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| 1 | Principles and technology for stepwise utilization of resources for mitigating deep mine heat hazards显示文摘As is well known, deep mines are hot. As mining depth increases, the temperature of the surrounding rock also increases. This seriously affects mine safety and production and has restricted the exploitation of deep coal resources. Therefore, reducing the working face temperature to improve working conditions by controlling these heat hazards is an urgent problem. Considering problems in cooling deep mines both domestically and abroad along with the actual conditions of the Zhangshuanglou coal mine, we propose a HEMS technology that uses heat resources from deep mines in a stepwise manner. HEMS means a high temperature ex-change machinery system. Mine inrush-water is used as a source of cooling. Twice the energy is extracted from the mine inrush water. Heat is used for building heating in the winter and cold water is used for cooling buildings in the summer. This opens a new technology for stepwise utilization of heat energy in deep mines. Energy conservation and reduced pollution, an improved environment and sustainable economic development are realized by this technique. The economic and social effects are obvious and illustrate a good prospect for the application and extension of the method. | HE Manchao CAO Xiuling XIE Qiao YANG Jiahua QI Ping YANG Qing CHEN Xueqian | 2010 | Mining Science and Technology2010，20，1： | 15 |
| 2 | Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs显示文摘干皮病 pigmentosum (XP ) 是联系 XP 的基因的变化引起的一组基因混乱,导致 DNA 修理的缺陷。XP 病人经常展出神经病学的退化,而是内在的机制是未知的,部分地由于合适的疾病模型的缺乏。这里,我们产生了包括 XPA, XPB, XPC, XPG,和 XPV 在五不同 XP 基因怀有变化的病人特定的导致的 pluripotent 干细胞(iPSCs ) 。这些 iPSCs 进一步被区分到神经房间,并且他们到 DNA 损坏应力的危险性被调查。在神经干细胞(NSC ) 或神经原的 XPA 的变化导致了严重 DNA 损坏修理缺点,并且有变异的 XPA 的这些神经房间对 DNA 导致损坏的 apoptosis 过分敏感。因此, XP 变异的神经房间代表珍贵工具在 XP 病人澄清神经病学的畸形的分子的机制。 | Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu | 2016 | Protein & Cell2016，7，3： | 11 |
| 3 | CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs显示文摘 | Lixia Wang Fei Yi Lina Fu Jiping Yang Si Wang Zhaoxia Wang Keiichiro Suzuki Liang Sun Xiuling Xu Yang Yu Jie Qiao Juan Carlos Izpisua Belmonte Ze Yang Yun Yuan Jing Qu Guang-Hui Liu | 2017 | Protein & Cell2017，8，5： | 10 |
| 4 | Self-powered nanofiber-based screen-print triboelectric sensors for respiratory monitoring显示文摘科学、商业的进展将高要求放为便携电子学。然而,便携电子学的电源供应, breathability,和大量生产仍然有需要被克服的许多挑战。在这研究,一个自我动力的基于 nanofiber 的摩擦电传感器(SNTS ) 被批规模制造技术用 electrospinning 制作并且为经由呼吸监视监视的健康打印屏幕。典型地,一个拱门结构的 SNTS 被 nanofiber 膜和一个 Ag nanoparticle 电极装配。nanofibers 的堆积和 Ag nanoparticles 的传导性的网络越过整个设备保证一条煤气的隧道。当时, SNTS 的煤气的渗透象 6.16 mm/s 一样高,它有压到优势的优点与由密封演员组电影组成的通常使用的便携设备相比。由于 nanofiber 膜的柔软,不管它是否被弄弯,扭曲,或合拢, SNTS 显示出优秀电子输出性能。优异性质 SNTS 的皮友好,自我力量,和批制造例如 breathability,在保健监视和多功能的聪明的系统为他们的申请提供巨大的潜力。 | Ran Cao diaona Wang Shuyu Zhao Wei Yang Zuqing Yuan Yingying Yin Xinyu Du Nian-Wu Li Xiuling Zhang Xiuyan Li Zhong Lin Wang Congju Li | 2018 | Nano Research2018，11，7： | 8 |
| 5 | Natural continuous influent nitrifier immigration effects on nitrification and the microbial community of activated sludge systems显示文摘Two sequencing batch reactors(SBRs) were operated for 100 days under aerobic conditions,with one being fed with unsterilized municipal wastewater(USBR), and the other fed with sterilized municipal wastewater(SSBR). Respirometric assays and fluorescence in situ hybridization(FISH) results show that active nitrifiers were present in the unsterilized influent municipal wastewater. The maximum ammonia utilization rate(AUR) and nitrite utilization rate(NUR) of the unsterilized influent were 0.32 ± 0.12 mg NH4+-N/(L·hr) and0.71 ± 0.18 mg NO2--N/(L·hr). Based on the maximum utilization rates, the estimated seeding intensity for the ammonia oxidizing bacteria(AOB) and nitrite oxidizing bacteria(NOB) of the USBR was 0.08 g AOB/(g AOB·day) and 0.20 g NOB/(g NOB·day) respectively. The fraction of nitrifiers/total bacteria in the influent was 5.35% ± 2.1%, the dominant AOB was Nitrosomonas spp., Nitrosococcus mobilis hybridizated with Nsm156, and the dominant NOB was Nitrospira hybridizated with Ntspa662. The influent nitrifiers potentially seeded the activated sludge of the bioreactor and hence demonstrated a mitigation of the acclimatization times and instability during start-up and early operation. The AUR and NUR in the USBR was 15% and 13% higher than the SSBR respectively during the stable stage, FISH results showed that nitrifiers population especially the Nitrospira in the USBR was higher than that in the SSBR. These results indicate that the natural continuous immigration of nitrifiers from municipal influent streams may have some repercussions on the modeling and design of bioreactors. | Lifang Yu Ren Li Robert Delatolla Ru Zhang Xiuling Yang Dangcong Peng | 2018 | Journal of Environmental Sciences2018，30，12： | 7 |
| 6 | The βC1 Protein of Gem,n,v,rus--Betasatellite Complexes:A Target and Repressor of Host Defenses显示文摘Geminiviruses are a family of plant viruses that cause devastating diseases in many economically important crops worldwide. These pathogens encapsidate circular,single-stranded DNAs (ssDNAs)of 2.5-3.0 kb that replicate through double-stranded DNA (dsDNA)intermediates.Members of the genus Begomovirus,which comprises by far the largest number of species in the family,are transmitted by whiteflies and have genomes consisting of one or two DNAs. | Fangfang Li Xiuling Yang David M.Bisaro Xueping Zhou | 2018 | Molecular Plant2018，11，12： | 5 |
| 7 | A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells显示文摘 | Zhichao Ding Lina Sui Ruotong Ren Yanjun Liu Xiuling Xu Lina Fu Ruijun Bai Tingting Yuan Ying Hao Weiqi Zhang Huize Pan Wensu Liu Han Yu Concepcion Rodriguez Esteban Xiaobing Yu Ze Yang Jian Li Xiaomin Wang Juan Carlos Izpisua Belmonte Guang-Hui Liu Fei Yi Jing Qu | 2015 | Protein & Cell2015，6，5： | 5 |
| 8 | Nucieocytoplasmic Shuttling of Geminivirus C4 Protein Mediated by Phosphorylation and Myristoylation Is Critical for Viral Pathogenicity显示文摘Many geminivirus C4 proteins induce severe developmental abnormalities in plants.We previously demon- strated that Tomato leaf curl Yunnan virus (TLCYnV)C4 induces plant developmental abnormalities at least partically by decreasing the accumulation of NbSKη,an ortholog of Arabidopsis BIN2 kinase involved in the brassinosteroid signaling pathway,in the nucleus through directing it to the plasma membrane.However, the molecular mechanism by which the membrane-associated C4 modifies the localization of NbSKη in the host cell remains unclear.Here,we show that TLCYnV C4 is a nucleocytoplasmic shuttle protein,and that C4 shuttling is accompanied by nuclear export of NbSKTI.TLCYnV C4 is phosphorylated by NbSKη in the nucleus,which promotes myristoylation of the viral protein.Myristoylation of phosphorylated C4 favors its interaction with exportin-α(XPO I);which in turn facilitates nuclear export of the C4/NbSKTI complex. Supporting this model,chemical inhibition of N-myristoyltransferases or exportin-α enhanced nuclear retention of C4,and mutations of the putative phosphorylation or myristoylation sites in C4 resulted in increased nuclear retention ofrC4 and thus decreased severity of C4-induced developmental abnormalities. The impact of C4 on development is also lessened when a nuclear localization signal or a nuclear export signal is added to its C-terminus,restricting it to a specific cellular niche and therefore impairing nucleocytoplasmic shuttling.Taken together,our results suggest that nucleocytoplasmic shuttling of TLCYnV C4,enabled by phosphorylation by NbSKη,myristoylation,and interaction with exportin-α is critical for its function as a pathogenicity factor. | Yuzhen Mei Yaqin Wang Tao Hu Xiuling Yang Rosa Lozano-Duran Garry Sunter Xueping Zhou | 2018 | Molecular Plant2018，11，12： | 5 |
| 9 | Rock paper scissors: CRISPR/Cas9-mediated interference with geminiviruses in plants显示文摘Geminiviruses are a group of circular single-stranded DNA viruses that constitute the largest family of plant viruses. Many diseases resulting from geminivirus infections, such as maize streak disease, cassava mosaic disease, tomato yellow leaf curl disease and cotton leaf curl diseases, cause significant problems in terms of economic losses, posing a serious threat to global crop productivity (Hanley-Bowdoin et al., 2013;Yang et al., 2019). As obligate intracellular parasites, geminiviruses cannot be controlled chemically. Conventional strategies to control geminiviruses rely heavily on the application of pesticides to limit insect vector populations, but it causes environmental concerns. To date, developing novel crop germplasms with durable disease resistance to geminiviruses is still the best strategy to manage viral infections due to its environmental friendliness. However, traditional breeding programs are time-intensive and labor-consuming processes, and transgene-based modern approaches by overexpressing the geminiviral proteins (e.g., the truncated form of the replication initiator protein) failed to confer resistance to geminiviruses due to activated virusinduced transgene silencing. | Xiuling Yang Huanbin Zhou Xueping Zhou | 2019 | Science China(Life Sciences)2019，62，10： | 4 |
| 10 | Target-triggered inhibiting oxidase-mimicking activity of platinum nanoparticles for ultrasensitive colorimetric detection of silver ion显示文摘The development of efficient methods for the detection of hazardous and toxic elements is extremely important for environmental security and public health. In this work, we developed a facile colorimetric assaying system for Ag+ detection in aqueous solution. Chitosan-stabilized platinum nanoparticles(ChPtNPs) were synthesized and severed as an artificial oxidase to catalyze the oxidation of the substrate3,30,5,50-tetramethylbenzidine(TMB) and generate color signal. In the presence of Ag+, due to the strong metallophilic interactions between Ag+ and Pt2+ on the surface of Ch-PtNPs, Ag+ can weaken the affinity to the substrates and inactivate the catalytic activity of Ch-PtNPs, leading to decreased absorbance signal to varying degrees depending on Ag+ amount. Combing the specific binding between Ch-PtNPs and Ag+ with signal amplification procedure based on the Ch-PtNPs-catalyzed TMB oxidation, a sensitive,selective, simple, cost-effective, and rapid detection method for Ag+ can be realized. Ag+ ions in tap and lake waters have been successfully detected. We ensured that the proposed method can be a potential alternative for Ag+ determination in environmental samples. | Haohua Deng Shaobin He Xiuling Lin Lu Yang Zhen Lin Ruiting Chen Huaping Peng Wei Chen | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
| 11 | Occurrence and distribution of geminiviruses in China显示文摘Geminiviruses are a group of plant viruses that cause severe diseases in many economically important crops worldwide, leading to devastating losses to agricultural production. Here we summarize the occurrence and distribution of geminiviruses in China,which provides valuable information for further epidemiological studies and supports the development of effective disease management strategies. | Fangfang Li Rui Qiao Zhanqi Wang Xiuling Yang Xueping Zhou | 2022 | Science China(Life Sciences)2022，65，8： | 3 |
| 12 | TEM and HRTEM Study of Microstructures in Omphacite from UHP Eclogites at Shima,Dabie Mountains,China显示文摘Transmission electron microscope (TEM) and high resolution transmission electron microscope (HRTEM) analyses have been performed on omphacite from ultra-high pressure (UHP) eclogites at the locality of Shima, Dabie Mountains, China. TEM reveals that the microstructures consist dominantly of dislocation substructures, including free dislocations, loops, tiltwalls, dislocation tangles and subboundaries. They were produced by high-temperature ductile deformation, of which the main mechanism was dislocation creep. Antiphase domain (APD) boundaries are common planar defects; an age of 470±6 Ma for UHP eclogite formation has been obtained from the equiaxial size of APDs in ordered omphacites from Shima, coincident with ages given by single-zircon U-Pb dating (471±2 Ma). HRTEM reveals C2/c and P2ln space groups in different parts of one single omphacite crystal, and no exsolution is observed in the studied samples, which is attributed to rapid cooling. It is suggested that the UHP eclogites underwent a | WU Xiuling HAN Yujing MENG Dawei YANG Weiran LI Douxing | 2000 | Acta Geologica Sinica(English Edition)2000，74，2： | 2 |
| 13 | Estrogen upregulates DNA2 expression through the PI3K-AKT pathway in endometrial carcinoma显示文摘Endometrial cancer is the most common gynecological malignancy,affecting up to 3%of women at some point during their lifetime(Morice et al.,2016;Li and Wang,2021).Based on the pathogenesis and bio‑logical behavioral characteristics,endometrial cancer can be divided into estrogen-dependent(I)and non-estrogen-dependent(II)types(Ulrich,2011).Type I accounts for approximately 80%of cases,of which the majority are endometrioid carcinomas,and the remaining are mucinous adenocarcinomas(Setiawan et al.,2013). | Xinyan WANG Xiuling XU Ting ZHANG Yang JIN Sheng XU Lifeng CHEN Yucheng LAI Ling ZHANG Ruolang PAN Yan YU | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，3： | 2 |
| 14 | Cyclopalladated ferrocenylimines as efficient catalysts for homogeneous catalysis:A brief introduction to our preliminary achievements显示文摘Cyclopalladated ferrocenylimines as a novel kind of highly efficient palladium catalyst precursors, which are air-stable and easy to handle, have been successfully applied in a wide variety of catalytic reactions ranging from classical reactions, such as Heck, Suzuki, Sonogashira and Buchwald-Hartwig couplings, to cyanation, addition reactions of arylboronic acids, and coupling reactions involving terminal alkynes. The preliminary achievements regarding their applications to homogeneous catalysis are concisely described herein. | WU YangJie YANG Fan ZHANG JinLi CUI XiuLing GONG JunFang SONG MaoPing LI TieSheng | 2010 | Chinese Science Bulletin2010，55，25： | 2 |
| 15 | Ultrafine medicated fibers electrospun from W/O emulsions显示文摘 | Xu Xiuling Yang Lixin Xu Xiaoyi | 2005 | J Controlled Release2005，108，1： | 1 |
| 16 | Dynamic expression of P-glycoprotein in the CA1,CA3 and dentate gyrus of the rat hippocampus following lithium-pilocarpine-induced status epilepticus显示文摘Epileptic seizures induce overexpression of P-glycoprotein in the blood-brain barrier. However,it is unclear whether hippocampal neurons also overexpress P-glycoprotein following seizure. This study confirmed that the clinical manifestation,pathological characteristics and electroencephalography in the rat model of lithium-pilocarpine-induced mesial temporal lobe epilepsy were consistent with clinical reports of mesial temporal lobe epilepsy in humans. Immunohistochemistry staining demonstrated that P-glycoprotein positive staining was found in neurons in the pyramidal layer of the hippocampus. Western blot assay and real-time polymerase chain reaction revealed that P-glycoprotein overexpression was exhibited in the CA1,CA3,and dentate gyrus of the hippocampus at 24 and 60 days following model induction,but no significant difference was detected in the same region at various time points. These results indicate that seizures led to overexpression of P-glycoprotein in neurons of the hippocampus,but no evidence was found for a positive association between P-glycoprotein expression and seizure frequency. | Shuda Chen Jueqian Zhou Xiuling Liang Ziyi Chen Libai Yang Liemin Zhou | 2010 | Neural Regeneration Research2010，5，24： | 1 |
| 17 | Uhrafine medicated fibers electrospun from W/O emulsions 显示文摘 | Xiuling Xu Lixin Yang Xiaoyi Xu | 2005 | Journal of Con- trolled Release2005，108，： | 1 |
| 18 | Ultrafine medicated fibers electrospun from W/O emulsions显示文摘 | Xiuling Xu Lixin Yang Xiaoyi Xu Xin Wang Xuesi Chen Qizhi Liang Jing Zeng Xiabin Jing | 2005 | Journal of Controlled Release2005，，1： | 1 |
| 19 | Manifold learning and its application in form processing 显示文摘 | XIULING HE YANG YANG ZENGZHAO CHEN | 2008 | World Congress on Intelligent and Automation2008，7，6： | 1 |
| 20 | Cyclopalladated ferrocenylimines: efficient catalysts for homocoupling and Sonogashira reaction of terminal alkynes显示文摘 | Fan Yang Xiuling Cui Ya-nan Li Jinli Zhang Ge-rui Ren Yangjie Wu | 2007 | Tetrahedron2007，，9： | 1 |
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