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| 1 | Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chemo-radiation?显示文摘AIM To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) performed in a highvolume tertiary cancer center. METHODS A retrospective review of patients undergoing esophagectomy was performed and patients with c T1 N0 and c T2 N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to compare variables. Logistic regression analysis was used to determine if clinical variables such as tumor location and tumor histology were associated with EUS accuracy.RESULTS Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectomy were identified. There were 25(18%) female and 114(82%) male patients. The tumor location included the middle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. Ninety-three percent of patients had adenocarcinoma. Preoperative EUS matched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron emission tomography(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom both EUS and PET were negative for nodal involvement. CONCLUSION EUS is less accurate in early EC and endoscopic mucosal resection might be useful in certain settings. The addition of PET to EUS improves staging accuracy. | Carrie Luu Marisa Amaral Jason Klapman Cynthia Harris Khaldoun Almhanna Sarah Hoffe Jessica Frakes Jose M Pimiento Jacques P Fontaine | 2017 | World Journal of Gastroenterology2017，23，46： | 8 |
| 2 | 血小板第4因子抑制巨核细胞系膜结合型c-kit的表达(英文)显示文摘细胞表面受体c-kit与干细胞因子(SCF)对维持血细胞的生成起重要作用。血小板第4因子(PF4)能特异性地抑制巨核细胞生成。在本实验中研究了PF4对两个巨核细胞系HEL和Dami的c-kit表达影响。结果显示,经PF4处理的两株细胞,其c-kit mRNA表达量均下降,细胞表面受体数量降低,SCF与c-kit的结合量亦下降,两组差异有显著意义。在对细胞膜CD34表达影响方面,PF4与TGFβ1的作用相反,PF4促进CD34的表达,而TGFβ1抑制CD34的表达。研究表明,PF4抑制巨核细胞生长的机理,部分途径可能是通过抑制c-kit/SCF而产生。 | 顾学范 奚晓东 Jacques P Caen | 1997 | 中国实验血液学杂志1997，5，2： | 4 |
| 3 | Diabetic nephropathy in Africa:A systematic review显示文摘AIM:To determine the prevalence and incidence of diabetic nephropathy in Africa.METHODS:We performed a systematic narrative review of published literature following the MOOSE Guidelines for Meta-Analysis and Systematic Reviewsof Observational Studies.We searched Pub MedMEDLINE for all articles published in English and French languages between January 1994 and July 2014 using a predefined strategy based on the combination of relevant terms and the names of each of the 54 African countries and African sub-regions to capture the largest number of studies,and hand-searched the reference lists of retrieved articles.Included studies reported on the prevalence,incidence or determinants of chronic kidney disease(CKD) in people with diabetes within African countries.RESULTS:Overall,we included 32 studies from 16 countries;two being population-based studies and the remaining being clinic-based surveys.Most of the studies(90.6%) were conducted in urban settings.Methods for assessing and classifying CKD varied widely.Measurement of urine protein was the most common method of assessing kidney damage(62.5% of studies).The overall prevalence of CKD varied from 11% to 83.7%.Incident event rates were 94.9% for proteinuria at 10 years of follow-up,34.7% for endstage renal disease at 5 years of follow-up and 18.4% for mortality from nephropathy at 20 years of followup.Duration of diabetes,blood pressure,advancing age,obesity and glucose control were the common determinants of kidney disease.CONCLUSION:The burden of CKD is important among people with diabetes in Africa.High quality data from large population-based studies with validated measures of kidney function are still needed to better capture the magnitude and characteristics of diabetic nephropathy in Africa. | Jean Jacques N Noubiap Jashira Naidoo Andre P Kengne | 2015 | World Journal of Diabetes2015，6，5： | 3 |
| 4 | C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study显示文摘 | Wilson PW Pencina M Jacques P | 2008 | Circ Cardiovasc Qual Outcomes2008，1，2： | 1 |
| 5 | Bioconversion of a L-carnitine precursor in a one-or two-phase system 显示文摘 | Bare G Jacques P Hubert J B | 1991 | Appl Biochem Biotechnol1991，2829，： | 1 |
| 6 | Codes for solar flux calculation dedicated to central receiver system applications: A comparative review显示文摘 | Garcia P FerriereA Jacques Bezian J | 2008 | Solar Energy2008，82，3： | 1 |
| 7 | Randomized study to compare balloon angioplasty and elective stent implantation in venous bypass grafts: the venestent study 显示文摘 | Hanekamp C E E Jacques J K den Heijer P | 2003 | Catheter Cardiovasc Interv2003，60，： | 1 |
| 8 | Localization of laminin,fibronectin,E-caderin,and integrins in endometrium and endometriosis显示文摘 | Aude Beliard M D Jacques Donnez P H D | 1997 | Fertil Steril1997，67，： | 1 |
| 9 | The developments of cold-rolled TRIP-assisted multiphase steels-low silicon TRIP-assisted multiphase steels显示文摘 | Jacques P J Girault E Harlet Ph | 2001 | ISIJ international2001，41，9： | 1 |
| 10 | Metallographic Methods for Revealing the Multiphase Microstructure of TRIP-Assisted Steels显示文摘 | GIRAULT E JACQUES P HARLET P | 1998 | Mater Char1998，40，： | 1 |
| 11 | Influence of culture conditions on lipopeptide production by Bacillus sub- tilis显示文摘 | Akpa E Jacques P Wathelet B | 2001 | Applied Biochemistry and Biotechnology2001，9193，19： | 1 |
| 12 | Competitive exclusion of salmonella using bacterial cultures and oligosaccharides显示文摘 | Lyons T P Jacques K A Nottingham A | 1995 | Biotecnology1995，16，38： | 1 |
| 13 | Immunocytochemical characterization of pulmonary histiocytosis X cells in lung biopsies显示文摘 | Soler P Chollet S Jacque C | 1985 | Am J Pathol1985，118，3： | 1 |
| 14 | Risk-based capital, portfolio risk, and bank capital: A simultaneous equations approach 显示文摘 | Jacques K Nigro P | 1997 | Journal of Economics and Business1997，49，6： | 1 |
| 15 | Systemic induction of hy- toalexins in cucumber in response to treatments with fluorescent seudomonas显示文摘 | Ongena M Daayf F Jacques P | 2000 | Plant Pathol2000，49，4： | 1 |
| 16 | The effect of fo-lic acid fortification on plasma folate and total homocysteine concen-trations 显示文摘 | JACQUES P F SELHUB J BOSTOM A G | 1999 | N Engl J Med1999，340，19： | 1 |
| 17 | Fasting plasma homocysteine levels in the insulin resistance syndrome:the Framingham offspring study显示文摘 | Meigs J B Jacques P F Selhub J | 2001 | Diabetes Care2001，24，： | 1 |
| 18 | Systemic induction of phytoalexins in cucumber in response to treatments with fluo- rescent pseudomonads 显示文摘 | Ongena M Daayf F Jacques P | 2000 | Plant Pathology2000，49，4： | 1 |
| 19 | Bacillus lipopeptides: versatile weapons for plant disease biocontrol 显示文摘 | Ongena M Jacques P | 2008 | Trends in Microbiology2008，16，3： | 1 |
| 20 | The γ,γ mismatch in Ni based superalloys: In situ measurements during creep test 显示文摘 | Diologent F Caron P Jacques A | 2002 | Nuclear Instruments and Methods in Physics Research B2002，200，： | 1 |
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