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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | The lipase monolayer film self-assembly on the negatively charged poly(ethylene terephthalate) substrate显示文摘The PET-CO2-film was prepared and the lipase was assembled on the surface of the PET-CO2- substrate The structure at the surface and activity of lipase/PET monolayer were studied by ATR-FTIR and AFM, and other methods. | Lin, XF He, L Xu, LH Lu, DS Chen, ZC | 2000 | Chinese Chemical Letters2000，11，3： | 3 |
| 3 | A model to predict 3-month mortality risk of acute-on-chronic hepatitis B liv-er failure using artificial neural network 显示文摘 | Zheng MH Shi KQ Lin XF | 2013 | J Viral Hep-at2013，20，4： | 1 |
| 4 | The anti-inflammatory effects of Caragana tangutica ethyl acetate extract显示文摘 | Niu XF Li YM Lin WF | 2014 | J Ethnopharmacol2014，15，2： | 1 |
| 5 | RXRalpha acts as a carrier for TR3 nuclear export in a 9-cisretinoic acid-dependent manner in gastric cancer cells显示文摘 | Lin XF Zhao BX Chen HZ | 2004 | J Cell Sci2004，117，23： | 1 |
| 6 | Comparison of clinical features between non-smokers with COPD and smokers with COPD : a retrospective observational study 显示文摘 | Zhang J Lin XF Bai CX | 2014 | Int J Chron Obstruct Pulmon Dis2014，9，： | 1 |
| 7 | Construction of the HBV S-eedCD40L fusion gene and effects of HBV S-ecdCD40L modification on function of dendritic cells显示文摘 | Wu JM Lin XF Huang ZM | 2011 | J Viral Hepat2011，18，10： | 1 |
| 8 | RXR alpha acts as a carrier for TR3 nuclear export in a 9-cisretinoic acid dependent manner in gastric cancer cells显示文摘 | Lin XF Zhao BX Chen HZ | 2004 | J Cell Sci2004，117，23： | 1 |
| 9 | Minocy-cline inhibits alkali bum-induced comeal neovascularizationin mice显示文摘 | XIAO O XIE ZL LIN BW YIN XF PI RB ZHOU SY | 2012 | PLoS One2012，7，41： | 1 |
| 10 | Draft genome of the kiwifruit Actinidia chinensis 显示文摘 | Huang SX Ding J Deng DJ Tang W Sun HH Liu DY Zhang L Niu XL Zhang X Meng M Yu JD Liu J Han Y Shi W Zhang DF Cao SQ Wei ZJ Cui YL Xia YH Zeng HP Bao K Lin L Min Y Zhang H Miao M Tang XF Zhu YZ Sui Y Li GW Sun HJ Yue JY Sun JQ Liu FF Zhou LQ Lei L Zheng XQ Liu M Huang L Song J Xu CH Li JW Ye KY Zhong SL Lu BR He GH Xiao FM Wang HL Zheng HK Fei ZJ Liu YS | 2013 | Nat Commun2013，4，： | 1 |
| 11 | Leptin receptor, NPY,POMC mRNA expression in the diet-induced obese mouse brain 显示文摘 | Lin S Storlien LH Huang XF | 2000 | Brain Res2000，875，： | 1 |
| 12 | Effect of epigallocatechingallate on ultraviolet B-induced photo-damage in keratinocyte cell line显示文摘 | Luo D Min W Lin XF | 2006 | Am J Chin Med2006，34，5： | 1 |
| 13 | Investigation of pulsed low dose rate radiotherapy using dynamic arc delivery techniques显示文摘 | Ma CM Lin MH Dai XF | 2012 | Phys Med Biol2012，57，14： | 1 |
| 14 | Long-term beta blockers for stable angina: systematic review and meta-analysis显示文摘 | Shu de F Dong BR Lin XF | 2012 | European journal of pre- ventive cardiology2012，19，3： | 1 |
| 15 | Over-expression of riO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium显示文摘 | Zeng B Lin GS Ren XF | 2010 | Journal of Biomedical Science2010，17，7： | 1 |
| 16 | Inhibitory effects of Baicalin on ultraviolet B-induced photo-damage in keratinocyte cell line显示文摘 | W Min XF Lin X Miao | 2008 | Am J Chin Med2008，36，4： | 1 |
| 17 | Expression cloning of the TGF-β1 receptor,a functional transmembrane serine 显示文摘 | Lin HY Wang XF Ng-Eaton E | 1992 | Cell1992，68，2： | 1 |
| 18 | The chnical analysis of prognosis of supratentorial intracerebral hematoma: the comparison of stereotactic aspiration with conservative therapy 显示文摘 | Fang YN Lin JW Li XF | 1999 | Apoplexyand Nervous Diseases1999，16，2： | 1 |
| 19 | Design and synthesis of benzenesulfonamide derivatives as potent Anti-Influenza hemagglutinin inhibitors显示文摘 | Tang GZ Lin XF Qiu ZX | | 0，，08： | 1 |
| 20 | Diffusion tensor imaging of symptomatic nerve roots in patients with cervical disc hernia- tion 显示文摘 | Chen YY Lin XF Zhang F | 2014 | Acad Radiol2014，21，3： | 1 |
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