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| 1 | 英国预防医院感染循证指南--导管相关血流感染的预防指南(Ⅱ)显示文摘1医务人员及患者的教育IVAD1为预防导管相关血流感染,参与护理血管导管患者的医务人员应经过培训,并经评估可以胜任正确使用和持续依从预防血管导管相关感染指南。Class D/GPP IVAD2医务人员应该了解不同导管、连接装置、输液系统的留置时间,消毒剂与其他液体兼容性的制造商建议,确保安全使用这些物品。新建议Class | 热伊拜.亚迪佧尔 Loveday H P Wilson J A Pratta R J | 2014 | 中国感染控制杂志2014，13，9： | 62 |
| 2 | 英国预防医院感染循证指南--预防留置导尿管相关感染的指南(Ⅲ)显示文摘本指南适用于成人及〉1岁儿童的短期留置导尿管(≤28 d),需要结合标准原则,推荐意见被分成6部分:(1)置管的必要性;(2)管道类型及置管方法的选择;(3)导管的插入;(4)导管的护理;(5)对患者、家属及医务人员的培训;(6)系统干预用于降低感染风险。 | 热伊拜.亚迪佧尔 Loveday H P Wilson J A Pratta R J | 2014 | 中国感染控制杂志2014，13，10： | 19 |
| 3 | 英国NHS医院——预防医院感染循证指南(Ⅰ)显示文摘现在呈现在读者面前的是英国国家医疗服务系统(NHS)医院预防医院感染的国家循证指南第3版。该指南初版于2001年发布,起源于受英国卫生部委托,由护理人员牵头众多专业的研究人员和临床专家在1998—2000年进行研究(epic1)。2007年,在epic2研究基础上进行了第1次更新(第2版)。该指南的一个显著特点是及时回顾新的研究成果,采用新的循证医学证据,维持它的有效性和权威性。虽然一份更新证据的重要评估报告表明2007年出版的第2版指南仍然保持其强有力的相关性及适时性(epic3),但2014年发布的第3版指南仍对一些指南推荐的级别要求进行了必要的调整,同时有证据支持的指南推荐意见也被更新。在英国,尽管第3版指南依据目前最有力的证据为医院及其他急救机构预防医院感染提供了最全面的推荐意见,而且国家循证指南是最好实践的宏观原则,但需结合当地的实践指南,以减少实践中的差异和维护患者安全。指南的作者认为,临床有效预防和控制感染,是保护患者的基本特征;希望通过将这些指南应用于日常临床实践,保障患者的安全,减少医院感染。本刊组织有关人员将英国NHS医院——预防医院感染的国家循证指南主要内容进行编译,分3期连续刊出,以飨读者,不正之处,敬请批评指正。 | 热伊拜·亚迪佧尔 吴安华(校) Loveday H P Wilson J A Pratta R J | 2014 | 中国感染控制杂志2014，13，7： | 10 |
| 4 | Pancreatic cancer and its stroma: A conspiracy theory显示文摘Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has received little attention until recent times. Given that treatments focusing on pancreatic cancer cells alone have failed to significantly improve patient outcome over many decades, research efforts have now moved to understanding the pathophysiology of the stromal reaction and its role in cancer progression. In this regard, our Group was the first to identify the cells(pancreatic stellate cells, PSCs) that produced the collagenous stroma of pancreatic cancer and to demonstrate that these cells interacted closely with cancer cells to facilitate local tumour growth and distant metastasis. Evidence is accumulating to indicate that stromal PSCs may also mediate angiogenesis, immune evasion and the well known resistance of pancreatic cancer to chemotherapy and radiotherapy. This review will summarise current knowledge regarding the critical role of pancreatic stellate cells and the stroma in pancreatic cancer biologyand the therapeutic approaches being developed to target the stroma in a bid to improve the outcome of this devastating disease. | Zhihong Xu Srinivasa P Pothula Jeremy S Wilson Minoti V Apte | 2014 | World Journal of Gastroenterology2014，20，32： | 10 |
| 5 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 6 | Chemical associations of lead, cadmium, copper and zinc in street dusts and roadside soils显示文摘 | Harrison R M Laxen D P H Wilson S J | 1981 | Environmental Science and Technology1981，15，11： | 2 |
| 7 | Reliability of ultrasound ovarian-adnexal reporting and data system amongst less experienced readers before and after training显示文摘BACKGROUND The 2018 ovarian-adnexal reporting and data system(O-RADS)guidelines are aimed at providing a system for consistent reports and risk stratification for ovarian lesions found on ultrasound.It provides key characteristics and findings for lesions,a lexicon of descriptors to communicate findings,and risk characterization and associated follow-up recommendation guidelines.However,the ORADS guidelines have not been validated in North American institutions or amongst less experienced readers.AIM To evaluate the diagnostic accuracy and inter-reader reliability of ultrasound ORADS risk stratification amongst less experienced readers in a North American institution with and without pre-test training.METHODS A single-center retrospective study was performed using 100 ovarian/adnexal lesions of varying O-RADS scores.Of these cases,50 were allotted to a training cohort and 50 to a testing cohort via a non-randomized group selection process in order to approximately equal distribution of O-RADS categories both within and between groups.Reference standard O-RADS scores were established through consensus of three fellowship-trained body imaging radiologists.Three PGY-4 residents were independently evaluated for diagnostic accuracy and inter-reader reliability with and without pre-test O-RADS training.Sensitivity,specificity,positive predictive value,negative predictive value(NPV),and area under the curve(AUC)were used to measure accuracy.Fleiss kappa and weighted quadratic(pairwise)kappa values were used to measure inter-reader reliability.Statistical significance was P<0.05.RESULTS Mean patient age was 40±16 years with lesions ranging from 1.2 to 22.5 cm.Readers demonstrated excellent specificities(85%-100%pre-training and 91%-100%post-training)and NPVs(89%-100%pre-training and 91-100%post-training)across the O-RADS categories.Sensitivities were variable(55%-100%pre-training and 64%-100%post-training)with malignant ORADS 4 and 5 Lesions pre-training and post-training AUC values of 0.87-0.95 and 0.94-098,respectively(P<0.001).Nineteen of 22(86%)misclassified cases in pre-training were related to mischaracterization of dermoid features or wall/septation morphology.Fifteen of 17(88%)of posttraining misclassified cases were related to one of these two errors.Fleiss kappa inter-reader reliability was‘good’and pairwise inter-reader reliability was‘very good’with pre-training and post-training assessment(k=0.76 and 0.77;and k=0.77-0.87 and 0.85-0.89,respectively).CONCLUSION Less experienced readers in North America achieved excellent specificities and AUC values with very good pairwise inter-reader reliability.They may be subject to misclassification of potentially malignant lesions,and specific training around dermoid features and smooth vs irregular inner wall/septation morphology may improve sensitivity. | Prayash Katlariwala Mitchell P Wilson Yeli Pi Baljot S Chahal Roger Croutze Deelan Patel Vimal Patel Gavin Low | 2022 | World Journal of Radiology2022，14，9： | 2 |
| 8 | The oxidative dehydrogenation of ethane over catalysts containing mixed oxides of molybdenum and vanadium显示文摘 | Thorsteinson E M Wilson T P Young F G | 1978 | J Catal1978，52，： | 2 |
| 9 | A nonconforming element for stress analysis显示文摘 | Toylor R L Beresford P J Wilson E L | 1976 | International Journal for Numerical Methods in Engineering1976，，10： | 2 |
| 10 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 11 | 血清铁蛋白是非酒精性脂肪肝患者组织炎症严重程度和晚期肝纤维化的独立预测指标显示文摘非酒精性脂肪肝(nonalcoholicfattyliverdisease。NAFLD)是肝脏疾病最常见的病因.在美国人群中发病率可达20%。铁蛋白是肝脏储存铁的主要形式.原发性或继发性铁代谢紊乱都会增加肝脏铁蛋白的分泌.从而导致肝内和循环中铁蛋白水平的增加。研究表明.炎症刺激和氧化应激能上调血清铁蛋白(sel3.1mferriritin,SF)的表达,其作用可能是通过特殊的氧化剂作用于蛋白质转录和翻译阶段而实现的。 | Kowdley KV Belt P Wilson LA 罗光成 闫惠平 | 2013 | 北京医学2013，35，3： | 2 |
| 12 | Estradiol moduaates bcl-2 in cerebral ischemia:a potential role for eatrogen receptors 显示文摘 | Dubal D B Shughrue P J Wilson M E | 1999 | J Neuroscience1999，19，15： | 1 |
| 13 | Report on the 12th International Society of Blood Transfusion platelet immunology workshop显示文摘 | Bessos H Wilson DWL Metcalfe P | 2005 | Vox Sanguinis2005，89，： | 1 |
| 14 | Detection of human papillomavirus DNA in cancer of the urinary bladder by in situ hybridization显示文摘 | Bryant P Davies P Wilson D | 1991 | Br J Urol1991，68，1： | 1 |
| 15 | C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study显示文摘 | Wilson PW Pencina M Jacques P | 2008 | Circ Cardiovasc Qual Outcomes2008，1，2： | 1 |
| 16 | Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ显示文摘 | Wilson M C Meredith D Halestrap A P | 2002 | J Biol Chem2002，277，5： | 1 |
| 17 | Comparison of numbers and enzymatic activities in surface soils and subsoils using various techniques显示文摘 | TAYLOR J P WILSON B MILLS M S | 2002 | Soil Biology Biochemical2002，34，： | 1 |
| 18 | On the experimental attainment of optimum condition显示文摘 | Box G E P Wilson K B | 1951 | J of the Royal Stat Society Series B1951，13，1： | 1 |
| 19 | Comparison of micro bial numbers and enzymatic activities in surface soils and sub soils using various techniques显示文摘 | Taylor T P Wilson B Mills M S | 2002 | Soil Biology and Biochemis try2002，34，： | 1 |
| 20 | Species competitive ability and position along a natural stress/disturbance gradient显示文摘 | Wilson S D Keddy P A | 1986 | Ecology1986，67，： | 1 |
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