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| 1 | Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis显示文摘The 'a disintegrin and metalloprotease' (ADAM) family contributes to regulation of the cell-cell and cell-matrix interactions that are critical determinants of malignancy. To determine the relationship between metastasis and ADAM proteins, we compared the mRNA levels of ADAM9,-10,-12,-15, and-17 in sublines of an EBC-1 lung cancer cell line that were highly metastatic to either brain or bone. ADAM9 mRNA levels were significantly higher in highly brain-metastatic sublines than in the parent or highly bonemetastalic sublines. To elucidate the role ofADAM9 in brain metastasis, we stably transfected A549 and EBC-1 cells with a fulllength ADAM9 expression vector. Compared with mock-transfectants, ADAM9 overexpression resulted in increased invasive capacity | Shintani Y Higashiyama S Ohta M Hirabayashi H Yamamoto S Yoshimasu T Matsuda H Matsuura N | 2004 | 中国神经肿瘤杂志2004，2，2： | 36 |
| 2 | 机器人辅助与传统腹腔镜低位前切除术治疗直肠癌的疗效比较:日本国家临床数据库的倾向性匹配研究显示文摘目的:机器人辅助腹腔镜手术与传统腹腔镜手术相比有一些优势。但基于人群的直肠癌低位前切除术的比较研究有限。本研究旨在比较机器人辅助腹腔镜低位前切除术(RALAR)和传统腹腔镜手术的围手术期结果。方法:采用回顾性队列研究的方法,分析日本国家临床数据库中2018年10月至2019年12月期间接受RALAR或传统腹腔镜低位前切除术(CLLAR)治疗的直肠癌患者的临床数据。 | 池诏丞 MATSUYAMA T ENDO H YAMAMOTO H | 2021 | 结直肠肛门外科2021，27，6： | 5 |
| 3 | Expression transforming growth factor-βeta isoforms in human glomerular disease显示文摘 | YAMAMOTO T NOBLE N A COHEN A H | 1996 | Kidney Int1996，49，2： | 2 |
| 4 | Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer:a randomised phase 3 study显示文摘 | Boku N Yamamoto S Fukuda H | | 0，，11： | 2 |
| 5 | Fourier-transform speckle profilometry: three-dimensional shape measurements of diffuse objects with Large height steps and/or spatially isolated surfaces显示文摘 | Takeda M Yamamoto H | 1994 | Appl Opt1994，33，34： | 2 |
| 6 | Indications for lymph node dissection in the treatment of extrmammary Paget's disease显示文摘 | Tsutaumida A Yamamoto Y Minakawa H | 2003 | Dermatol Surg2003，29，1： | 2 |
| 7 | Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol,independent of body mass index,in the Japanese population显示文摘 | Yamamoto Y Hirose H Saito I | 2002 | Clin Sci (Lond)2002，103，： | 2 |
| 8 | Chemical analysis of surfaces by total-reflection-angle X-ray spectroscopy in rheed experiments (rheed-traxs)显示文摘 | HASEGAWA S YAMAMOTO 1 Y DAIMON H | 1985 | Jpn J Appl Phys1985，24，6： | 2 |
| 9 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 10 | 胃肠道T细胞淋巴瘤的临床病理谱系:基于T细胞受体免疫表型的重新评估分析显示文摘胃肠道原发性EBV相关T细胞淋淋巴瘤(GITCL)的鉴别诊断包括肠病相关性T细胞淋巴瘤(EATL)、非特指外周T细胞淋巴瘤、成人T细胞性白血病/淋巴瘤以及间变大细胞淋巴瘤。Ⅱ型EATL被认为是一种上皮内淋巴细胞肿瘤。然而活检标本中对于上皮内淋巴细胞增多的诊断具有挑战性,导致在EATL及非特指外周T细胞淋巴瘤之间的诊断困难。这就要求我们建立更实用的GITCL诊断策略。 | Tanaka T Yamamoto H Elsayed A A 魏建国 刘勇 | 2016 | 临床与实验病理学杂志2016，32，9： | 2 |
| 11 | 初产妇和经产妇妊娠期间的诊室和家庭血压显示文摘妊娠高血压可导致分娩时产生严重的并发症,如脑卒中、早产或低出生体质量。初产妇被认为是妊娠高血压的一个危险因素。产次与妊娠期间家庭血压相关性仍不明确。方法:入选初产妇和经产妇共575名,评估妊娠高血压和先兆子痫的发病率。收集在一家日本产科医院接受产前检查的530名正常血压孕妇的家庭和诊室血压值。诊室血压为产前检查2次测量的血压平均值,参与者妊娠期间每日清晨在家自测血压。 | Ishikuro M Obara T Metoki H Ohkubo T Yamamoto M Akutsu K Sakurai K Iwama N Katagiri M Yagihashi K Yaegashi N Mori S Suzuki M Kuriyama S Imai Y 罗冬梅 叶鹏 | 2013 | 中华高血压杂志2013，21，6： | 2 |
| 12 | Hindlimb suspension induces the expression of multiple myosin heavy chain isoforms in single fibres of the rat soleus muscle显示文摘 | Oishi Y Ishihara A Yamamoto H | 1998 | Acta Physiol Scand1998，162，2： | 2 |
| 13 | Protective effect of Irsogladine on monochloramineinduced gastric mucosallesions in rats:a comparative study with rebamipide显示文摘AIM To examine the effect of irsogladine, a novel antiulcer drug, on the mucosal ulcerogenic response to monochloramine (NH 2Cl) in rat stomach, in comparison with rebamipide, another antiulcer drug with cytoprotective activity. METHODS AND RESULTS Oral administration of NH 2Cl (120*!mM) produced severe hemorrhagic lesions in unanesthetized rat stomachs. Both irsogladine ( 1*!mg/*!kg - 10*!mg/*!kg , po ) and rebamipide ( 30*!mg/*!kg - 100*!mg/*!kg , po ) dose dependently prevented the development of these lesions in response to NH 2Cl, the effect of irsogladine was significant at 3*!mg/*!kg or greater, and that of rebamipide only at 100*!mg/*!kg . The protective effect of irsogladine on NH 2Cl induced gastric lesions was significantly reduced by N G nitro L arginine methyl ester (L NAME) but not by indomethacin, while that of rebamipide was significantly mitigated by indomethacin but not by L NAME. Topical application of NH 2Cl (20*!mM) caused a marked reduction of potential difference (PD) in ex vivo stomachs. This PD reduction was not affected by mucosal application of irsogladine, but significantly prevented by rebamipide. The mucosal exposure to NH 4OH (120*!mM) also caused a marked PD reduction in the ischemic stomach (bleeding from the carotid artery), resulting in gastric lesions. These ulcerogenic and PD responses caused by NH 4OH plus ischemia were also significantly mitigated by rebamipide, in an indomethacin sensitive manner, while irsogladine potently prevented such lesions without affecting the PD response, in a L NAME sensitive manner. CONCLUSION These results suggest that ① NH 2Cl generated either exogenously or endogenously damages the gastric mucosa, ② both irsogladine and rebamipide protect the stomach against injury caused by NH 2Cl, and ③ the mechanism underlying the protective action of irsogladine is partly mediated by endogenous nitric oxide, while that of rebamipide is in part mediated by endogenous prostaglandins. | H Yamamoto, M Umeda, H Mizoguchi, S Kato and K Takeuchi | 1999 | World Journal of Gastroenterology1999，5，6： | 2 |
| 14 | Temperature-dependent distribution of internal magnetic fields at 57Fe nuclei in FCC iron-nickel alloys显示文摘 | Tomiyoshi S Yamamoto H Watanabe H | 1971 | J Phys Soc JPN1971，30，： | 2 |
| 15 | Metallothionein expression correlates with the pathological response of patients with esophageal cancer undergoing preoperative chemoradiation therapy显示文摘 | Yamamoto M Tsujinake T Shiozaki H | 1999 | Oncology1999，56，4： | 1 |
| 16 | Activation of AMP-activated Protein Kinase Induces p53-dependent Apoptotic Cell Death in Response to Energetic Stress 显示文摘 | Okoshi R Ozaki T Yamamoto H | 2008 | J Biol Chem2008，283，7： | 1 |
| 17 | Mechanism of zeolite synthesis from coal fly ash by alkali hydrothermal reaction显示文摘 | MURAYAMA N YAMAMOTO H SH1BATA J | 2002 | International Journal of Mineral Processing2002，，： | 1 |
| 18 | Ductile aluminum-base amorphous alloys with two separate phases显示文摘 | Inoue A Yamamoto M Kimura H M | 1987 | J Mater Sci Lett1987，6，1： | 1 |
| 19 | Bisphenol A in hazardous waste landfill leachates 显示文摘 | Yamamoto T Yasuhara A Shiraishi H Yamamoto A Yasuhara H Shiraishi H Nakasugi O | 2001 | Chemosphere2001，42，： | 1 |
| 20 | In vitro and in vivo release of vas~:ular endothelial growth factor from gelatin microparticles and biodegradable composite scaffolds 显示文摘 | Patel ZS Ueda H Yamamoto M | 2008 | Pharm Res2008，25，10： | 1 |
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