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| 1 | Chloramination of wastewater effluent: Toxicity and formation of disinfection byproducts显示文摘The reclamation and disinfection of waters impacted by human activities(e.g., wastewater effluent discharges) are of growing interest for various applications but has been associated with the formation of toxic nitrogenous disinfection byproducts(N-DBPs). Monochloramine used as an alternative disinfectant to chlorine can be an additional source of nitrogen in the formation of N-DBPs. Individual toxicity assays have been performed on many DBPs, but few studies have been conducted with complex mixtures such as wastewater effluents. In this work, we compared the cytotoxicity and genotoxicity of wastewater effluent organic matter(Ef OM) before and after chloramination. The toxicity of chloraminated Ef OM was significantly higher than the toxicity of raw Ef OM, and the more hydrophobic fraction(HPO)isolated on XAD-8 resin was more toxic than the fraction isolated on XAD-4 resin.More DBPs were also isolated on the XAD-8 resin. N-DBPs(i.e., haloacetonitriles or haloacetamides) were responsible for the majority of the cytotoxicity estimated from DBP concentrations measured in the XAD-8 and XAD-4 fractions(99.4% and 78.5%, respectively).Measured DBPs accounted for minor proportions of total brominated and chlorinated products, which means that many unknown halogenated compounds were formed and can be responsible for a significant part of the toxicity. Other non-halogenated byproducts(e.g.,nitrosamines) may contribute to the toxicity of chloraminated effluents as well. | Julien Le Roux Michael J.Plewa Elizabeth D.Wagner Maolida Nihemaiti Azra Dad Jean-Philippe Croué | 2017 | Journal of Environmental Sciences2017，29，8： | 8 |
| 2 | Seed Priming Influence on Early Crop Growth, Phenological Development and Yield Performance of Linola (Linum usitatissimum L.)显示文摘Reduced early crop growth and limited branching are amongst yield limiting factors of linola. Field response of seed priming treatments viz. 50 mmol L-1 salicylic acid(SA), 2.2% CaCl2 and 3.3% moringa leaf extract(MLE) including untreated dry and hydropriming controls was evaluated on early crop growth and yield performance of linola. Osmopriming with CaCl2 reduced emergence time and produced the highest seedling fresh and dry weights including Chl. a contents. Osmopriming with CaCl2reduced crop branching and fl owering and maturity times and had the maximum plant height, number of branches, tillers, pods and seeds per pod followed by MLE. Increase in seed weight, biological and seed yields was 9.30, 34.16 and 39.49%, harvest index(4.12%) and oil contents(13.39%) for CaCl2 osmopriming. Positive relationship between emergence and seedling vigor traits, 100-seed weight, seed yield with maturity time, 100-seed weight and seed yield were found. The study concludes that seed osmopriming with CaCl2 or MLE can play signifi cant role to improve early crop growth and seed yields of linola. | Hafeez ur Rehman Muhammad Qaiser Nawaz Shahzad Maqsood Ahmed Basra Irfan Afzal Azra Yasmeen Fayyaz ul-Hassan | 2014 | Journal of Integrative Agriculture2014，13，5： | 4 |
| 3 | Induced pluripotent stem cells from Huntington's disease patients:a promising approach to define and correct disease-related alterations显示文摘Adult somatic cells such as skin or blood cells from either health donors or patients can be reprogrammed into induced pluripotent stem cells(iPSCs).Given their unlimited self-renewal and differentiation capacities,iPSCs are an invaluable resource to generate terminally differentiated cells.Thus,iPSCs can facilitate the study of human diseases and drug screening,holding great promise for regenerative medicine.Another significant advantage of iPSC disease-modeling is that normal and mutant proteins are expressed at endogenous levels.In addition,subtle phenotypes and the effects of genetic background variations can be assessed by comparison between iPSC lines obtained from different patients and healthy donors as well as isogenic lines,in which disease-related mutations are corrected. | Azra Fatima Ricardo Gutiérrez-Garcia David Vilchez | 2019 | Neural Regeneration Research2019，14，5： | 3 |
| 4 | Determination of captopril in patient human urine using ferrocenemonocarboxylic acid modified carbon nanotubes paste electrode显示文摘In this work,we describe a new strategy for the electrochemical determination of captopril(CA) using ferrocenemonocarboxylic acid as a mediator and multiwall carbon nanotubes as sensors in aqueous solution at pH 7.0.The diffusion coefficient(D),and the kinetic parameters such as electron transfer coefficient(α).and heterogeneous rate constant(k_h),for CA were also determined using electrochemical approaches.Under the optimized conditions,the electrocatalytic oxidation peak current of captopril showed two linear dynamic ranges with a detection limit of 0.3×10^(-6) mol L^(-1) captopril.The linear calibration range was 0.8×10^(-6) to 65×10^(-6) mol L^(-1) using cyclic voltammetry.Finally,this modified electrode was also examined as a selective,simple and precise new electrochemical sensor for the determination of captopril in real samples such as drug and patient human urine. | Mohammad A.Khalilzadeh Hassan Karimi-Maleh Azra Amiri Fathali Gholami Robabeh Motaghed Mazhabi | 2010 | Chinese Chemical Letters2010，21，12： | 2 |
| 5 | 罗氏沼虾蜕皮过程中释放的氨基酸组分是引发同类残杀的因素?显示文摘目的:确定罗氏沼虾在蜕皮过程(该过程引起同类残杀)中释放的氨基酸组分,并明确其中差异的氨基酸成分。创新点:了解罗氏沼虾蜕皮过程中生化组分的变化对于理解同类残杀的重要意义。目前,还没有关于同类残杀和蜕皮过程与生化组分之间关系的研究报道。本研究以此为切入点,采用统计学方法探究二者之间的关联,并鉴定其中差异的氨基酸成分。方法:在人工饲养条件下,测定了蜕皮阶段和非蜕皮阶段的罗氏沼虾肌肉、外骨骼和养殖水体中的总氨基酸及自由氨基酸组分,采用双因素方差分析法比较分析了两个阶段氨基酸组分的差异,同时鉴定了差异的氨基酸成分。结论:在蜕皮阶段,组织中的总氨基酸以脯氨酸和肌氨酸的含量最高,而水体中的自由氨基酸含量以色氨酸和脯氨酸为主。研究结果表明,这些氨基酸组分在罗氏沼虾蜕皮过程中释放了促进同类残杀的化学信号。 | Abu Seman JUNETA-NOR Noordiyana Mat NOORDIN Mohamad Nor AZRA Hong-yu MA Norainy Mohd HUSIN Mhd IKHWANUDDIN | 2020 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2020，21，10： | 2 |
| 6 | Curcumin preconditioning enhances the efficacy of adipose-derived mesenchymal stem cells to accelerate healing of burn wounds显示文摘Background:Following recent findings from our group that curcumin preconditioning augments the therapeutic efficacy of adipose-derived stem cells in the healing of diabetic wounds in rats,we aimed to investigate the regenerative effects of curcumin preconditioned adipose-derived mesenchymal stem cells(ASCs)for better recovery of acid inflicted burns in this study.Methods:ASCs were preconditioned with 5μM curcumin for 24 hours and assessed for proliferation,migration,paracrine release potential and gene expression comparative to naive ASCs.Subsequently,the healing capacity of curcumin preconditioned ASCs(Cur-ASCs)versus naive ASCs was examined using acidic wounds in rats.For this,acid inflicted burns of 20 mm in diameter were made on the back of male Wistar rats.Then,2×10^(6) cells of Cur-ASCs and naive ASCs were intradermally injected in the wound periphery(n=6)for comparison with an untreated saline control.Post-transplantation,wounds were macroscopically analysed and photographed to evaluate the percentage of wound closure and period of re-epithelization.Healed wound biopsies were excised and used for histological evaluation and expression analysis of wound healing markers at molecular level by quantitative PCR and western blotting.Results:We found that Cur-ASCs exhibited greater proliferation,migration and paracrine potential in vitro.Further,Cur-ASCs showed more effective recovery than naive ASCs as exhibited by gross morphology,faster wound closure and earlier re-epithelialization.Masson’s trichrome and hematoxylin and eosin staining demonstrated the improved architecture of the healing burns,as evidenced by reduced infiltration of inflammatory cells,compact collagen and marked granulation in Cur-ASC treated rats.Corroborating these findings,molecular assessment showed significantly reduced expressions of pro-inflammatory factors(interleukin-1 beta,interleukin-6,tumor necrosis factor alpha)a with striking upsurge of an oxidative marker(superoxide dismutase 1),proangiogenic factors(vascular endothelial growth factor,hepatocyte growth factor,hypoxia-inducible factor-1 alpha)and collagen markers(transforming growth factor beta 1,fibroblast growth factor-2,collagen type 1 alpha 1),verifying that Cur-ASCs modulate the regulation of pro-inflammatory and healing markers at burn sites.Conclusions:Treatment with Cur-ASCs resulted in faster re-epithelization of acid inflicted burns compared to the treatment with naive ASCs.Based on observed findings,we suggest the transplantation of Cur-ASCs is a valuable therapy for the potent clinical management of acidic burns. | Maryam Azam Hafiz Ghufran Hira Butt Azra Mehmood Ramla Ashfaq Asad M.Ilyas Muhammad R.Ahmad Sheikh Riazuddin | 2021 | Burns & Trauma2021，9，1： | 2 |
| 7 | The role of acute and early HIV infection in the spread of HIV and implications for transmission prevention strategies in Lilongwe, Malawi: a modelling study显示文摘 | Kimberly A Powers Azra C Ghani William C Miller Irving F Hoffman Audrey E Pettifor Gift Kamanga Francis EA Martinson Myron S Cohen | 2011 | The Lancet . 2011 (9787)2011，，： | 1 |
| 8 | Clinical and radiological features of intracerebral haemorrhage in hyperteasive patients显示文摘 | Azra Zafar Farrukh Shohab Khan | 2008 | JPMA2008，356，： | 1 |
| 9 | Discovery of substituted N ′-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay显示文摘 | Nilantha Sirisoma Azra Pervin John Drewe Ben Tseng Sui Xiong Cai | 2009 | Bioorganic & Medicinal Chemistry Letters2009，，10： | 1 |
| 10 | Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong显示文摘 | Christl A Donnelly Azra C Ghani Gabriel M Leung | 2003 | Lancet2003，361，： | 1 |
| 11 | How efficient are Bosnian stock market indexes?显示文摘 | ARNAUT B A AZRA Z | 2012 | Eastern European Economics2012，50，1： | 1 |
| 12 | Defining the dynamics of self-assembled Fas-receptor activation显示文摘 | Suneel D Mundle Azra Raza | 2002 | Trends in Immunology2002，23，4： | 1 |
| 13 | Functional connectivity from area 5 to primary motor cortex via paired-pulse transcranial magnetic stimulation显示文摘 | Angela Ziluk Azra Premji Aimee J.Nelson | | 0，，： | 1 |
| 14 | Hot-nanoparticle-mediated fusion of selected cells显示文摘二个选择房间的完全的熔化允许有从两个原来的房间的继承基因性质的新奇混合房间的创造。经由有一个选择的泡的一个选择房间的熔化,或者,化学药品或基因罐头直接被交付进兴趣的房间,到控制细胞的反应或基因表示。这里,我们表明怎么执行二个选择房间或一个房间和一个泡的光学地控制的熔化。熔化被激光照耀调停光学地在二个房间之间套住的 plasmonic 金牌 nanoparticles (或一个泡和一个房间) 兴趣。这 hot-particle-mediated 熔化引起二细胞质和与跟随熔化的未经触动的房间膜和酶的活动导致一个新混合房间的形成的二房间膜的全部的混合。同样,在一个泡之间的熔化和一个房间导致泡货物的交货到细胞质,并且在熔化以后,生存能力的房间表演符号。方法是在单个房间的水平的指向的药交货的实现并且为细胞的控制和设计有一个大潜力。 | Azra Bahadori Lene B. Oddershede Poul M. Bendix | 2017 | Nano Research2017，10，6： | 1 |
| 15 | Post stroke depression 显示文摘 | Azra A Jasminka DV Amina N | 2014 | Med Arh2014，68，1： | 1 |
| 16 | Post Stroke Depres- sion显示文摘 | AZRA A JASMINKA D V SALEM A | 2014 | Med Arh2014，68，1： | 1 |
| 17 | Assessment of pollution in the West Black Sea Coast of Turkey using biomarker responses in fish 显示文摘 | AZRA B CANAN S ZULEYHA A | 2009 | Marine Environmental Research2009，67，45： | 1 |
| 18 | Long term clinical benefit of lenalidomide (Revlimid)treatment in patients with myelodysplastic syndrome without Del 5q cytogenetic abnormalities显示文摘 | Azra R James E Reeves EJ | 2006 | Blood2006，10，2： | 1 |
| 19 | Combined solid oxide fuel cell and gas turbine systems for efficient power and heat generation显示文摘 | Jens Palsson Azra Selimovic Lars Sjunnesson | 2000 | Journal of Power Sources2000，86，1： | 1 |
| 20 | Acute exacerbation impairs endothelial function in patients with chronic obstructive pulmonary disease显示文摘 | Beste Uzben Emel Eryuksel Azra Meryem Tanrikulu | 2010 | Arch Turk Soc Cardiol2010，38，1： | 1 |
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