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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Unusual life-threatening Rosai-Dorfman disease of the trachea. role of NF-kappa B显示文摘 | Zhou, LF Chen, LA Zhu, QA Wang, C Xu, H Cui, XF Jiang, LF He, Ski Huang, M Yin, KS | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 21 |
| 3 | Orthotopic liver transplantation for fulminant hepatitis B显示文摘INTRODUCTION When fulminant hepatitis progress to deep encephalopathy,with stage Ⅲ or Ⅳ coma,it is commonly irreversible with a high mortality rate(80%-100%).Liver transplantation may be | He XS Huang JF Chen GH Fu Q Zhu XF Lu MQ Wang GD Guan XD | 2000 | World Journal of Gastroenterology2000，6，3： | 14 |
| 4 | Dietary factors and smoking as risk factors for PD in a rural population in China: a nested case-control study显示文摘 | Ma L Zhang L Gao XH Chen W Wu YP Wang Y Li XF Como P Kieburtz K Qiao YL | 2006 | 中国生物学文摘2006，20，8： | 13 |
| 5 | Toward rapamycin analog (rapalog)-based precision cancer therapy显示文摘Rapamycin 和它的类似物(rapalogs ) 是 mTOR 禁止者的第一代,它有一样的分子的支架,而是不同 physiochemical 性质。Rapalogs 作为 monotherapy 和联合治疗的一个部件在大量人的肿瘤正在被测试。在他们之中, temsirolimus 和 everolimus 为胸和肾的癌症的治疗被同意了。然而,有在临床的试用的 rapalogs 的客观反应率谦虚、可变。预言反应到 rapalogs 的 biomarkers 的鉴定,和有改进功效和容忍的毒性的药联合的发现对向前移动指向的治疗学的这个班批评。这评论为 rapalog 功效作为预兆的 biomarkers 在人的肿瘤房间或纸巾在 PI3K/mTOR 小径集中于错误。用 rapalogs 和另外的 anticancer 药的 combinational 治疗的最近的结果被记录。与下一代的 genomic 定序和精确药的快速的发展, rapalogs 将提供更大的好处给癌症病人。 | Ling-hua MENG XF Steven ZHENG | 2015 | Acta Pharmacologica Sinica2015，36，10： | 11 |
| 6 | Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes显示文摘 | Yang, JA Luan, XF Gui, HY Yan, P Yang, DF Song, XL Liu, W Hu, G Yah, BF | 2011 | 南京医科大学学报(自然科学版)2011，31，4： | 8 |
| 7 | 戊肝疫苗的长期保护效果观察显示文摘中国的一项研究评价了戊肝疫苗的长期保护效果。超过11万名受试对象参与了这项随机双盲临床试验研究,随访时间达4.5年。结果显示:在观察时间内,接种组戊肝发病率0.3/万,对照组发病率2.1/万,疫苗保护率为86.8%(95%CI:71%~94%)。说明接种戊肝疫苗能够提供良好的长期保护效果。 | Zhang J Zhang XF Huang SJ 潘兴强 | 2015 | 中华预防医学杂志2015，49，6： | 6 |
| 8 | Retention Behaviors of Uronic Acid-containing Polysaccharides and Neutral Polysaccharides in HPGPC显示文摘The chromatographic behaviors of several uronic acid-containing polysaccharides and neutral polysaccharides were investigated in HPGPC for the first time. The effects of sample concentration and ionic strength of mobile phase on retention time were studied. The mechanism for the effects on Mw determination results of polysaccharides by HPGPC was also discussed. | Liu, CP Bao, XF Fang, JN | 2001 | Chinese Chemical Letters2001，12，10： | 6 |
| 9 | Relationship between alcohol consumption and clinical manifestation of patients with fatty liver:a single-center study显示文摘BACKGROUND:Fatty liver is a common chronic liver disease worldwide.It is associated with an increasing morbidity in China in recent years.The aim of this study was to analyze the effect of drinking alcohol on the hemoglobin and biochemical values of patients with fatty liver.METHODS:We investigated the clinical and laboratory data of 669 patients with fatty liver.Of the 669 patients,166 consumed alcohol more than 60 g per week for at least 2 years,and 503 did not have a history of long-term alcohol consumption.We further analyzed the relationship between alcohol consumption and clinical characteristics of these patients.RESULTS:The values of aspartate transaminase (AST),gammaglutamyl transpeptidase (GGT),and hemoglobin in the long-term consumption group were significantly higher than those in the non long-term consumption group (P<0.05).In the patients without long-term alcohol consumption,the values of GGT and hemoglobin in patients with light alcohol consumption were significantly higher than those in non alcohol consumers (P<0.05).CONCLUSION:Alcohol consumption is associated with significantly increased values of AST,GGT,and hemoglobin in patients with fatty liver,suggesting their potential roles in hepatic steatosis. | International Health Care Center (Wang XF) and Department of Gastroenterology (Yue M),First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 5 |
| 10 | The lipase monolayer film self-assembly on the negatively charged poly(ethylene terephthalate) substrate显示文摘The PET-CO2-film was prepared and the lipase was assembled on the surface of the PET-CO2- substrate The structure at the surface and activity of lipase/PET monolayer were studied by ATR-FTIR and AFM, and other methods. | Lin, XF He, L Xu, LH Lu, DS Chen, ZC | 2000 | Chinese Chemical Letters2000，11，3： | 3 |
| 11 | Distribution of angiotensin Ⅱ AT1 and AT2 receptor subtypes in the rat kidney 显示文摘 | Miyata N Park F Li XF | 1999 | Am JPhysiol1999，277，32： | 2 |
| 12 | Study on seismogenesis of the 1997 Jiashi earthquake swarm, western China | Zhou, SY Chen, XF | 2002 | Progress in Natural Science:Materials International2002，12，1： | 2 |
| 13 | PHASE TRANSFORMATION OF Al-Ti COATINGS ON Co-BASE SUPERALLOY DZ40M DURING HIGH TEMPERATURE OXIDATION显示文摘INTRODUCTIONThereisaseriousproblemofhightemperatureoxidationonturbinecomponents,hence,variouscoatingswithaluminidearemanufac... | Liu, PS Sun, XF Jin, T Guan, HR Hu, ZQ | 1998 | 中国有色金属学会会刊:英文版1998，8，4： | 2 |
| 14 | The Role of Cyclin-dependent Kinase Inhibitor p27^Kip1 in Anti-HER2 Antibody induced G1 Cell Cycle Arrest and Tumor Growth Inhibition显示文摘 | Le XF Claret FX Lammayot A | 2003 | J Biol Chem2003，278，23： | 1 |
| 15 | The relationship between higher blood pressure and ischaemic, haemorrhagic stroke among Chinese and Caucasians:meta-analysis 显示文摘 | Zhang XF Atria J D'Este C | 2006 | Eur J Cardiovasc Prey Rehabil2006，13，3： | 1 |
| 16 | Role of the C terminus Gag protein in human immunodeficiency virus type 1 virion assembly and maturation显示文摘 | Yu XF Matsuda Z Yu QC | 1995 | J Gen Virol1995，76，： | 1 |
| 17 | LOXL1 and LOXL4 are epigeneticully silenced and can inhibit ras/extracellular signalregulated kinase signaling pathway in human bladder cancer显示文摘 | Wu GJ Guo ZG Chang XF | 2007 | Cancer Res2007，67，： | 1 |
| 18 | Adsorption of fluoride from water by aligned carbon nanotubes 显示文摘 | Li Y H Wang S G Zhang XF | 2003 | Materials Research Bulletin2003，，38： | 1 |
| 19 | Periodontal ligament and gingival fibroblast adhesion to dentin-like textured surfaces显示文摘 | Bruckmann C Walboomers XF Matsuzaka K | 2005 | Biomaterials2005，26，3： | 1 |
| 20 | Effect of cryotop vitrifica-tion on preimplantation developmental competence of murinemorula and blastocyst stage embryos显示文摘 | Ling XF Zhang JQ Cao SR | 2009 | Reprod BiomedOnline2009，19，5： | 1 |
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