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| 1 | Influence of soil type and genotype on Cd bioavailability and uptake by rice and implications for food safety显示文摘Cadmium(Cd) entering the human body via the food chain is of increasing concern.This study investigates the effects of soil type and genotype on variations in the Cd concentrations of different organs of nine rice plants grown on two types of soils with two Cd levels.Cd concentrations in nine rice cultivars varied significantly with genotype and soil type(P < 0.01).The Cd concentration was higher in red paddy soil(RP) than in yellow clayey paddy soil(YP).The average Cd concentrations of different organs in three rice types were indica > hybrid > japonica for the Cd treatments and controls.The polished grain concentration in YP and RP soils had a range of 0.055-0.23 mg/kg and 0.13-0.36 mg/kg in the Cd treatment,respectively.Two rice cultivars in YP soil and five rice cultivars in RP soil exceeded the concentration limits in the Chinese Food Hygiene Standard(0.2 mg/kg).The Cd concentrations in roots,stems,and leaves were all significantly and positively correlated to that in polished grain in a single test.The Cd concentrations in polished grain were positively and significantly(P < 0.01) correlated with the calculated transfer factors of stem to grain and leaf to grain Cd transfer.The results indicated that the variations of Cd concentration in grain were related to Cd uptake and the remobilization of Cd from stem and leaf to grain.Also,the cultivars with a strong tendency for Cd-accumulation should be avoided in paddy soil with low soil pH and low organic matter content to reduce the risks to human health from high Cd levels in rice. | Xinxin Ye Yibing Ma Bo Sun | 2012 | Journal of Environmental Sciences2012，24，9： | 34 |
| 2 | Distribution of organic carbon fractions in soil aggregates in Chinese fir plantations with different stand ages显示文摘Background:Revealing the variations in soil aggregate-related organic carbon(OC)and labile organic carbon(LOC)fractions in a chronosequence of Chinese fir plantations plays an important role in better understanding the impact of soil carbon sink or source on the Chinese fir plantation ecosystem.In this study,soil samples in a depth of 0–20 cm were collected from Chinese fir plantations at different stand ages(0,9,17,and 26 years old)in Guangxi,China.With the optimal moisture sieving method adopted,the soil aggregates of 4 different sizes were obtained,including>2-mm,2–1-mm,1–0.25-mm,and<0.25-mm aggregates.Soil OC and LOC fractions were measured in the aggregates of different sizes.The LOC fractions included readily oxidizable carbon(ROC),particulate organic carbon(POC),microbial biomass carbon(MBC),water-soluble organic carbon(WOC),and mineralized organic carbon(MOC).Results:Soil aggregate stability,as indicated by the mean weight diameter(MWD),was the highest in the 17-yearold Chinese fir plantations and was significantly positively related(p<0.05)to the concentrations of OC and LOC fractions(except for the ROC and MOC),with the POC in particular.As for all stand ages of Chinese fir plantations,the concentrations of soil OC and LOC fractions were significantly increased as the aggregate size decreased.Consequently,there were more OC and LOC fractions distributed in the<0.25-mm aggregates.During the stand development,the concentrations of soil OC and LOC fractions first increased and then decreased,with the highest levels detected in the 17-year-old Chinese fir plantations,indicating that the 17-year-old Chinese fir plantations were conducive to the accumulation of soil OC and LOC fractions.Conclusion:After 17 years of planting,promoted soil carbon(especially for the POC)accumulation contributes significantly to enhancing soil aggregate stability for the Chinese fir plantations in Guangxi,China. | Xinxin He Yongzhen Huang Qianchun Zhang Shaoming Ye Shengqiang Wang | 2021 | Ecological Processes2021，10，1： | 11 |
| 3 | The Security Analysis of Quantum SAGR04 Protocol in Collective-Rotation Noise Channel显示文摘Noise exists in the actual communication environment. It is necessary and significant to analyze the security of SAGR04 protocol in the noise environment. An excellent model of collective rotation noise analysis is introduced and the discussing of the security of SAGR04 protocol is based on the method of information theory. The eavesdropping can be detected for the increment of the qubit error rate and eavesdropper can maximally get about50% of the keys. It can be concluded that the SAGR04 protocol, used as quantum key distribution, is secure. | LI Jian PAN Zeshi ZHENG Jun SUN Fengqi YE Xinxin YUAN Kaiguo | 2015 | Chinese Journal of Electronics2015，24，4： | 6 |
| 4 | Mandible exosomal ssc-mir-133b regulates tooth development in miniature swine via endogenous apoptosis显示文摘Signal transduction between different organs is crucial in the normal development of the human body. As an important medium for signal communication, exosomes can transfer important information, such as microRNAs(miRNAs), from donors to receptors.MiRNAs are known to fine-tune a variety of biological processes, including maxillofacial development; however, the underlying mechanism remains largely unknown. In the present study, transient apoptosis was found to be due to the expression of a miniature swine maxillofacial-specific miRNA, ssc-mir-133b. Upregulation of ssc-mir-133b resulted in robust apoptosis in primary dental mesenchymal cells in the maxillofacial region. Cell leukemia myeloid 1(Mcl-1) was verified as the functional target, which triggered further downstream activation of endogenous mitochondria-related apoptotic processes during tooth development.More importantly, mandible exosomes were responsible for the initial apoptosis signal. An animal study demonstrated that ectopic expression of ssc-mir-133 b resulted in failed tooth formation after 12 weeks of subcutaneous transplantation in nude mice. The tooth germ developed abnormally without the indispensable exosomal signals from the mandible. | Ye Li Xinxin Wang Jiali Ren Xiaoshan Wu Guoqing Li Zhipeng Fan Chunmei Zhang Ang Li Songlin Wang | 2018 | Bone Research2018，6，4： | 5 |
| 5 | Screening hydroxyapatite for cadmium and lead immobilization in aqueous solution and contaminated soil:The role of surface area显示文摘Hydroxyapatite(HAP) has been widely used to immobilize many cationic metals in water and soils. The specific reason why an increase in the surface area of HAP enhances cadmium(Cd) uptake, but has no effect on lead(Pb) uptake, is not clear. The aim of this study was to determine the factors causing the differences in sorption behavior between Cd and Pb by evaluating HAPs with different surface areas. We synthesized HAPs with two different surface areas, which were characterized by X-ray diffraction, N_2 adsorption, and scanning electron microscopy, and then evaluated them as sorbents for Cd and Pb removal by testing in single and binary systems. The sorption capacity of large surface area HAP(1.85 mmol/g) for Cd in the single-metal system was higher than that of small surface area HAP(0.64 mmol/g), but there were no differences between single- and binary-metal solutions containing Pb. After the Cd experiments, the HAP retained a stable structure and intact morphology, which promotes the accessibility of reactive sites for Cd. However, a newly formed precipitate covered the surface and blocked the channels in the presence of Pb, which reduced the number of potential adsorption sites on HAP for Cd and Pb.Remediation experiments using Cd- and Pb-contaminated soil produced similar results to the solution tests. These results indicate that alterations of the structure and morphology during the reaction is an important factor influencing metal sorption to HAP. | Hongying Li Xisheng Guo Xinxin Ye | 2017 | Journal of Environmental Sciences2017，29，2： | 5 |
| 6 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 7 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 8 | Improved Eavesdropping Detection Strategy Based on Extended Three-particle Greenberger-Horne-Zeilinger State in Two-step Quantum Direct Communication Protocol显示文摘 | LI Jian YE Xinxin LI Ruifan ZOU Yongzhong LU Xiaofeng | 2012 | Chinese Journal of Electronics2012，21，4： | 4 |
| 9 | A comparison study of the start-up of a MnO_x filter for catalytic oxidative removal of ammonium from groundwater and surface water显示文摘As an efficient method for ammonium(NH_4^+)removal,contact catalytic oxidation technology has drawn much attention recently,due to its good low temperature resistance and short start-up period.Two identical filters were employed to compare the process for ammonium removal during the start-up period for ammonium removal in groundwater(Filter-N)and surface water(Filter-S)treatment.Two types of source water(groundwater and surface water)were used as the feed waters for the filtration trials.Although the same initiating method was used,Filter-N exhibited much better ammonium removal performance than Filter-S.The differences in catalytic activity among these two filters were probed using X-ray diffraction(XRD),scanning electron microscopy(SEM),X-ray photoelectron spectroscopy(XPS),and compositional analysis.XRD results indicated that different manganese oxide species were formed in Filter-N and Filter-S.Furthermore,the Mn3p XPS spectra taken on the surface of the filter films revealed that the average manganese valence of the inactive manganese oxide film collected from Filter-S(FS-MnO_x)was higher than in the film collected from Filter-N(FN-MnO_x).Mn(IV)was identified as the predominant oxidation state in FS-MnO_xand Mn(III)was identified as the predominant oxidation state in FN-MnO_x.The results of compositional analyses suggested that polyaluminum ferric chloride(PAFC)used during the surface water treatment was an important factor in the mineralogy and reactivity of MnO_x.This study provides the theoretical basis for promoting the wide application of the technology and has great practical significance. | Ya Cheng Ye Li Tinglin Huang Yuankui Sun Xinxin Shi Yuezong Shao | 2018 | Journal of Environmental Sciences2018，30，3： | 4 |
| 10 | Enrichment of Cd^(2+) from water with a calcium alginate hydrogel filtration membrane显示文摘A new method was developed for effective enrichment of Cd2+ ions from water with a calcium alginate(CaAlg) hydrogel filtration membrane. First, the CaAlg hydrogel filtration membrane was prepared without a pore-forming agent. This membrane was used to remove Cd^(2+) via ion exchange with Ca^(2+), and the Cd^(2+) was preserved in the CaAlg hydrogel. Then, the CaAlg hydrogel containing Cd^(2+) was soaked in a sodium citrate solution, and the hydrogel was fully dissolved. The removal rate of the CaAlg filtration membrane reached almost 100% within 120 min when the Cd^(2+) concentration was under 1 mg/L. Factors affecting the removal rate were investigated, such as NaAlg concentration, operating pressure, operating time and the initial concentration of Cd^(2+). The effects of initial Cd^(2+) concentration, pressure and filtration time on the enrichment factor were also investigated. The results show that the enrichment factor reached 87.3 when the pressure was 0.18 MPa and the filtration time was 240 min. Different enrichment factors could be achieved by adjusting the operating pressure and filtration time. | ZHAO YuJie ZHAO KongYin LI Ye LIU Liang ZHANG XinXin LI JinGang CHEN Min WANG XiaoLei | 2018 | Science China(Technological Sciences)2018，61，3： | 2 |
| 11 | Bidirectional Clone Node Model of Optimizing Performance of Structured P2P Overlay Network显示文摘In order to reduce the maintenance cost of structured Peer-to-Peer (P2P),Clone Node Protocol (CNP) based on user behavior is proposed.CNP considers the regularity of user behavior and uses the method of clone node.A Bidirectional Clone Node Chord model (BCNChord) based on CNP protocol is designed and realized.In BCNChord,Anticlockwise Searching Algorithm,Difference Push Synchronize Algorithm and Optimal Maintenance Algorithm are put forward to increase the performances.In experiments,according to the frequency of nodes,the maintenance cost of BCNChord can be 3.5%~32.5% lower than that of Chord.In the network of 212 nodes,the logic path hop is steady at 6,which is much more prior to 12 of Chord and 10 of CNChord.Theoretical analysis and experimental results show that BCNChord can effectively reduce the maintenance cost of its structure and simultaneously improve the query efficiency up to (1/4)O(logN).BCNChord is more suitable for highly dynamic environment and higher real-time system. | Zhang Yu Hao Ying Ye Xinxin Li Yongzhen | 2012 | China Communications2012，9，4： | 1 |
| 12 | The next steps in academic integrity-education,awareness,norms,duty and law显示文摘We conducted and analyzed several internet surveys in order to understand the profile of global research integrity and ethical awareness,encompassing global population distribution.These were(1)the global distribution of Committee of Publishing Ethics(COPE)membership;(2)the global distribution of“Integrity”or“Ethics”journals;(3)the level of academic integrity awareness in European higher education institutions and(4)awareness of academic integrity in the top universities of Asia and Africa.The results of this survey series highlight seriously imbalanced awareness of research integrity and publishing ethics across the world,especially in developing areas with the highest population density.We therefore propose a new index,the“Academic Integrity Awareness Index”for future discussions across the linked spheres of publishing and research. | Yuehong(Helen)Zhang Hanfeng Lin Xinxin Zhang Qing Ye | 2021 | Forensic Sciences Research2021，6，3： | 1 |
| 13 | Controlled Teleportation of Two-Partic le Entanglement via a Cluster State显示文摘In order to teleport an unknown two-particle entangled state via a cluster state,a controlled teleportation scheme is proposed.It is shown that an unknown two-particle entangled state can be successfully transmitted from the sender Alice to the receiver Bob with the help of the supervisor Charlie via the only one four-particle cluster state.The receiver can reconstruct the teleported state according to the measurement results of the sender and supervisor.Quantum Controlled-NOT (CNOT) gate and POVM are used,which have been accomplished in a quantum experiment,so it is believed that this scheme will be realized by experiment.By analysis,the success probability of the proposed scheme reaches 1.0. | Li Jian Ye Xinxin Li Ling | 2012 | China Communications2012，9，9： | 1 |
| 14 | Direct Conversion of Glucose to 5-Hydroxymethylfurfural over Zirconium Phosphate Catalyst in a Biphasic System显示文摘Efficient and selective production of 5-hydroxymethylfurfural(HMF) from glucose was achieved in the presence of zirconium phosphate(ZrPO) catalyst in a biphasic system.With the use of this catalyst,a high HMF yield of 56.8% was obtained from glucose in a water-tetrahydrofuran(THF) biphasic system.Characterization results showed that such catalyst had weak to strong acid sites and contained both Lewis and Br?nsted acid sites.The results of comparative experiments over some other solid acid catalysts demonstrated that the Lewis acid sites on the ZrPO catalyst played a crucial role in the isomerization of glucose to fructose and the Br?nsted ones were active in the dehydration of generated fructose to HMF.Moreover,less levulinic acid(LA) and formic acid(FA)(0.5%) were detected in the reaction solution,indicating that this ZrPO catalyst exhibited high selectivity towards the formation of HMF.Furthermore,the ZrPO catalyst was very stable and could maintain its activity after being used for six times. | Zhao Hong Ye Xinxin Yan Rui Liu Xiaohui Guo Yong Wang Yanqin | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，2： | 1 |
| 15 | Efficient control of chronic LCMV infection by a CD4 T cell epitope-based heterologous prime-boost vaccination in a murine model显示文摘CD4^(+)T cells are essential for sustaining CD8^(+)T cell responses during a chronic infection.The adoptive transfer of virus-specific CD4^(+)T cells has been shown to efficiently rescue exhausted CD8^(+)T cells.However,the question of whether endogenous virus-specific CD4^(+)T cell responses can be enhanced by certain vaccination strategies and subsequently reinvigorate exhausted CD8^(+)T cells remains unexplored.In this study,we developed a CD4^(+)T cell epitope-based heterologous prime-boost immunization strategy and examined the efficacy of this strategy using a mouse model of chronic lymphocytic choriomeningitis virus(LCMV)infection.We primed chronically LCMV-infected mice with a Listeria monocytogenes vector that expressed the LCMV glycoprotein-specific I-Ab-restricted CD4^(+)T cell epitope GP61–80(LM-GP61)and subsequently boosted the primed mice with an influenza virus A(PR8 strain)vector that expressed the same CD4^(+)T cell epitope(IAV-GP61).This heterologous prime-boost vaccination strategy elicited strong anti-viral CD4^(+)T cell responses,which further improved both the quantity and quality of the virusspecific CD8^(+)T cells and led to better control of the viral loads.The combination of this strategy and the blockade of the programmed cell death-1(PD-1)inhibitory pathway further enhanced the anti-viral CD8^(+)T cell responses and viral clearance.Thus,a heterologous prime-boost immunization that selectively induces virus-specific CD4^(+)T cell responses in conjunction with blockade of the inhibitory pathway may represent a promising therapeutic approach to treating patients with chronic viral infections. | Ran He Xinxin Yang Cheng Liu Xiangyu Chen Lin Wang Minglu Xiao Jianqiang Ye Yuzhang Wu Lilin Ye | 2018 | Cellular & Molecular Immunology2018，15，9： | 1 |
| 16 | Double‐Filtration Plasmapheresis for Treatment of Acute Renal Failure in a Multiple Myeloma Patient显示文摘 | Xinxin Jiang Jian Feng Youxin Ye | 2014 | Ther Apher Dial2014，，3： | 1 |
| 17 | Highly selective electrocatalytic Cl− oxidation reaction by oxygen-modified cobalt nanoparticles immobilized carbon nanofibers for coupling with brine water remediation and H2 production显示文摘Combining the H2 production with brine remediation is regarded as a sustainable approach to achieving clean H2 energy. However, designing stable Cl− oxidation reaction (COR) electrocatalyst is the key to realize this route. Herein, a type of oxygen-modified Co nanoparticles anchored graphitic carbon nanofibers catalyst (Co/GCFs) was synthesized through a two-step strategy of adsorption and pyrolysis. The Co/GCFs-2.4 exhibits high selectivity and stability for COR at neutral electrolyte. It is worth noting that unlike the water oxidation, the chemical valence of cobalt has not changed during the COR. Further results demonstrated that the oxygen-modified Co nanoparticles provide active sites for selective COR, meanwhile, the graphitic carbon gives rise to strong catalytic stability. Thanks to the superior COR and H2 production activity of Co/GCFs-2.4, a two-electrode brine electrocatalysis system employing Co/GCFs-2.4 as both cathode and anode for H2 production exhibited robust stability, efficient and high Faraday efficiency (98%-100%). We propose that this work provides a novel strategy for designing efficient and stable catalysts with electrocatalytic COR and HER activities at neutral brine water for practically coupling with H2 production by water electrolysis and brine water remediation. | Qizhong Xiong Xian Zhang Qipeng Cheng Guoqiang Liu Gang Xu Junli Li Xinxin Ye Hongjian Gao | 2021 | Nano Research2021，14，5： | 1 |
| 18 | Dental stem cell-derived extracellular vesicles transfer miR-330-5p to treat traumatic brain injury by regulating microglia polarization显示文摘Traumatic brain injury(TBI)contributes to the key causative elements of neurological deficits.However,no effective therapeutics have been developed yet.In our previous work,extracellular vesicles(EVs)secreted by stem cells from human exfoliated deciduous teeth(SHED)offered new insights as potential strategies for functional recovery of TBI.The current study aims to elucidate the mechanism of action,providing novel therapeutic targets for future clinical interventions.With the mi RNA array performed and Real-time PCR validated,we revealed the crucial function of mi R-330-5p transferred by SHED-derived EVs(SHED-EVs)in regulating microglia,the critical immune modulator in central nervous system.Mi R-330-5p targeted Ehmt2 and mediated the transcription of CXCL14 to promote M2 microglia polarization and inhibit M1 polarization.Identified in our in vivo data,SHED-EVs and their effector mi R-330-5p alleviated the secretion of inflammatory cytokines and resumed the motor functional recovery of TBI rats.In summary,by transferring mi R-330-5p,SHED-EVs favored anti-inflammatory microglia polarization through Ehmt2 mediated CXCL14transcription in treating traumatic brain injury. | Ye Li Meng Sun Xinxin Wang Xiaoyu Cao Na Li Dandan Pei Ang Li | 2022 | International Journal of Oral Science2022，14，4： | 1 |
| 19 | Peroxiredoxin 1 is a tumor-associated antigen in esophageal squamouscell carcinoma显示文摘 | Pengfei Ren Hua Ye Liping Dai Mei Liu Xinxin Liu Yurong Chai Qing Shao Yang Li Ningjing Lei Bo Peng Wu Yao Jianying Zhang | 2013 | Oncology Reports2013，，5： | 1 |
| 20 | Proliferative capacity of stem/progenitor-like cells in the kidney may associate with the outcome of patients with acute tubular necrosis显示文摘 | Youxin Ye Bingyin Wang Xinxin Jiang Weiming Hu Jian Feng Hua Li Mei Jin Yingjuan Ying Wenjuan Wang XiaoOu Mao Kunlin Jin | 2011 | Human Pathology2011，，8： | 1 |
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