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| 1 | Helicobacter pylori vacA genotypes and cagA status and their relationship to associated diseases显示文摘INTRODUCTIONHelicobacter pylori(H.pylori)is a major causativebacterium of chronic gastritis,peptic ulcer and mucosa-associated lymphoid tissue lymphoma in humans,andassociated with an increased risk of gastric cancer. | Hou P Tu ZX Xu GM Gong YF Ji XH Li ZS | 2000 | World Journal of Gastroenterology2000，6，4： | 27 |
| 2 | Ultrasonically activated scalpel versus monopolar electrocautery shovel in laparoscopic total mesorectal excision for rectal cancer显示文摘AIM: To investigate the feasibility and safety of monopolar electrocautery shovel (ES) in laparoscopic total mesorectal excision (TME) with anal sphincter preservation for rectal cancer in order to reduce the cost of the laparoscopic operation, and to compare ES with the ultrasonically activated scalpel (US). METHODS: Forty patients with rectal cancer, who underwent laparoscopic TME with anal sphincter preservation from June 2005 to June 2007, were randomly divided into ultrasonic scalpel group and monopolar ES group, prospectively. White blood cells (WBC) were measured before and after operation, operative time, blood loss, pelvic volume of drainage, time of anal exhaust, visual analogue scales (VAS) and surgery-related complications were recorded. RESULTS: All the operations were successful; no one was converted to open procedure. No significant differences were observed in terms of preoperative and postoperative d 1 and d 3 WBC counts (P = 0.493, P = 0.375, P = 0.559), operation time (P = 0.235), blood loss (P = 0.296), anal exhaust time (P = 0.431), pelvicdrainage volume and VAS in postoperative d 1 (P = 0.431, P = 0.426) and d 3 (P = 0.844, P = 0.617) between ES group and US group. The occurrence of surgery-related complications such as anastomotic leakage and wound infection was the same in the two groups. CONCLUSION: ES is a safe and feasible tool as same as US used in laparoscopic TME with anal sphincter preservation for rectal cancer on the basis of the skillful laparoscopic technique and the complete understanding of laparoscopic pelvic anatomy. Application of ES can not only reduce the operation costs but also benef it the popularization of laparoscopic operation for rectal cancer patients. | Bao-Jun Zhou, Wei-Qing Song, Qing-Hui Yan, Jian-Hui Cai, Feng-An Wang, Jin Liu, Guo-Jian Zhang, Guo-Qiang Duan, Zhan-Xue Zhang, Department of Gastrointestinal Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China Author contributions: Zhou BJ, Song WQ, Yan QH, Cai JH, Wang FA, Liu J, Zhang GJ, Duan GQ and Zhang ZX contributed equally to this work Zhou BJ, Song WQ, Yan QH, Cai JH and Wang FA designed the research Zhou BJ, Liu J and Zhang GJ performed the research Duan GQ and Zhang ZX analyzed the data and Zhou BJ, Song WQ and Yan QH wrote the paper. | 2008 | World Journal of Gastroenterology2008，14，25： | 25 |
| 3 | Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi显示文摘BACKGROUND:Many Chinese herbs,especially herbal injections,have been shown to have anti-tumor effects in recent years.However,since most reports focus on the clinical effectiveness of these herbs,their mechanisms of action are not well understood.In this study,we assessed apoptosis in the hepatocellular carcinoma (HCC) cell line HepG2 induced by an injectable extract from the seed of Coix lacryma-jobi (Semen coicis,SC),and monitored the expression of Bcl-2 and caspase-8.METHODS:Injectable SC was applied to HepG2 cells at different concentrations and the cells were collected 12,24 and 48 hours later.5-fluorouracil was used as a positive control group,and fluorescence-activated cell-sorting cytometry was used to measure the apoptosis rate of HepG2 cells and the expression of Bcl-2 and caspase-8 proteins.RESULTS:SC induced apoptosis in HepG2 cells in a concentration and time-dependent manner,and the expression of caspase-8 was elevated and prolonged.However,it did not significantly influence the expression of Bcl-2.CONCLUSION:Injectable SC may induce apoptosis in HCC cells by regulating the expression of caspase-8. | Department of General Surgery (Lu Y and Zhang BY),Department of Bio-Information (Jia ZX),Affiliated Medical College Hospital,Qingdao University,Qingdao 266003,China Shanghai Jiaotong University School of Medicine,Shanghai 200025,China (Wu WJ) Department of Medicine,Heze Medical College,Heze 274000,China (Lu ZQ) | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 17 |
| 4 | Effect of extracorporeal bioartificial liver support system on fulminant hepatic failure rabbits显示文摘AIM To evaluate the possibility of usingcultured human hepatocytes as a bridge betweenbioartificial liver and liver transplantation.METHODS In this experiment,the efficacy ofextracorporeal bioartificial liver support system(EBLSS)consisting of spheriodal human livercells and cultured hepatocytes supernatant wasassessed in vivo using galactosamine inducedrabbit model of fulminant hepatic failure.RESULTS There was no difference of survivalbetween the two groups of rabbits,but in thesupported rabbits serum alanineaminotransferase,total bilirubin and creatininewere significantly lower and hepatocyte necrosiswas markedly milder than those in controlanimals.In addition,a good viability of humanliver cells was noted after the experiment.CONCLUSION EBLSS plays a biologic role inmaintaining and compensating the function ofthe liver. | Wang YJ Li MD Wang YM Chen GZ Lu GD Tan ZX | 2000 | World Journal of Gastroenterology2000，6，2： | 17 |
| 5 | Parkinson's disease in China: prevalence in Beijing, Xian, and Shanghai.显示文摘 | Zhang ZX Roman GC Hong Z Wu CB Qu QM Huang JB Zhou B Geng ZP Wu JX Wen HB Zhao H Zahner GE | 2006 | 中国生物学文摘2006，20，8： | 9 |
| 6 | The compression of IR spectra by using wavelet neural network显示文摘IR spectra play an important role in determining the structure of compounds qualitatively andquantitatively.In general a great number of data are required to exactly show the features ofthe compounds.Regarding various compounds,there are massive IR spectra.With the basicfeatures of IR spectra being reserved,it is important to compress IR spectra for improving thestorage,index and process of IR spectra.The wavelet neural network(WNN)is a newneural network model based on wavelet analysis.However,its introduction and applica-tion in chemistry have not been reported.In this note,WNN is applied to the compression ofthe IR spectra of polystyrene.The results show that the original spectra can be | Liu, W Li, JP Xiong, JH Pan, ZX Zhang, MS | 1997 | Chinese Science Bulletin1997，42，10： | 8 |
| 7 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 8 | Clinicopathologic study of primary intestinal B cell malignantlymphoma显示文摘 | Zhou Q Xu TR Fan QH Zhen ZX | 1999 | World Journal of Gastroenterology1999，5，6： | 6 |
| 9 | DETERMINATION OF EFFECTIVE MODULI FOR FOAM PLASTICS BASED ON THREE PHASE SPHEROIDAL MODEL显示文摘The relations of bulk modulus,shear modulus,Young’s modulus and the Poisson’s ra-tio with porosity of foam plastics are determined by a three phase spheroidal model commonly used inComposite Mechanics.The results are compared with those using differential scheme.It is shownthat the material properties derived from the present model normally are larger than those obtained bydifferential scheme for foam plastics with identical porosity.The differences in shear moduli andYoung’s moduli obtained by the two methods are small,but they are larger for bulk moduli of incom-pressible matrix and Poisson’s ratios.The Young’s moduli of high density foam plastics derived by thepresent model agree better with experimental ones. | Lu, ZX Huang, ZP Wang, R | 1995 | Acta Mechanica Solida Sinica1995，8，4： | 3 |
| 10 | Expression of gap junctions and inhibition of cell growth in communication-defected cells after transfection with gap junction gene Cx43 cDNA显示文摘Gap junctions form intercellular channels for direct exchange of metabolites and second messengers between adjacent cells. The existence of a multi-gene family encoding gap junction proteins, i. e. the connexins (Cx), has been recently demonstrated. Despite the overall sequence homologies and a similar predicted structural motif, their functional properties differ in various tissues. Because of coexpression of two or more connexin proteins in one tissue, determination of properties specific for each connexin is complicated. The regulation of expression of gap junctions and their roles in cellular activities remain mostly unelucidative. Controlled manipulation of connexin molecules in Xenopus oocyte expression system has been use- | Zhang, ZQ Lin, ZX Wang, NQ Han, YL | 1997 | Chinese Science Bulletin1997，42，5： | 3 |
| 11 | A NEW TRITERPENOID FROM THE FUNGUS GANODERMA LUCIDUM显示文摘A NEW TRITERPENOID FROM THE FUNGUS GANODERMA LUCIDUMFangShengWANG;HuiCAI;ZaiXinJING(UniversityofAgricultureandAnimalScience.P... | Wang, FS Cai, H Jing, ZX Yang, JS Zhang, YM | 1995 | Chinese Chemical Letters1995，6，12： | 2 |
| 12 | 延髓头端腹内侧区的P2X7受体参与骨癌痛:下行易化机制显示文摘大约70%~90%的癌症晚期或癌症转移的患者都经受着严重的慢性疼痛折磨。癌症痛一个重要的来源就是癌症骨转移导致的骨癌痛。延髓头端腹内侧区(RVM)是疼痛的内源性下行调制系统的重要组成。以往研究表明,RVM介导的下行易化系统参与慢性痛的发病机制。 | Huang ZX 张钰 | 2015 | 中国疼痛医学杂志2015，21，1： | 2 |
| 13 | Effect of HSP70 antisense RNA on normal sorghum pollen formation显示文摘IT has been found that heat shock proteins (hsp) exist universally in animals, plants, microbesand human beings. Some of hsps possess functions of molecular chaperons, such as hsp60,hsp70 and hsp90, which participate in folding and assembling polypeptides to functional struc-tures and transferring them into suitable sites. They also undertake repairing damaged cellularDNA and nucleolus. Therefore, they are house-keeping proteins and play an importantrole in maintaining normal cellular life and functions and in cellular response to environmentalstresses. There exists high homology in DNA sequence among the hsp of the same molecularweight across species. We have first reported the close relationship between hsps | Chen, JN Fu, HY Lu, ZX Qin, HY Zhang, L Guo, ZB | 1997 | Chinese Science Bulletin1997，42，23： | 2 |
| 14 | 大鼠门静脉右支介入栓塞的实验研究显示文摘目的 研究各种栓塞剂对门静脉分支栓塞后肝脏在形态学上的变化和对肝功能的影响。方法 以 45只大鼠为实验对象 ,除 5只留作对照组外 ,40只分成 4组 ,用 4种不同的栓塞材料进行门静脉右支栓塞 ,术后第 14天和第 2 1天分别处死每组 5只动物 ,剖腹观察肝脏各叶的形态变化 ,然后分离各叶进行称重 ,并计算右叶与全肝的重量比 (比例 1)和肝脏与体重的重量比 (比例 2 )。然后用t检验方法对各组结果进行统计学分析。结果 栓塞后见肝右叶明显变苍白 ,表面呈斑纹状 ,各组之间差异不大 ,在术后 14d及 2 1d ,第 1、2、3组的大鼠肝右叶均见明显变小 ,表面见大小不等淡黄色小瘢痕 ,第 4组小鼠的肝脏形态变化不明显。统计学分析显示 ,碘油酒精 2∶1的高浓度混合液的栓塞作用明显好于碘油酒精 4∶1混合物 (P <0 .0 5 ) ,明胶海绵粉的栓塞作用也十分明显 ,效果与碘油酒精 4∶1混合物相仿 (P>0 .0 5 ) ,但明显好于明胶海绵小块 (P <0 .0 5 )。结论 本实验结果提示 ,门静脉分支的栓塞既可引起该肝叶的萎缩 ,又可促使其他肝叶的代偿性增生 ,门静脉分支栓塞是安全有效的 ,但不同的栓塞剂或栓塞材料有不同的栓塞效果 ,其中碘油酒精 | 詹松华 韩洪杰 王国良 杨振燕 Kan Zx | 2001 | 介入放射学杂志2001，10，3： | 2 |
| 15 | Lymphangioleiomyomatosis (LAM) :a review of clinical and morphological features显示文摘 | Ferrans V J Yu ZX Nelson WK | 2000 | J Nippon Med Sch2000，67，5： | 1 |
| 16 | Ocular flmgal isolates and antifungal susceptibility in northern China 显示文摘 | Sun XG Wang ZX Wang ZQ Luo SY Li R | 2007 | Am J Ophthalmol2007，143，： | 1 |
| 17 | Identification of a pre2 viously unknown antigen2specific regulatory T cell a nd its mechanism of suppression显示文摘 | Zhang ZX Yang L Young K J | 2000 | Nat Med2000，6，7： | 1 |
| 18 | Prevalence of Parkinson's disease and related disorders in the elderly population of greater Beijing, China 显示文摘 | Zhang ZX Anderson DW Huang JB | 2003 | Movement Disorders2003，18，7： | 1 |
| 19 | Cocaine-induced brain activation detected by dynamic manganese-enhanced magnetic resonance imaging (MEMRI)显示文摘 | Lu H Xi ZX Gitajn L | 2007 | Proc Natl Acad Sci USA2007，104，7： | 1 |
| 20 | Three antinematodal diterpenes from Euphorbia kanbsui 显示文摘 | Shi JX Li ZX Nitoda T | 2007 | Biosci Biotechnol Biochem2007，71，4： | 1 |
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