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| 1 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 2 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 3 | Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels 显示文摘 | Shevchenko A Wilm M Vorm O | 1996 | Anal Chem1996，68，： | 2 |
| 4 | Effect of growth factors on cell proliferation by human nasal septal chondrocytes cultured in monolayer显示文摘 | Sittinger M Wilmes E | 1994 | Acta Otolaryngol( Stockh )1994，114，： | 1 |
| 5 | Intracranial meningiomast correlation between MR imaging and histology in fifty patients显示文摘 | DEMAEREL P WILMS G LAMMENS M | 1991 | J Comput Assist Tomogr1991，15，1： | 1 |
| 6 | Long-term outcome of split liver transplantation using right extended grafts in adulthood:a matched pair analysis显示文摘 | Wilms C Walter J Kaptein M | | 0，，06： | 1 |
| 7 | Welding and sensor application with rotating torch 显示文摘 | Dihhey U Wilms G Sevim A M | 2005 | Industrial Robot2005，32，4： | 1 |
| 8 | Hsp90 is a core centrosomal component and is required at different stages of the centrosome cycle in Drosophila and vertebrates 显示文摘 | Lange BM Bachi A Wilm M | 2000 | EMBO J2000，19，： | 1 |
| 9 | Thickening of dura surrounding meningiomas: MR features显示文摘 | Wilms G Lammens M Marchal G | 1989 | Comput Assist Tomogr1989，13，： | 1 |
| 10 | Primary Gastric B-Cell Lymphoma: Results of a Prospective Multicenter Study显示文摘 | Wolfgang Fischbach* Brigitte Dragosics? Maria-Elisabeth Kolve-Goebeler§ Christian Ohmann∥ Axel Greiner? Qin Yang∥ Stephan B?hm? Patrick Verreet∥ Olaf Horstmann# Martin Busch** Eckhart Dühmke** Hans-Konrad Müller-Hermelink? Klaus Wilms§ | 2000 | Gastroenterology2000，，5： | 1 |
| 11 | Triple tibial osteotomyfor the correction of severe bilateral varus deformity in apatient with late-onset Blount’s disease显示文摘 | PUTZEYS P WILMES P MERLE M | 2013 | Knee Surg SportsTraumatol Arthrosc2013，21，3： | 1 |
| 12 | Mass spectrometric sequen- cing of proteins silver-stained polyacrylamide gels 显示文摘 | Shevchenko A Wilm M Vorm O | 1996 | Anal Chem1996，68，5： | 1 |
| 13 | Glucosylation of rho proteins by Closdium ch'flicile toxin B显示文摘 | JUST I SELZER J WILM M | 1995 | Nature1995，375，6531： | 1 |
| 14 | Preparation of ^15N-^13C-fulminicacid显示文摘 | Wilmes R Winnewisser M J | 1993 | Labelled Compd Radiopharm1993，33，： | 1 |
| 15 | Carbon and nitrogen in soil and vegetation at sites differing in successional age显示文摘 | De Kovel C G Van Mierlo E M Wilms Y J O | 2000 | Plant Ecology2000，149，： | 1 |
| 16 | A genetic protein purification method for protein complex characterization and proteome exploration显示文摘 | Rigaut G Shevchenko A Rutz B Wilm M Mann M Séraphin B | 1999 | Nature Biotechnol1999，17，10： | 1 |
| 17 | Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci显示文摘 | Sass V Schneider T Wilmes M | | 0，，06： | 1 |
| 18 | Is glutamine a conditionally essential amino acid? 显示文摘 | LACEY J M WILM ORE D W | 1990 | Nutr Rev1990，48，8： | 1 |
| 19 | mRNA silencing in erythroid differentiation:hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3 'end显示文摘 | Ostareck D H Ostareck-Lederer A Wilm M | 1997 | Cell1997，89，： | 1 |
| 20 | Stimulation of Na+/K+ATPase activity and Na+coupled glucose transport byβ-catenin显示文摘 | Sopjani M Alesutan I Wilmes J | 2010 | Biochem Biophys Res Commun2010，402，3： | 1 |
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