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| 1 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 2 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 3 | Intracranial meningiomast correlation between MR imaging and histology in fifty patients显示文摘 | DEMAEREL P WILMS G LAMMENS M | 1991 | J Comput Assist Tomogr1991，15，1： | 1 |
| 4 | Epidermoid cyst of the fourth ventricle:diffusion-weighted and flair MR imaging findings 显示文摘 | Mermuys K Wilms G Demaerel P | 2008 | JBR- BTR : organe de la Societe royale beige de radiologie ( SRBR ) = or- gaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)2008，91，： | 1 |
| 5 | Triple tibial osteotomyfor the correction of severe bilateral varus deformity in apatient with late-onset Blount’s disease显示文摘 | PUTZEYS P WILMES P MERLE M | 2013 | Knee Surg SportsTraumatol Arthrosc2013，21，3： | 1 |
| 6 | The application of two-dimensional polyacrylamide gel electrophoresis and downstream analyses to a mixed community of prokaryotie microorganisms 显示文摘 | WILMES P BOND P L | 2004 | Environ Microbiol2004，6，9： | 1 |
| 7 | Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications显示文摘 | Wilms H Zecca L Rosenstiel P | 2007 | Curr Pharm Des2007，13，18： | 1 |
| 8 | MRI of herpes simplex encephalitis显示文摘 | Demaeral P Wilm G Robberecht W | 1992 | Neuroradiology1992，，34： | 1 |
| 9 | Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson' s disease 显示文摘 | Wilms H Rosenstiel P Sievers J | 2003 | FASEB J2003，17，3： | 1 |
| 10 | Metaproteomics:studying functional gene expression in microbial ecosystems显示文摘 | Wilmes P Bond PL | | 0，，14： | 1 |
| 11 | Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's disease显示文摘 | Wilms H Rosentiel P Sievers J | 2003 | FASEB J2003，17，： | 1 |
| 12 | Gadolinium-enhanced MR imaging of cerebral venous angiomas with emphasis on their drainage 显示文摘 | Wilms G Demaerel P Marchal G | 1991 | J Comput Assist Tomogr1991，15，： | 1 |
| 13 | Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo 显示文摘 | Anagnostakos K Wilmes P Schmitt E | 2009 | Acta Orthop2009，80，2： | 1 |
| 14 | Echocontrast-enhanced transcranial ultrasound:frequency of use,diagnostic benefit,and validity of results compared with MRA显示文摘 | Zunker P Wilms H Brossmann J | 2002 | Stroke2002，33，11： | 1 |
| 15 | Intracranial meningiomas:correlation between MR imaging and histology in fifty patients显示文摘 | Demaerel P Wilms G Lammens M | | 0，，： | 1 |
| 16 | CT volumetry of lumbar vertebral bodies in patients with hypoplasia 15 and bilateral spondylolysis and in normal controls显示文摘 | Wilms GE Willems E Demaerel P et el | 2012 | Neuroradiology2012，54，8： | 1 |
| 17 | Editorial:Determinants of synaptic information transfer:from Ca2+binding proteins to Ca2+signaling domains显示文摘 | Isope P Wilms CD Schmidt H | 2016 | Front Cell Neurosci2016，10，： | 1 |
| 18 | Culture and cryopreservation of chondrocytes from human cartilage : relevance for cartilage allografting in otolaryngology 显示文摘 | Bujia J Pitzke P Wilmes E | 1992 | J Otorhinolaryngol Relat Spec1992，54，2： | 1 |
| 19 | Inflammation in Par- kinson's diseases and other neurodegenerative diseases: cause and therapeutic implications 显示文摘 | Wilms H Zecca L Rosenstie | 2007 | Curr Pharm Des2007，13，18： | 1 |
| 20 | Gadolinium enhanced MR imaging of cerebral venous angiomas with emphasis on their drainage显示文摘 | Wilms G Demaeral P Marchal G | | 0，，： | 1 |
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