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| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | Is the evolution in tumors Darwinian or non-Darwinian?显示文摘Although Darwinian selection driving the genetic diversity within tumors has been widely assumed by the field of cancer biology,recent studies that employ the rigorous tests of population genetics have increasingly suggested otherwise.In these new studies[1-5],the non-Darwinian,or neutral,model of evolution can adequately explain the documented diversities in tumors without invoking natural selection.Therefore,the half-century-old debate of selectionism vs.neutralism[6-8]on the role of natural selection in populations is | hurng-yi wang yuxin chen ding tong shaoping ling zheng hu yong tao xuemei lu chung-i wu | 2018 | National Science Review2018，5，1： | 3 |
| 3 | Transcriptional regulation of oil biosynthesis inseed plants: Current understanding, applications,and perspectives显示文摘Plants produce and accumulate triacylglycerol(TAG)in their seeds as an energy reservoir to support the processes of seed germination and seedling development.Plant seed oils are vital not only for the human diet but also as renewable feedstocks for industrial use.TAG biosynthesis consists of two major steps:de novo fatty acid biosynthesis in the plastids and TAG assembly in the endoplasmic reticulum.The latest advances in unraveling transcriptional regulation have shed light on the molecular mechanisms of plant oil biosynthesis.We summarize recent progress in understanding the regulatory mechanisms of wellcharacterized and newly discovered transcription factors and other types of regulators that control plant fatty acid biosynthesis.The emerging picture shows that plant oil biosynthesis responds to developmental and environmental cues that stimulate a network of interacting transcriptional activators and repressors,which in turn fine-tune the spatiotemporal regulation of the pathway genes. | Yuzhou Yang Que Kong Audrey R.Q.Lim Shaoping Lu Hu Zhao Liang Guo Ling Yuan Wei Ma | 2022 | Plant Communications2022，3，5： | 2 |
| 4 | Current state and future of co-inhibitory immune checkpoints for the treatment of glioblastoma显示文摘In the interaction between a tumor and the immune system,immune checkpoints play an important role,and in tumor immune escape,co-inhibitory immune checkpoints are important.Immune checkpoint inhibitors(ICIs)can enhance the immune system's killing effect on tumors.To date,impressive progress has been made in a variety of tumor treatments;PD1/PDL1 and CTLA4 inhibitors have been approved for clinical use in some tumors.However,glioblastoma(GBM)still lacks an effective treatment.Recently,a phase III clinical trial using nivolumab to treat recurrent GBM showed no significant improvement in overall survival compared to bevacizumab.Therefore,the use of immune checkpoints in the treatment of GBM still faces many challenges.First,to clarify the mechanism of action,how different immune checkpoints play roles in tumor escape needs to be determined;which biomarkers predict a benefit from ICIs treatment and the therapeutic implications for GBM based on experiences in other tumors also need to be determined.Second,to optimize combination therapies,how different types of immune checkpoints are selected for combined application and whether combinations with targeted agents or other immunotherapies exhibit increased efficacy need to be addressed.All of these concerns require extensive basic research and clinical trials.In this study,we reviewed existing knowledge with respect to the issues mentioned above and the progress made in treatments,summarized the state of ICIs in preclinical studies and clinical trials involving GBM,and speculated on the therapeutic prospects of ICIs in the treatment of GBM. | Shaoping Shen Ling Chen Jialin Liu Lin Yang Mengna Zhang Lingxiong Wang Rong Zhang Yasushi Uemura Qiyan Wu Xinguang Yu Tianyi Liu | 2020 | Cancer Biology & Medicine2020，17，3： | 0 |
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