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| 1 | Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis显示文摘The 'a disintegrin and metalloprotease' (ADAM) family contributes to regulation of the cell-cell and cell-matrix interactions that are critical determinants of malignancy. To determine the relationship between metastasis and ADAM proteins, we compared the mRNA levels of ADAM9,-10,-12,-15, and-17 in sublines of an EBC-1 lung cancer cell line that were highly metastatic to either brain or bone. ADAM9 mRNA levels were significantly higher in highly brain-metastatic sublines than in the parent or highly bonemetastalic sublines. To elucidate the role ofADAM9 in brain metastasis, we stably transfected A549 and EBC-1 cells with a fulllength ADAM9 expression vector. Compared with mock-transfectants, ADAM9 overexpression resulted in increased invasive capacity | Shintani Y Higashiyama S Ohta M Hirabayashi H Yamamoto S Yoshimasu T Matsuda H Matsuura N | 2004 | 中国神经肿瘤杂志2004，2，2： | 36 |
| 2 | ^(11)C-methionine (MET) and ^(18)F-fluorothymidine (FLT) PET in patients withnewly diagnosed glioma显示文摘Eur J Nucl Med Mol Imaging. 2008 Jun 10.PURPOSE: The purpose of this prospective study was to clarify the individual and combined role of L: -methyl-(11)C-methionine-positron emission tomography (MET-PET) and 3' -deoxy-3' -[(18)F]fluorothymidine (FLT)-PET in tumor detection,noninvasive grad-ing, and assessment of the cellular proliferation rate in newly diagnosed histologically verified gliomas of different grades. MATERI- | Hatakeyama T Kawai N Nishiyama Y Yamamoto Y Sasakawa Y Ichikawa T Tamiya T | 2008 | 中国神经肿瘤杂志2008，6，2： | 11 |
| 3 | In vitro anti-human immunodeficiency virus activity of polysaccharide from Rhizophora mucronata 显示文摘 | Premanathan M Kathiresan K Yamamoto N | 1999 | Biosci Biotechnol Biochem1999，63，7： | 2 |
| 4 | Expression transforming growth factor-βeta isoforms in human glomerular disease显示文摘 | YAMAMOTO T NOBLE N A COHEN A H | 1996 | Kidney Int1996，49，2： | 2 |
| 5 | Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer:a randomised phase 3 study显示文摘 | Boku N Yamamoto S Fukuda H | | 0，，11： | 2 |
| 6 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 7 | 初产妇和经产妇妊娠期间的诊室和家庭血压显示文摘妊娠高血压可导致分娩时产生严重的并发症,如脑卒中、早产或低出生体质量。初产妇被认为是妊娠高血压的一个危险因素。产次与妊娠期间家庭血压相关性仍不明确。方法:入选初产妇和经产妇共575名,评估妊娠高血压和先兆子痫的发病率。收集在一家日本产科医院接受产前检查的530名正常血压孕妇的家庭和诊室血压值。诊室血压为产前检查2次测量的血压平均值,参与者妊娠期间每日清晨在家自测血压。 | Ishikuro M Obara T Metoki H Ohkubo T Yamamoto M Akutsu K Sakurai K Iwama N Katagiri M Yagihashi K Yaegashi N Mori S Suzuki M Kuriyama S Imai Y 罗冬梅 叶鹏 | 2013 | 中华高血压杂志2013，21，6： | 2 |
| 8 | Nucleotide sequence and molecular characterization of a dextranase gene from streptococcus downei 显示文摘 | Igarashi T Yamamoto A Goto N | 2001 | Microbiol Immunol2001，45，5： | 1 |
| 9 | Mechanism of zeolite synthesis from coal fly ash by alkali hydrothermal reaction显示文摘 | MURAYAMA N YAMAMOTO H SH1BATA J | 2002 | International Journal of Mineral Processing2002，，： | 1 |
| 10 | Zero-strain insertion material of Li O4 for rechargeable lithium cells 显示文摘 | OHZUKU T UEDA A YAMAMOTO N | 1995 | J Electrochem Soc1995，142，： | 1 |
| 11 | 显示文摘 | Baba N Tajima S | 1981 | Nature1981，289，： | 1 |
| 12 | Stromal cell-de-rived factor- 1 (SDF- 1 ) acts together with thrombopoietin to enhance the development of megakaryeeytic progenitor cells (CFU-MK)显示文摘 | Fujii N Yamamoto N | 2000 | Blood2000，95，3： | 1 |
| 13 | The prognostic value of both neuron-specific-enolase (NSE) and Cyfra21-1 in small cell lung cancer显示文摘 | ANDO S SUZUKI M YAMAMOTO N | 2004 | Anticacer Res2004，24，3： | 1 |
| 14 | The transsphenoidal removal of nonfunetioning pituitary adenomas with suprasellar extensions: the open sella methold and intentionally staged operation 显示文摘 | Saito K Kuwayama A Yamamoto N | 1995 | Neurosurgery1995，36，4： | 1 |
| 15 | 显示文摘 | Ohzuku T Yamamoto N Ueda A | 1995 | J Electrochem Soc1995，142，5： | 1 |
| 16 | Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study 显示文摘 | Boku N Yamamoto S Fukuda H | 2009 | Lancet Oncol2009，10，11： | 1 |
| 17 | Transcriptional roles of nuclear factor B and nuclear factor-interleukin-6 in the tumor nec- rosis factor α-dependent induction of cyclooxygenase-2 in MC3T3- E1 cells显示文摘 | Yamamoto K Arakawa T Ueda N | 1995 | J Biol Chem1995，270，31： | 1 |
| 18 | Establishment and characterization of an erythropoietin-dependent subline, UT-7/EPO, derived from human leukemia cell line, UT-7 显示文摘 | Komatsu N Yamamoto M Fujita H | 1993 | Blood1993，82，2： | 1 |
| 19 | Randomized phase III study of 5-fluorouracil (5-FU) alone versus combination of irinotecan and cisplatin (CP) versus S-1 alone in advanced gastric cancer (JCOG9912)显示文摘 | Boku N Yamamoto S Shirao K | | Proc Am Soc Clin Oncol0，25，： | 1 |
| 20 | Human Urine Dnase Ⅰ :Immunological Identity with Human Pancreatic DNase Ⅰ , and Enzymic and Proteochemical Properties of the Enzyme显示文摘 | Ito K Minamiura N Yamamoto T | 1984 | J Biochem1984，95，： | 1 |
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