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| 1 | An 8.1Ma calcite record of Asian summer monsoon evolution on the Chinese central Loess Plateau显示文摘Carbonates in loess-red clay sequences consist mainly of calcite and dolomite. The EDTA analysis of carbonates in different size fractions and magnetic susceptibility reveal that calcite is a sensitive index of summer monsoon. The chemical analysis of carbonates and calcite from an 8.1 Ma loess-red clay sequence at Chaona on the Chinese central Loess Plateau shows that the evolution of the Asian summer monsoon experienced four stages, namely 8.1―5.5 Ma, 5.5―2.8 Ma, 2.8―1.5 Ma and 1.5―0 Ma, with increasing intensification and fluctuation, suggesting a possible combining impacts of uplift of the Tibetan Plateau and global changes on the Asian summer monsoon. | CHEN XiuLing FANG XiaoMin AN ZhiSheng HAN WenXia WANG Xin BAI Yan HONG Ye | 2007 | Science China Earth Sciences2007，50，3： | 16 |
| 2 | Fracture detection by using full azimuth P wave attributes显示文摘特定的折断的烃水库的一种类型,页岩折断了水库,在 Shengli 油矿存在。由于这种类型,到石油化学的性质参数的变化的低敏感,和强壮的 anisotropy 的很小的孔,为他们探索是很困难的。到目前为止,没有为由综合分析的破裂的方向,分发,和密度的识别的成熟方法的集合地质,地球物理,井木头,钻的数据,和等等。这篇论文与方位角(IPVA ) 为声学的阻抗变化论述一个新方法,基于存在破裂察觉方法。地震获得,处理,并且识别技术为在 Luojia 区域与页岩破裂的地震、地质的特征在联合用多方位角 P 波浪数据检测方向性的垂直破裂被开发。IPVA 研究为认识到基于有方位角(VVA ) 的速度变化和有为完整的方位角 P 的方位角(AVA ) 的振幅变化的学习的破裂的分发,罢工,和密度在不同 CMP 位置挥动数据被执行。通过在 Luojia 区域的实际申请,主要结果被获得了它证实 IPVA 方法为平行、高角度的量的察觉提供好潜力,页岩破裂。 | Qu Shouli Ji Yuxin Wang Xin Wang Xiuling Chen xinrong Shen Guoqiang | 2007 | Applied Geophysics2007，4，3： | 15 |
| 3 | Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs显示文摘干皮病 pigmentosum (XP ) 是联系 XP 的基因的变化引起的一组基因混乱,导致 DNA 修理的缺陷。XP 病人经常展出神经病学的退化,而是内在的机制是未知的,部分地由于合适的疾病模型的缺乏。这里,我们产生了包括 XPA, XPB, XPC, XPG,和 XPV 在五不同 XP 基因怀有变化的病人特定的导致的 pluripotent 干细胞(iPSCs ) 。这些 iPSCs 进一步被区分到神经房间,并且他们到 DNA 损坏应力的危险性被调查。在神经干细胞(NSC ) 或神经原的 XPA 的变化导致了严重 DNA 损坏修理缺点,并且有变异的 XPA 的这些神经房间对 DNA 导致损坏的 apoptosis 过分敏感。因此, XP 变异的神经房间代表珍贵工具在 XP 病人澄清神经病学的畸形的分子的机制。 | Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu | 2016 | Protein & Cell2016，7，3： | 11 |
| 4 | CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs显示文摘 | Lixia Wang Fei Yi Lina Fu Jiping Yang Si Wang Zhaoxia Wang Keiichiro Suzuki Liang Sun Xiuling Xu Yang Yu Jie Qiao Juan Carlos Izpisua Belmonte Ze Yang Yun Yuan Jing Qu Guang-Hui Liu | 2017 | Protein & Cell2017，8，5： | 10 |
| 5 | Self-powered nanofiber-based screen-print triboelectric sensors for respiratory monitoring显示文摘科学、商业的进展将高要求放为便携电子学。然而,便携电子学的电源供应, breathability,和大量生产仍然有需要被克服的许多挑战。在这研究,一个自我动力的基于 nanofiber 的摩擦电传感器(SNTS ) 被批规模制造技术用 electrospinning 制作并且为经由呼吸监视监视的健康打印屏幕。典型地,一个拱门结构的 SNTS 被 nanofiber 膜和一个 Ag nanoparticle 电极装配。nanofibers 的堆积和 Ag nanoparticles 的传导性的网络越过整个设备保证一条煤气的隧道。当时, SNTS 的煤气的渗透象 6.16 mm/s 一样高,它有压到优势的优点与由密封演员组电影组成的通常使用的便携设备相比。由于 nanofiber 膜的柔软,不管它是否被弄弯,扭曲,或合拢, SNTS 显示出优秀电子输出性能。优异性质 SNTS 的皮友好,自我力量,和批制造例如 breathability,在保健监视和多功能的聪明的系统为他们的申请提供巨大的潜力。 | Ran Cao diaona Wang Shuyu Zhao Wei Yang Zuqing Yuan Yingying Yin Xinyu Du Nian-Wu Li Xiuling Zhang Xiuyan Li Zhong Lin Wang Congju Li | 2018 | Nano Research2018，11，7： | 8 |
| 6 | Branched alkanes with quaternary carbon atoms in Chinese soils: Potential environmental implications显示文摘Lipids extracted from 26 modern soils collected from different climate zones in China and Mongolia are analyzed using gas chromatography- mass spectrometry. These extracts contain pseudo- homologous families of 5,5-diethylalkanes (5,5- DEAs), 6,6-diethylalkanes, 5-butyl-5-ethylalkanes and 6-butyl-6-ethylalkanes, which are first detected in modern soils. All these pseudohomologous series display exclusively odd or exclusively even carbon numbers, clearly indicating a biosynthetic origin, and their carbon number distributions generally covary. The distributions of 5,5-DEAs exhibit strong regional variations, correlated with the spatial distributions of climate and vegetation. The lower molecular weight 5,5-DEAs, maximizing at C21 or C23, dominate in southeast and southwest China samples, while the higher molecular weight 5,5-DEAs with a mode at C29 dominate in cold, arid northwest China and Mongolia. The results demonstrate that the distribution of 5,5-DEAs can serve as a new independent proxy, indicating variations in soil ecosystems and climates, just like the well-known proxy of n-C15—21/n-C22—33 ratios. | BAI Yan FANG Xiaomin WANG Yongli Fabien Kenig CHEN Xiuling WANG Youxiao | 2006 | Chinese Science Bulletin2006，51，9： | 6 |
| 7 | Mechanical regulation of bone remodeling显示文摘Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via a balance between bone formation by osteoblasts and resorption by osteoclasts. These opposite processes allow the accommodation of bones to dynamic mechanical forces, altering bone mass in response to changing conditions. Mechanical forces are indispensable for bone homeostasis;skeletal formation, resorption, and adaptation are dependent on mechanical signals, and loss of mechanical stimulation can therefore significantly weaken the bone structure, causing disuse osteoporosis and increasing the risk of fracture. The exact mechanisms by which the body senses and transduces mechanical forces to regulate bone remodeling have long been an active area of study among researchers and clinicians. Such research will lead to a deeper understanding of bone disorders and identify new strategies for skeletal rejuvenation. Here, we will discuss the mechanical properties, mechanosensitive cell populations, and mechanotransducive signaling pathways of the skeletal system. | Lijun Wang Xiuling You Lingli Zhang Changqing Zhang Weiguo Zou | 2022 | Bone Research2022，10，1： | 6 |
| 8 | Introduction of antisense waxy gene into main parent lines of indica hybrid rice显示文摘Amylose content in rice endosperm is one of the key determinants of rice eating and cooking quality, and the poor quality of indica hybrid rice is closely related to the high amylose level in rice grains. In order to improve the grain quality of the indica hybrid rice by genetic engineering, an antisense fragment of rice waxy gene, driven by the 5’-franking sequences of the rice waxy gene, was successfully introduced into three major parent lines of indica hybrid rice, all contain a high amylose level in the grains, via Agrobacte-rium, and more than 100 hygromycin-resistant plants were regenerated. The analysis of PCR amplification and Southern blots indicated that the T-DNA containing the antisense waxy gene had been integrated into the genome of transgenic rice plants. Most of the primary transgenic rice plants grew normally, and the mature seeds from these transgenic plants were performed for analysis of the amylose content. The results showed that the amylose content in the endosperm of some grains | CHEN Xiuhua LIU Qiaoquan WANG Zongyang WANG Xingwen CAI Xiuling ZHANG Jingliu GU Minghong | 2002 | Chinese Science Bulletin2002，47，14： | 5 |
| 9 | A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells显示文摘 | Zhichao Ding Lina Sui Ruotong Ren Yanjun Liu Xiuling Xu Lina Fu Ruijun Bai Tingting Yuan Ying Hao Weiqi Zhang Huize Pan Wensu Liu Han Yu Concepcion Rodriguez Esteban Xiaobing Yu Ze Yang Jian Li Xiaomin Wang Juan Carlos Izpisua Belmonte Guang-Hui Liu Fei Yi Jing Qu | 2015 | Protein & Cell2015，6，5： | 5 |
| 10 | Nucieocytoplasmic Shuttling of Geminivirus C4 Protein Mediated by Phosphorylation and Myristoylation Is Critical for Viral Pathogenicity显示文摘Many geminivirus C4 proteins induce severe developmental abnormalities in plants.We previously demon- strated that Tomato leaf curl Yunnan virus (TLCYnV)C4 induces plant developmental abnormalities at least partically by decreasing the accumulation of NbSKη,an ortholog of Arabidopsis BIN2 kinase involved in the brassinosteroid signaling pathway,in the nucleus through directing it to the plasma membrane.However, the molecular mechanism by which the membrane-associated C4 modifies the localization of NbSKη in the host cell remains unclear.Here,we show that TLCYnV C4 is a nucleocytoplasmic shuttle protein,and that C4 shuttling is accompanied by nuclear export of NbSKTI.TLCYnV C4 is phosphorylated by NbSKη in the nucleus,which promotes myristoylation of the viral protein.Myristoylation of phosphorylated C4 favors its interaction with exportin-α(XPO I);which in turn facilitates nuclear export of the C4/NbSKTI complex. Supporting this model,chemical inhibition of N-myristoyltransferases or exportin-α enhanced nuclear retention of C4,and mutations of the putative phosphorylation or myristoylation sites in C4 resulted in increased nuclear retention ofrC4 and thus decreased severity of C4-induced developmental abnormalities. The impact of C4 on development is also lessened when a nuclear localization signal or a nuclear export signal is added to its C-terminus,restricting it to a specific cellular niche and therefore impairing nucleocytoplasmic shuttling.Taken together,our results suggest that nucleocytoplasmic shuttling of TLCYnV C4,enabled by phosphorylation by NbSKη,myristoylation,and interaction with exportin-α is critical for its function as a pathogenicity factor. | Yuzhen Mei Yaqin Wang Tao Hu Xiuling Yang Rosa Lozano-Duran Garry Sunter Xueping Zhou | 2018 | Molecular Plant2018，11，12： | 5 |
| 11 | A Hierarchically Porous Metal-Organic Framework from Semirigid Ligand for Gas Adsorption显示文摘层次地多孔的材料在便于集体运输和吸附和分离过程的改善效率起一个重要作用。在这份报纸,新策略被建议认识到一个层次地多孔的金属器官的框架([Cu 2(OH)(L)]·(DMF)0.8(FJU-11, H 3L=3,5-(4-carboxybenzyloxy ) 安息香的酸, DMF=N, N-dimethylformamide ) 经由使用半硬的多羧基的酸。有趣地, FJU-11 向公司 2 拥有大吸附能力和小 isosteric 热。为 FJU-11 的列突破实验在烟道气体的分离加亮它的潜在的申请。 | Lizhen Liu Yingxiang Ye Zizhu Yao Liuqin Zhang Ziyin Li Lihua Wang Xiuling Ma Qian-Huo Chen Zhangjing Zhang Shengchang Xiang | 2016 | Chinese Journal of Chemistry2016，34，2： | 4 |
| 12 | Competition Growth of α and β Phases in Ti-50 at.%Al Peritectic Alloy during the Rapid Solidification by Laser Melting Technique显示文摘Rapid solidification of Ti-50 at.%Al peritectic alloy is realized by laser melting technique at diferent conditions of laser power and scanning speed.The temperature field and the cooling rate under the corresponding conditions are derived from the finite element simulation.Comparing the measured pool size with the simulated result,the laser absorptivity of Ti-50 at.%Al peritectic alloy at diferent conditions can be deduced to establish the relationships between the laser absorptivity,the laser power and the scanning speed.The morphology evolution and the phase selection of Ti-50 at.%Al peritectic alloy are described by the temperature gradient and the cooling rate.With the increase of temperature gradient and cooling rate,βphase replacesαphase to become the leading growth phase.And the growth ofαphase experiences the transition from facet to non-facet manner,whileβphase is refined.To understand the underlying mechanism of the competition growth can bring benefit to the industrial application of Ti-Al alloy. | Wenjing YAO Xiuling NIU Long ZHOU Nan WANG Jehyun LEE | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，5： | 4 |
| 13 | Human endogenous retrovirus W env increases nitric oxide production and enhances the migration ability of microglia by regulating the expression of inducible nitric oxide synthase显示文摘Human endogenous retrovirus W env(HERV-W env) plays a critical role in many neuropsychological diseases such as schizophrenia and multiple sclerosis(MS). These diseases are accompanied by immunological reactions in the central nervous system(CNS). Microglia are important immunocytes in brain inflammation that can produce a gasotransmitter – nitric oxide(NO). NO not only plays a role in the function of neuronal cells but also participates in the pathogenesis of various neuropsychological diseases. In this study, we reported increased NO production in CHME-5 microglia cells after they were transfected with HERV-W env. Moreover, HERV-W env increased the expression and function of human inducible nitric oxide synthase(hi NOS) and enhanced the promoter activity of hi NOS. Microglial migration was also enhanced. These data revealed that HERV-W env might contribute to increase NO production and microglial migration ability in neuropsychological disorders by regulating the expression of inducible NOS. Results from this study might lead to the identification of novel targets for the treatment of neuropsychological diseases, including neuroinflammatory diseases, stroke, and neurodegenerative diseases. | Ran Xiao Shan Li Qian Cao Xiuling Wang Qiujin Yan Xiaoning Tu Ying Zhu Fan Zhu | 2017 | Virologica Sinica2017，32，3： | 3 |
| 14 | Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult显示文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult. | Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong | 2023 | Science China(Life Sciences)2023，66，5： | 3 |
| 15 | Effects of argon gas flow rate and guide shell on oxygen concentration in Czochralski silicon growth显示文摘φ 2 00 公里硅单身者晶体在φ 4 被种 50 公里 aCzochralski (CZ ) 的热地区炉子。由修改模式和氩流动的速度,有不同的氧集中的硅壁炉晶体被获得。通过数字模拟,氩气体流动的速度第一次被阴谋。实验结果被分析,有最低的氧集中的氩流动的最佳条件被获得。 | REN Bingyan ZHAO Long ZHAO Xiuling WANG Huixian CAO Zhongqian ZHU Huimin FU Hongbo | 2006 | Rare Metals2006，25，1： | 3 |
| 16 | Human leukemia antigen-A0201-restricted epitopes of humanendogenous retrovirus W family envelope(HERV-W env)inducestrong cytotoxic T lymphocyte responses显示文摘Human endogenous retrovirus W family(HERV-W) envelope(env) has been reported to be related to several human diseases, including autoimmune disorders, and it could activate innate immunity.However, there are no reports investigating whether human leukemia antigen(HLA)-A~*0201^+restriction is involved in the immune response caused by HERV-W env in neuropsychiatric diseases. In the present study, HERV-W env-derived epitopes presented by HLA-A~*0201 are described with the potential for use in adoptive immunotherapy. Five peptides displaying HLAA~*0201-binding motifs were predicted using SYFEPITHI and BIMAS, and synthesized. A CCK-8 assay showed peptides W, Q and T promoted lymphocyte proliferation. Stimulation of peripheral blood mononuclear cells from HLA-A~*0201^+ donors with each of these peptides induced peptidespecific CD8^+ T cells. High numbers of IFN-γ-secreting T cells were also detectable after several weekly stimulations with W, Q and T. Besides lysis of HERV-W env-loaded target cells, specific apoptosis was also observed. These data demonstrate that human T cells can be sensitized toward HERV-W env peptides(W, Q and T) and, moreover, pose a high killing potential toward HERV-W env-expressing U251 cells. In conclusion, peptides W Q and T, which are HERV-W env antigenic epitopes, have both antigenicity and immunogenicity, and can cause strong T cell immune responses. Our data strengthen the view that HERV-W env should be considered as an autoantigen that can induce autoimmunity in neuropsychiatric diseases, such as multiple sclerosis and schizophrenia. These data might provide an experimental foundation for a HERV-W env peptide vaccine and new insight into the treatment of neuropsychiatric diseases. | Xiaoning Tu Shan Li Lijuan Zhao Ran Xiao Xiuling Wang Fan Zhu | 2017 | Virologica Sinica2017，32，4： | 3 |
| 17 | Occurrence and distribution of geminiviruses in China显示文摘Geminiviruses are a group of plant viruses that cause severe diseases in many economically important crops worldwide, leading to devastating losses to agricultural production. Here we summarize the occurrence and distribution of geminiviruses in China,which provides valuable information for further epidemiological studies and supports the development of effective disease management strategies. | Fangfang Li Rui Qiao Zhanqi Wang Xiuling Yang Xueping Zhou | 2022 | Science China(Life Sciences)2022，65，8： | 3 |
| 18 | Variation of the Vaginal Microbiome During and After Pregnancy in Chinese Women显示文摘A comprehensive profiling of the vaginal microbial communities and their variability enables an accurate description of the microbiome in women.However,there is a lack of studies available on Chinese women.In the present study,the composition of the vaginal microbiota during pregnancy and the 6-week postpartum period of 454 Chinese women was characterized by sequencing the V3-V4 region of the 16S ribosomal RNA(rRNA)gene.The vaginal microbiome showed variations during pregnancy and the postpartum period based on the abortion history,hypertensive disorders,delivery mode,and maternal age.Co-variation of 22 bacterial taxa,including the Lactobacillus genus and two of its species,may account for the common characteristics of the vaginal microbiome under scenarios of different medical histories and pregnancy outcomes.In contrast,discriminant bacterial species were significantly different between women who had preterm birth(PTB)with and without premature rupture of membranes(PROM),and the community state type(CST)IV-A without any predominant Lactobacillus species in the microbiota was more prevalent during pregnancy in the PROM-PTB cases,suggesting that specific bacterial species could be considered to distinguish between different types of PTB.By providing data on Chinese women,this study will enrich the knowledge of the human microbiome and contribute to a better understanding of the association between the vaginal microbiome and reproductive health. | Xiaoai Zhang Qingzhi Zhai Jinfeng Wang Xiuling Ma Bo Xing Hang Fan Zhiying Gao Fangqing Zhao Wei Liu | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 2 |
| 19 | Omentin-1 is associated with carotid atherosclerosis in patients with metabolic syndrome显示文摘 | Rong Liu Xiuling Wang Peili Bu | 2011 | Diabetes Research and Clinical Practice2011，，1： | 2 |
| 20 | Antibiotic resistance gene abundances associated with antibiotics and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai; China显示文摘 | Xiuling Ji Qunhui Shen Fang Liu Jing Ma Gang Xu Yuanlong Wang Minghong Wu | 2012 | Journal of Hazardous Materials2012，，： | 2 |
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