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您的检索式：作者名="Aaron Farnsworth"
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| 1 | 红树林的全球保护现状显示文摘尽管在科技文献中已对红树林给予了很大的关注,对其生物学与经济学的价值取得了明显的全球共识,并颁布实施了一些保护性法规,但作为人类活动的直接结果,这些热带沿海森林在全球范围内仍在不断减少。根据与当地的专业土地管理者、高等学校的科学家、村民和村领导、当地政府官员的讨论,我们对16个国家和地区38个地点的红树林目前的状况、威胁红树林的主要问题进行了分析和排序。虽然在科技文献中已有相当多的关于保护措施的资料,但它们必须以当地非专业工作者能够使用的方式进行更广泛地传播。我们还必须收集林分结构的资料,分析森林消失速度和原因,对森林恢复技术和保护红树林群落效益与成本的社会经济进行评估,并使结果共享。若要使红树林生态系统得以持续,应当促进区域内部与区域之间生物学家与非专业人员之间的联系,必须重视社会学家与生物学家之间的合作,并强化政府对于保护和恢复工作的支持。 | Elizabeth Farnsworth Aaron Ellison 闵庆文 | 1997 | 人类环境杂志1997，26，6： | 4 |
| 2 | The molecular determinants governing the immunogenicity of Japanese encephalitis live attenuated vaccines显示文摘In the course of isolating the attenuated Japanese encephalitis vaccine SA14-14-2,two attenuated strains SA14-9-7 and SA14-5-3 were also obtained that elicited low antibody responses in humans(o10%and 62%,respectively)and exerted much weaker immune protection in animal challenge experiments.However,the reason for these differences remains unknown.In order to understand why SA14-14-2 is superior to SA14-9-7 and SA14-5-3,we employed a reverse genetics method to identify the key mutations in the virus genome that determine the immunogenicity of live attenuated Japanese encephalitis viruses.We first sequenced the full genomic sequences of SA14-9-7 and SA14-5-3 and found mutations that changed four amino-acid base pairs when compared to the envelope gene of SA14-14-2.We mutated the genome of SA14-14-2 to generate these mutations both singly(E-177,E-264,E-279 and E-315)and in combination(E-177/264,E-279/315 and E-177/264/279/315)and tested these mutants along with parental strains SA14-14-2,SA14-9-7 and SA14-5-3 for their immunogenicity in vivo.When mice were immunized with SA14-9-7 and SA14-5-3,lower levels of neutralizing antibodies were generated compared with the immune response to SA14-14-2.Furthermore,SA14-5-3 was more immunogenic than SA14-9-7,which replicated the results previously seen in humans.Point mutations E-177,E-264,E-279 and E-315 diminished the immunogenicity of SA14-14-2 with E-264 and E-315,contributing the most to this phenotype.The mutant rJEV(E-177/E-264/E-279/E-315)containing all four point mutations exhibited the lowest immunogenicity with a seroconversion rate of 0 at an inoculation dose of 103 PFU(plaque-forming unit).We have identified the key amino acids in the envelope protein that account for the superior immunogenicity of SA14-14-2. | Yuhua Li Yin Fu Xinyu Liu Huiqiang Yang Yongxin Yu Lili Jia Xuguang Li Aaron Farnsworth Junzhi Wang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 3 |
| 3 | Simulated sea level change alters anatomy, physiology, growth, and reproduction of red mangrove (Rhizophora mangle L.)显示文摘 | Aaron M. Ellison Elizabeth J. Farnsworth | 1997 | Oecologia1997，，4： | 1 |
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