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| 1 | 在 esophagogastroduodenoscopy 使用 lidocaine 的实用性与 propofol 表现在镇静下面显示文摘 AIM:To determine whether topical lidocaine benefits esophagogastroduoduenoscopy(EGD) by decreasing propofol dose necessary for sedation or procedurerelated complications.METHODS:The study was designed as a prospective,single centre,double blind,randomised clinical trial and was conducted in 2012 between January and May(NCT01489891).Consecutive patients undergoing EGD were randomly assigned to receive supplemental topical lidocaine(L;50 mg in an excipient solution which was applied as a spray to the oropharynx) or placebo(P;taste excipients solution without active substance,similarly delivered) prior to the standard propofol sedation procedure.The propofol was administered as a bolus intravenous(iv) dose,with patients in the L and P groups receiving initial doses based on the patient’s American Society of Anaesthesiologists(ASA) classification(ASAⅠ-Ⅱ:0.50-0.60 mg/kg;ASA Ⅲ-Ⅳ:0.25-0.35 mg/kg),followed by 10-20 mg iv dose every 30-60 s at the anaesthetist’s discretion.Vital signs,anthropometric measurements,amount of propofol administered,sedation level reached,examination time,and the subjective assessments of the endoscopist’s and anaesthetist’s satisfaction(based upon a four point Likert scale) were recorded.All statistical tests were performed by the Stata statistical software suite(Release 11,2009;StataCorp,LP,College Station,TX,United States).RESULTS:No significant differences were found between the groups treated with lidocaine or placebo in terms of total propofol dose(310.7 ± 139.2 mg/kg per minute vs 280.1 ± 87.7 mg/kg per minute,P = 0.15) or intraprocedural propofol dose(135.3 ± 151.7 mg/kg per minute vs 122.7 ± 96.5 mg/kg per minute,P = 0.58).Only when the L and P groups were analysed with the particular subgroups of female,< 65-year-old,and lower anaesthetic risk level(ASA Ⅰ-Ⅱ) was a statistically significant difference found(L:336.5 ± 141.2 mg/kg per minute vs P:284.6 ± 91.2 mg/kg per minute,P = 0.03) for greater total propofol requirements).The total incidence of complications was also similar between the two groups,with the L group showing a complication rate of 32.2%(95%CI:21.6-45.0) and the P group showing a complication rate of 26.7%(95%CI:17.0-39.0).In addition,the use of lidocaine had no effect on the anaesthetist’s or endoscopist’s satisfaction with the procedure.Thus,the endoscopist’s satisfaction Likert assessments were equally distributed among the L and P groups:unsatisfactory,[L:6.8%(95%CI:2.2-15.5) vs P:0%(95%CI:0-4.8);neutral,L:10.1%(95%CI:4.2-19.9) vs P:15%(95%CI:7.6-25.7)];satisfactory,[L:25.4%(95%CI:10-29.6) vs P:18.3%(95%CI:15.5-37.6);and very satisfactory,L:57.6%(95%CI:54-77.7) vs P:66.6%(95%CI:44.8-69.7)].Likewise,the anaesthetist’s satisfaction Likert assessments regarding the ease of maintaining a patient at an optimum sedation level without agitation or modification of the projected sedation protocol were not affected by the application of lidocaine,as evidenced by the lack of significant differences between the scores for the placebo group:unsatisfactory,L:5.8%(95%CI:1.3-13.2) vs P:0%(95%CI:0-4.8);neutral,L:16.9%(95%CI:8.9-28.4) vs P:16.7%(95%CI:8.8-27.7);satisfactory,L:15.2%(95%CI:7.7-26.1) vs P:20.3%(95%CI:11.3-31.6);and very satisfactory,L:62.7%(95%CI:49.9-74.3) vs P:63.3%(95%CI:50.6-74.7).CONCLUSION:Topical pharyngeal anaesthesia is safe in EGD but does not reduce the necessary dose of propofol or improve the anaesthetist’s or endoscopist’s satisfaction with the procedure. | Felipe de la Morena Cecilio Santander Carlos Esteban Beatriz de Cuenca Juan Antonio García Javier Sánchez Ricardo Moreno | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，5： | 3 |
| 2 | Gossypol inhibits proliferation of endometrioma cells in culture显示文摘瞄准:为了在子宫内膜瘤评估 anti-proliferative 活动和棉子酚的 mitochondrial 毒性,房间在短期的文化维持了。方法:三 endometriomacell 从病人衬里的(A) 与 25 或 50 nmol/L 棉子酚被对待多达 12 天。细胞生长上的棉子酚的效果被记录。(B) A 磷光氧分析器被用来从病人在六根子宫内膜瘤房间线的 mitochondrial 耗氧量上决定棉子酚的效果。(C) 在从病人的三根子宫内膜瘤房间线的细胞的棉子酚累积被高压的液相色谱法测量。结果:endometriomacells 的增长被 25 和 50 nmol/L 棉子酚禁止。子宫内膜瘤房间的呼吸被 10 μ m ol/L 棉子酚禁止。细胞的棉子酚在与 10 和 0.3 μ m ol/L 棉子酚为 24 h 被对待的子宫内膜瘤房间线被检测。结论:棉子酚在有教养的子宫内膜瘤房间上调用有势力毒性。 | Shawky Z. A. Badawy Abdul-Kader Souid Violeta Cuenca Nicholas Montalto Frances Shue | 2007 | Asian Journal of Andrology2007，9，3： | 3 |
| 3 | A key‘foxy’aroma gene is regulated by homologyinduced promoter indels in the iconic juice grape‘Concord’显示文摘‘Concord’,the most well-known juice grape with a parentage of the North American grape species Vitis labrusca L.,possesses a special‘foxy’aroma predominantly resulted from the accumulation of methyl anthranilate(MA)in berries.This aroma,however,is often perceived as an undesirable attribute by wine consumers and rarely noticeable in the common table and wine grape species V.vinifera.Here we discovered homology-induced promoter indels as a major genetic mechanism for species-specific regulation of a key‘foxy’aroma gene,anthraniloyl-CoA:methanol acyltransferase(AMAT),that is responsible for MA biosynthesis.We found the absence of a 426-bp and/or a 42-bp sequence in AMAT promoters highly associated with high levels of AMAT expression and MA accumulation in‘Concord’and other V.labrusca-derived grapes.These promoter variants,all with direct and inverted repeats,were further confirmed in more than 1,300 Vitis germplasm.Moreover,functional impact of these indels was validated in transgenic Arabidopsis.Superimposed on the promoter regulation,large structural changes including exonic insertion of a retrotransposon were present at the AMAT locus in some V.vinifera grapes.Elucidation of the AMAT genetic regulation advances our understanding of the‘foxy’aroma trait and makes it genetically trackable and amenable in grapevine breeding. | Yingzhen Yang JoséCuenca Nian Wang Zhenchang Liang Honghe Sun Benjamin Gutierrez Xiaojun Xi Jie Arro YiWang Peige Fan Jason Londo Peter Cousins Shaohua Li Zhangjun Fei Gan-Yuan Zhong | 2020 | Horticulture Research2020，7，1： | 3 |
| 4 | Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. | Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 5 | Good results with unreamed nail and bone grafting for humeral nonunion显示文摘 | ángel A Martínez Antonio Herrera Jorge Cuenca | 2002 | Acta Orthopaedica2002，，3： | 2 |
| 6 | Efficient Micropropagation of Chestnut Hybrids(Castanea spp.)Using Modified Woody Plant Medium and Zeatin Riboside显示文摘The chestnuts genus(Castanea spp.)is comprised of economically important trees native to the Northern hemisphere that are used as food and hardwood timber.Here,a very efficient method for micropropagation of European×Japanese chestnut hybrids(Castanea sativa×C.crenata)is described.Woody Plant Medium was used as the basal medium.In vitro shoots of four rootstock cultivars were micropropagated without shoot-tip necrosis on multiplication medium containing 5.7 or 11.4μmol·L^(−1)zeatin riboside,and were rooted on rooting medium containing 2.46μmol·L^(−1)indolebutyric acid.Monthly shootmultiplication rates for each cultivarwere 2–5 folds.In vitro rooting percentages for four cultivars were 87%for‘Maraval’,67%for‘Marigoule’,93%for‘Marsol’,and 97%for‘Précoce Migoule’.Within a 5 week period,80%–95%of rooted shoots were successfully acclimated under high humidity conditions after they were planted in either soil or rockwool. | Guoqing Song Qiuxia Chen Pete Callow Mario Mandujano Xiaoyan Han Beatriz Cuenca Gregory Bonito Carmen Medina-Mora Dennis Wayne Fulbright Daniel EGuyer | 2021 | Horticultural Plant Journal2021，7，2： | 2 |
| 7 | Patients with pertrochanteric hip fracture may benefit fron preoperative intravenous iron therapy: a pilot study 显示文摘 | Cuenca J Garcia Erce JA Munoz M | 2004 | Transfusion2004，44，： | 1 |
| 8 | Random ized clinical trial of fixation vs nonfixation of mesh in total extrapertioneal inguinal hemiop lasty显示文摘 | Moreno-Egea A Torralba Martinez JA Morales Cuenca G | 2004 | Arch Surg2004，139，12： | 1 |
| 9 | Haematological parameters in postweaning multisystemic wasting syndrome affected pigs 显示文摘 | Segalé s J Pastor J Cuenca R | 2000 | Veterinary Record2000，146，： | 1 |
| 10 | Regression of primary gastric B-cell mucosa-associated lymphoid tissue (MALT) lymphoma after eradication of Helicobacter pylori显示文摘 | Falco Jover G Martinez EgeaA Sanchez Cuenca J | 1999 | Rev Esp Enferm Dig1999，91，8： | 1 |
| 11 | Novel retinoic acid generating activities in the neural tube and beart identified by conditional rescue of Raldh2 null mutant mice显示文摘 | Mic F A Haselback R J Cuenca A E | 2002 | Development2002，129，9： | 1 |
| 12 | Epidemiology and cost of herpes zoster and postherpetic neu? ralgia among patients treated in primary care centres in the valen? cian community of Spain显示文摘 | Cebrian - Cuenca AM Diez - Domingo J San - Martin - Ro- driguez M | 2011 | BMC Intect Dis2011，11，5： | 1 |
| 13 | Flavonoids from Inula viscosa 显示文摘 | Grande M Piera F Cuenca A | 1985 | Planta Med1985，51，4： | 1 |
| 14 | Breast Cancer with Chest Wall Progression: Treatment with Photodynamic Therapy显示文摘 | Cuenca RE Allison RR Sibata C | 2004 | Ann Surg Oncol2004，11，3： | 1 |
| 15 | Randomized clinical trial of fixation vs nonfixation of mesh in total extraperitoneal inguinal hemioplasty显示文摘 | Moreno-Egea A Torralba Martinez JA Morales Cuenca G | 2004 | Arch Surg2004，139，12： | 1 |
| 16 | Efficacy and tol- erability of human fibrinogen concentrate administration to patients with acquired fibrinogen deficiency and active or in high-risk severe bleeding显示文摘 | Danes AF Cuenca LG Bueno SR | 2008 | Vox Sang2008，94，3： | 1 |
| 17 | Persistent inflammation and immunosuppression : a common syndrome and new horizon for surgical intensive care 显示文摘 | Gentile LF Cuenca AG Efron PA | 2012 | J Trauma Acute Care Surg2012，72，6： | 1 |
| 18 | Angular variation of thermal Infrared emissivity for some natural surfaces from experimental measurements显示文摘 | Sobrino J A Juan Cuenca | 1999 | Applied Optics-LP1999，38，18： | 1 |
| 19 | Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor:analysis of dopamine receptor expression,location,development,and function in wild-type and knock-out mice显示文摘 | Li ZS Schmauss C Cuenca A | 2006 | J Neurosci2006，26，10： | 1 |
| 20 | Lipoxin A4 impair- ment of apoptotic signaling in macrophages: implication of the PI3 K/ Akt and the ERKlNrf - 2 defense pathways 显示文摘 | PRIETO P CUENCA J TRA YES P G et a1 | 2010 | Cell Death Differ2010，17，7： | 1 |
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