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| 1 | Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs显示文摘干皮病 pigmentosum (XP ) 是联系 XP 的基因的变化引起的一组基因混乱,导致 DNA 修理的缺陷。XP 病人经常展出神经病学的退化,而是内在的机制是未知的,部分地由于合适的疾病模型的缺乏。这里,我们产生了包括 XPA, XPB, XPC, XPG,和 XPV 在五不同 XP 基因怀有变化的病人特定的导致的 pluripotent 干细胞(iPSCs ) 。这些 iPSCs 进一步被区分到神经房间,并且他们到 DNA 损坏应力的危险性被调查。在神经干细胞(NSC ) 或神经原的 XPA 的变化导致了严重 DNA 损坏修理缺点,并且有变异的 XPA 的这些神经房间对 DNA 导致损坏的 apoptosis 过分敏感。因此, XP 变异的神经房间代表珍贵工具在 XP 病人澄清神经病学的畸形的分子的机制。 | Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu | 2016 | Protein & Cell2016，7，3： | 11 |
| 2 | Self-powered nanofiber-based screen-print triboelectric sensors for respiratory monitoring显示文摘科学、商业的进展将高要求放为便携电子学。然而,便携电子学的电源供应, breathability,和大量生产仍然有需要被克服的许多挑战。在这研究,一个自我动力的基于 nanofiber 的摩擦电传感器(SNTS ) 被批规模制造技术用 electrospinning 制作并且为经由呼吸监视监视的健康打印屏幕。典型地,一个拱门结构的 SNTS 被 nanofiber 膜和一个 Ag nanoparticle 电极装配。nanofibers 的堆积和 Ag nanoparticles 的传导性的网络越过整个设备保证一条煤气的隧道。当时, SNTS 的煤气的渗透象 6.16 mm/s 一样高,它有压到优势的优点与由密封演员组电影组成的通常使用的便携设备相比。由于 nanofiber 膜的柔软,不管它是否被弄弯,扭曲,或合拢, SNTS 显示出优秀电子输出性能。优异性质 SNTS 的皮友好,自我力量,和批制造例如 breathability,在保健监视和多功能的聪明的系统为他们的申请提供巨大的潜力。 | Ran Cao diaona Wang Shuyu Zhao Wei Yang Zuqing Yuan Yingying Yin Xinyu Du Nian-Wu Li Xiuling Zhang Xiuyan Li Zhong Lin Wang Congju Li | 2018 | Nano Research2018，11，7： | 8 |
| 3 | Designing near-natural planting patterns for plantation forests in China显示文摘Background: China has a long tradition of managing planted forests. Different species of Populus, Eucalyptus, Larix, Cunninghamia and Pinus are planted to satisfy the local demand for wood products and provide ecological services at the same time. Evidence of the greater resilience of natural forests provides the motivation to develop asymmetric planting patterns, which is the focus of this study. We present a new method for designing plantation patterns that follow those observed in natural ecosystems and to maintain some regularity for operational convenience. Methods: Based on the uniform angle index, we analyzed the spatial structure of six natural forests in different regions of China. The uniform angle index describes the degree of spatial uniformity of the n nearest neighbors of a given reference tree. Accordingly, we identified all possible patterns of a neighborhood group within a regular planting pattern and developed a method to optimize planting point arrangements that contain some randomness as well as a minimum degree of regularity. Results:(1) There are 13 types of structural units in a regular planting, including seven random units, five even units and one cluster unit;(2) Five near-natural arrangements are presented with a minimum proportion of 50% of random units. These five arrangements represent a combination of regularity for operational convenience and asymmetry. Conclusions: The new planting patterns developed in this study are expected to increase the asymmetric competition and resilience of these important ecosystems. Some experimental plantings, based on our findings, have already been established, e.g., in Pinus tabulaeformis plantations in Tianshui, Gansu Province, and in a Populus deltoides plantation in Fangshan near Beijing. | Gongqiao Zhang Gangying Hui Yanbo Hu Zhonghua Zhao Xiuling Guan Klaus von Gadow Ganggang Zhang | 2019 | Forest Ecosystems2019，6，3： | 6 |
| 4 | Effects of argon gas flow rate and guide shell on oxygen concentration in Czochralski silicon growth显示文摘φ 2 00 公里硅单身者晶体在φ 4 被种 50 公里 aCzochralski (CZ ) 的热地区炉子。由修改模式和氩流动的速度,有不同的氧集中的硅壁炉晶体被获得。通过数字模拟,氩气体流动的速度第一次被阴谋。实验结果被分析,有最低的氧集中的氩流动的最佳条件被获得。 | REN Bingyan ZHAO Long ZHAO Xiuling WANG Huixian CAO Zhongqian ZHU Huimin FU Hongbo | 2006 | Rare Metals2006，25，1： | 3 |
| 5 | Coal petrology and genesis of Jurassic coal in the Ordos Basin,China显示文摘简单结构和浅埋葬深度描绘的厚煤床的多重集合在 Ordos 盆的早、中间的侏罗记阶层被开发,西北的中国。这高质量的煤的巨大的储备有高商业的价值。我们学习了煤岩石学的特征和它的 maceral 分发到决定 macerals 贡献到油和气体的产生。结果证明因为主要是在上面的河的系统的一系列高看台的沼泽地的盆唯一的 depositional 环境,在 Ordos 盆的侏罗记煤有特殊 petrological 特征。这些 petrographic 特征是一些沙身体被移植河形成的典型内陆湖的发展的结果。在埋葬以后,泥炭继续经历氧化条件,产生广泛的更高的 inertinite 在煤满足的这个过程和 vitrinite 部件被改变到 semi-vitrinite。这些侏罗记煤的宏观的 petrographic 类型主要是半迟钝的煤,迟钝的煤, semilustrous 和有光泽的煤。半迟钝的煤和迟钝的煤的比例在盆边缘是更高的,特别在北边缘附近的区域。semilustrous 和有光泽的煤的数字向南并且向中央盆增加。这种状况显示不同形成煤的沼泽地环境让学生在煤部件上控制效果。另一观察是在 Ordos 煤序列,特别在更低的部分,一些沙岩床是厚的,直到有一种粗糙的谷物尺寸的 20 m。在 macerals 的更高的 fusinite 内容与更多的完全、常规的植物房间结构伴随一个更高的 semi-vitrinite 内容。fusinite 结构清楚、很好保存。在埋葬以后,房顶和地板岩石的岩性学能继续影响煤岩石学的进化。在房顶和地板的沙身体展出好物理条件以便毛孔水能维持氧化,循环和连接的一个长期的状态到煤。煤部件因此很长时间留在氧化环境。在盆中心,在埋葬和随后的煤床很快进入了减少的环境以后,相反地,开发的湖的外形和泥炭被 mudstone 很快盖住。作为结果,丰富的胶凝化作用发生了, vitrinite 内容增加了。Exinite 经常在煤床上在一个特定的位置积累了。尽管平均 exinite 内容不总体上高,它显著地确实贡献全部的烃产生。exinite 内容被低估了,特别非结晶的沥青的液体和它的重要性这里被强调。原因是液体容易流进有强壮的刚硬的 fusinite,或流进一些裂缝,在它通常被忽视的地方。 | Weihua Ao Wenhui Huang Chengmin Weng Xiuling Xiao Dameng Liu Xiuyi Tang Ping Chen Zhigen Zhao Huan Wan Robert B.Finkelman | 2012 | Geoscience Frontiers2012，3，1： | 3 |
| 6 | Human leukemia antigen-A0201-restricted epitopes of humanendogenous retrovirus W family envelope(HERV-W env)inducestrong cytotoxic T lymphocyte responses显示文摘Human endogenous retrovirus W family(HERV-W) envelope(env) has been reported to be related to several human diseases, including autoimmune disorders, and it could activate innate immunity.However, there are no reports investigating whether human leukemia antigen(HLA)-A~*0201^+restriction is involved in the immune response caused by HERV-W env in neuropsychiatric diseases. In the present study, HERV-W env-derived epitopes presented by HLA-A~*0201 are described with the potential for use in adoptive immunotherapy. Five peptides displaying HLAA~*0201-binding motifs were predicted using SYFEPITHI and BIMAS, and synthesized. A CCK-8 assay showed peptides W, Q and T promoted lymphocyte proliferation. Stimulation of peripheral blood mononuclear cells from HLA-A~*0201^+ donors with each of these peptides induced peptidespecific CD8^+ T cells. High numbers of IFN-γ-secreting T cells were also detectable after several weekly stimulations with W, Q and T. Besides lysis of HERV-W env-loaded target cells, specific apoptosis was also observed. These data demonstrate that human T cells can be sensitized toward HERV-W env peptides(W, Q and T) and, moreover, pose a high killing potential toward HERV-W env-expressing U251 cells. In conclusion, peptides W Q and T, which are HERV-W env antigenic epitopes, have both antigenicity and immunogenicity, and can cause strong T cell immune responses. Our data strengthen the view that HERV-W env should be considered as an autoantigen that can induce autoimmunity in neuropsychiatric diseases, such as multiple sclerosis and schizophrenia. These data might provide an experimental foundation for a HERV-W env peptide vaccine and new insight into the treatment of neuropsychiatric diseases. | Xiaoning Tu Shan Li Lijuan Zhao Ran Xiao Xiuling Wang Fan Zhu | 2017 | Virologica Sinica2017，32，4： | 3 |
| 7 | Seismic Denoising with Curvelet Shrinkage显示文摘 | Aidi Wu Xiuling Zhao | 2010 | 通讯和计算机(中英文版)2010，7，9： | 2 |
| 8 | Variation of the Vaginal Microbiome During and After Pregnancy in Chinese Women显示文摘A comprehensive profiling of the vaginal microbial communities and their variability enables an accurate description of the microbiome in women.However,there is a lack of studies available on Chinese women.In the present study,the composition of the vaginal microbiota during pregnancy and the 6-week postpartum period of 454 Chinese women was characterized by sequencing the V3-V4 region of the 16S ribosomal RNA(rRNA)gene.The vaginal microbiome showed variations during pregnancy and the postpartum period based on the abortion history,hypertensive disorders,delivery mode,and maternal age.Co-variation of 22 bacterial taxa,including the Lactobacillus genus and two of its species,may account for the common characteristics of the vaginal microbiome under scenarios of different medical histories and pregnancy outcomes.In contrast,discriminant bacterial species were significantly different between women who had preterm birth(PTB)with and without premature rupture of membranes(PROM),and the community state type(CST)IV-A without any predominant Lactobacillus species in the microbiota was more prevalent during pregnancy in the PROM-PTB cases,suggesting that specific bacterial species could be considered to distinguish between different types of PTB.By providing data on Chinese women,this study will enrich the knowledge of the human microbiome and contribute to a better understanding of the association between the vaginal microbiome and reproductive health. | Xiaoai Zhang Qingzhi Zhai Jinfeng Wang Xiuling Ma Bo Xing Hang Fan Zhiying Gao Fangqing Zhao Wei Liu | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 2 |
| 9 | Changes of plant species diversity and biomass with reclaimed marshes restoration显示文摘Wetland restoration had been implemented for more than two decades in Sanjiang Plain,Northeast China.To assess the restoration effi ciency of wetland vegetation,we investigated plants composition of community,plant species diversity and aboveground biomass of restored sites in a chronosequence of restoration(1,2,3,6,8,11,15 and 25 years)in the Sanjiang Nature Reserve.As comparison,we also investigated the same factors in a cropland and a natural marsh adjacent to the restored sites.The results showed that wetland plant species can invade quickly after croplands were abandoned when there were suitable hydrology conditions.On the early stage of the restoration,weeds were main plant species in the restored sites.Wetland species appeared at the same time but diff ered from the dominant species from the adjacent natural marshes.Common native wetland species could dominance the community after 3-year restoration.Species richness and diversity increased on the early stage,and then decreased to the similar level of the natural marsh with the extension of restoration.Plant biomass could restore easier than the species composition and diversity.Our results indicated that plant species composition and diversity of abandoned reclaimed wetlands can restore gradually by natural succession in Sanjiang Plain.However,25-year restoration site had similarity index of only 56%with the natural marsh,which revealed that two decades are not enough for complete restoration of vegetation. | Xin Jin Xiaoxin Sun Haixing Li Danhui Zhao Dong Li Lei Wang Xiuling Man | 2021 | Journal of Forestry Research2021，32，1： | 2 |
| 10 | New mechanism revealed for light-state transition in cyanobacterium Arthrospira platensis according to 77-K fluorescence kinetics显示文摘The mechanisms of oxygen evolution and carbon fixation in oxygenic organisms depend on the equal distribution of excitation energy to photosystems Ⅰ and Ⅱ, which is regulated by a mechanism referred to as light-state transition. In this work, a novel mechanism, energy spillover from PS Ⅰ to PS Ⅱ referred to as 'inverse spillover', was revealed besides 'mobile phycobilisome (PBS)' and the 'spillover' of energy from PS Ⅱ to PS Ⅰ in cyanobacteria. Under continuous illumination with blue light, time-dependent 77-K fluorescence spectra demonstrated heterogeneous kinetics for the PBS and photosystem components, indicating that inverse spillover and mobile PBS work successively to regulate the excitation to a balanced distribution in cyanobacterial cells under blue light. Inverse spillover and mobile PBS occur under both 100 and 300 μmol m-2 s-1 blue-light conditions but they are accelerated under the latter. | XU XiuLing ZHANG Rui XIE Jie ZHAO JingQuan | 2012 | Chinese Science Bulletin2012，57，11： | 1 |
| 11 | Emergence of Fatal PRRSV Variants: Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark 显示文摘 | Kegong Tian Xiuling Yu Tiezhu Zhao | 2007 | PloSone2007，6，： | 1 |
| 12 | Emergence of Fatal PRRSV Variants: Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hall- mark显示文摘 | Kegong Tian Xiuling Yu Tiezhu Zhao | 2007 | PLoS ONE2007，，6： | 1 |
| 13 | Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark 显示文摘 | Tian Kegong Yu Xiuling Zhao Tiezhu | 2007 | PLoS ONE2007，，6： | 1 |
| 14 | Emergence of Fatal PRRSV Variants: Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark 显示文摘 | Kegong Tian Xiuling Yu Tiezhu Zhao | 2007 | PLoS ONE2007，2，6： | 1 |
| 15 | Emergence of Fatal PRRSV Variants:Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark显示文摘 | Kegong Tian Xiuling Yu Tiezhu Zhao | 2007 | Plos One2007，，6： | 1 |
| 16 | Emergence of Fatal PRRSV Variants: Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark显示文摘 | Kegong Tian Xiuling Yu Tiezhu Zhao et d | 2007 | PLoS 0NE2007，2，6： | 1 |
| 17 | Development and validation of a machine learning-based nomogram for prediction of intrahepatic cholangiocarcinoma in patients with intrahepatic lithiasis显示文摘Background:Accurate diagnosis of intrahepatic cholangiocarcinoma(ICC)caused by intrahepatic lithiasis(IHL)is crucial for timely and effective surgical intervention.The aim of the present study was to develop a nomogram to identify ICC associated with IHL(IHL-ICC).Methods:The study included 2,269 patients with IHL,who received pathological diagnosis after hepatectomy or diagnostic biopsy.Machine learning algorithms including Lasso regression and random forest were used to identify important features out of the available features.Univariate and multivariate logistic regression analyses were used to reconfirm the features and develop the nomogram.The nomogram was externally validated in two independent cohorts.Results:The seven potential predictors were revealed for IHL-ICC,including age,abdominal pain,vomiting,comprehensive radiological diagnosis,alkaline phosphatase(ALK),carcinoembryonic antigen(CEA),and cancer antigen(CA)19-9.The optimal cutoff value was 2.05μg/L for serum CEA and 133.65 U/mL for serum CA 19-9.The accuracy of the nomogram in predicting ICC was 82.6%.The area under the curve(AUC)of nomogram in training cohort was 0.867.The AUC for the validation set was 0.881 from The Second Affiliated Hospital of Wenzhou Medical University,and 0.938 from The First Affiliated Hospital of Fujian Medical University.Conclusions:The nomogram holds promise as a novel and accurate tool to predict IHL-ICC,which can identify lesions in IHL in time for hepatectomy or avoid unnecessary surgical resection. | Xian Shen Huanhu Zhao Xing Jin Junyu Chen Zhengping Yu Kuvaneshan Ramen Xiangwu Zheng Xiuling Wu Yunfeng Shan Jianling Bai Qiyu Zhang Qiqiang Zeng | 2021 | Hepatobiliary Surgery and Nutrition2021，10，6： | 1 |
| 18 | Emergence of Fatal PRRSV Variants:Unparalleled outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark显示文摘 | Kegong Tian Xiuling Yu Tiezhu Zhao | 2007 | PLoS ONE2007，2，6： | 1 |
| 19 | Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallma 显示文摘 | Kegong Tian Xiuling Yu Tiezhu Zhao Youjun Feng | 2007 | PLOS ONE2007，，6： | 1 |
| 20 | Template synthesis and characterization of a new 2-D layered titanium phosphate显示文摘 | Zhao Yongnan Zhu Guangshan Jiao Xiuling | 2000 | Journal Materials Chemistry2000，10，： | 1 |
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