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| 1 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 2 | Nonhuman primate models of focal cerebral ischemia显示文摘Rodents have been widely used in the production of cerebral ischemia models. However, successful therapies have been proven on experimental rodent stroke model, and they have often failed to be effective when tested clinically. Therefore, nonhuman primates were recommended as the ideal alternatives, owing to their similarities with the human cerebrovascular system, brain metabolism, grey to white matter ratio and even their rich behavioral repertoire. The present review is a thorough summary of ten methods that establish nonhuman primate models of focal cerebral ischemia; electrocoagulation, endothelin-1-induced occlusion, microvascular clip occlusion, autologous blood clot embolization, balloon inflation, microcatheter embolization, coil embolization, surgical suture embolization, suture, and photochemical induction methods. This review addresses the advantages and disadvantages of each method, as well as precautions for each model, compared nonhuman primates with rodents, different species of nonhuman primates and different modeling methods. Finally it discusses various factors that need to be considered when modelling and the method of evaluation after modelling. These are critical for understanding their respective strengths and weaknesses and underlie the selection of the optimum model. | Jingjing Fan Yi Li Xinyu Fu Lijuan Li Xiaoting Hao Shasha Li | 2017 | Neural Regeneration Research2017，12，2： | 14 |
| 3 | Enhancement of acellular cartilage matrix scaffold by Wharton’s jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration显示文摘Articular cartilage defect repair is a problem that has long plagued clinicians.Although mesenchymal stem cells(MSCs)have the potential to regenerate articular cartilage,they also have many limitations.Recent studies have found that MSC-derived exosomes(MSC-Exos)play an important role in tissue regeneration.The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix(ACECM)scaffold and to explore the underlying mechanism.The results of in vitro experiments show that human umbilical cord Wharton’s jelly MSC-Exos(hWJMSC-Exos)can promote the migration and proliferation of bone marrow-derived MSCs(BMSCs)and the proliferation of chondrocytes.We also found that hWJMSC-Exos can promote the polarization of macrophages toward the M2 phenotype.The results of a rabbit knee osteochondral defect repair model confirmed that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration.We demonstrated that hWJMSC-Exos can regulate the microenvironment of the articular cavity using a rat knee joint osteochondral defect model.This effect was mainly manifested in promoting the polarization of macrophages toward the M2 phenotype and inhibiting the inflammatory response,which may be a promoting factor for osteochondral regeneration.In addition,microRNA(miRNA)sequencing confirmed that hWJMSC-Exos contain many miRNAs that can promote the regeneration of hyaline cartilage.We further clarified the role of hWJMSC-Exos in osteochondral regeneration through target gene prediction and pathway enrichment analysis.In summary,this study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. | Shuangpeng Jiang Guangzhao Tian Zhen Yang Xiang Gao Fuxin Wang Juntan Li Zhuang Tian Bo Huang Fu Wei Xinyu Sang Liuqi Shao Jian Zhou Zhenyong Wang Shuyun Liu Xiang Sui Quanyi Guo Weimin Guo Xu Li | 2021 | Bioactive Materials2021，6，9： | 11 |
| 4 | Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line treatment: a retrospective study of 251 cases显示文摘有在 2002 和 2008 之间治疗的上皮的卵巢的癌症(EOC ) 的 251 个病人的一个总数回顾地被分析调查长期的结果和这些病人的预示的因素,特别地,经历了主要 debulking 外科的那些由基于铂的化疗列在后面。包括没有前进的幸存(PFS ) 和全面幸存(OS ) , Clinicopathological 参数也被分析。从到 2010 年 6 月的起始的治疗的结束的中部的后续时期是 58 个月。三年的 PFS 率为妇科学和产科学(FIGO ) I-II 的国际联盟是 61.7% , 19.9% 为 FIGO III-IV,并且 33.9% 为所有阶段。由比较,五年的 PFS 率为 FIGO I-II 是 44.6% , 17.7% 为 FIGO III-IV,并且 28.3% 为所有阶段。三年的 OS 率为 FIGO I-II 是 67.9% , 41.7% 为 FIGO III-IV,并且 50.2% 为所有阶段。五年的 OS 率为 FIGO I-II 是 52.7% , 30.8% 为 FIGO III-IV,并且 39.2% 为所有阶段。Univariate 分析表明先进 FIGO 舞台,浆液 CA125,和非最优的 debulking 是影响 PFS 和 OS 的重要因素。在 multivariate 分析, PFS 被 FIGO 舞台和非最优的 debulking 显著地影响。然而, OS 被先进 FIGO 舞台显著地仅仅影响。我们的学习证实外科的功效为 EOC 由基于铂的化疗列在后面。FIGO 舞台与 EOC 被看作病人的预后的最可靠的预言者之一。 | Yunfeng Fu Xinyu Wang Zimin Pan Xing Xie | 2014 | Frontiers of Medicine2014，8，1： | 6 |
| 5 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 6 | Catalytic Enantioselective Simultaneous Control of Axial Chirality and Central Chirality in Allenes显示文摘 | Jianxin Dai Xinyu Duan Jing Zhou Chunling Fu Shengming Ma | 2018 | Chinese Journal of Chemistry2018，36，5： | 5 |
| 7 | A Self-Powered Breath Analyzer Based on PANI/PVDF Piezo-Gas-Sensing Arrays for Potential Diagnostics Application显示文摘The increasing morbidity of internal diseases poses serious threats to human health and quality of life.Exhaled breath analysis is a noninvasive and convenient diagnostic method to improve the cure rate of patients. In this study, a self-powered breath analyzer based on polyaniline/polyvinylidene fluoride(PANI/PVDF) piezogas-sensing arrays has been developed for potential detection of several internal diseases. The device works by converting exhaled breath energy into piezoelectric gassensing signals without any external power sources. The five sensing units in the device have different sensitivities to various gas markers with concentrations ranging from 0 to 600 ppm. The working principle can be attributed to the coupling of the in-pipe gas-flow-induced piezoelectric effect of PVDF and gas-sensing properties of PANI electrodes. In addition, the device demonstrates its use as an ethanol analyzer to roughly mimic fatty liver diagnosis.This new approach can be applied to fabricating new exhaled breath analyzers and promoting the development of self-powered systems. | Yongming Fu Haoxuan He Tianming Zhao Yitong Dai Wuxiao Han Jie Ma Lili Xing Yan Zhang Xinyu Xue | 2018 | Nano-Micro Letters2018，10，4： | 4 |
| 8 | Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy显示文摘Nanoparticulate drug delivery systems(Nano-DDSs) have emerged as possible solution to the obstacles of anticancer drug delivery. However, the clinical outcomes and translation are restricted by several drawbacks, such as low drug loading, premature drug leakage and carrier-related toxicity.Recently, pure drug nano-assemblies(PDNAs), fabricated by the self-assembly or co-assembly of pure drug molecules, have attracted considerable attention. Their facile and reproducible preparation technique helps to remove the bottleneck of nanomedicines including quality control, scale-up production and clinical translation. Acting as both carriers and cargos, the carrier-free PDNAs have an ultra-high or even100% drug loading. In addition, combination therapies based on PDNAs could possibly address the most intractable problems in cancer treatment, such as tumor metastasis and drug resistance. In the present review, the latest development of PDNAs for cancer treatment is overviewed. First, PDNAs are classified according to the composition of drug molecules, and the assembly mechanisms are discussed. Furthermore, the co-delivery of PDNAs for combination therapies is summarized, with special focus on the improvement of therapeutic outcomes. Finally, future prospects and challenges of PDNAs for efficient cancer therapy are spotlighted. | Shuwen Fu Guanting Li Wenli Zang Xinyu Zhou Kexin Shi Yinglei Zhai | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 4 |
| 9 | The molecular determinants governing the immunogenicity of Japanese encephalitis live attenuated vaccines显示文摘In the course of isolating the attenuated Japanese encephalitis vaccine SA14-14-2,two attenuated strains SA14-9-7 and SA14-5-3 were also obtained that elicited low antibody responses in humans(o10%and 62%,respectively)and exerted much weaker immune protection in animal challenge experiments.However,the reason for these differences remains unknown.In order to understand why SA14-14-2 is superior to SA14-9-7 and SA14-5-3,we employed a reverse genetics method to identify the key mutations in the virus genome that determine the immunogenicity of live attenuated Japanese encephalitis viruses.We first sequenced the full genomic sequences of SA14-9-7 and SA14-5-3 and found mutations that changed four amino-acid base pairs when compared to the envelope gene of SA14-14-2.We mutated the genome of SA14-14-2 to generate these mutations both singly(E-177,E-264,E-279 and E-315)and in combination(E-177/264,E-279/315 and E-177/264/279/315)and tested these mutants along with parental strains SA14-14-2,SA14-9-7 and SA14-5-3 for their immunogenicity in vivo.When mice were immunized with SA14-9-7 and SA14-5-3,lower levels of neutralizing antibodies were generated compared with the immune response to SA14-14-2.Furthermore,SA14-5-3 was more immunogenic than SA14-9-7,which replicated the results previously seen in humans.Point mutations E-177,E-264,E-279 and E-315 diminished the immunogenicity of SA14-14-2 with E-264 and E-315,contributing the most to this phenotype.The mutant rJEV(E-177/E-264/E-279/E-315)containing all four point mutations exhibited the lowest immunogenicity with a seroconversion rate of 0 at an inoculation dose of 103 PFU(plaque-forming unit).We have identified the key amino acids in the envelope protein that account for the superior immunogenicity of SA14-14-2. | Yuhua Li Yin Fu Xinyu Liu Huiqiang Yang Yongxin Yu Lili Jia Xuguang Li Aaron Farnsworth Junzhi Wang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 3 |
| 10 | Abnormal overpressure distribution and natural gas accumulation in foreland basins, Western China显示文摘Abnormal overpressure occurs in the forelandbasins of Kuqa, South Junggar and West Sichuan in China.The pressure coefficients are high. Overpressure exists inwide areas and various strata. The layers of overpressurehave a very close relationship with lithology, and the area ofoverpressure is controlled by the piedmont depression. Themechanisms of overpressure formation in the Kuqa andSouth Junggar Depression include disequilibrium compac-tion and tectonic compression; the importance of these twofactors varies in different basins and in different stages of thesame basin. Different models of gas accumulation are estab-lished to explain the relationship between overpressure dis-tribution and gas pool formation, and the influence of over-pressure on the gas pools. These models include: (i) theviolent tectonic movement leads to the pool formation inoverpressure belt (Kela-2 gas field in Kuqa); (ii) the pres-sure releases at shallow part and the gas pool forms in latetime (Hutubi gas field in southern Junggar Basin); (iii)through the pressure transfer the gas migrates and accumu-lates (Xinchang gas field in Western Sichuan Basin). | SONG Yan XIA Xinyu HONG Feng QIN Shengfei FU Guoyou | 2002 | Chinese Science Bulletin2002，47，S1： | 3 |
| 11 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 12 | Characterization and Proteomic Analysis of Novel Rice Lesion Mimic Mutant with Enhanced Disease Resistance显示文摘Lesion mmic mutants(LMMs)are plants that spontaneously form lesions without pathogeninfection or external stimulus and exhibit resistance to pathogens.Here,a rice LMM was created by ethylmethane sulfonate mutagenesis,named as hpil(hydrogen peroxide induced lesion).Diaminobenzidineand trypan blue staining showed that large amounts of H_(2)O_(2) were produced and cell death was occurredat and around the parts of lesion mimic in the rice leaves.The phenotype of hpil is controlled by a singlerecessive gene,localized at a 2 Mb interval on chromosome 2.The data suggested that hpil is a novelLMM with enhanced bacterial and fungal disease resistance,and multiple pathogenesis-related proteins(PRs)were up-regulated.The proteomes of leaves at three positions(different degrees of lesion mimicseverity)were characterized in hpil compared with its wild type plant.Differentially expressed proteinswere detected by two dimensional difference gel electrophoresis and 274 proteins were identified byMALDITOF/TOFTM.These proteins were related to metabolic process,cellular process and response tostimulus,with mostly down-regulated in hpil leaves.Many of these proteins were related to the Calvincycle,photosynthetic electron transport chain,glycolysis/gluconeogenesis and phosphonates pathways.Some resistance-related proteins including 14-3-3 proteins,OsPR10 and antioxidases such asperoxidase,superoxide dismutase and ascorbate peroxidase were up-regulated in leaves with lesionmimic.These results provide the foundation for cloning of the target gene and shed light on themechanism involved in autaimmunity of rice. | Yang Yong Lin Qiujun Chen Xinyu Liang Weifang Fu Yuwen Xu Zhengjin Wu Yuanhua Wang Xuming Zhou Jie Yu Chulang Yan Chengqi Mei Qiong Chen Jianping | 2021 | Rice science2021，28，5： | 2 |
| 13 | Optimization of an in vitro method to measure the bioaccessibility of polybrominated diphenyl ethers in dust using response surface methodology显示文摘To more reasonably evaluate human intake of PBDEs via dust ingestion,bioaccessibility should be taken into account.Previously,we developed an in vitro method to determine the bioaccessibility of PBDEs in food.Here,this method was adapted to determine the bioaccessibility of PBDEs in dust and the digestion conditions that influenced the bioaccessibility of PBDEs were optimized.The digestion conditions included the incubation time of dust in the intestinal digestion solution (T),the bile concentration in the intestinal digestion solution (C bile),and the ratio of the volume of the intestinal digestion solution to dust (R).The influence of the concentrations of individual PBDE congeners (C PBDE) on the bioaccessibility of PBDEs was also investigated.Central composite design was used to build an experimental model and set experimental parameters,and response surface methodology was used to analyze the obtained data.The results showed that the bioaccessibility of PBDEs increased with the increases of C bile and R,and was independent of T and C PBDE.Under the digestion conditions with C bile and R being at 4.0-7.0 g/L and 150-250,respectively,the bioaccessibility of PBDEs in the method-dust varied from 39.2% to 72.8%,which were comparable with the bioaccessibility or bioavailability of PBDEs in dust/soil in the literature.Thus,the in vitro method to measure the bioaccessibility of PBDEs in dust was established and validated.Finally,the bioaccessibility of PBDEs in four natural dust samples,which ranged from 36.1% to 43.3%,were determined using the adapted method. | Yingxin Yu Yuping Pang Xinyu Zhang Chen Li Zhiqiang Yu Jiamo Fu | 2011 | Journal of Environmental Sciences2011，23，10： | 2 |
| 14 | A paper-based microfluidic platform with shapememory-polymer-actuated fluid valves for automated multi-step immunoassays显示文摘Smart fluid manipulation with automatically controlled paper valves will enable automated and multi-step immunoassays on paper-based microfluidic devices.In this work,we present an integrated paper-based microfluidic platform with shape-memory polymer(SMP)-actuated fluid valves capable of automated colorimetric enzyme-linked immunosorbent assays(ELISAs).A single-layer microfluidic paper-based analytical device(μPAD)was designed to store all the reagents on the chip,and sequentially transfer reagents to a paper test zone following a specific ELISA protocol through automatic fluidic flow control by the multiple SMP-actuated valves.The actuation of a paper valve was based on the thermally responsive,duel-state shape transformation of a SMP sheet attached to the root of a paper cantilever beam for driving a hydrophilic paper bridge to connect and disconnect two paper channels.A portable colorimetric reader was developed to control the on-chip valve operations,quantify the colorimetric signal output,display the assay result,and wirelessly transmit the data to a smart phone for the application of telemedicine.Reliable operations of the paper valve and the entireμPAD were demonstrated with success rates of 97%and 93%,respectively.A detection mechanism for valve malfunction was designed and confirmed effective to identify any mal-operation of individual valves,thus rendering our platform reliable in real assays.For device calibration,we conducted direct ELISAs of rabbit IgG in phosphate-buffered saline(PBS),and achieved a low limit of detection(LOD)of 27 pM(comparable to that of standard and paper-based ELISAs).In order to demonstrate the clinical application of our multi-step immunoassay platform,we also conducted sandwich ELISAs to quantify the protein level of an inflammatory cytokine,namely tumor necrosis factor(TNF)-α,in surgically injured laryngeal tissues of rats.The protein levels of TNF-αwere shown similar between the conventional andμPAD ELISAs. | Hao Fu Pengfei Song Qiyang Wu Chen Zhao Peng Pan Xiao Li Nicole YKLi-Jessen Xinyu Liu | 2019 | Microsystems & Nanoengineering2019，5，1： | 2 |
| 15 | Trace elements in fish from Taihu Lake, China: Levels, associated risks, and trophic transfer显示文摘 | Ying Hao Liang Chen Xiaolan Zhang Dongping Zhang Xinyu Zhang Yingxin Yu Jiamo Fu | 2013 | Ecotoxicology and Environmental Safety2013，，： | 1 |
| 16 | Maximum likelihood estimation of nonlinear mixed-effects models with crossed random effects by combining first-order conditional linearization and sequential quadratic programming显示文摘Nonlinear mixed-eirects (NLME) modek have become popular in various disciplines over the past several decades.However,the existing methods for parameter estimation imple-mented in standard statistical packages such as SAS and R/S-Plus are generally limited k) single-or multi-level NLME models that only allow nested random effects and are unable to cope with crossed random effects within the framework of NLME modeling.In t his study,wc propose a general formulation of NLME models that can accommodate both nested and crassed random effects,and then develop a computational algorit hm for parameter estimation based on normal assumptions.The maximum likelihood estimation is carried out using the first-order conditional expansion (FOCE) for NLME model linearization and sequential quadratic programming (SCJP) for computational optimization while ensuring positive-definiteness of the estimated variance-covariance matrices of both random effects and error terms.The FOCE-SQP algorithm is evaluated using the height and diameter data measured on trees from Korean larch (L.olgeiisis var,Chang-paienA.b) experimental plots aa well as simulation studies.We show that the FOCE-SQP method converges fast with high accuracy.Applications of the general formulation of NLME models are illustrated with an analysis of the Korean larch data. | Liyong Fu Mingliang Wang Zuoheng Wang Xinyu Song Shouzheng Tang | 2019 | International Journal of Biomathematics2019，12，5： | 1 |
| 17 | Analysis on Biological Stability and Influencing Factors of Northern Living District Water Distribution System显示文摘A northern living strict water network was employed to investigate interaction among biological stability and classical water quality indexes. Key water quality indexes on water quality were determined by the static test,then the correlations between biological stability and traditional water quality parameters were analyzed. Traditional water quality parameters and limited factors on bacteria were measured in summer and winter respectively. The results show that BDOC concentration change differently in summer and winter.Among classical parameters turbidity has a positive relation with BDOC but pH has a negative relation with BDOC. Total bacteria number shows a positive correlation with BDOC in the water distribution system.Residual chlorine shows a negative relation with total bacteria number. Fe content increasing will induce turbidity rising in water. To guarantee water safety,BDOC and chlorine content control must be incorporated together to restrict bacteria regrowth. | Xinyu Zhang Ying Fu | 2018 | Journal of Harbin Institute of Technology(New Series)2018，25，1： | 1 |
| 18 | Anti-inflammatory properties of Fu brick tea water extract contribute to the improvement of diarrhea in mice显示文摘Fu brick tea,a special kind of dark tea fermented dominantly by Eurotium cristatum,is traditionally used for diarrhea therapy in China.However,limited reports are available on the anti-diarrhea of Fu brick tea water extract(FTE)and its potential mechanisms.In the present study,the treatment effects of FTE on the senna-induced diarrhea in mice were investigated.We found that FTE effectively improved diarrhea index and inhibited gut peristalsis.Additionally,histopathological examination revealed that FTE protected the integrity and reduced inflammatory infiltration of the ileum mucosal barrier.Furthermore,FTE significantly decreased the levels of the pro-inflammatory factor 5-hydroxytryptamine(5-HT)and increased the expression of sodium–hydrogen exchanger 3(NHE-3).The association among both intestinal damage and electrolyte balance and inflammation has been reported by many studies.Collectively,our study showed that FTE had anti-diarrhea activity,which may be associated with anti-inflammatory properties. | Xinyue Dai Binggang Ge Mingzhi Zhu Huiwen Wang Tingyu Zeng Zhonghua Liu Donghe Fu | 2022 | Beverage Plant Research2022，2，1： | 1 |
| 19 | A bio-inspired and self-powered triboelectric tactile sensor for underwater vehicle perception显示文摘Marine mammals relying on tactile perception for hunting are able to achieve a remarkably high prey capture rate without visual or acoustic perception.Here,a self-powered triboelectric palm-like tactile sensor(TPTS)is designed to build a tactile perceptual system for underwater vehicles.It is enabled by a three-dimensional structure that mimics the leathery,granular texture in the palms of sea otters,whose inner neural architecture provides additional clues indicating the importance of tactile information.With the assistance of palm structure and triboelectric nanogenerator technology,the proposed TPTS has the ability to detect and distinguish normal and shear external load in real-time and approximate the external stimulation area,especially not affected by the touch frequency,that is,it can maintain stable performance under high-frequency contact.The results show that the TPTS is a promising tool for integration into grippers mounted on underwater vehicles to complete numerous underwater tasks. | Peng Xu Jianhua Liu Xiangyu Liu Xinyu Wang Jiaxi Zheng Siyuan Wang Tianyu Chen Hao Wang Chuan Wang Xianping Fu Guangming Xie Jin Tao Minyi Xu | 2022 | npj Flexible Electronics2022，6，1： | 1 |
| 20 | Nude mouse metastatic models of human stomach cancer constructed using orthotopic implantation of histologically intact tissue显示文摘 | Toshiharu Furukawa Xinyu Fu Tetsuro Kubota | 1993 | Cancer Res1993，53，： | 1 |
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