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| 1 | 阴道微生态与辅助生殖结局的相关性研究进展显示文摘不孕严重影响女性的身心健康及生活质量,困扰着很多有生育意愿的不孕家庭,辅助生殖技术仍是不孕女性寻求生育的最常用手段。阴道微生态为目前研究的热点,被认为在女性的生殖健康方面发挥着重要作用,一些观察性研究已发现阴道微生态与女性的妊娠结局有相关性,但目前阴道微生态与辅助生殖结局的因果关联及机制未明。本文作者从阴道微生态与辅助生殖结局相关的流行病学证据、潜在机制及实验性证据等方面及两者相关性作一综述。 | 高丽婷 洪翔 施勇 陈梦珠 彭维 王蓓 彭丹红 | 2023 | 东南大学学报(医学版)2023，42，6： | 0 |
| 2 | Maternal and neonatal viromes indicate the risk of offspring's gastrointestinal tract exposure to pathogenic viruses of vaginal origin during delivery显示文摘A cumulative effect of enterovirus and gluten intake on the risk of celiac disease autoimmunity in infants highlights the significance of viral exposure in early life on the health of children.However,pathogenic viruses may be transmitted to the offspring in an earlier period,raising the possibility that women whose vaginas are inhabited by such viruses may have had their babies infected as early as the time of delivery.A high‐resolution intergenerational virome atlas was obtained by metagenomic sequencing and virome analysis on 486 samples from six body sites of 99 mother–neonate pairs.We found that neonates had less diverse oral and enteric viruses than mothers.Vaginally delivered newborns seconds after birth had a more similar oral virome and more viruses of vaginal origin than cesarean‐section(C‐section)newborns(56.9%vs.5.8%).Such viruses include both Lactobacillus phage and potentially pathogenic viruses,such as herpesvirus,vaccinia virus,and hepacivirus,illustrating a relatively high variety of the pioneer viral taxa at the time of delivery and a delivery‐dependent mother‐to‐neonate transmission along the vaginal–oral–intestinal route.Neonates are exposed to vaginal viruses as they pass through the reproductive tract,and viruses of vaginal origin may threaten their health.These findings challenge the conventional notion that vaginal delivery is definitely better than cesarean delivery from the perspective of microbial transmission.Screening for vaginal virome before delivery is a worthwhile step to advocate in normal labor to eliminate the risk of intergenerational transmission of pathogenic viruses to offspring. | Jinfeng Wang Liwen Xiao Baichuan Xiao Bing Zhang Zhenqiang Zuo Peifeng Ji Jiayong Zheng Xiaoqing Li Fangqing Zhao | 2022 | mLife2022，1，3： | 0 |
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