssp. sativa) Berry: A Quantitative Trait Locus to Quantitative Trait Nucleotide Integrated Study显示文摘 | Fournier-Level Alexandre Le Cunff Lo?c Gomez Camila Doligez Agnès Ageorges Agnès Roux Catherine Bertrand Yves Souquet Jean-Marc Cheynier Véronique This Patrice | 2009 | Genetics2009，，3： | 1 |
| 16 | Oxidative injury and antioxidant genes regulation in cadmium-exposed radicles of six contrasted Medicago truncatula genotypes显示文摘 | Sondès Rahoui Cécile Ben Abdelilah Chaoui Yves Martinez Ahad Yamchi Martina Rickauer Laurent Gentzbittel Ezzeddine El Ferjani | 2014 | Environmental Science and Pollution Research2014，，13： | 1 |
| 17 | Structural and functional analysis of E6 oncoprotein:insights in the molecular pathways of human papillomavirus-mediated pathogenesis显示文摘 | Yves N Murielle M Sebastian C | 2006 | Molecular Cell2006，21，5： | 1 |
| 18 | Endogenous control 0f hippocampal epileptogenesis:a molecular cascade involving BDNF and NPY显示文摘 | Sophie R Yves L Josette C et a1 | 2000 | Epilepsia2000，6，： | 1 |
| 19 | Quantitative DSC evaluation of phase segregation rate in linear segmented polyurethanes and polyurethaneureas显示文摘 | Pierre P J C Yves | 1983 | Journal of Polymer Science: Polymer Chemistry Edition1983，21，： | 1 |
| 20 | β1 -Integrin Signaling Mediates Premyelinating Oligodendrocyte Survival But Is Not Required for CNS Myelination and Remyelination显示文摘 | Yves B Holly C Tina T | 2006 | J Neurosci2006，26，7： | 1 |
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