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| 1 | Elevated blood pressure: Our family's fault?The genetics of essential hypertension显示文摘AIM: To provide an updated review on current genetic aspects possibly affecting essential hypertension(EH), and to further elucidate their role in EH. METHODS: We searched for genetic and epigenetic factors in major studies associated with EH between Jan 2008-Oct 2013 using PubMed. We limited our search to reviews that discussed mostly human studies, and were accessible through the university online re-source. We found 11 genome wide association studies(GWAS), as well as five methylation and three miRNA studies that fit our search criteria. A distinction was not made between genes with protective effects or nega-tive effects, as this article is only meant to be a sum-mary of genes associated with any aspect of EH.RESULTS: We found 130 genes from the studies that met our inclusion/exclusion criteria. Of note, genes withmultiple study references include: STK39, CYP17A1, MTHFR-NPPA, MTHFR-NPPB, ATP2B1, CSK, ZNF652, UMOD, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, CSK-ULK3, CYP1A2, NT5C2, CYP171A, PLCD3, SH2B3, ATXN2, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, and HFE. The following genes overlapped between the genetic studies and epigenetic studies: WNK4 and BDKRB2. Several of the identified genes were found to have functions associated with EH. Many epigenetic factors were also correlated with EH. Of the epigenetic factors, there were no articles discussing siRNA and its effects on EH that met the search criteria, thus the topic was not included in this review. Among the miRNA tar-gets found to be associated with EH, many of the genes involved were also identified in the GWAS studies.CONCLUSION: Genetic hypertension risk algorithms could be developed in the future but may be of limited benefit due to the multi-factorial nature of EH. With emerging technologies, like next-generation sequenc-ing, more direct causal relationships between genetic and epigenetic factors affecting EH will likely be discov-ered creating a tremendous potential for personalized medicine using pharmacogenomics. | Aniket Natekar Randi L Olds Meghann W Lau Kathleen Min Karra Imoto Thomas P Slavin | 2014 | World Journal of Cardiology2014，6，5： | 7 |
| 2 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 3 | Activation and homologous desensitization of human endothelial cells by CD40 ligand, tumor necrosis factor, and interleukin 1 显示文摘 | Karmann K Min W Fanslow WC | 1996 | J Exp Med1996，184，1： | 2 |
| 4 | CD24 expression predicts distant metastasis in extrahepatic bile duct cancer显示文摘AIM: To evaluate the prognostic significance of CD24 expression in patients undergoing adjuvant chemoradiotherapy for extrahepatic bile duct (EHBD) cancer. METHODS: Eighty-four patients with EHBD cancer who underwent curative resection followed by adjuvant chemoradiotherapy were enrolled in this study. Postoperative radiotherapy was delivered to the tumor bed and regional lymph nodes up to a median of 40 Gy (range: 40-56 Gy). All patients also received fluoropyrimidine chemotherapy for radiosensitization during radiotherapy. CD24 expression was assessed with immunohistochemical staining on tissue microarray. Clinicopathologic factors as well as CD24 expression were evaluated in multivariate analysis for clinical outcomes including loco-regional recurrence, distant metastasisfree and overall survival. RESULTS: CD24 was expressed in 36 patients (42.9%). CD24 expression was associated with distant metastasis, but not with loco-regional recurrence nor with overall survival. The 5-year distant metastasis-free survival rates were 55.1% and 29.0% in patients with negative and positive expression, respectively (P=0.0100). On multivariate analysis incorporating N stage, histologic differentiation and CD24 expression, N stage was the only significant factor predicting distant metastasis-free survival (P=0.0089), while CD24 expression had borderline significance (P=0.0733). In subgroup analysis, CD24 expression was significantly associated with 5-year distant metastasis-free survival in node-positive patients (38.4% with negative expression vs 0% with positive expression, P=0.0110), but not in nodenegative patients (62.0% with negative expression vs 64.0% with positive expression,P=0.8599). CONCLUSION: CD24 expression was a significant predictor of distant metastasis for patients undergoing curative resection followed by adjuvant chemoradiotherapy especially for node-positive EHBD cancer. | Kyubo Kim Hye Sook Min Eui Kyu Chie Jin-Young Jang Sun Whe Kim Sae-Won Han Do-Youn Oh Seock-Ah Im Tae-You Kim Yung-Jue Bang Ja-June Jang Sung W Ha | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 5 | Correlation between characteristics of grain boundary carbides and creep-fatigue properties in AISI 321 stainless steel 显示文摘 | Min K S Nam S W | 2003 | Journal of Nuclear Materials2003，322，： | 1 |
| 6 | Adjuvant effects of IL-1beta,IL-2,IL-8,IL-15,IFN-alpha,IFN-gamma TGF-beta and μLymphotactin on DNA vaccination against Eimeria acervulina显示文摘 | MIN W LILLEHOJ H S BURNSIDE J | 2001 | Vaccine2001，20，： | 1 |
| 7 | Tench farming in Chi- na: present status and future prospects 显示文摘 | Wang J X Min W Q E Guan M | 2006 | Aquaculture2006，，2006： | 1 |
| 8 | Anthoeyanin biosynthesis in distinct genoty Pes of China aster (Calliste Phuschinensis ) 显示文摘 | HENKEL J FORKMANN G MIN B W | 1998 | Acta Hortieulturae1998，508，： | 1 |
| 9 | New Aspects of Score-shell Emulsion Polymerization Polybutylacrylate and Styrene Pair Systems显示文摘 | Min T I Klein A El-Aasser M S Vanderhoff J W | 1981 | Org Coat Appl Polym Sci Proc1981，46，： | 1 |
| 10 | Molecular, cellular,and functional characterization of chicken cytokines homologous to mammalian IL-15 and IL-2 显示文摘 | Lillehoj H S Min W Choi K D | 2001 | Vet Immunol Immunopathol2001，82，34： | 1 |
| 11 | Burial of organic carbon in Holocene sediments of the Zhujiang (Pearl River) and Changjiang (Yangtze River) estuaries 显示文摘 | Yang Shouye Tang Min Yim W W S Zong Yongqiang Huang Guangqing Switzer A D Saito Y | 2011 | Mar Chem2011，123，14： | 1 |
| 12 | Assessing the impact of ERP on supplier performance 显示文摘 | Hwang W Min H | 2013 | Industrial Management & Data Systems2013，113，7： | 1 |
| 13 | Fas siRNA reduces apoptotic cell death of allogeneic-transplanted hepatocytes in mouse spleen显示文摘 | Wang J Li W Min J | 2003 | Transplant Proc2003，35，4： | 1 |
| 14 | Proximal femoral nail for the treatment of reverse obliquity intertrochanteric fractures compared with gamma nail显示文摘 | MIN W K KIM S Y KIM T K | 2007 | J Trauma2007，63，5： | 1 |
| 15 | Determinants of Psy-chological Distress Over Time among Older Korean Im-migrant and Non-Hispanic White Elders Evidence from a Two-wave Panel Study显示文摘 | Min J W Moon A Lubben J E | 2009 | Aging Mental Health2009，9，3： | 1 |
| 16 | Genetic algorithm solution for a risk-based partner selection problem in a virtual enterprise显示文摘 | IP W H Huang Min Yung K L | 2003 | Computers & Operations Research2003，30，2： | 1 |
| 17 | Effects of chromium picolinate (CrPic) on growth performance, carcass characteristics and serum traits in growing - finishing pigs 显示文摘 | MIN J K KIM W Y CHAE B J | 1997 | Asian - Australa J Anim Sci1997，10，： | 1 |
| 18 | Application of biotechno-logical tools for cooccidian vaccine development显示文摘 | Min W Dalloul R A Lillehoj H S | 2004 | Vet Sci2004，5，： | 1 |
| 19 | Reliability improvement using receive mode selection in the device-to-device uplink period underlaying cellular networks 显示文摘 | Min H Seo W Lee J | 2011 | IEEE Transactions on Wireless Communications2011，10，2： | 1 |
| 20 | Microstructure and mechanical properties of Mg-Al based alloy with calcium and rare earth additions显示文摘 | Du W W Sun Y S Min X G | | 0，，： | 1 |
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