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| 1 | Roadmap for single-molecule surface-enhanced Raman spectroscopy显示文摘In the near future,single-molecule surface-enhanced Raman spectroscopy(SERS)is expected to expand the family of popular analytical tools for single-molecule characterization.We provide a roadmap for achieving single molecule SERS through different enhancement strategies for diverse applications.We introduce some characteristic features related to single-molecule SERS,such as Raman enhancement factor,intensity fluctuation,and data analysis.We then review recent strategies for enhancing the Raman signal intensities of single molecules,including electromagnetic enhancement,chemical enhancement,and resonance enhancement strategies.To demonstrate the utility of single-molecule SERS in practical applications,we present several examples of its use in various fields,including catalysis,imaging,and nanoelectronics.Finally,we specify current challenges in the development of single-molecule SERS and propose corresponding solutions. | Yang Yu Ting-Hui Xiao Yunzhao Wu Wanjun Li Qing-Guang Zeng Li Long Zhi-Yuan Li | 2020 | Advanced Photonics2020，2，1： | 7 |
| 2 | Influence of submerged entry nozzle clogging on the behavior of molten steel in continuously cast slab molds显示文摘The influence of submerged entry nozzle clogging on the behavior of molten steel in continuously cast slab molds was studied using commercial code CFX4.3. The results indicate that clogging at the top part of the nozzle port not only increases the velocity of molten steel, but also enhances the wall shear stress, F number and heat flux. This clogging has the greatest effect on the behavior of molten steel. However, clogging at the top 1/3 of the nozzle only increases the velocity of molten steel and has little influence. Clogging at the bottom of the nozzle almost has no influence. | Huixiang Yu Guosen Zhu Xinhua Wang Jiongming Zhang Wanjun Wang | 2005 | Journal of University of Science and Technology Beijing2005，12，4： | 4 |
| 3 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 4 | Strain in solidifying shell of continuous casting slabs显示文摘Two-dimension unsteady heat transfer model was applied to obtain the surface temperature and the shell thickness of continuous casting slabs during the process of solidification. On the basis of which, the mathematical model of strain at the interface of solid and liquid steel was set up. Through which, the strain in the solidifying shell under normal and abnormal operation conditions was gained. The results indicate that the strain is small under the normal operation conditions and the internal crack never happens.However, when the variation of the roll gap is above 2 mm, the strain caused by which is greater than that caused by bulging. Furthermore, the total strain exceeds the critical one and the internal crack is the result. So it is of great importance to maintain the fine state of continuous casting machine to avoid the appearance of internal crack. | Guosen Zhu, Xinhua Wang, Huixiang Yu, and Wanjun WangMetallurgical Engineering School, University of Science and Technology Beijing, Beijing 100083, China | 2003 | Journal of University of Science and Technology Beijing2003，10，6： | 3 |
| 5 | Silicon photonic network-on-chip and enabling components显示文摘As the transistor's feature scales down and the integration density of the monolithic circuit increases continuously,the traditional metal interconnects face significant performance limitation to meet the stringent demands of high-speed,low-power and low-latency data transmission for on-and off-chip communications.Optical technology is poised to resolve these problems.Due to the complementary metal-oxide-semiconductor(CMOS) compatible process,silicon photonics is the leading candidate technology.Silicon photonic devices and networks have been improved dramatically in recent years,with a notable increase in bandwidth from the megahertz to the multi-gigahertz regime in just over half a decade.This paper reviews the recent developments in silicon photonics for optical interconnects and summarizes the work of our laboratory in this research field. | HU Ting QIU Chen YU Ping YANG LongZhi WANG WanJun JIANG XiaoQing YANG Mei ZHANG Lei YANG JianYi | 2013 | Chinese Science Bulletin2013，58，7： | 2 |
| 6 | Specific Regulation of m^(6)A by SRSF7 Promotes the Progression of Glioblastoma显示文摘Serine/arginine-rich splicing factor 7(SRSF7),a known splicing factor,has been revealed to play oncogenic roles in multiple cancers.However,the mechanisms underlying its oncogenic roles have not been well addressed.Here,based on N6-methyladenosine(m^(6)A)co-methylation network analysis across diverse cell lines,we find that the gene expression of SRSF7 is positively correlated with glioblastoma(GBM)cell-specific m^(6)A methylation.We then indicate that SRSF7 is a novel m^(6)A regulator,which specifically facilitates the m^(6)A methylation near its binding sites on the mRNAs involved in cell proliferation and migration,through recruiting the methyltransferase complex.Moreover,SRSF7 promotes the proliferation and migration of GBM cells largely dependent on the presence of the m^(6)A methyltransferase.The two m^(6)A sites on the mRNA for PDZ-binding kinase(PBK)are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2).Together,our discovery reveals a novel role of SRSF7 in regulating m^(6)A and validates the presence and functional importance of temporal-and spatial-specific regulation of m^(6)A mediated by RNA-binding proteins(RBPs). | Yixian Cun Sanqi An Haiqing Zheng Jing Lan Wenfang Chen Wanjun Luo Chengguo Yao Xincheng Li Xiang Huang Xiang Sun Zehong Wu Yameng Hu Ziwen Li Shuxia Zhang Geyan Wu Meisongzhu Yang Miaoling Tang Ruyuan Yu Xinyi Liao Guicheng Gao Wei Zhao Jinkai Wang Jun Li | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 7 | Continuous culture of urine-derived bladder cancer cells for precision medicine显示文摘Dear Editor,Bladder cancer is the most common type of genitourinary cancer in China,with an estimated 80,500 new cases and 32,900 related deaths in 2015 alone(Chen et al.,2016).Unlike many other cancers,there has been no significant improvement in survival rates for bladder cancer over the last three decades.Specific treatment regimens for bladder cancer and their efficacy vary depending not only on clinical stages,but also on associated risk factors and other personal clinical characteristics.Patients with non-muscle invasive bladder cancer(NMIBC)have a high 5-year recurrence rate of 60%-70%(Berdik,2017)and those with muscle invasive bladder cancer(MIBC)has a relatively poor prognosis with approximately 65%risk of death within 5-year follow-up(Kamat et al.,2016).Therefore,there is an urgent need to develop models for bladder cancer to screen for rational treatment strategies by personalized medicine to improve the clinical assessment and treatment of bladder cancer. | Shuai Jiang Jiaqi Wang Chen Yang Renke Tan Jun Hou Yuan Shi Huihui Zhang Shiyu Ma Jianan Wang Mengmeng Zhang George Philips Zengxia Li Jian Ma Wanjun Yu Guohua Wang Yuanming Wu Richard Schlegel Huina Wang Shanbo Cao Jianming Guo Xuefeng Liu Yongjun Dang | 2019 | Protein & Cell2019，10，12： | 1 |
| 8 | Resist to kill insect amidine monoclonal antibody preparation and peculiarity identify that显示文摘 | YU WANJUN Mid JIAWAN LU CHANGHAO | 1995 | Chinese public health academic journal1995，14，1： | 1 |
| 9 | Tracing infiltration and recharge using stable isotope in Taihang Mt., North China显示文摘 | Fadong Li Xianfang Song Changyuan Tang Changming Liu Jingjie Yu Wanjun Zhang | 2007 | Environmental Geology2007，，3： | 1 |
| 10 | Molecular spectrum of thalassemia in tropical Hainan Island of southern China:high allele frequency with low health burden显示文摘Thalassemia is the most common monogenetic disorder prevalent in tropical and subtropical regions.It is mainly classified into aandβ-thalassemia according to which globin chain is affected(Taher et al.,2018).Thalassemia mutations present significant genetic diversity,which causing absent(a~0 andβ~0)or reduced(a+andβ+)synthesis of globin chains.Consequently,homozygotes or compound heterozygotes of different thalassemia alleles can lead to various clinical phenotypes. | Yanquan Lai Fangchao Tao Yu Zou Min Huang Kaiting Lin Yang Li Weilun Huang Wanjun Zhou | 2022 | Journal of Genetics and Genomics2022，49，12： | 1 |
| 11 | Expression of serum miR-221 in human hepatocellular carcinoma and its prognostic significance显示文摘 | Jipeng Li Yiping Wang Wanjun Yu Jun Chen Jianping Luo | 2011 | Biochemical and Biophysical Research Communications2011，，1： | 1 |
| 12 | Imbalance of Th17/Treg cells in mice with chronic cigarette smoke exposure显示文摘 | Huaying Wang Weidong Peng Yuesong Weng Huajuan Ying Hequan Li Dajing Xia Wanjun Yu | 2012 | International Immunopharmacology2012，，4： | 1 |
| 13 | Expression of serum miR-221 in human hepatocellular carcinoma and its prognostic significance显示文摘 | Jipeng Li Yiping Wang Wanjun Yu Jun Chen Jianping Luo | 2011 | Biochemical and Biophysical Research Communications2011，，1： | 1 |
| 14 | An Approach to Achieve Carbon Neutrality with Integrated Multi-Energy Technology显示文摘1.Introduction At the 75th session of the United Nations General Assembly on 22 September 2020,President Xi Jinping pledged that China would peak its carbon emissions before 2030 and achieve carbon neutrality by 2060(hereinafter referred to as“peak carbon emissions and carbon neutrality”).This statement indicated that China would contribute to the global community in order to aim toward a shared future for humankind and would establish a schedule for the promotion of green,low-carbon,and highquality development,which will benefit China’s overall and long-term development.China’s total carbon dioxide(CO_(2))emissions surpassed those of the United States in 2005,making China the world’s largest carbon emitter.Due to the nation’s rapid and sustained economic growth,China’s emissions reached 9.83 billion tonnes in 2019,accounting for 28.8%of the global total[1]. | Wanjun Li Hanxiong Zhu Yu Xiao Rui Cai Zhongmin Liu | 2022 | Engineering2022，，12： | 0 |
| 15 | Ridge Covering High-yield Cultivation Techniques of Jinhong Apple in Cold Region显示文摘After five years of study,it was found that compared with the conventional cultivation techniques,the average yield per plant of3-5-year-old Jinhong apple trees cultivated under the ridge covering mode was increased by 2. 12 times,the stem diameter was increased by20%,the branch number was increased by 73. 5%,and the underground root number was increased by 38. 3%. Under the ridge covering mode,the main distribution area of the underground roots of Jinhong apple trees was moved down to 15-55 cm,the temperature of soil 20 cm beneath the surface of the ridges increased by 1. 3-1. 5℃,the temperature of soil 40 cm beneath the surface of the ridges rose by 0. 9-1. 0℃,and the water content of soil 20-40 cm from the ground was maintained around 5%. Under the ridge covering mode,the Jinhong apple trees grew robustly,began to fruit 3 years later and yielded highly 5 years later. In addition,the ridge covering model also has illumination-enhancing,pest-controlling and tillage-free characteristics. | Chang LIU Zhangli FENG Siyang TANG Haidong BU Minggang XIAO Guangjun GU Xianmin CHENG Wenquan YU Wanjun YE | 2019 | Asian Agricultural Research2019，11，4： | 0 |
| 16 | Shared and Distinct Topographic Alterations of Alpha-Range Resting EEG Activity in Schizophrenia,Bipolar Disorder,and Depression显示文摘DearEditor,Schizophrenia(SCZ),bipolar disorder(BD),and major depressive disorder(MDD)are common psychiatric disorders that share several characteristics such as risk genes,and cognitive,neural,and structural abnormalities[1-3].Despite this,the boundaries between the three disorders are not clearly defined in clinical practice,and the'crosscutting'dimensional assessment of symptoms and clinical phenomena is controversial[2,4].To improve the classification criteria,it is essential to explore the underlying relationships among these disorders and address the fuzzy divergence that exists. | Rui Xue Xiaojing Li Jianning Chen Sugai Liang Hua Yu Yamin Zhang Wei Wei Yan Xu Wei Deng Wanjun Guo Tao Li | 2023 | Neuroscience Bulletin2023，39，12： | 0 |
| 17 | Feasible fabrication of o-phenanthroline-based polymer adsorbent for selective capture of aqueous Ag(Ⅰ)显示文摘Devising a desirable adsorbent for efficiently selective capture of Ag(Ⅰ) from wastewater has attracted much attention but faced with huge challenges. Herein, a novel linear o-phenanthroline-based polymer L-PRL was prepared via chemical oxidative polymerization for the adsorption of Ag(Ⅰ). The maximum adsorption capacity for Ag(Ⅰ) by L-PRL is 325.8 mg/g at pH 0. In addition, L-PRL owes ascendant selectivity for Ag(Ⅰ) from aqueous solutions containing various interfering metal ions of Pb(Ⅱ), Co(Ⅱ), Ni(Ⅱ), Cd(Ⅱ)and Fe(Ⅲ). Multiple characterizations of FT-IR and XPS uncover that the N groups on L-PRL act as adsorption sites to coordinate with Ag(Ⅰ). Density functional theory(DFT) calculations further evidence the mechanism that L-PRL is provided with the admirable adsorptivity and selectivity for Ag(Ⅰ). It is mainly attributed to the most stable complexes of L-PRL with Ag(Ⅰ), which possesses shortest Ag-N bond length compared with other heavy metal ions. Furthermore, 93.5% of initial adsorption capacity is reserved after four continuous regeneration cycles, indicating that L-PRL is equipped with superior recyclability and durability, and L-PRL is capable of removing Ag(Ⅰ) in low-concentration actual Ag(Ⅰ)-containing wastewater completely. This study shed light on the rational design of polymer adsorbents and in-depth insight into selective removal of aqueous Ag(Ⅰ). | Xuan Ding Wanjun Yu Xin Sheng Hui Shi Deng You Mingming Peng Penghui Shao Liming Yang Lingling Liu Xubiao Luo | 2023 | Chinese Chemical Letters2023，34，3： | 0 |
| 18 | A new photolabeling probe for efficient enrichment and deep profiling of cell surface membrane proteome by mass spectrometry显示文摘The cell surface membrane proteome is a class of proteins encoded by ~25% of all protein-coding genes in living organisms and plays a key role in mediating communication between the cells and their surrounding environment. However, most cell surface membrane proteins(CSMPs) are naturally expressed at very low levels compared with intracellular proteins. The difficulties in their purification with high specificity further hinder the understanding of their structure and function. In this study, we developed a new photolabeling probe to achieve efficient tagging and facile enrichment of the CSMPs. The probe is composed of a lipid tail for cell surface localization, a polyethylene glycol(PEG) spacer for increased water solubility, two 4-(N-maleimido)benzophenone(MBP) groups for UV-active tagging of the CSMPs, and a biotin tag for subsequent isolation. Application of this photolabeling probe resulted in the successful enrichment and identification of 3098 annotated CSMPs in HT22 cells with close to 70% selectivity. The proposed photolabeling probe and enrichment strategy were demonstrated to be a powerful method for deep cell surface proteome profiling, representing one of the largest groups of current drug targets. | Yuanyuan Li Chaoshuang Xia Hongxian Zhao Yuping Xie Yangjun Zhang Wanjun Zhang Yongliang Yu Jianhua Wang Weijie Qin | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
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