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| 1 | Ovarian autoimmune disease: clinical concepts and anima models显示文摘卵巢不是一个 immunologically 给予优惠的机关,但是在为卵巢特定的抗原的 tolerogenic 机制的一个故障在生育力上有灾难性的后果在里面女人,和这在自体免疫的疾病的鼠科的模型被复制。孤立的卵巢的自体免疫的疾病在女人是稀罕的,由于疾病和无能到的严厉可能播送越过代授与卵巢的疾病的基因信息。尽管如此,自体免疫的卵巢炎经常与另外的自体免疫的疾病联合被观察,特别地自体免疫的肾的疾病,并且在社会和单个健康上拿使用费。在老鼠的研究揭示了保护卵巢免受自体免疫的攻击的伤害的至少二机制。这些机制为自体免疫的管理者(亚耳河) 由导出胸腺的规章的 T 房间,以及一个角色包括 autoreactive T 房间的控制,在髓的 thymic 导致限制织物的抗原的表示的一个 transcriptional 管理者上皮的房间在 T 房间的开发期间。尽管后者机制不完全地被定义,也的失败导致自体免疫调停指向和卵巢的滤泡的弄空,这很好被建立。在这评论,我们将探讨自体免疫调停的临床的特征和后果在女人的卵巢的不孕,以及由动物揭示了的疾病的可能的机制当模特儿。 | Bryce D Warren William K Kinsey Lynda K McGinnis Lane K Christenson Susmita Jasti Anne M Stevens Brian K Petroff Margaret G Petroff | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 2 | Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection显示文摘AIM: To test antibiotic-loaded coating for efficacy in reducing bacterial biofilm and development of osteomyelitis in an orthopaedic model of implant infection. METHODS: Phosphatidylcholine coatings loaded with 25% vancomycin were applied to washed and sterilized titanium wires 20 mm in length. A 10 mm segment was removed from rabbit radius(total = 9; 5 coated, 4 uncoated), and the segment was injected with 1 × 106 colony forming units(CFUs) of Staphylococcus aureus(UAMS-1 strain). Titanium wires were inserted throughthe intramedullary canal of the removed segment and into the proximal radial segment and the segment was placed back into the defect. After 7 d, limbs were removed, X-rayed, swabbed for tissue contamination. Wires were removed and processed to determine attached CFUs. Tissue was swabbed and streaked on agar plates to determine bacteriological score.RESULTS: Antibiotic-loaded coatings resulted in significantly reduced biofilm formation(4.7 fold reduction in CFUs; P < 0.001) on titanium wires and reduced bacteriological score in surrounding tissue(4.0 ± 0 for uncoated, 1.25 ± 0.5 for coated; P = 0.01). Swelling and pus formation was evident in uncoated controls at the 7 d time point both visually and radiographically, but not in antibiotic-loaded coatings.CONCLUSION: Active antibiotic was released from coated implants and significantly reduced signs of osteomyelitic symptoms. Implant coatings were well tolerated in bone. Further studies with additional control groups and longer time periods are warranted. Antibiotic-loaded phosphatidylcholine coatings applied at the point of care could prevent implant-associated infection in orthopaedic defects. | Jessica Amber Jennings Karen E Beenken Robert A Skinner Daniel G Meeker Mark S Smeltzer Warren O Haggard Karen S Troxel | 2016 | World Journal of Orthopedics2016，7，8： | 2 |
| 3 | Aggressive surgery for metastatic liver neuroendocrine tumors显示文摘 | Jeffrey A Norton Robert S Warren Mary G Kelly Marlene B Zuraek Robert T Jensen | 2003 | Surgery2003，，： | 2 |
| 4 | A histological evaluation of peritoneal injury and repair: implications for adhesion formation 显示文摘 | Elkins T E Stovall T G Warren J | 1987 | Obstet Gynecol1987，70，2： | 1 |
| 5 | Extmsion cooking and feed ingredients:the effects of processing on extrudedfeed and feed ingredients,particuliarly for animal performance显示文摘 | Warren G D | 2003 | Worid Grain2003，，： | 1 |
| 6 | The SENSITIVE TO FREEZING2 gene, required for freezing tolerance in Arabidopsis thaliana, encodes a {beta}-glucosidase显示文摘 | Thorlby G Fanrrier N Warren G | 2004 | Plant Cell2004，16，8： | 1 |
| 7 | Thecontribution of azo dyes to the mutagenic activity of theCristais River显示文摘 | Umbuzeiro G A Freeman H S Warren S H | 2005 | Chemosphere2005，60，： | 1 |
| 8 | Old age and the hepatic sinusoid 显示文摘 | Le Couteur D G Warren A Cogger V C | 2008 | Anat Rec ( Hoboken)2008，291，6： | 1 |
| 9 | Solvent extraelion of lipid components from egg yolk solids显示文摘 | Warren M W Brown H G Davis D R | 1988 | Journal of the American oil chemistry society1988，65，7： | 1 |
| 10 | Cardiac function before and after surgery for pectus excavatum 显示文摘 | Warren G Guntheroth Philip S et ai | 2007 | Am J Cardiol2007，99，12： | 1 |
| 11 | Hydroly- sis of secreted sialoglycoprotein immunoglobulin a (IgA) in ex vivo and biochemical models of bacterial vaginosis显示文摘 | Warren G Lewis Lloyd S Robinson Justin Perry etal | 2012 | The Journal of Biological Chemistry2012，287，3： | 1 |
| 12 | Growth and form of spherulites 显示文摘 | Granasy L P T Tegze G Warren J A | 2005 | Physical Review E2005，72，1： | 1 |
| 13 | Vip3A, a novel Bacillus thuringiensis vegetative insecticidal protein with a wide spectrum of activities against lepidopteran insects显示文摘 | Estruch J J Warren G W Mullins M A | 1996 | Proceedings of the National Academy of Sciences of the United States of America1996，93，11： | 1 |
| 14 | Arthroscopic acromioplasty显示文摘 | Warren RF Wickiewicz TL Skyhar MJ Ortiz G and Schwartz E | 1990 | J Bone Joint Surg(Am)1990，72，： | 1 |
| 15 | Comprehensive numerical modeling of vertical cavity surfaceemitting lasers显示文摘 | HADLEY G R LEAR K L WARREN M E | 1996 | IEEE J Quant Electron1996，32，4： | 1 |
| 16 | Vip3A,a novel Bacillus thuringiensis vegetative insecticidal protein with a wide spectrum of activities against lepidopteran insects显示文摘 | Estruch J J Warren G W Mullins M A | 1996 | Proc Natl Acad Sci USA1996，93，11： | 1 |
| 17 | Spatial modeling of wind speedaround windbreaks显示文摘 | VIGIAK O STERK G WARREN A | 2003 | Catena2003，53，： | 1 |
| 18 | Solar Water Splitting Cells显示文摘 | Walter M G Warren E L McKone J R | 2010 | Chemical Reviews2010，110，11： | 1 |
| 19 | Results of targeted anti-tumor necrosis factor therapy with etanercep(ENBREL) in patients with advanced heart failure显示文摘 | Bozkurt B Torre-Amione G Warren MS | 2001 | Circulation2001，103，： | 1 |
| 20 | Field trims to assess the up- take of arsenic by vegetables from contaminated soils and soil remedia- tion with iron oxides显示文摘 | Warren G P Alloway B J Lepp N W | 2003 | Science of the Total Environment2003，311，： | 1 |
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