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| 1 | Eosinophilic esophagitis: Updated consensus recommendations for children and adults显示文摘 | Chris A. Liacouras Glenn T. Furuta Ikuo Hirano Dan Atkins Stephen E. Attwood Peter A. Bonis A. Wesley Burks Mirna Chehade Margaret H. Collins Evan S. Dellon Ranjan Dohil Gary W. Falk Nirmala Gonsalves Sandeep K. Gupta David A. Katzka Alfredo J. Lucendo Jo | 2011 | The Journal of Allergy and Clinical Immunology2011，，1： | 3 |
| 2 | High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis显示文摘Background:Schistosomiasis,a parasitic disease also known as bilharzia and snail fever,is caused by different species of flatworms,such as Schistosoma mansoni(S.mansoni).Thioredoxin glutathione reductase(TGR)from S.mansoni(SmTGR)is a well-characterized drug target for schistosomiasis,yet no anti-SmTGR compounds have reached clinical trials,suggesting that therapeutic development against schistosomiasis might benefit from additional scaffolds targeting this enzyme.Methods:A high-throughput screening(HTS)assay in vitro against SmTGR was developed and applied to a diverse compound library.SmTGR activity was quantified with ThioGlo®,a reagent that fluoresces upon binding to the free sulfhydryl groups of the reaction product GSH(reduced glutathione).Results:We implemented an HTS effort against 59,360 synthetic compounds.In the primary screening,initial hits(928 or 1.56%)showing greater than 90%inhibition on SmTGR activity at a final concentration of 10μM for each compound were identified.Further tests were carried out to confirm the effects of these hits and to explore the concentration-dependent response characteristics.As a result,74 of them(0.12%)representing 17 chemical scaffolds were confirmed and showed a great concentration-dependent inhibitory trend against SmTGR,including structures previously shown to be lethal to schistosomal growth.Of these,two scaffolds displayed a limited structure-activity relationship.When tested in cultured larvae,39 compounds had cidal activity in 48 h,and five of them killed larvae completely at 3.125μM.Of these,three compounds also killed adult worms ex vivo at concentrations between 5μM and 10μM.Conclusion:These confirmed hits may serve as starting points for the development of novel therapeutics to combat schistosomiasis. | Ting Li Peter D.Ziniel Pan-qing He Valerie P.Kommer Gregory J.Crowther Min He Qing Liu Wesley C.Van Voorhis David L.Williams Ming-Wei Wang | 2015 | Infectious Diseases of Poverty2015，4，1： | 3 |
| 3 | Redicting Business Failure: A Macroeconomic Perspective 显示文摘 | Rose Peter S Andrews Wesley T Giroux Gary A P | 1982 | Journal of Accounting Auditing and Finance1982，，1： | 1 |
| 4 | Eosinophilic esophagitis: Updated consensus recommendations for children and adults显示文摘 | Chris A. Liacouras Glenn T. Furuta Ikuo Hirano Dan Atkins Stephen E. Attwood Peter A. Bonis A. Wesley Burks Mirna Chehade Margaret H. Collins Evan S. Dellon Ranjan Dohil Gary W. Falk Nirmala Gonsalves Sandeep K. Gupta David A. Katzka Alfredo J. Lucendo Jo | 2011 | The Journal of Allergy and Clinical Immunology2011，，1： | 1 |
| 5 | The pathobiology of eosinophilie gastroenteritis of ehildhood: is it really the eosinophil, allergie mediated,or something else ? 显示文摘 | sNgo Peter Furuta Glenn Burks Wesley | 2004 | Curr Gastroenterol Rep2004，6，6： | 1 |
| 6 | Dissolution testing of a poorly soluble compound using the flow-through cell dissolution apparatus显示文摘 | Shobha N Bhattachar James A Wesley Ann Fioritto Peter J Martin Suresh R Babu | 2002 | International Journal of Pharmaceutics2002，，1： | 1 |
| 7 | Sleep deprivation alters pupillary reactivity to emotional stimuli in healthy young adults显示文摘 | Peter L. Franzen Daniel J. Buysse Ronald E. Dahl Wesley Thompson Greg J. Siegle | 2008 | Biological Psychology2008，，3： | 1 |
| 8 | Modeling social interactions: Identification, empirical methods and policy implications显示文摘 | Wesley R. Hartmann Puneet Manchanda Harikesh Nair Matthew Bothner Peter Dodds David Godes Kartik Hosanagar Catherine Tucker | 2008 | Marketing Letters . 2008 (3-4)2008，，3： | 1 |
| 9 | 2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS Guideline on the Management of Patients With Extracranial Carotid and Vertebral Artery Disease: Executive Summary显示文摘 | Thomas G. Brott Jonathan L. Halperin Suhny Abbara J. Michael Bacharach John D. Barr Ruth L. Bush Christopher U. Cates Mark A. Creager Susan B. Fowler Gary Friday Vicki S. Hertzberg E. Bruce McIff Wesley S. Moore Peter D. Panagos Thomas S. Riles Robert H. | 2011 | Journal of the American College of Cardiology2011，，8： | 1 |
| 10 | Modeling social interactions: Identification, empirical methods and policy implications显示文摘 | Wesley R. Hartmann Puneet Manchanda Harikesh Nair Matthew Bothner Peter Dodds David Godes Kartik Hosanagar Catherine Tucker | 2008 | Marketing Letters2008，，： | 1 |
| 11 | Depsipeptides from a Guamanian marine cyanobacterium, Lyngbya bouillonii , with selective inhibition of serine proteases显示文摘 | Brent K. Rubio Stephen M. Parrish Wesley Yoshida Peter J. Schupp Tom Schils Philip G. Williams | 2010 | Tetrahedron Letters2010，，51： | 1 |
| 12 | The use of oxygen in gold cyanidation 显示文摘 | Peter D Wesley F Javier O | 1996 | Canadian Institute of mining and metallurgy1996，35，1： | 1 |
| 13 | 2011年ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS颅外颈动脉和椎动脉疾病患者处理指南(续前)显示文摘7血运重建术
7.1关于颈动脉血运重建术患者选择的推荐意见
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1对于在6个月内有过非致残性缺血性卒中或TIA症状(包括半球事件或一过性黑噱)且手术风险中等或较低的患者, | Thomas G. Brott Jonathan L. Halperin Suhny Abbara J. Michael Bacharach John D. Barr Ruth L. Bush Christopher U. Cates Mark A. Creager Susan B. Fowler Gary Friday Vicki S. Hertzberg E. Bruce Mclff Wesley S. Moore Peter D. Panagos Thomas S. Riles Robert H. Rosenwasser Allen J. Taylor 曲东锋 陈兴洲(译) | 2013 | 国际脑血管病杂志2013，21，10： | 1 |
| 14 | The introducer technique is the optimal method for placing percutaneous endoscopic gastrostomy tubes in head and neck cancer patients显示文摘 | Jason M. Foster Peter Filocamo Hector Nava Michael Schiff Wesley Hicks Nestor Rigual Judy Smith Thom Loree John F. Gibbs | 2007 | Surgical Endoscopy2007，，6： | 1 |
| 15 | Modeling social interactions: Identification, empirical methods and policy implications显示文摘 | Wesley R. Hartmann Puneet Manchanda Harikesh Nair Matthew Bothner Peter Dodds David Godes Kartik Hosanagar Catherine Tucker | 2008 | Marketing Letters (-)2008，，3： | 1 |
| 16 | Precast Concrete Double-Tee Connections, part 1: Tension Behavior 显示文摘 | Naito C Liling Cao Wesley Peter | 2009 | PCI Journal2009，，2： | 1 |
| 17 | 丹尼尔斯大厦 加拿大多伦多显示文摘多伦多大学丹尼尔斯建筑、景观和设计学院的设计采用了分期的方法,包括修复和扩建以前称为“知识学院”的标志性建筑,将现有建筑物改造成与教学和需求更相关的框架体系。这个十九世纪遗址的总体规划是通过对预期用途模式和场地生态的分析而制定的,目的是重新定位校园西南角与安大略湖的轴线,并为学院创造新的特性。丹尼尔斯建筑、景观和设计学院需要一个可持续发展的新型工作原型.以适应工作室、金属加工车间、教室、办公室、图书馆、 | richard lee tom beresford john houser amin tadj alda black marta guerra animations james juricevich parke macdowell dane asmussen laura williams peter sprowls noora al musallam tammy teng wesley hiatt john mars mazyar kahali | 2018 | 世界建筑导报2018，33，2： | 0 |
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