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| 1 | Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer显示文摘Colorectal cancer(CRC) is the third most frequent cancer type and the incidence of this disease is increasing gradually per year in individuals younger than 50 years old. The current knowledge is that early-onset CRC(EOCRC) cases are heterogeneous population that includes both hereditary and sporadic forms of the CRC. Although EOCRC cases have some distinguishing clinical and pathological features than elder age CRC, the molecular mechanism underlying the EOCRC is poorly clarified. Given the significance of CRC in the world of medicine, the present review will focus on the recent knowledge in the molecular basis of genetic and epigenetic mechanism of the hereditary forms of EOCRC, which includes Lynch syndrome, Familial CRC type X, Familial adenomatous polyposis, Mut YH-associated polyposis, Juvenile polyposis syndrome, Peutz-Jeghers Syndrome and sporadic forms of EOCRC. Recent findings about molecular genetics and epigenetic basis of EOCRC gave rise to new alternative therapy protocols. Although exact diagnosis of these cases still remains complicated, the present review paves way for better predictions and contributes to more accurate diagnostic and therapeutic strategies into clinical approach. | gulcin tezcan berrin tunca secil ak gulsah cecener unal egeli | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 5 |
| 2 | Arterial complication of irreversible electroporation procedure for locally advanced pancreatic cancer显示文摘Irreversible electroporation(IRE) is a non-thermal ablation technique used especially in locally advanced pancreatic carcinomas that are considered surgically unresectable.We present the first case of acute superior mesenteric artery(SMA) occlusion secondary to pancreatic IRE procedure that has not been reported before in the literature.A 66-year-old man underwent neoadjuvant chemoradiotherapy for locally advanced pancreatic ductal adenocarcinoma.IRE procedure was applied to the patient during laparotomy under general anesthesia.After finishing the procedure,an acute intestinal ischemia was detected.A conventional vascular angiography was performed and a metallic stent was successfully placed to the SMA and blood flow was maintained.It is important to be careful in such cases of tumor involvement of SMA when evaluating for IRE procedure of pancreatic tumor. | Yahya Ekici Tugan Tezcaner Hüseyin Onur Aydin Fatih Boyvat G?khan Moray | 2016 | World Journal of Gastrointestinal Oncology2016，8，10： | 5 |
| 3 | 肛门内括约肌侧切术对慢性肛裂患者生活质量的影响 | Mente B.B. Tezcaner T. Yilmaz U. 孟欣颖 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，12： | 5 |
| 4 | Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite显示文摘Hydroxyapatite(HA) co-doped with Zn2+ tand F- ions was synthesized by precipitation method for the first time in this study.FTIR spectroscopy revealed Zn2+ tand F ions incorporation into HA structure.Co-doping of Zn2+ tand F- ions decreased unit cell volume of HA and decreased grain sizes.Zn2+ tor 5 mol% F addition into HA significantly improved its density.Microhardness was increased with Zn2+ taddition and further increase was detected with F co-doping.Zn2+ tand F co-doped samples had higher fracture toughness than pure HA.Zn2+ tincorporation to the structure resulted in an increase in cell proliferation and ALP activity of cells,and further increase was observed with 1 mol%F addition.With superior mechanical properties and biological response 2Zn1 F is a good candidate for biomedical applications. | Idil Uysal Feride Severcan Aysen Tezcaner Zafer Evis | 2014 | Progress in Natural Science:Materials International2014，24，4： | 4 |
| 5 | Profiles of serum microRNAs; miR-125b-5p and miR223-3p serve as novel biomarkers for HBV-positive hepatocellular carcinoma显示文摘 | Burcu Gurer Giray Gurol Emekdas Seda Tezcan Mahmut Ulger Mehmet Sami Serin Orhan Sezgin Engin Altintas Eyup Naci Tiftik | 2014 | Molecular Biology Reports2014，，7： | 2 |
| 6 | Correlation of myocardial fractional flow reserve with thallium-201 SPECT imaging in intermediate-severity coronary artery lesions显示文摘 | Caymaz O Fak A S Tezcan H | 2000 | J Invasive Cardiol2000，12，7： | 2 |
| 7 | Evaluation of sericin/collagen membranes as prospective wound dressing biomaterial显示文摘 | Omer Akturk Aysen Tezcaner Hasan Bilgili M. Salih Deveci M. Rusen Gecit Dilek Keskin | 2011 | Journal of Bioscience and Bioengineering2011，，3： | 2 |
| 8 | Acute myocardial infarction and sub-acute stent thrombosis associated with occult essential thrombocythemia显示文摘A70-year-old female with no previous cardiac history presented with complaints of severe chest and back pain lasting for 20 minutes.She had a past history of type 2 diabetes mellitus for five years and hypertension for twenty years,but denied a history of hyperlipidemia,smoking or hemorrhagic disorder.There was no family history of coronary artery or hematologic disease.On physical examination,the blood pressure was 145/90 mmHg and the heart rate was 102 beats/min.Cardiac examination revealed normal S1 and S2 sounds.There were no murmors or clicks.The lungs were clear on auscultation.Hepatosplenomegaly or lymphadenopathy was not detected.Her electrocardiogram showed ST elevations in lead V1-V6,consistent with acute anterior MI and echocardiogram supported the diagnosis with a slight reduction in wall motion in the anterior region. | Zafer Isilak Mehmet Tezcan Murat Atalay Ejder Kardesoglu | 2014 | Chinese Medical Journal2014，，19： | 2 |
| 9 | Tangent stiffness properties of fi- nite elements 显示文摘 | SINDEL Z TEZCAN S S | 1996 | Computer Structures1996，58，2： | 1 |
| 10 | Coronary stent implantation in Behcet's disease显示文摘 | Tezcan H Yavuz S Fak AS | | 0，，： | 1 |
| 11 | The effect of standard posterolateralversus muscle-sparing thoracotomy on multiple parameters显示文摘 | Akcali Y Demir H Tezcan B | 2003 | AnnThorac Surg2003，76，： | 1 |
| 12 | Serum leptin levels in pa- tients with premature ejacu - lation 显示文摘 | Atmaca M Kuloglu M Tezcan E | 2002 | Arch Androl2002，48，： | 1 |
| 13 | The efficiency of routine endotracheal aspirate cultures compared to bronchoalveolar lavage cultures in ventilator-associated pneumonia diagnosis显示文摘 | Yagmurdur H Tezcan AH Karakurt O | 2016 | Niger J Clin Pract2016，19，1： | 1 |
| 14 | Many-server diffusion limits for G / Ph / n + GI queues显示文摘 | Dai J.G He S Tezcan T | | 0，，： | 1 |
| 15 | Heart Rate Variability in Patients with Thalassemia Major显示文摘 | Firat Kardelen Gulsun Tezcan Gayaz Akcurin Halil Ertug Akif Yesilipek | 2008 | Pediatric Cardiology2008，，5： | 1 |
| 16 | Optimal control of parallel server systems with many servers in heavy traffic显示文摘 | Dai J.G Tezcan T | | 0，，： | 1 |
| 17 | Uncontrolled hypertension due to volume overload contributes to higher left ventricular mass index in CAPD patients 显示文摘 | Koc M Toprak A Tezcan H | 2002 | Nephrol Dial Transplant2002，17，9： | 1 |
| 18 | Serum leptin and triglyceride levels in patients on treatment with atypical antipsychotics 显示文摘 | Atmaca M Kuloglu M Tezcan E | 2003 | J Clin Psychiatry2003，64，5： | 1 |
| 19 | The effect of standard posterolateral versus muscle-sparing thoracotomy on multiple parameters显示文摘 | AKCALI Y DEMIR H TEZCAN B | 2003 | Ann Thorac Surg2003，76，4： | 1 |
| 20 | Posterior tibial nerve stimulation for faecal incontinence after partial spinal injury: preliminary report显示文摘 | B. B. Mentes O. Yüksel A. Aydin T. Tezcaner A. Levento?lu B. Ayta? | 2007 | Techniques in Coloproctology2007，，2： | 1 |
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