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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Dietary factors and smoking as risk factors for PD in a rural population in China: a nested case-control study显示文摘 | Ma L Zhang L Gao XH Chen W Wu YP Wang Y Li XF Como P Kieburtz K Qiao YL | 2006 | 中国生物学文摘2006，20，8： | 13 |
| 3 | Distribution of angiotensin Ⅱ AT1 and AT2 receptor subtypes in the rat kidney 显示文摘 | Miyata N Park F Li XF | 1999 | Am JPhysiol1999，277，32： | 2 |
| 4 | Adsorption of fluoride from water by aligned carbon nanotubes 显示文摘 | Li Y H Wang S G Zhang XF | 2003 | Materials Research Bulletin2003，，38： | 1 |
| 5 | Four-dimensional echocardio graphy: methods and clinical application显示文摘 | Wang XF Li ZA Cheng TO | 1996 | Am Heart J1996，132，3： | 1 |
| 6 | Synthesis and SAR of a- cyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties显示文摘 | LI XF ZHANG S ZHANG YK | 2011 | Bioorg Med Chem Lett2011，21，7： | 1 |
| 7 | miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN显示文摘 | Yang SM Huang C Li XF | | 0，，： | 1 |
| 8 | Differential role of cortieotrophin-relcasing factor receptor types Ⅰ and 2 in stressinduced suppression of pulsatile luteinising hormone secretion in the female rat显示文摘 | Li XF Bowe JE Kinsey-Jones J | | 0，，8： | 1 |
| 9 | Late Paleoproterozoic to early Mesoproterozoic Dong Chuan Group in Yunnan, SW China:Implications for tectonic evolution of t he Yangtze Block 显示文摘 | Zhao XF Zhou MF Li JW | 2010 | Precambrian Research2010，182，3： | 1 |
| 10 | Supine lithotomy venus prone position in minimally invasive percutaneous nephrolithotomy for upper urinary tract calculi显示文摘 | Zhan HL Li ZC Zhou XF | 2013 | Urol Int2013，91，3： | 1 |
| 11 | Japanese encephalitis in mainland China 显示文摘 | Wang HY Li YX Liang XF | 2009 | Jpn J Infect Dis2009，62，5： | 1 |
| 12 | A new noninvasive method for evaluation of coronary endothelial function in hypertensive patients based on change in diameter of the left main coronary artery induced hy cold pressor test using echocardiography显示文摘 | Deng YB Wang XF Li CL | 2001 | Clin Cardiol2001，24，4： | 1 |
| 13 | Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 pro- tease 显示文摘 | LI XF ZHANG YK LIU Y | 2010 | Bioorg Med Chem Lett2010，20，12： | 1 |
| 14 | Safety of influenza A (H1N1)vaccine in postmarketing surveillance in China显示文摘 | Liang XF Li L Liu DW | | 0，，07： | 1 |
| 15 | ELISA analysis of urinary nephrin and podocalyxin standardized by aquaporin-2 in adult patients with nephrotic syndrome 显示文摘 | Zhu B Li XF Zhu XL | 2014 | J Nephrol2014，27，4： | 1 |
| 16 | A miniaturized spatial temperature gradient capillary electrophoresis system with radiative heating and automated sample introduction for DNA mutation detection 显示文摘 | Xu ZR Li Q Fan XF | 2010 | Electrophoresis2010，31，18： | 1 |
| 17 | Prognostic role of neutrophil- to-lymphocyte ratio in colorectal cancer: a systematic review and meta-analysis显示文摘 | Li MX Liu XM Zhang XF | 2014 | Int J Cancer2014，134，10： | 1 |
| 18 | Localisation of placenta growth factor (PLGF) in human term placenta显示文摘 | Khalig A Li XF Shams M | 2004 | Growth Factors2004，13，： | 1 |
| 19 | Three dimensional finite element model of the cer-vical spinal cord:preliminary results of injury mechanism analysis显示文摘 | Li XF Dai LY | 2009 | Spine2009，34，11： | 1 |
| 20 | Percutaneous injection of intradiscal an Parasplnal space with O2-O3mixture to treat lumbar disc herniation显示文摘 | He XF Yu ZJ Li YH | 2003 | Rivista Italian adiOssigeno-Ozono terapia2003，2，2： | 1 |
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