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| 1 | No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory显示文摘获得的免疫学的记忆是惹人注目的现象。致命的流行病通过 naï 扫; ve 人口,许多死但是幸存的那些从来不是 “攻击了 ― 两次;从未至少 fatally”,在 430 BCE 观察的历史学家修西得底斯。抗体记忆为对许多人的传染疾病的保护是批评的并且是的基础将近所有当前的人的疫苗。部分地,抗体记忆被编码为切换适应于不同地区生活的动物的免疫球蛋白(Ig ) 在对抗原的主要反应被产生并且产生的表示 G 记忆 B 房间快速,高亲密关系并且在有一样的抗原的挑战之上的 high-titered 抗体回答。IgG-B-cell 受体(BCR ) 并且导致抗原的 IgG-BCR 发信号怎么贡献记忆抗体回答,充分没被理解。在这评论,我们总结在抗体记忆在玩正在揭示细胞、分子的机制并且讨论怎么用不同试验性的途径学习的令人激动的新进展帮助将阐明 B 房间记忆的复杂现象。 | Yinsheng Xu Liling Xu Meng Zhao ChenGuang Xu Yilin Fan Susan K Pierce Wanli Liu | 2014 | Cell Research2014，24，6： | 4 |
| 2 | Tracking of time-evolving sound speed profiles with an auto-regressive state-space model显示文摘An approach for time-evolving sound speed profiles tracking in shallow water is discussed.The inversion of time-evolving sound speed profiles is modeled as a state-space estimation problem,which includes a state equation for predicting the time-evolving sound speed profile and a measurement equation for incorporating local acoustic measurements.In the paper,auto-regression(AR) method is introduced to obtain a high-order AR evolution model of the sound speed field time variations,and the ensemble Kalman filter is utilized to track the sound speed field.To validate the approach,the accuracy in sound speed estimation is analyzed via a numerical implementation using the ASIAEX experimental environment and the sound velocity measurement data.Compared with traditional approaches based on the state evolution represented as a random walk,simulation results show the proposed AR method can effectively reduce the tracking errors of sound speed,and still keep good tracking performance at low signal-to-noise ratios. | JIN Liling LI Jianlong XU Wen | 2017 | Chinese Journal of Acoustics2017，36，3： | 4 |
| 3 | rransmembrane domain dependent inhibitory unction of FcyRIIB显示文摘FcyRIIB,the only inhibitory IgG Fc receptor,functions to suppress the hyper-activation of immune cells.Numerous studies have illustrated its inhibitory function through the ITIM motif in the cytoplasmic tail of FcyRIIB. However,later studies revealed that in addition to the ITIiVI,the transmembrane (TM)domain of FcyRIIB is also indispensable for its inhibitory function.Indeed,recent epidemiological studies revealed that a non-synonymous single nucleotide polymorphism (rs1050501) within the TM domain of FcyRIIB,responsible for the 1232T substitution,is associated with the susceptibility to systemic lupus erythematosus (SLE).In this review, we will summarize these epidemiological and functional studies of FcyRIIB-1232T in the past few years,and will further discuss the mechanisms accounting for the functional loss of FcyRIIB-1232T.Our review will help the reader gain a deeper understanding of the importance of the TM domain in mediating the inhibitory function of FcyRIIB and may provide insights to a new therapeutic target for the associated diseases. | Junyi Wang Zongyu Li Liling Xu Hengwen Yang Wanli Liu | 2018 | Protein & Cell2018，9，12： | 1 |
| 4 | The structural significance of the interlayer distances of the layered hybrids (CnH2n+1NH3)2MCl4显示文摘 | GUO Liling XU Shengdong ZHAO Guanghui | 2012 | J Phys Chem Solids2012，73，： | 1 |
| 5 | Sensitivity and specificityof the ankle brachial index to diagnose peripheral artery disease :a structured review显示文摘 | Dachun Xu Jue Li Liling Zou | 2010 | Vase Med2010，15，5： | 1 |
| 6 | Sensitivity and specificity of the ankle--brachial index to diagnose peripheral artery disease:a structured review显示文摘 | Dachun Xu Jue Li Liling Zou | 2010 | Vasc Med2010，15，5： | 1 |
| 7 | PIP2和PIP3平衡以及Dock2的招募和活化调控B细胞抗原受体微簇体成熟显示文摘文章简介B淋巴细胞作为抗体免疫应答过程中的重要参与者,维系着人类的健康,其免疫活化是启动体液免疫反应的关键步骤。B淋巴细胞的免疫活化进程在其质膜表面的B细胞抗原受体(BCR)识别外来病原体抗原后快速启动,具有瞬时性和高度动态性特点,一直是免疫学领域的研究热点和难点。 | Jing Wang Liling Xu Samina Shaheen Sichen Liu Wenjie Zheng Xiaolin Sun Zhanguo Li 刘万里 | 2018 | 科学新闻2018，0，4： | 0 |
| 8 | Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases显示文摘越来越多的 cyclopeptides 作为 ribosomal 的产品被发现了合成小径。这些 cyclopeptides 的 biosynthetic 学习为环合揭示了有趣的新机制。这评论在环合机制加亮最近的发现因为 cyclopeptides 独立于 non-ribosomal 肽合成酶综合了,包括催化 endopeptidase 的环合,调停 intein 的环合,和肽催化合成酶的环合。这个信息可以帮助设计混合 ribosomal 和 non-ribosomal biosynthetic 系统与各种各样的 bioactivities 生产新奇 cyclopeptides。 | Wenyan Xu Liling Li Liangcheng Du Ninghua Tan | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 0 |
| 9 | CPAL, as a New Mediator of Cardiomyocyte Metabolic Alterations and Pyroptosis, Regulates Myocardial Infarction Injury in Mice显示文摘Myocardial infarction (MI), the most serious of the ischemic heart diseases, is accompanied by myocardial metabolic disorders and the loss of cardiomyocytes. Increasing evidence has shown that long noncoding RNAs (lncRNAs) are involved in various pathological conditions such as cancer and cardiovascular diseases (CVDs), and are emerging as a novel biomarker for these disorders. This study aims to investigate the regulatory role and mechanisms of lncRNAs in myocardial remodeling in the setting of MI. We find that post-infarcted hearts exhibit a reduction of adenosine triphosphate (ATP) and an alteration of the glucose and lipid metabolism genes cluster of differentiation 36 (CD36), hexokinase 1 (HK1), and clucose transporter 4 (GLUT4), accompanied by cardiomyocyte pyroptosis. We then identify a previously unknown conserved lncRNA, AK009126 (cardiomyocyte pyroptosis-associated lncRNA, CPAL), which is remarkably upregulated in the myocardial border zone of MI mice. Importantly, the adeno-associated virus 9 (AAV9)-mediated silencing of endogenous CPAL by its short hairpin RNA (shRNA) partially abrogates myocardial metabolic alterations and cardiomyocyte pyroptosis during MI in mice. Mechanistically, CPAL is shown to bind directly to nuclear factor kappa B (NFκB) and to act as an activator of NFκB to induce NFκB phosphorylation in cardiomyocytes. We also find that CPAL upregulates caspase-1 expression at the transcriptional level and consequently promotes the release of interleukin (IL)-18 and IL-1β from cardiomyocytes. Collectively, our findings reveal the conserved lncRNA CPAL as a new regulator of cardiac metabolic abnormalities and cardiomyocyte pyroptosis in the setting of MI and suggest CPAL as a new therapeutic target to protect cardiomyocytes against ischemic injury in infarcted hearts. | Jiamin Li Hongru Xue Ning Xu Liling Gong Ming Li Sijia Li Di Huang Qingwei Zhang Pengyu Li Qingsui Li Hang Yu Yining Liu Yadong Xue Haixin Chen Jiali Liu Wanyu Zhang Mingbin Liu Siyu Chang Xianzhi Lang Xingmiao Zhao Weijie Du Benzhi Cai Ning Wang Baofeng Yang | 2023 | Engineering2023，，1： | 0 |
| 10 | Dual inhibition of glucose uptake and energy supply synergistically restrains the growth and metastasis of breast cancer显示文摘Metastatic breast cancer(MBC) is one of the most common and knotty diseases in female population which could place them in a life-threatening condition. For malignant proliferation and migration, cancer cells require a large amount of glucose and energy to meet the demand of rapid metabolism. Hence,efficiently diminishing the utilization of energy substances by cancer cells is emerging as validated therapeutic strategies for cancer therapy. Herein, a nanoplatform with dual-inhibition of glucose uptake and oxidative phosphorylation(OXPHOS) was designed, which consisted of albendazole(ABZ) and atovaquone(ATO) by simple carrier-free self-assembling. The introduction of ABZ could evidently decrease glucose uptake to reduce the main “energy fuel” of cancer cells. Meanwhile, as a blocker of OXPHOS, ATO would reduce adenosine triphosphate(ATP) production and ameliorate hypoxia microenvironment by suppressing mitochondrial respiratory chain. Under such dual inhibition of energy metabolism, AA NPs exerted synergistic energy exhaustion effect and outstanding hypoxia improvement function, efficiently inhibiting tumor growth and metastasis. This research not only illustrates the feasibility of energy metabolism therapy by co-inhibiting glucose uptake and OXPHOS, but also provides an ingenious tactic to diminish metastasis during MBC treatment. | Yuan Xu Liling Huang Yuyang Bi Qi Song Mengmeng Zhang Lingfeng Zhang Tianjiao Zhou Lei Xing Hulin Jiang | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
| 11 | AM真菌和枯落物互作下两种喀斯特植物种间竞争较种内竞争更能促进植物养分利用显示文摘枯落物是植物养分获取和土壤养分转化的关键载体。丛枝菌根(Arbuscular mycorrhizae,AM)对植物养分摄取的影响已被广泛认知。然而,在养分亏缺的喀斯特生境中,不同竞争方式的植物如何通过AM真菌和枯落物利用养分尚不清楚。本研究对两种喀斯特适生植物构树(Broussonetia papyrifera)和云贵鹅耳枥(Carpinus pubescens)进行种内竞争和种间竞争种植处理,并通过幼套球囊霉(Glomus etunicatum)接种或不接种处理,以及土壤中添加或不添加两物种叶片混合枯落物处理,测定了植物生物量以及氮、磷、钾浓度等指标,研究植物的生长和养分利用。研究结果表明,AM真菌对两种植物养分摄取影响不同,AM真菌显著提高了种内和种间竞争下构树的养分摄取量,但降低了云贵鹅耳枥的养分摄取量。种间竞争下接种AM真菌,枯落物添加促进了云贵鹅耳枥对氮的摄取,抑制了构树对氮的摄取。接种AM真菌和添加枯落物条件下,种间竞争的构树对氮、磷和钾的摄取量及云贵鹅耳枥对氮的摄取量均高于种内竞争;种间竞争下两物种养分竞争力呈现明显差异,即构树对磷和钾养分竞争力显著提高,对氮则不显著;云贵鹅耳枥仅对钾的养分竞争力显著降低,对氮和磷则无显著影响。这些结果说明,在AM真菌与枯落物相互作用下,两种喀斯特植物种间竞争较种内竞争更能促进植物养分利用。 | Yun Guo Yuejun He Pan Wu Bangli Wu Yan Lin Minhong He Xu Han Tingting Xia Kaiping Shen Liling Kang Qiyu Tan Wenda Ren Yan Sun Qing Li | 2022 | Journal of Plant Ecology2022，15，2： | 0 |
| 12 | 能量匮乏条件下Snf1-Mec1-Atg1通过控制线粒体呼吸作用调控细胞自噬的发生显示文摘文章简介m TOR和AMPK两个信号分子在细胞自噬的发生过程中扮演着非常重要的调控作用。近年来,人们对于m TOR信号分子如何调控细胞自噬的研究比较清楚,但是对于在能量匮乏条件下,AMPK信号分子如何调控细胞自噬的发生尚不清楚。 | Cong Yi Jingjing Tong Puzhong Lu Yizheng Wang Jinxie Zhang Chen Sun Kangning Yuan Renyu Xue Bing Zou Nianzhong Li Shuhua Xiao Chong Dai Yuwei Huang Liling Xu Lin Li She Chen Di Miao Haiteng Deng Hongliang Li 俞立 | 2018 | 科学新闻2018，0，4： | 0 |
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