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| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | Application of a Support Vector Machine Algorithm to the Safety Precaution Technique of Medium-low Pressure Gas Regulators显示文摘In the gas pipeline system, safe operation of a gas regulator determines the stability of the fuel gas supply, and the medium-low pressure gas regulator of the safety precaution system is not perfect at the present stage in the Beijing Gas Group; therefore, safety precaution technique optimization has important social and economic significance. In this paper, according to the running status of the medium-low pressure gas regulator in the SCADA system, a new method for gas regulator safety precaution based on the support vector machine(SVM) is presented. This method takes the gas regulator outlet pressure data as input variables of the SVM model, the fault categories and degree as output variables, which will effectively enhance the precaution accuracy as well as save significant manpower and material resources. | HAO Xuejun AN Xaioran WU BO HE Shaoping | 2018 | Journal of Thermal Science2018，27，1： | 5 |
| 3 | Is the evolution in tumors Darwinian or non-Darwinian?显示文摘Although Darwinian selection driving the genetic diversity within tumors has been widely assumed by the field of cancer biology,recent studies that employ the rigorous tests of population genetics have increasingly suggested otherwise.In these new studies[1-5],the non-Darwinian,or neutral,model of evolution can adequately explain the documented diversities in tumors without invoking natural selection.Therefore,the half-century-old debate of selectionism vs.neutralism[6-8]on the role of natural selection in populations is | hurng-yi wang yuxin chen ding tong shaoping ling zheng hu yong tao xuemei lu chung-i wu | 2018 | National Science Review2018，5，1： | 3 |
| 4 | The Existence Theorems for a Class of Sublinear Elliptic Equations in R^N | Wu Shaoping Yang Haitao (Department of Mathematics,Zhejiang University,Hangzhou 310027,China) | 1997 | Acta Mathematica Sinica,English Series1997，13，3： | 2 |
| 5 | Multi-channel multiplexing quantum teleportation based on the entangled sideband modes显示文摘Quantum teleportation is a key primitive across a number of quantum information tasks and represents a fundamental ingredient for many quantum technologies. Channel capacity, other than the fidelity, becomes another focus of quantum communication. Here, we present a 5-channel multiplexing continuous-variable quantum teleportation protocol in the optical frequency comb system, exploiting five-order entangled sideband modes.Because of the resonant electro-optical modulation(EOM) that is specifically designed, the fidelities of five channels are greater than 0.78, which are superior to the no-cloning limit of 2∕3. This work provides a feasible scheme for implementing efficient quantum information processing. | YIMIAO WU QINGWEI WANG LONG TIAN †XIAOLI ZHANG JIAWEI WANG SHAOPING SHI YAJUN WANG YAOHUI ZHENG | 2022 | Photonics Research2022，10，8： | 2 |
| 6 | Generation of two- mode photon- added SU(2) coherent state and its quantum nonlocality property 显示文摘 | LI Gaoxiang WU Shaoping HUANG Guangming | 2002 | Phys Lett A2002，303，： | 1 |
| 7 | Accumulation and risk assessment of polycyclic aromatic hydrocarbons (PAHs) in soils around oil sludge in Zhongyuan oil field, China显示文摘 | Shaoping Kuang Zhanchao Wu and Laishi Zhao | 2011 | Environ Earth Sci2011，，64： | 1 |
| 8 | Vitamin D receptor negatively regulates Bacterial-Stimulated NF-kappa B activity in intestine显示文摘 | Wu Shaoping Liao AP Xia Yinglin | 2010 | American Journal of Pathology2010，177，2： | 1 |
| 9 | Comibined effects of singular and superlinear nonlinearities in some singular boundary value problems 显示文摘 | Sun Yijing Wu Shaoping Long Yiming | 2001 | J Differential Equations2001，176，： | 1 |
| 10 | Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation显示文摘 | Sundar IK Hwang JW Wu Shaoping | 2011 | Biochem Biophys Res Commun2011，406，1： | 1 |
| 11 | A study on the water-separation property of marine lubricating oil with arust inhibitor显示文摘 | Wu Caiping Li Shaoping Zhang Liqun | 2013 | Petroleum Science and Technology2013，31，20： | 1 |
| 12 | of Polycyclic Aromatic Hydrocarbons (PAHs) in Soils Around Oil Sludge in Zhongyuan Oil Field, China显示文摘 | Shaoping Kuang Accumulation and Zhanchao Wu Risk Assessment Laishi Zhao | 2011 | Environ Earth Sci2011，，64： | 1 |
| 13 | Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation显示文摘 | Isaac K. Sundar Jae-Woong Hwang Shaoping Wu Jun Sun Irfan Rahman | 2011 | Biochemical and Biophysical Research Communications2011，，1： | 1 |
| 14 | Combined effects of singular and superlinear nonlinearities in some singular boundary value problems显示文摘 | Wu Shaoping Long Yiming | 2001 | J Diff Eqns2001，176，： | 1 |
| 15 | Melting intercalation method to prepare lauric acid/organophilic montmorillonite shape-stabilized phase change material显示文摘 | Meizhu Chen Shaoping Zheng Shaopeng Wu Guangji Xu | 2010 | Journal of Wuhan University of Technology - Mater Sci Ed2010，，4： | 1 |
| 16 | The influence of macronitrogen (NO_3^- and NH_4^+) addition with U lva pertusa on dissolved inorganic carbon system显示文摘The influence of macronitrogen (NO - 3 and NH + 4 ) addition with Ulva pertusa on dissolved inorganic carbon system in seawater was studied. The results indicate that p(CO 2 ) and HCO 3 concentration decrease significantly, while pH and CO 2- 3 concentration increase significantly. When the concentration of NO 3 was less than 71 μmol/dm 3 or NH + 4 was less than 49.7 μmol/dm 3 , dissolved inorganic carbon (DIC) absorption rates by Ulva pertusa generally increased with the increasing of nitrogen concentration. The DIC decreased 151 μmol/dm 3 with the addition of 71 μmol/dm 3 NO 3 and decreased 232 μmol/dm 3 with the addition of 49.7 μmol/dm 3 NH + 4 after the experiment compared with DIC measured without nitrogen addition. A significant negative-correlation was found between c(DIC) and growth rate (μ) of Ulva pertusa (r = -0.91, P <0.000 1, n=11). NH + 4 had more influence on the species of inorganic carbon system than NO 3 . | ZHANG Naixing SONG Jinming CAO Conghua REN Rongzhu WU Fengcong ZHANG Shaoping SUN Xu | 2012 | Acta Oceanologica Sinica2012，31，1： | 1 |
| 17 | ON MULTIPLE POSITIVE SOLUTIONS FOR A NONLINEAR ELLIPTIC PROBLEM IN R^N显示文摘By making use of Variational method, the authors obtain some results about existence of multiple positive solutions and their asymptotic behavior as the parameter →+∞ for a semilinear elliptic problem in RN. | YANG HAITAO(Department of Mathematics, Zhejiang University, HangZhou 310027, China.) WU SHAOPING(Department of Mathematics, Zhejiang University, HangZhou 310027, China.) | 2000 | Chinese Annals of Mathematics,Series B2000，21，3： | 1 |
| 18 | Combined effects of singular and superlinear nonlinearities in some singular boundary value problems显示文摘 | Wu Shaoping Yiming Long | 2001 | J Differential Equations2001，176，： | 1 |
| 19 | Accumulation and risk assessment of polycyclic aromatic hydrocarbons (PAHs) in soils around oil sludge in Zhongyuan oil field, China显示文摘 | Shaoping Kuang Zhanchao Wu Laishi Zhao | 2011 | Environ Earth Sci2011，64，5： | 1 |
| 20 | A recombinant cell-permeable p53 fusion protein is selectively stabilized under hypoxia and inhibits tumor cell growth显示文摘 | Zhao Yu Junhua Wu Shaoping Wu Peiyuan Jia Ying Tong Xumin Wu Yuxia Wang | 2009 | Cancer Letters2009，，1： | 1 |
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