|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical Observation of Transepithelial Corneal Collagen Cross-linking by Iontophoresis of Riboflavin in Treatment of Keratoconus显示文摘Purpose: To evaluate the efficacy and safety of transepithelial collagen cross-linking by iontophoretic delivery of riboflavin in treatment of progressive keratoconus.Methods:.Eleven patients(15 eyes) with progressive keratoconus were enrolled. After 0.1% riboflavin-distilled water solution was deliveried via transepithelial iontophpresis for 5 min with 1 m A current, and ultraviolet radiation(370 nm,.3 m W /cm2) was performed at a 1.5 cm distance for 30 min. The follow up were 6 months in all eyes. The uncorrected visual acuity, corrected visual acuity,endothelial cell counting, corneal thickness,.intraocular pressure, corneal curvature, corneal topography,.OCT and corneal opacity before and 6-month after surgery were analyzed.Results: At 6 month postoperatively, mean uncorrected visual acuity and corrected visual acuity changed from 0.36 to 0.30 and from 0.42 to 0.57 without statistical significance..The mean value of each index of corneal curvature declined without statistical significance.Kmax value dereased from 60.91 to59.91, and the astigmatism declined from 3.86 to 3.19. Central corneal thickness decreased from 460.93 μm to 455.40μm,.and thinnest corneal thickness declined from 450.87 μm to 440.60 μm with no statistical significance..Intraocular pressure was significantly elevated from 10.85 mm Hg to 12.62 mm Hg. Endothelial cell count did not change significantly. No corneal haze occurred. Mean depth of corneal demarcation line was 288.46 μm at 1 month postoperatively..Conclusion:.Transepithelial corneal collagen cross-linking by iontophoresis is effective and safe in the treatment of progressive keratoconus, and yields stable clinical outcomes during 6-month follow up..However,.long-term follow up is urgently required. | Na Li Zhengjun Fan Xiujun Peng Xu Pang Chunyu Tian | 2014 | Eye Science2014，29，3： | 15 |
| 2 | Preparation of carbon-coated iron oxide nanoparticles dispersed on graphene sheets and applications as advanced anode materials for lithium-ion batteries显示文摘 | Huilong Fei Zhiwei Peng Lei Li Yang Yang Wei Lu Errol L. G. Samuel Xiujun Fan James M. Tour | 2014 | Nano Research2014，7，4： | 10 |
| 3 | Iontophoretic Delivery of Riboflavin into the Rabbit Cornea:a Primary Study显示文摘Purpose: To determine the penetrability of riboflavin into the corneal stroma by iontophoresis and to compare the permeability effects of different solvents.Methods: Twenty rabbits were randomly divided into four groups: a group that received 0.1% riboflavin-balanced salt solution(BSS) by iontophoresis, a group that received 0.1%riboflavin-saline solution by iontophoresis, a group that received 0.1% riboflavin-distilled water solution by iontophoresis, and a control group that received classical riboflavin instillation after corneal de-epithelialization. The degree of yellowing of the de-epithelialized corneal stromal button from each rabbit was compared.Results: The yellow color scores for the corneal stromal buttons in the three iontophoresis groups were compared with those of control group. Iontophoretic delivery of a 0.1% riboflavin-distilled water solution yielded similar yellow changes in the corneal stromal button when compared with classical riboflavin instillation after de-epithelialization. However, the other two solvents did not sufficiently enhance the permeability of riboflavin.Conclusion: Riboflavin can effectively penetrate into the corneal stroma to saturation levels by iontophoresis. Using distilled water as the solvent can promote penetrability. | Na Li Xiujun Peng Zhengjun Fan Yu Xia | 2014 | Eye Science2014，29，1： | 9 |
| 4 | The role of P2X7 receptor in ATP-mediated human leukemia cell death: calcium influx-independent显示文摘P2X7 受体的激活导致阳离子的快速的、双向流动,引起包括 cytotoxicity 的生物回答的宽广范围。然而,调停 P2X7 的 cytotoxicity 的机制仍然保持大部分未经勘探。在我们的以前的学习,在正常条件下面的调停 P2X7 的钙反应的缺乏在 P2X7+ 造血的房间线被发现。在这研究,在房间的不同类型的调停 P2X7 的 cytotoxicity (P2X7 ? ,有钙反应的 P2X7+ ,和没有钙反应的 P2X7+) 被调查。我们的结果证明 P2X7 收缩筋,腺苷 5-triphosphate ( ATP )或2,3-O-( 4 benzoylbenzoyl )-ATP, dose-dependently 在测试的所有P2X7+房间减少了房间生存能力,包括为 调停P2X7 的钙反应否定的 J6-1 , LCL ,和 Namalva 房间,尽管这些效果比在有正常 P2X7 功能的 KG1a 房间观察的那些低。细胞毒素的效果能被 P2X7 对手,氧化 ATP 和 1- 堵住[N, O 二度(5-isoquinolinesulfonyl )-N-methyl-l-tyrosyl]-4-phenylpiperazine。另外, phosphatidylserine 的外表表现能以一种时间依赖者方式和 apoptotic 被检测词法变化能在 J6-1 房间在 P2X7 受体的激活以后被观察。而且,调停 P2X7 的毛孔形成能在低离子的条件下面,然而并非在低二价的条件下面在 KG1a 和 J6-1 房间被检测。这些效果不能在 P2X7 被观察吗?Ramos 房间。这些结果建议 P2X7 调停受体的细胞毒素的效果可以发生独立于钙反应。 | Xiujun Zhang Lijun Meng Baoling He Jing Chen Peng Liu Jie Zhao Yufen Zhang Ming Li Dong An | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 7 |
| 5 | Corneal refractive surgery and phakic intraocular lens for treatment of amblyopia caused by high myopia or anisometropia in children显示文摘 | Tian Chunyu Peng Xiujun Fan Zhengjun Yin Zhengqin | 2014 | Chinese Medical Journal2014，，11： | 6 |
| 6 | Clinical Evaluation of Pranoprofen Combined with Fluorometholone Eye Drops on Postoperative Reaction of Corneal Cross-linking显示文摘Purpose:To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL). Methods:Twenty-seven patients (38 eyes) with keratoconus undergoing CXL were examined and randomly divided into control (12 cases; 18 eyes) and experimental groups (15 cases;20 eyes).The patients in the control group were given fluorometholone eye drops,and those in the experimental group were administered with fluorometholone combined with pranoprofen eye drops.Corneal irritation and haze were compared between the two groups at 1 month postoperatively. Results:At 1 to 3 days after surgery,the corneal irritation in the experimental group was significantly reduced compared with that in the control group (P<0.05), but there was no significant difference on 5 to 7 days postoperatively (P>0.05). The average degree of haze in the experimental group was significantly lower than that in the control group 1 month after surgery (P<0.05), but there was no significant difference in the best-corrected vision acuity and intraocular pressure between the two groups. There were 2 cases with >20 mmHg intraocular pressure in the control group. Conclusion:The combined use of fluorometholone and pranoprofen can significantly reduce inflammatory response,alleviate corneal irritation at early stage after CXL,effectively prevent and control the average of haze,and reduce the incidence of steroid-induced ocular hypertension after surgery. | Xu Pang Zhengjun Fan Xiujun Peng Hongzhen Jia Tengfei Wu | 2012 | Eye Science2012，27，4： | 4 |
| 7 | Surface Roughness and Roundness of Bearing Raceway Machined by Floating Abrasive Polishing and Their Effects on Bearing's Running Noise显示文摘As the two most important indexes of bearing raceway,surface roughness and roundness have significant influence on bearing noise.Some researchers have carried out studies in this field,however,reason and extent of the influence of raceway surface geometric characteristics on bearing running noise are not perfectly clear up to now.In this paper,the raceway of 6309 type bearing’s inner and outer ring is machined by floating abrasive polishing adopting soft abrasive pad.Surface roughness parameters,arithmetical mean deviation of the profile Ra,the point height of irregularities Rz,maximum height of the profile Rmax and roundness f of raceways,are measured before and after machining,and the change rules of the measured results are studied.The study results show that the floating abrasive polishing can reduce the surface geometric errors of bearing raceway evidently.The roundness error is reduced by 25%,Rmax value is reduced by 35.5%,Rz value is reduced by 22%and Ra value is reduced by 5%.By analyzing the change of the geometrical parameters and the shape difference of the raceway before and after machining,it is found that the floating abrasive polishing method can affect the roundness error mainly by modifying the local deviation of the raceway’s surface profile.Bearings with different raceway surface geometrical parameter value are assembled and the running noise is tested.The test results show that Ra has a little,Rmax and Rz have a measurable,and the roundness error has a significant influence on the running noise.From the viewpoint of controlling bearings’running noise,raceway roundness error should be strictly controlled,and for the surface roughness parameters,Rmax and Rz should be mainly controlled.This paper proposes an effective method to obtain the low noise bearing by machining the raceway with floating abrasive polishing after super finishing. | PANG Guibing QI Xuezhi MA Qinyi ZHAO Xiujun WEN Chunsheng XU Wenji PENG Yanping | 2014 | Chinese Journal of Mechanical Engineering2014，27，3： | 3 |
| 8 | 2020 Roadmap on two-dimensional nanomaterials for environmental catalysis显示文摘Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical processes.Photocatalysis and electrocatalysis play important roles in these fields.They can decompose and remove organic pollutants from the aqueous environment,and prepare some fine chemicals.Moreover,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted reactions.In recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural characteristics.Great progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and others.This content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental catalysis.We hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions. | Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei Song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 9 | HSP70 alleviates sepsis-induced cardiomyopathy by attenuating mitochondrial dysfunction-initiated NLRP3 inflammasome-mediated pyroptosis in cardiomyocytes显示文摘Background:Sepsis-induced cardiomyopathy(SIC)is an identified serious complication of sepsis that is associated with adverse outcomes and high mortality.Heat shock proteins(HSPs)have been implicated in suppressing septic inflammation.The aim of this study was to investigate whether HSP70 can attenuate cellular mitochondrial dysfunction,exuberated inflammation and inflammasome-mediated pyroptosis for SIC intervention.Methods:Mice with cecal ligation plus perforation(CLP)and lipopolysaccharide(LPS)-treated H9C2 cardiomyocytes were used as models of SIC.The mouse survival rate,gross profile,cardiac function,pathological changes and mitochondrial function were observed by photography,echocardiography,hematoxylin-eosin staining and transmission electron microscopy.In addition,cell proliferation and the levels of cardiac troponin I(cTnI),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)were determined by Cell Counting Kit-8,crystal violet staining and enzyme-linked immunosorbent assay.Moreover,mitochondrial membrane potential was assessed by immunofluorescence staining,and dynamin-related protein 1 and pyroptosis-related molecules[nucleotide-binding domain,leucine-rich-repeat containing family pyrin domain-containing 3(NLRP3),caspase-1,gasdermin-D(GSDMD),gasdermin-D N-terminal(GSDMD-N)]were measured by western blotting,immunoprecipitation and immunoblotting.Finally,hsp70.1 knockout mice with CLP were used to verify the effects of HSP70 on SIC and the underlying mechanism.Results:Models of SIC were successfully established,as reduced consciousness and activity with liparotrichia in CLP mice were observed,and the survival rate and cardiac ejection fraction(EF)were decreased;conversely,the levels of cTnI,TNF-αand IL-1βand myocardial tissue damage were increased in CLP mice.In addition,LPS stimulation resulted in a reduction in cell viability,mitochondrial destabilization and activation of NLRP3-mediated pyroptosis molecules in vitro.HSP70 treatment improved myocardial tissue damage,survival rate and cardiac dysfunction caused by CLP.Additionally,HSP70 intervention reversed LPS-induced mitochondrial destabiliza-tion,inhibited activation of the NLRP3 inflammasome,caspase-1,GSDMD and GSDMD-N,and decreased pyroptosis.Finally,knockout of hsp70.1 mice with CLP aggravated cardiac dysfunction and upregulated NLRP3 inflammasome activity,and exogenous HSP70 significantly rescued these changes.It was further confirmed that HSP70 plays a protective role in SIC by attenuating mitochondrial dysfunction and inactivating pyroptotic molecules.Conclusions:Our study demonstrated that mitochondrial destabilization and NLRP3 inflammasome activation-mediated pyroptosis are attributed to SIC.Interestingly,HSP70 ameliorates sepsis-induced myocardial dysfunction by improving mitochondrial dysfunction and inhibiting the acti-vation of NLRP3 inflammasome-mediated pyroptosis,and such a result may provide approaches for novel therapies for SIC. | Chenlu Song Yiqiu Zhang Qing Pei Li Zheng Meiyu Wang Youzhen Shi Shan Wu Wei Ni Xiujun Fu Yinbo Peng Wen Zhang Min Yao | 2022 | Burns & Trauma2022，10，1： | 2 |
| 10 | Completed Laparoscopic Pancreaticoduodenectomy显示文摘 | Xiujun Cai Yifan Wang Hong Yu Xiao Liang Bin Xu Shuyou Peng | 2008 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2008，，4： | 1 |
| 11 | Lap- aroscopic hepatectomy for hepatolithiasis: a feasibility and safety study in 29 patients 显示文摘 | Xiujun Cai Yifan Wang Hong Yu Xiao Liang Shuyou Peng | 2007 | Surg Endosc2007，21，： | 1 |
| 12 | Research Progress in Corneal Cross-linking Agents显示文摘Corneal collagen cross-linking with UVA-riboflavin is currently the only method for preventing the progression of keratoconus from the pathological perspective. Topical application of a direct cross-linking agent is now attracting widespread attention in clinical settings..This article reviews the research progress in the application of indirect or direct cross-linking agents(e.g., riboflavin, glucose, ribose, glutaraldehyde,formaldehyde,.glyceraldehyde,.short chain aliphatic β-nitro alcohol, and genipin) in the treatment of corneal diseases and analyzes the cross-linking efficacy,.toxicity,.and merits and disadvantages of each cross-linking agent,.providing clinical information for further studies. | Na Li Xiujun Peng Zhengjun Fan | 2014 | Eye Science2014，29，2： | 1 |
| 13 | New techniques to improve classical corneal collagen cross-linking treatment显示文摘 | Li Na Peng Xiujun Fan Zhengjun Xia Yu Wu Tengfei | 2014 | Chinese Medical Journal2014，，8： | 1 |
| 14 | Identification of publication characteristics and research trends in the management of gallbladder cancer显示文摘Background:To date,no comprehensive analysis of gallbladder cancer(GBC)management has been reported.We aimed to identify the publication characteristics and research trends in managing GBC over the past three decades.Methods:We selected the 100 most cited articles and performed a bibliometric analysis to summarize the publication characteristics,explore research hotspots,and identify research trends in the management of GBC.Results:The total citations of the included articles ranged from 123 to 1822.Period II(2001–2010)yielded the highest number of included articles,whereas the lowest was in Period III(2011–2020).The United States and Japan published the most papers,in which the Memorial Sloan–Kettering Cancer Center and Nagoya University were the leading institutions,respectively.The most influential authors were Blumgart LH and Fong YM from the United States.Cooperation among countries,institutions,and authors was weak.The Annals of Surgery contributed the most articles with the highest number of total citations.The most researched topic was surgery,followed by systemic therapy and adjuvant therapy.Since Period I,the percentage of surgery-related publications continuously decreased(Periods II and III versus Period I,both p<0.001),with a concomitant increase in those of adjuvant therapy(Period III versus Period I,p=0.004)and systemic therapy(Period II versus Period I,p=0.004;Period III versus Period I,p=0.002).Conclusions:Surgery remains the preferred treatment,while there is a tendency toward adjuvant and systemic therapy in GBC management.An increase in local and international collaboration for managing GBC is required. | Jiasheng Cao Jiahao Hu Jiliang Shen Bin Zhang Win Topatana Shijie Li Tianen Chen Sarun Jeungpanich Yitong Tian Ziyi Lu Shuyou Peng Xiujun Cai Mingyu Chen | 2022 | iLIVER2022，1，2： | 0 |
| 15 | In vivo Implantation of Hydrophobic Acrylic Intraocular Lenses with Surface Modification显示文摘Purpose:To assess the surface properties of modified hydrophobic acrylic intraocular lenses (IOL) implanted in rabbits.Methods:.The hydrophobic acrylic IOLs were modified with monomer vinyl pyrrolidone by surface modification technique.Phacoemulsification combined with IOL implantation was conducted in 9 rabbits (18 eyes).Postoperative responses were observed by slit-lamp microscope at 3,.7,.15,.30,.90 days after surgery.Results:.During the early stage after IOL implantation,corneal edema and anterior chamber fibrin exudation were observed.The exudate fluid was almost absorbed at the 15th day postoperatively.At 7th day,the anterior chamber exudation in the modification group was significantly less severe than that in non-modification group(P<0.05).Posterior capsular opacification occurred at 30th day after surgery and was aggravated90 days later.IOL dislocation was seen in 5 eyes and occlusion of pupil in 3 eyes.Conclusion:The hydrophobic acrylic IOLs with surface modification have improved surface properties and higher uveal biocompatibility. | Guiqin Wang Liqun Cao Na Li Xiujun Peng Huiqin Tang Rongxin Wan Hanqing Gu | 2013 | Eye Science2013，28，4： | 0 |
| 16 | Variation in Central Corneal Thickness during Open- or Closed-Eye Riboflavin Instillation for Corneal Collagen Cross-linking显示文摘Purpose:To assess the effect of having an open or closed eye on the variation in central corneal thickness during riboflavin instillation for corneal collagen cross-linking (CXL).Methods:.Thirty eyes of 15 New Zealand White rabbits underwent an in vivo anterior segment optical coherence tomography (OCT) examination at 0,10,20,and 30 min after riboflavin instillation on the de-epithelialized corneal surface.Each eye of every rabbit was randomly placed into one of two different treatment groups(open-eye or closed-eye)during the instillation;.the examinations were performed one after the other.After instillation for 30 min,the changes in the corneal stroma and anterior chamber were observed by slit lamp.Results:.A significant decrease in the central corneal thickness(CCT).was demonstrated during riboflavin instillation;.the variations were smaller in the measurements performed with the eye closed than with the eye open.(81.36±15.13μm and129.20±12.05μm respectively)..Both methods turned the corneal stroma and anterior chamber yellow.Conclusion:Keeping the eye closed during riboflavin instillation reduced the decrease in the CCT..The same yellow change in the corneal stroma and anterior chamber occurred,but the exposure time of the ocular surface was shorter.Therefore,.keeping the eye closed was a more effective and safer method than keeping the eye open. | Na Li Xiujun Peng Zhengjun Fan Xu Pang Yu Xia | 2013 | Eye Science2013，28，4： | 0 |
| 17 | Comparison of Central Corneal Thickness using Ultrasound Pachymetry during Corneal Collagen Cross-linking显示文摘Purpose:To study variation in central corneal thickness (CCT) during corneal collagen cross-linking(CXL) using ultrasound pachymetry. Methods:Twenty patients (26 eyes) with progressing keratoconus undergoing riboflavin-UVA-induced CXL were involved in this study. Intraoperative CCT measurement using ultrasonic pachymetry was performed during the procedure.Measurements were obtained before operation, after epithelial removal, after riboflavin drop instillation, and after UVA irradiation. Results:Mean CCT was 495±56 and 450±52 μm before and after epithelial removal, respectively. Mean CCT was 443±42 and 411±39 μm after riboflavin drop instillation and after UVA irradiation, respectively. Statistically significant decreases in CCT occurred between the preoperative period and after epithelial removal, after riboflavin drop instillation and after UVA irradiation. Twenty-six eyes from 20 patients undergoing CXL were divided into 2 groups (I with CCT≥400 μm after UVA irradiation and II with CCT<400 μm after UVA irradiation). No statistically significant difference was noted between I and II in preoperative endothelial cell count, but a statistically greater postoperative endothelial cell count was noted in I compared to II. A statistically significant difference was evident between preoperative and postoperative endothelial cell counts in Group II (P<0.05). Conclusion:Performing CXL with the use of riboflavin and UVA irradiation resulted in a statistically significant decrease in CCT, to a level where the corneal endothelium may be damaged.(Eye Science 2013; 28:15-19) | Xu Pang Xiujun Peng Zhengjun Fan Hongzhen Jia Tengfei Wu | 2013 | Eye Science2013，28，1： | 0 |
| 18 | A histological examination of corneal epithelium after iontophoresis with different riboflavin solutions显示文摘To the Editor:Currently,from a pathological point of view,corneal collagen crosslinking(CXL)with riboflavin is the only new therapy for controlling keratoconus progression.Riboflavin,as a photosensitizer,can be activated after the ultraviolet radiation in the cornea and prevent it from damaging intraocular organizations.Therefore,the concentration of riboflavin in the corneal stroma must be maintained at a sufficient level during the treatment.[1]Riboflavin,a type of water-soluble macromolecule,is resistant to permeating the corneal epithelial barrier.Thus,de-epithelial eye-dripping was adopted conventionally with complications such as inevitable pain,long recovery time,potential risk of infection,and so on;transepithelial corneal CXL is increasingly becoming a research hotspot.It is thus critically important to improve the transepithelial penetration of riboflavin.Although iontophoresis was reported,it had a slightly higher effect with no clear mechanism analysis.[2,3,4]Corneal epithelium is lipophilic and hydrophobic,and hydrophilic drugs enter corneal stroma via intercellular pathways.In this study,permeability effects of riboflavin in different solvents into the cornea via iontophoresis were compared,and the changes of corneal epithelial cell layer organizations were analyzed to examine the solvent components that are most beneficial to iontophoresis and investigate the underlying mechanism of the penetration effect. | Na Li Zhengjun Fan Xiujun Peng | 2022 | Chinese Medical Journal2022，，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员