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| 1 | Podoplanin是一种优于calretinin的较好的诊断肉瘤样间皮瘤免疫标记物显示文摘 | Padgett D M Cathro H P Wick M R 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，1： | 12 |
| 2 | 钠-葡萄糖共转运蛋白-2抑制剂或胰高血糖素样肽-1受体激动剂治疗成人2型糖尿病:临床实践指南显示文摘临床问题对于存在不同心血管风险及肾脏结局的2型糖尿病患者,在原有生活方式干预和/或其他降糖药物的基础上加用钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂的获益及风险是什么?现行做法几十年来,2型糖尿病的治疗决策都以控制血糖为主导。SGLT-2抑制剂和GLP-1受体激动剂在传统观念中常被用于二甲双胍治疗后血糖仍控制不佳的患者。目前这一现状已经发生了改变,这得益于多项临床研究结果。研究显示SGLT-2抑制剂和GLP-1受体激动剂拥有独立于药物降糖作用之外的对于动脉粥样硬化性心血管病(CVD)和慢性肾脏病(CKD)的获益。建议本指南阐述了针对不同风险分层的成人2型糖尿病患者使用SGLT-2抑制剂或GLP-1受体激动剂的建议。•伴有3种或更少的心血管风险因素且不存在CVD或CKD:不建议启动SGLT-2抑制剂或GLP-1受体激动剂治疗。(推荐等级:弱)•伴有3种以上心血管风险因素且不存在CVD或CKD:建议启动SGLT-2抑制剂治疗,不建议启动GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD或CKD:建议启动SGLT-2抑制剂治疗和GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD和CKD:建议启动SGLT-2抑制剂治疗(推荐等级:强)和GLP-1受体激动剂治疗。(推荐等级:弱)•对于那些想要进一步降低CVD和CKD结局风险的患者:推荐优先启用SGLT-2抑制剂治疗而非GLP-1受体激动剂治疗。(推荐等级:弱)这项指南是如何制订的一个由患者、临床医生和方法学家共同组成的国际小组提出了这些推荐意见。这些推荐意见基于可信度较高的指南的标准,并使用GRADE分级方法进行评估。该小组采用了息者个体化的观点。证据一项关于获益与风险的系统综述和网络meta分析(764项随机对照研究,包括421346例参与者)发现SGLT-2抑制剂和GLP-1受体激动剂可以降低总体死亡率、心肌梗死发生率、终末期肾病或肾衰竭的发生率(中等至高等质量的证据)。在不同的亚组中这些药物对卒中、因心力衰竭所致住院和其他主要不良事件有不同的影响。药物绝对获益的程度因患者个体风险的不同有很大的差异。(例如,对于接受了超过5年药物治疗的1000例患者,在最低风险人群中死亡人数减少了5人,在最高风险人群中死亡人数减少了48人)。一项关于预后的综述确认了14种风险预测模型,其中一种(RECODe)在证据总结中报告了大部分基线风险评估数据,小组利用该模型以支持风险分层的建议。考虑到患者的价值观及个体差异,指南推荐的支撑证据包括一项对已发表论文的系统综述、一项患者焦点小组研究、一项临床问题总结,以及一项指南调查。指南解读我们依据不同的CVD和CKD风险水平,综合考虑获益、风险和其他因素的平衡,以及每一个风险组别的实际问题,来对推荐意见进行分层。本指南强烈建议CVD和CKD患者使用SGLT-2抑制剂治疗,这说明专家组认为其具有显著的获益。而对于其他成人2型糖尿病患者,推荐等级较弱,这说明专家组想要在获益、风险及治疗花费上取得一个更好的平衡。临床医生通过该指南可以使用可靠的风险计算模型,如RECODe,来明确其患者的个体心血管和肾脏疾病风险。医患交互式总结临床证据和制订决策有助于患者知晓治疗选择,包括进行共同决策。2型糖尿病人群(全球患病率不断增长1-2)正面临着不断增加的心血管疾病、肾脏病和其他并发症的风险3。数十年来,2型糖尿病的管理始终以控制血糖及糖化血红蛋白(HbA1c)为治疗目标4-5,但是,最近的高质量随机对照研究已经对这种以血糖为中心的治疗模式发起了挑战。研究结果显示,强化血糖控制未必会降低大血管不良事件,它还可能带来不利影响监管机构现在要求新型糖尿病药物必须证明其具有心血管和肾脏获益才能获得批准。对两类新药--钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂(见框图1)的临床试验结果显示,在现有治疗方案(常规治疗)之上加用这些药物,对死亡、心肌梗死、卒中、心力衰竭和肾脏的结局(如进展为终末期肾病)都有获益8-12。 | Sheyu Li Per Olav Vandvik Lyubov Lytvyn Gordon H Guyatt Suetonia C Palmer Rene Rodriguez-Gutierrez Farid Foroutan Thomas Agoritsas Reed A C Siemieniuk Michael Walsh Lawrie Frere David J Tunnicliffe Evi V Nagler Veena Manja Bjφrn Olav Asvold Vivekanand Jha Mieke Vermandere Karim Gariani Qian Zhao Yan Ren Emma Jane Cartwright Patrick Gee Alan Wickes Linda Fems Robin Wright Ling Li Qiukui Hao Reem A Mustafa 无 郭鹤鸣(译) | 2021 | 英国医学杂志中文版2021，24，9： | 7 |
| 3 | Carbon Dioxide and Nitrous Oxide Emissions from Naturally Occurring Sulfate-Based Saline Soils at Different Moisture Contents显示文摘Soil salinization may negatively affect microbial processes related to carbon dioxide(CO_2) and nitrous oxide(N_2O) emissions. A short-term laboratory incubation experiment was conducted to investigate the effects of soil electrical conductivity(EC) and moisture content on CO_2 and N_2O emissions from sulfate-based natural saline soils. Three separate 100-m long transects were established along the salinity gradient on a salt-affected agricultural field at Mooreton, North Dakota, USA. Surface soils were collected from four equally spaced sampling positions within each transect, at the depths of 0–15 and 15–30 cm. In the laboratory, artificial soil cores were formed combining soils from both the depths in each transect, and incubated at 60% and 90% water-filled pore space(WFPS) at 25?C. The measured depth-weighted EC of the saturated paste extract(EC_e) across the sampling positions ranged from 0.43 to 4.65 dS m^(-1). Potential nitrogen(N) mineralization rate and CO_2 emissions decreased with increasing soil EC_e, but the relative decline in soil CO_2 emissions with increasing ECe was smaller at 60% WFPS than at 90% WFPS. At 60% WFPS, soil N_2O emissions decreased from 133 μg N_2O-N kg^(-1) soil at EC_e < 0.50 dS m^(-1) to 72 μg N_2O-N kg^(-1) soil at EC_e = 4.65 dS m^(-1). In contrast, at 90% WFPS,soil N_2O emissions increased from 262 μg N_2O-N kg^(-1) soil at EC_e = 0.81 dS m^(-1) to 849 μg N_2O-N kg^(-1) soil at EC_e = 4.65 dS m^(-1), suggesting that N_2O emissions were linked to both soil ECe and moisture content. Therefore, spatial variability in soil EC_e and pattern of rainfall over the season need to be considered when up-scaling N_2O and CO_2 emissions from field to landscape scales. | Resham THAPA Amitava CHATTERJEE Abbey WICK Kirsten BUTCHER | 2017 | Pedosphere2017，27，5： | 5 |
| 4 | 外科医生和病理医生对胸腺恶性肿瘤切除标本的处理方法和程序显示文摘胸腺恶性肿瘤发病率低,临床病例分散,需要结合多中心经验才能进行良好的研究,但由于在诸多方面没有统一标准,使得研究与研究之间的可比性差。其中外科医生和病理医生对胸腺恶性肿瘤切除标本的处理是统一标准中至关重要的部分。针对目前胸腺瘤的常用手术方式胸骨劈开根治性R0切除术的标本处理作如下规定,包括切除胸腺瘤及周围的受累结构说明如何处理手术切除标本。活检或细胞学标本的处理另文描述[1]。本文首先由国际胸腺肿瘤协作组织(International hTymic Malignacy Interest Group, ITMIG)中病理医生和外科医生组成的小组回顾相关文献形成初步建议[2,3],交扩展组审议提炼后分发给ITMIG成员进讨论,再将ITMIG成员回馈的建议和几个大中心试点的情况进行提炼,最终形成的建议经ITMIG批准并被采用。因此,既强调证据又代表ITMIG成员的广泛共识。 | 付浩 中国胸腺瘤协作组全体成员 Frank C.Detterbeck Cesar Moran James Huang Saul Suster Garrett Walsh Lawrence Kaiser Mark Wick | 2014 | 中国肺癌杂志2014，17，2： | 3 |
| 5 | 基于相场法的酸压裂缝连通孔洞数值模拟显示文摘碳酸盐岩孔洞连通成串、成群可以有效提高改造体积,但受到高应力差、非均质性和孔洞随机分布等影响,孔洞连通性通常较差。针对碳酸盐岩酸压孔洞连通成串的工程问题,考虑酸压过程中酸液对于岩石的动态影响,引入描述酸岩反应的相场参数,提出一种基于相场法的酸压裂缝扩展模拟方法,对碳酸盐岩储层酸压孔洞连通成串现象进行模拟。对比了酸压与滑溜水压裂的裂缝扩展特征,分析了不同孔洞大小与分布情况下孔洞结构对酸压裂缝扩展的影响。根据模拟分析结果可知:(1)与普通水力裂缝相比,酸压裂缝扩展时缝宽增大,缝长降低,裂缝扩展速度降低;同时裂缝表面岩石被酸液腐蚀,裂缝表面粗糙程度明显上升;(2)孔洞结构会诱导酸压裂缝扩展,裂缝在酸化区域扩展时,靠近孔洞处的扩展速度更高;(3)缝洞型储层酸压过程中,孔洞半径越大,距离裂缝原扩展路径越近,裂缝越易发生转向,且越容易沟通多个孔洞,多孔洞连通成串可以有效提高泄流面积。 | 侯冰 戴一凡 范濛 张鲲鹏 Wick Thomas Lee Sanghyun | 2022 | 石油学报2022，43，6： | 2 |
| 6 | A large scale distributed intrusion detection framework based on attack strategy analysis显示文摘 | Huang M Jasper R Wicks T | 1999 | Computer Networks1999，31，3： | 2 |
| 7 | 脑卒中血栓切除术后血压与短期和长期功能转归的相关性显示文摘缺血性脑卒中机械性血栓切除术后的转归可能受血压的影响。该研究旨在评估全身麻醉期间和清醒镇静期间血压变化与机械性血栓切除术后功能性转归的关系。血管内治疗脑卒中的镇静与气管插管研究是一项涉及血压目标值的,比较在全身麻醉与在清醒镇静的条件下行机械血栓切除疗效的单中心随机试验。 | 刘青 叶鹏 Schnenberger S Uhlmann L Ungerer M Pfaff J Nagel S Klose C Bendszus M Wick W Ringleb PA Kieser M Mhlenbruch MA Bsel J | 2018 | 中华高血压杂志2018，26，7： | 2 |
| 8 | Brain metastases: pathobiology and emerging targeted therapies显示文摘 | Matthias Preusser David Capper Aysegül Ilhan-Mutlu Anna Sophie Berghoff Peter Birner Rupert Bartsch Christine Marosi Christoph Zielinski Minesh P. Mehta Frank Winkler Wolfgang Wick Andreas Deimling | 2012 | Acta Neuropathologica2012，，2： | 2 |
| 9 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 10 | Continuous quality improvement:A problem solving approach ( part 2) ( Educational Supplement ) 显示文摘 | Wick G | 1993 | Nephrology Nursing Today1993，3，： | 2 |
| 11 | Psychotherapeutic counseling and pregnancy rates in in vitro fertilization 显示文摘 | Poehl M Bichler K Wicke V | 1999 | J Assist Reprod Genet1999，16，6： | 1 |
| 12 | New (alternative) temozolomide regimens for the treatment of glioma显示文摘 | Wick W Platten M Weller M | 2009 | Neuro Oncol2009，11，1： | 1 |
| 13 | Activation of PDGF receptor alpha in vascular smooth muscle cells by mechanical stress 显示文摘 | Hu Y Bock G Wick G Xu Q | 1998 | FASEB J1998，12，12： | 1 |
| 14 | Thymoma : a clinicopathologic review 显示文摘 | Lewis JE Wick MR Scheithauer BW | 1987 | Cancer1987，60，： | 1 |
| 15 | Performance characterization of a hybrid STAP architecture incorporating elevation interferometry显示文摘 | Hale T Temple M Wicks M Raquet J Oxley M | 2002 | IEE Part-F2002，149，2： | 1 |
| 16 | Effect of cell number at freezing upon survival and viability of cleaving embryos generated from stimulated IVF cycles 显示文摘 | Hartshorne GM Wick K Elder K | 1990 | Hum Reprod1990，5，7： | 1 |
| 17 | From ideas to action: Creating a learning organization 显示文摘 | Wick C W Leon L S | 1995 | Human Resource Management1995，34，2： | 1 |
| 18 | Prevalence of depress ion in a 12-month consecutive sample of patients with AES显示文摘 | Wicks P Abrahams S Masi D | 2007 | EurJ Neuro12007，14，9： | 1 |
| 19 | The influence of the ionic concentration, concentration of the polymer, degree of neutralization and chain ex- tension on aqueous polyurethane dispersions prepared by the acetone process 显示文摘 | Nanda A K Wicks D A | 2006 | Polymer2006，47，6： | 1 |
| 20 | The effect of a confining unit on the geochemical evolution of ground water in the Upper Floridan aquifer system显示文摘 | Wicks C M Herman J S | 1994 | Journal of Hydrology1994，153，1： | 1 |
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