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| 1 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 2 | The application of DGGE and AFLP-derived SCAR for discrimination between Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss)显示文摘 | Zhang JB Wang H J Cai ZP | 2007 | 中国生物学文摘2007，21，8： | 6 |
| 3 | A novel solid state Michael addition reaction of N-heterocyclic compounds containing active C-H bond显示文摘In this paper,a novel solid state Michael-type addition reaction of N-heterocyclic compounds containing the active-CH group was investigated.3-Methyl-l-phenyl-5-pyrazolone (MPP) and indole (In) reacted with 4-arylmethylene-3-methyl-l-phenyl-5-pyrazolone (1) hi the solid state at room temperature to give the corresponding adducts,aryl-4,4’-bis(5-hydroxy-3-methyl-l-phenyl-pyrazolyl) methane (2a-n) and l-aryl-l-(5’-hydroxy-3’-methyl-1’-phenyl-4’-pyrazolyl)-l-(3'-indolyl) methane (3a-n),respectively.This is a feasible method for preparing the compound which contains two heterocyclic groups on the same carbon. | Li, XL Wang, YM Tian, B Meng, JB | 1996 | Chinese Journal of Chemistry1996，14，5： | 3 |
| 4 | The Influence of Diabetes, Hypertension, and Hyperlipidemia on the Onset of Age-Related Macular Degeneration in North China: The Kailuan Eye Study显示文摘Objective To analyze the prevalence of dry and wet age-related macular degeneration(AMD)in patients with diabetes,hypertension and hyperlipidemia,and to analyze the risk factors for AMD.Methods A population-based cross-sectional epidemiologic study was conducted involving 14,440 individuals.We assessed the prevalence of dry and wet AMD in diabetic and non-diabetic subjects and analyzed the risk factors for AMD.Results The prevalence of wet AMD in diabetic and non-diabetic patients was 0.3%and 0.5%,respectively,and the prevalence of dry AMD was 17%and 16.4%,respectively.The prevalence of wet AMD in healthy,hypertensive,hyperlipidemic,and hypertensive/hyperlipidemic populations was 0.5%,0.3%,0.2%,and 0.7%,respectively.The prevalence of dry AMD in healthy,hypertensive,hyperlipidemic,and hypertensive/hyperlipidemic populations was 16.6%,16.2%,15.2%,and 17.2%,respectively.Age,sex,body mass index,and use of hypoglycemic drugs or lowering blood pressure drugs were corrected in the risk factor analysis of AMD.Diabetes,diabetes/hypertension,diabetes/hyperlipidemia,and diabetes/hypertension/hyperlipidemia were analyzed.None of the factors analyzed in the current study increased the risk for the onset of AMD.Conclusion There was no significant difference in the prevalence of wet and dry AMD among diabetic and non-diabetic subjects.Similarly,there was no significant difference in the prevalence of wet and dry AMD among subjects with hypertension and hyperlipidemia.Diabetes co-existing with hypertension and hyperlipidemia were not shown to be risk factors for the onset of dry AMD. | ZHANG Yong Peng WANG Ya Xing ZHOU Jin Qiong WANG Qian YAN Yan Ni YANG Xuan YANG Jing Yan ZHOU Wen Jia WANG Ping SHEN Chang YANG Ming LUAN Ya Nan WANG Jin Yuan WU Shou Ling CHEN Shuo Hua WANG Hai Wei FANG Li Jian WAN Qian Qian ZHU Jing Yuan NIE Zi Han CHEN Yu Ning XIE Ying JONAS JB WEI Wen Bin | 2022 | Biomedical and Environmental Sciences2022，35，7： | 2 |
| 5 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 6 | H-2 Kd-restricted hepatitis B virus-derived epitope whose specific CD8+T lymphocytes can produce gamma interferon without cytotox-icity显示文摘 | Chen A Wang L Zhang JB | 2005 | J Virol2005，79，9： | 1 |
| 7 | Estimation of cancer incidence and mor- tality attributable to alcohol drinking in China显示文摘 | Liang H Wang JB Xiao H J | 2010 | BMC Public Health2010，10，： | 1 |
| 8 | A region in the first exon/intron of rat carnitine palmitoyltransferase Ibeta is involved in enhancement of basal transcription 显示文摘 | Wang GL Moore ML McMillin JB | 2002 | Biochem2002，362，3： | 1 |
| 9 | Large scale identification, mapping, and genotyping of single nucleotide polymorphisms in the human genome显示文摘 | Wang DG Fan JB Siao CJ | 1998 | Science1998，280，5366： | 1 |
| 10 | Incidence of nonarteritic anterior isehemie optic neuropathy in adult Chinese: the Beijing Eye Study 显示文摘 | Xu L Wang Y Jonas JB | 2007 | Eur J Ophthalmol2007，17，3： | 1 |
| 11 | Forecasting cancellation rates for services booking revenue management using data mining显示文摘 | Morales DR Wang JB | 2010 | European Journal of Opera- tional Research2010，，202： | 1 |
| 12 | Major eye diseases and risk factors associated with systemic hypertension in an adult Chinese population: the Beijing Eye Study 显示文摘 | WANG S XU L JONAS JB | 2009 | Ophthalmology2009，116，12： | 1 |
| 13 | Isolation and genetic characterization of hantaviruses carried by Microtus voles in China 显示文摘 | Zou Y Wang JB Gaowa HS | 2008 | J Med Virol2008，80，4： | 1 |
| 14 | Large-scale identification,mapping,and genotyping of single-nucleotide polymorphisms in the human genome显示文摘 | Wang DG Fan JB Siao C J | 1998 | Science1998，280，5366： | 1 |
| 15 | Comparative analysis of a large dataset indicates that internal transcribed spacer(ITS)should be incorporated into the core barcode for seed plants显示文摘 | Li DZ Gao LM Li H Wang H Ge X J Liu JQ Chen ZD Zhou SL Chen SL Yang JB | | 0，，： | 1 |
| 16 | Expression of neural cell adhesion molecule in salivary adenoid cystic carcinoma and its correlation with perineural invasion显示文摘 | Shang JB Sheng L Wang K | 2007 | Oncol Reports2007，18，6： | 1 |
| 17 | Common genetic determinams of vitamin D insufficiency:a genome-wide association study显示文摘 | Wang TJ Zhang F Richards JB | 2010 | Lancet2010，376，3： | 1 |
| 18 | Recombinant tuberculosis vaccine AEC/BC02 induces antigen-specific cellular responses in mice and protects guinea pigs in a model of latent infection 显示文摘 | Lu JB Chen BW Wang GZ | 2015 | J Microbiol Immunol Infect2015，48，6： | 1 |
| 19 | Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes显示文摘 | Wang GW Klein JB Kang YJ | 2001 | J Pharmacol Exp Ther2001，298，2： | 1 |
| 20 | Effect of heat stress on calcium ultrastructural distribution in pepper anther显示文摘 | Yan CHL Wang JB Li RQ | 2002 | Environ Exp Bot2002，48，： | 1 |
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