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| 1 | Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock显示文摘Inflammasomes 是触发 caspase-1 的激活和 interleukin-1β 的成熟的多蛋白质建筑群;(IL-1β) ,然而,这些建筑群的规定仍然保持糟糕描绘了。这里,我们显示出那氮的氧化物(没有) 禁止了调停 NLRP3 的 ASC pyroptosome 形成, caspase-1 激活和 IL-1β在从老鼠和人的 myeloid 房间的分泌物。同时,内长不否定地也源于 iNOS (没有 synthase 的可诱导的形式) 调整 NLRP3 inflammasome 激活。iNOS 的弄空响应 LPS 和 ATP 导致了不正常的线粒体的增加的累积,它为增加的 IL-1β 负责;生产和 caspase-1 激活。没有生产的 iNOS 缺乏或药理学抑制在 vivo 提高了 NLRP3 依赖的 cytokine 生产,因此在老鼠从导致 LPS 的败血增加死亡,它被 NLRP3 阻止缺乏。我们的结果因此经由线粒体的稳定作为 NLRP3 inflammasome 的一个批评否定管理者不识别。这研究有重要含意让新策略的设计控制 NLRP3 相关的疾病。 | Kairui Mao Shuzhen Chen Mingkuan Chen Yonglei Ma Yan Wang Bo Huang Zhengyu He Yan Zeng Yu Htl Shuhui Sun Jing Li Xiaodong Wu Xiangrui Wang Warren Strober Chang Chen Guangxun Meng Bing Sun | 2013 | Cell Research2013，23，2： | 59 |
| 2 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 3 | Authoritarian Deliberation: The Deliberative Turn in Chinese Political Development显示文摘 | Baogang He Mark E. Warren | 2011 | Perspectives on Politics2011，，2： | 2 |
| 4 | Authoritarian Deliberation: The Deliberative Turn in Chinese Political Development显示文摘 | Baogang He Mark E. Warren | 2011 | Perspectives on Politics2011，，2： | 1 |
| 5 | Modeling the impact of summer temperatures on national electricity consumption显示文摘 | Le Comte D M Warren HE | 1981 | Journal of Applied Meteorolo-gy1981，，20： | 1 |
| 6 | Impact of climate on energy sector in economic analysis显示文摘 | Warren HE LeDuc S K | 1981 | Journal of Applied Meteorology1981，，20： | 1 |
| 7 | Network succession reveals the importance of competition in response to emulsified vegetable oil amendment for uranium bioremediation显示文摘 | Ye Deng Ping Zhang Yujia Qin Qichao Tu Yunfeng Yang Zhili He Christopher Warren Schadt Jizhong Zhou | 2016 | Environ Microbiol2016，，1： | 1 |
| 8 | Projecting monthly natural gas sales for space heating using a monthly updated model and degree-days from monthlyoutlooks显示文摘 | Lehman R L Warren HE | 1994 | Journal of Applied Meteorology1994，，33： | 1 |
| 9 | Golgi biogenesis in Toxoplasma gondii显示文摘 | Pelletier L Stern CA Pypaert M Sheff D Ngo HM Roper N He CY Hu K Toomre D Coppens I Roos DS Joiner KA Warren G | 2002 | Nature2002，418，6897： | 1 |
| 10 | Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-1ike macrophages 显示文摘 | He H Xu J Warren CM | 2012 | Blood2012，120，： | 1 |
| 11 | Development of a Genomic Metric That Can Be Rapidly Used to Predict Clinical Outcome in Severely Injured Trauma Patients*显示文摘 | Alex G. Cuenca Lori F. Gentile M. Cecilia Lopez Ricardo Ungaro Huazhi Liu Wenzhong Xiao Junhee Seok Michael N. Mindrinos Darwin Ang Tezcan Ozrazgat Baslanti Azra Bihorac Philip A. Efron Joseph Cuschieri H. Shaw Warren Ronald G. Tompkins Ronald V. Maier He | 2013 | Critical Care Medicine2013，，5： | 1 |
| 12 | Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer’s disease显示文摘 | Steven P. Braithwaite Ralf S. Schmid Dong Ning He Mei-Li A. Sung Seongeon Cho Lynn Resnick Michael M. Monaghan Warren D. Hirst Christian Essrich Peter H. Reinhart Donald C. Lo | 2010 | Neurobiology of Disease2010，，3： | 1 |
| 13 | A PERTURBATION THEOREM AND ITS APPLICATION显示文摘This paper is concerned with operators of abstract equations which are de-pendent on a multi-parameter. A general theorem, which may be viewed as aperturbation theorem, is developed first. The result is then applied to an abstractintegrodifferential equation and is used to study differentiability with respect toparameters of solutions of this integrodifferential equation. An application to aviscoelastic equation is also given. | He Min(Dept. of Math. and Computer Science, Kent State University-Trumbull Campus, Warren, OH 44483, USA) | 1999 | Annals of Differential Equations1999，15，4： | 0 |
| 14 | A novel bio‑active microsphere for meniscus regeneration via inducing cell migration and chondrocyte differentiation显示文摘Abstract Meniscus injury is a common disease in clinic.If it was not treated in time,it leads to osteoarthritis which brings unbearable pain and heavy economic burden to the patients.At present,meniscectomy and meniscus suture are widely used in the treatment for meniscus injury.Nevertheless,It is not ideal for poor self-healing ability of meniscus.The recruitment of endogenous stem cells is an attractive option for wounded meniscus healing.Fully reduced high-mobility group box 1 protein(HMGB1)can accelerate the regeneration of multiple tissues by endogenous stem cell activation,migration and differentiation.Kartogenin(KGN)has shown to induce the chondrogenesis of the stem cells.However,no study has explored such effects of HMGB1 and KGN in wounded meniscus healing.Therefore,in order to improve the regeneration of meniscus,we intend to use a novel bioactive microsphere which was developed by combining fully reduced high mobility group box 1(frHMGB1)and kartogenin(KGN)with alginate gel which slowly release high concentrations of HMGB1 and KGN to activate rat bone marrow stem cells(BMSCs)and promote cell proliferation.The results showed that this HMGB1–KGN microsphere released and kept high concentrations of HMGB1 and KGN in the wound area for more than 2 weeks.In vitro experimental results showed that the HMGB1–KGN microsphere can promote cell proliferation via recruiting rat bone marrow stem cells(BMSCs)and activating the BMSCs from G_(0) to G_(Alert) stage as evidenced by cell migration testing and 5-bromo-2′-deoxyuridine(BrdU)incorporation assay.In vivo results indicated that this HMGB-KGN microsphere can recruit GFP-labeled BMSCs from tail vein to wounded meniscus and induce these GFP-labeled BMSCs to differentiate into chondrocytes.Our results demonstrated that the HMGB1–KGN-containing bioactive microsphere induced cell migration in vitro and recruited the cells to wound area to promote wounded rat meniscus healing in vivo. | Hongyao Xu He Huang Xiangjie Zou Pengcheng Xia Warren A.L.S.Foon Jinwen Wang | 2021 | Bio-Design and Manufacturing2021，4，2： | 0 |
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