|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The approach to calculate the aerodynamic drag of maglev train in the evacuated tube显示文摘In order to study the relationships between the aerodynamic drag of maglev and other factors in the evacuated tube,the formula of aerodynamic drag was deduced based on the basic equations of aerodynamics and then the calculated result was confirmed at a low speed on an experimental system developed by Superconductivity and New Energy R&D Center of South Jiaotong University.With regard to this system a high temperature superconducting magnetic levitation vehicle was motivated by a linear induction motor(LIM) fixed on the permanent magnetic guideway.When the vehicle reached an expected speed,the LIM was stopped.Then the damped speed was recorded and used to calculate the experimental drag.The two results show the approximately same relationship between the aerodynamic drag on the maglev and the other factors such as the pressure in the tube,the velocity of the maglev and the blockage ratio.Thus,the pressure,the velocity,and the blockage ratio are viewed as the three important factors that contribute to the energy loss in the evacuated tube transportation. | Jiaqing Ma Dajing Zhou Lifeng Zhao Yong Zhang Yong Zhao | 2013 | Journal of Modern Transportation2013，21，3： | 10 |
| 2 | Combinational adenovirus-mediated gene therapy and dendritic cell vaccine in combating well-established tumors显示文摘在肿瘤免疫学和生物工学的最近的开发使癌症基因治疗和免疫疗法可行。为癌症基因治疗的当前的努力主要集中于使用基因, chemogenes 和肿瘤压制的免疫或基因。对所有这些治疗中央是为基因治疗的有效向量的发展。迄今为止,侵入人体气管粘膜的病菌(副词) 调停了基因治疗是最有希望的途径之一,作为由关于动物肿瘤模型和临床的试用的研究证实了。树枝状的房间(DC ) 是高度有效的,专业化介绍抗原的房间,并且基于 DC 的肿瘤疫苗被认为是有在癌症免疫疗法的许多潜力。有 DC 的种痘与肿瘤肽, lysates,或 RNA 搏动了,或与 apoptotic/necrotic 肿瘤房间装载了,或设计了表示某些 cytokines 或 chemokines 能导致重要的反肿瘤细胞毒素的 T 淋巴细胞(CTL ) 回答和反肿瘤免疫。尽管两个都调停副词的基因治疗和 DC 疫苗的罐头两个都刺激反肿瘤免疫者回答,他们的治疗学的效率被限制了到预防的反肿瘤免疫的产生对与父母肿瘤细胞或到小肿瘤的生长抑制重新质问。然而,这条途径在在动物模型与生长得很好的肿瘤作斗争是失败的。因此,当前的癌症免疫疗法的一个主要战略目标成为了能与生长得很好的肿瘤作斗争的新奇治疗学的策略的发展,自从与重要疾病通常在场的癌症病人的一个好比例,因此类似于真实临床的实践。在这篇论文,我们在调停副词的癌症基因治疗和基于 DC 的癌症疫苗考察最近的进步,并且讨论包括基因治疗和 DC 疫苗的联合免疫疗法。我们强调那联合治疗可以在与作为单音的治疗管理的任何一个形式相比与生长得很好的肿瘤作斗争有一些优点的事实。 | Dajing Xia Terence Moyana Jim Xiang | 2006 | Cell Research2006，16，3： | 7 |
| 3 | Peptide fraction from sturgeon muscle by pepsin hydrolysis exerts anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages via MAPK and NF-κB pathways显示文摘Previous studies have suggested that polypeptides extracted from milk, soybean, fish, eggs, and meat possess potential anti-inflammatory effects. To date, few studies have reported the anti-inflammatory function of sturgeon peptides and their underlying mechanisms are unknown. The current study was therefore to determine the anti-inflammatory potential of sturgeon peptides with lipopolysaccharide (LPS)-induced RAW264.7 inflammatory model. Pepsin hydrolysate (PeH) was purified by ultrafiltration and Sephadex G-15 gel filtration chromatography. PeH significantly reduced the inflammatory mediator (NO) and inflammatory cytokines (IL-6, TNF-α and IL-1β) expression in a dose-dependent manner. Moreover, the purified sturgeon peptide (F2) possessed strong antioxidant potential and effectively inhibited DPPH and ABTS free radicals. F2 significantly suppressed the expression of MAPK, IκBα, and NF-κB p65, indicating that F2 exerted anti-inflammatory influence by the inhibition of MAPK and NF-κB pathways. | Ruichang Gao Wanghui Shu Yang Shen Quancai Sun Wengang Jin Dajing Li Ying Li Li Yuan | 2021 | Food Science and Human Wellness2021，10，1： | 6 |
| 4 | Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y_(12 ) signaling pathway显示文摘Ticagrelor is the first reversibly binding oralP2Y_(12) receptor antagonist to inhibit platelet activation and has been approved by the Food and Drug Administration for the treatment of coronary artery disease. At present, the other pharmacological functions of ticagrelor remain poorly understood. The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a critical role in the innate immune system, but its excessive activation also contributes to the pathogenesis of complex diseases. In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on theP2Y_(12) signaling pathway. Further mechanistic studies demonstrate that ticagrelor attenuates the oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) by blocking chloride efflux, an effect achieved through the degradation of chloride intracellular channel proteins (CLICs) and blockade of the translocation of CLICs to the plasma membrane. Moreover, experiments on lipopolysaccharide-induced sepsis and alum-induced peritonitis in mice confirmed that ticagrelor mitigates the severity of systemic inflammation independent ofP2Y_(12) receptor antagonism. Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome. Overall, our study reveals a novel pharmacological function of ticagrelor in addition to its classic antiplatelet properties, which suggests that ticagrelor may serve as a potential therapeutic agent for use in NLRP3-associated diseases. | Bo Huang Yufeng Qian Shujun Xie Xianhua Ye Hanwen Chen Zhifeng Chen Lihuan Zhang Jinming Xu Hu Hu Shenglin Ma Paul Héroux Di Wang Han-Ming Shen Yihua Wu Dajing Xia | 2021 | Cellular & Molecular Immunology2021，18，5： | 3 |
| 5 | Assessing the relative role of climate change and human activities in desertification of North China from 1981 to 2010显示文摘Desertification is a severe environmental problem induced by both climate change and human activities.This study assessed the relative contribution of climate change,human activities,and different climatic and anthropogenic factors in desertification reversion and expansion of North China from 1981 to 2010.The results showed that the desertification of North China had changed significantly over the past 30 years;desertification reversion and expansion covered an area of 750,464 km^2, and the spatial distribution of these regions exhibited considerable heterogeneity.For desertification reversion, climate change and human activity accounted for 22.6% and 26%,respectively of total reverted land.Wind speed reduction and the improvement ofhydrothermal conditions were the most important climatic factors for desertification reversion in the arid region of Northwest China (ARNC) and the Three-River Headwaters region (TRHR),and the reduction in grassland use intensity was the most important anthropogenic factor related to desertification reversion in Inner Mongolia and regions along the Great Wall (IMGW). For desertification expansion,the relative role of climate change was more obvious,which was mainly attributed to the continuous reduction in precipitation in eastern IMGW, and the increase in grassland use intensity was the main factor underlying regional human-induced desertification expansion. | Duanyang XU Alin SONG Dajing LI Xue DING Ziyu WANG | 2019 | Frontiers of Earth Science2019，13，1： | 2 |
| 6 | Integrated design of topology and material for composite morphing trailing edge based compliant mechanism显示文摘The morphing trailing edge based compliant mechanism is a developing technology which can increase lift-drag ratio for variable flight modes by bending down the trailing edge.Composite material design is integrated into topology optimization for the morphing trailing edge based compliant mechanism in the paper.A two-step optimization strategy is established to solve the integrated design problem.Initially,lamination parameters are introduced and viewed as a bridge between structure stiffness and fiber angles for composite material.Design variables include the lamination parameters and element density.The least-squares between actual and desired displacements at output points along trailing edge is adopted to evaluate the deformed capability of the trailing edge.An integrated optimization model for the composite morphing trailing edge is established with the volume constraints.The optimal topologic shape and lamination parameters are initially obtained.Subsequently,a least-squares optimization between fiber angles and the optimal lamination parameters is implemented to obtain optimal fiber angles.Finally,morphing capability of composites trailing edge based compliant mechanism is investigated by simulation and experiments.The results indicate the composites trailing edge based compliant mechanism can approximately bend down 8 degrees and satisfies the design requirement. | Xinxing TONG Wenjie GE Zhenyi YUAN Dajing GAO Xinqin GAO | 2021 | Chinese Journal of Aeronautics2021，34，5： | 2 |
| 7 | The time and space characteristics of magnetomotive force in the cascaded linear induction motor显示文摘To choose a reasonable mode of three-phase winding for the improvement of the operating efficiency of cascaded linear induction motor,the time and space characteristics of magnetomotive force were investigated.The ideal model of the cascaded linear induction motor was built,in which the B and C-phase windings are respectively separated from the A-phase winding by a distance of d and e slots pitch and not overlapped.By changing the values of d and e from 1 to 5,we can obtain 20 different modes of three-phase winding with the different combinations of d and e.Then,the air-gap magnetomotive forces of A-,B-,and C-phase windings were calculated by the magnetomotive force theory.According to the transient superposition of magnetomotive forces of A-,B-,and C-phase windings,the theoretical and simulated synthetic fundamental magnetomotive forces under 20 different arrangement modes were obtained.The results show that the synthetic magnetomotive force with d = 2 and e = 4 is close to forward sinusoidal traveling wave and the synthetic magnetomotive force with d = 4 and e = 2 is close to backward sinusoidal traveling wave,and their amplitudes and wave velocities are approximately constant and equal.In both cases,the motor could work normally with a high efficiency,but under other 18 arrangement modes(d = 1,e = 2;d = 1,e = 3;d = 1,e = 4;…),the synthetic magnetomotive force presents obvious pulse vibration and moves with variable velocity,which means that the motor did not work normally and had high energy loss. | Dajing Zhou Jiaqing Ma Lifeng Zhao Xiao Wan Yong Zhang Yong Zhao | 2013 | Journal of Modern Transportation2013，21，3： | 2 |
| 8 | NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia显示文摘 | Dajee M Lazarov M Zhang JY | 2003 | Nature2003，421，6923： | 1 |
| 9 | NFκB blockade and oncogenic ras trigger invasive human epidermal neoplasia显示文摘 | Dajee M Lazarov M Zhang J Y | 2003 | Nature2003，421，6923： | 1 |
| 10 | NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia显示文摘 | Dajee M Lazarov M Zhang JY | 2003 | Nature2003，421，6923： | 1 |
| 11 | Study of an Environment-friendly Insulating Coating with High Corrosion Resistanceon Electrical Steel显示文摘 | Lin An Zhang Xian Fang Dajing | 2010 | Anti-Corrosion Methods andMaterials2010，57，6： | 1 |
| 12 | Impact of antitumor regimens on the outcomes of cancer patients with COVID-19:a pooled analysis显示文摘Since the outbreak of coronavirus disease 2019(COVID-19),which is caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)discovered in December 2019,the disease has emerged as a global pandemic(Shi et al.,2020;World Health Organization,2020).Several studies have shown a higher incidence of COVID-19,as well as related poor outcomes in patients with malignancies as compared with those without them(Liang et al.,2020;Tian et al.,2020). | Haohua LU Yu SHI Kelie CHEN Zhi CHEN Haihong ZHU Yuequn NIU Dajing XIA Yihua WU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，10： | 1 |
| 13 | Prevention of experimental colitis by a selective inhibitor of the immunoproteasome显示文摘 | Basler M Dajee M Moll C | 2010 | J Immunol2010，185，1： | 1 |
| 14 | NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia 显示文摘 | DAJEE M LAZAROV M ZHANG JY | 2003 | Nature2003，421，6923： | 1 |
| 15 | Optimized microwave-assisted extraction of total phenolics (TP) from Ipomoea batatas leaves and its antioxidant activity显示文摘 | Jiangfeng Song Dajing Li Chunquan Liu Ying Zhang | 2011 | Innovative Food Science and Emerging Technologies2011，，3： | 1 |
| 16 | Geologic characteristics and metallogenic model of the Hercynian volcanic rock-type epithermal gold deposit in the north of the Zhungaer Basin显示文摘 | Chen Dajing Yang Jiren | 1996 | Transactions of Nonferrous Metals Society of China1996，6，1： | 1 |
| 17 | LIFU-responsive nanomedicine enables acoustic droplet vaporization-induced apoptosis of macrophages for stabilizing vulnerable atherosclerotic plaques显示文摘Due to the high risk of tearing and rupture,vulnerable atherosclerotic plaques would induce serious cardiovascular and cerebrovascular diseases.Despite the available clinical methods can evaluate the vulnerability of plaques and specifically treat vulnerable plaques before a cardiovascular event,but the efficiency is still low and undesirable.Herein,we rationally design and engineer the low-intensity focused ultrasound(LIFU)-responsive FPD@CD nanomedicine for the highly efficient treatment of vulnerable plaques by facilely loading phase transition agent perfluorohexane(PFH)into biocompatible PLGA-PEG-PLGA nanoparticles(PPP NPs)and then attaching dextran sulphate(DS)onto the surface of PPP NPs for targeting delivery.DS,as a typical macrophages-targeted molecule,can achieve the precise vaporization of NPs and subsequently controllable apoptosis of RAW 264.7 macrophages as induced by acoustic droplet vaporization(ADV)effect.In addition,the introduction of DiR and Fe3O4 endows nanomedicine with near-infrared fluorescence(NIRF)and magnetic resonance(MR)imaging capabilities.The engineered FPD@CD nanomedicine that uses macrophages as therapeutic targets achieve the conspicuous therapeutic effect of shrinking vulnerable plaques based on in vivo and in vitro evaluation outcomes.A reduction of 49.4%of vascular stenosis degree in gross pathology specimens were achieved throughout the treatment period.This specific,efficient and biosafe treatment modality potentiates the biomedical application in patients with cardiovascular and cerebrovascular diseases based on the relief of the plaque rupture concerns. | Jingxin Hou Jun Zhou Meiqi Chang Guangcheng Bao Jie Xu Man Ye Yixin Zhong Shuling Liu Junrui Wang Wei Zhang Haitao Ran Zhigang Wang Yu Chen Dajing Guo | 2022 | Bioactive Materials2022，7，10： | 1 |
| 18 | Lysostaphin treatment of methieillin-resistant Staphylococcus aureus keratitis in the rabbit显示文摘 | Dajes JJ Hume EB Moreau JM | 2000 | Invest Ophthalmol Vis Sei2000，41，6： | 1 |
| 19 | Designs and applications of electrohydrodynamic 3D printing显示文摘This paper mainly reviews the designs of electrohydrodynamic(EHD)inkjet printing machine and related applications.The review introduces the features of EHD printing and its possible research directions.Significant progress has been identified in research and development of EHD high-resolution printing as a direct additive manufacturing method,and more effort will be driven to this direction soon.An introduction is given about current trend of additive manufacturing and advantages of EHD inkjet printing.Designs of EHD printing platform and applications of different technologies are discussed.Currently,EHD jet printing is in its infancy stage with several inherent problems to be overcome,such as low yielding rate and limitation of stand-off height.Some potential modifications are proposed to improve printing performance.EHD highresolution printing has already been applied to precision components for electronics and biotechnology applications.This paper gives a review about the latest research regarding EHD used for high-resolution inkjet printing.A starting base is given to help researchers and students to get a quick overview on the recent development of EHD printing technology. | Dajing Gao Jack G.Zhou | 2019 | International Journal of Bioprinting2019，5，1： | 1 |
| 20 | Cardiac valve replacement in systemic lupus erythematosus:a review显示文摘 | Dajee H Hurley EJ Szarnicki RJ | 1983 | J Thorac Cardiovasc Surg1983，85，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员