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| 1 | Identification of a Stable Quantitative Trait Locus for Percentage Grains with White Chalkiness in Rice (Oryza sativa)显示文摘High chalkiness is a major problem in many rice-producing areas of the world, especially in hybrid rice (Oryza sativa L.) in China. We previously showed a major quantitative trait locus for the percentage of grains with white chalkiness (QTLqPGWC-8) in the interval G1149-R727 on chromosome 8 using a chromosome segment substitution line (CSSL). Here, we selected the line-CSSL50 harboring the QTLqPGWC-8 allele from the CSSLs derived from a cross between Asominori (as a recurrent parent) and IR24 (as a donor parent), which had higher percentage chalkiness, markedly different from that of Asominori. There were also significant differences in starch granules, appearance of amylose content (AAC) and milling qualities between Asominori and CSSL50, but not in grain size or thousand grain weight (TGW). The BC4F2 and BC4F3 populations from a cross between CSSL50 and Asominori were used for fine mapping of qPGWC-8. We narrowed down the location of this QTL to a 142 kb region between Indel markers 8G-7 and 8G-9. QTLqPGWC-8 accounted for 50.9% of the difference in PGWC between the parents. The markers tightly linked to qPGWC-8 should facilitate cloning of the gene underlying this QTL and will be of value for marker-assisted selection in breeding rice varieties with better grain quality. | Tao Guo Xiaolu Liu Xiangyuan Wan Jianfeng Weng Shijia Liu Xi Liu Mingjiang Chen Jingjing Li Ning Su Fuqing Wu Zhijun Cheng Xiuping Guo Cailin Lei Jiulin Wang Ling jiang Jianmin Wan | 2011 | Journal of Integrative Plant Biology2011，53，8： | 25 |
| 2 | Epidemiology of Sepsis-3 in a sub-district of Beijing: secondary analysis of a population-based database显示文摘Background: With the publication of Sepsis-3 definition, epidemiological data based on Sepsis-3 definition from middle-income countries including China are scarce, which prohibits understanding of the disease burden of this newly defined syndrome in these settings. The purpose of this study was to describe incidence and outcome of Sepsis-3 in Yuetan sub-district of Beijing and to estimate the incidence rate of Sepsis-3 in China. Methods: The medical records of all adult residents hospitalized from July 1, 2012 to June 30, 2014 in Yuetan sub-district of Beijing were reviewed. Patients with sepsis-3 and severe sepsis/septic shock were identified. The incidence rates and mortality rate of sepsis-3 and sepsis/septic shock were calculated, incidence rates and in-hospital mortality rates were normalized to the population distribution in the 2010 National Census. Population incidence rate and case fatality rate between sexes were compared with the Z test, as the data conformed to Poisson distribution. Results: Of the 21,191 hospitalized patients, 935 patients were diagnosed with Sepsis-3, and 498 cases met severe sepsis/septic shock criteria. The crude annual incidence rate of Sepsis-3 in Yuetan sub-district was 363 cases per 100,000 population, corresponding to standardized incidence rates of 236 cases per 100,000 population per year, respectively. The overall case fatality rate of Sepsis-3 was 32.0%, the crude population mortality rates of Sepsis-3 was 116 cases per 100,000 population per year, the standardized mortality rate was 67 cases per 100,000 population per year, corresponding to a speculative extrapolation of 700,437 deaths in China. The incidence rate and mortality rate of Sepsis-3 were significantly higher in males, elderly people, and patients with more comorbidities. The 62.1% of patients with Sepsis-3 had community-acquired infections, compared with 75.3% of infected patients without Sepsis-3 (P < 0.001). The most common infection in patients with Sepsis-3 was lower respiratory tract infection. When compared with patients with Sepsis-3, patients diagnosed as severe sepsis/septic shock were more likely to have higher case fatality rate (53.4% vs. 32.0%, P < 0.001) Conclusions: This study found the standardized incidence rate of 236 cases per 100,000 person-year for Sepsis-3, which was more common in males and elderly population. This corresponded to about 2.5 million new cases of Sepsis-3 per year, resulting in more than 700,000 deaths in China. | Hong-Cheng Tian Jian-Fang Zhou Li Weng Xiao-Yun Hu Jin-Min Peng Chun-Yao Wang Wei Jiang Xue-Ping Du Xiu-Ming Xi You-Zhong An Mei-Li Duan Bin Du 无 | 2019 | Chinese Medical Journal2019，，17： | 9 |
| 3 | Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference显示文摘Mesenchymal stem cells(MSCs)are multipotent stem cells and capable of differentiating into multiple cell types including osteoblastic,chondrogenic and adipogenic lineages.We previously identified BMP9 as one of the most potent BMPs that induce osteoblastic differentiation of MSCs although exact molecular mechanism through which BMP9 regulates osteogenic differentiation remains to be fully understood.Here,we seek to develop a recombinant adenovirus system to optimally silence mouse BMP9 and then characterize the important role of BMP9 in osteogenic differentiation of MSCs.Using two different siRNA bioinformatic prediction programs,we design five siRNAs targeting mouse BMP9(or simB9),which are expressed under the control of the converging H1 and U6 promoters in recombinant adenovirus vectors.We demonstrate that two of the five siRNAs,simB9-4 and simB9-7,exhibit the highest efficiency on silencing exogenous mouse BMP9 in MSCs.Furthermore,simB9-4 and simB9-7 act synergistically in inhibiting BMP9-induced expression of osteogenic markers,matrix mineralization and ectopic bone formation from MSCs.Thus,our findings demonstrate the important role of BMP9 in osteogenic differentiation of MSCs.The characterized simB9 siRNAs may be used as an important tool to investigate the molecular mechanism behind BMP9 osteogenic signaling.Our results also indicate that recombinant adenovirus-mediated expression of siRNAs is efficient and sustained,and thus may be used as an effective delivery vehicle of siRNA therapeutics. | Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C.Haydon Michael J.Lee Russell R.Reid Jennifer Moriatis Wolf Qiong Shi Hue H.Luu Tong-Chuan He Yaguang Weng | 2018 | Genes & Diseases2018，5，2： | 8 |
| 4 | In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells显示文摘Circulating tumor cells(CTCs)is an established biomarker of cancer metastasis.The circulation dynamics of CTCs are important for understanding the mechanisms underlying tumor cell dissemination.Although studies have revealed that the circadian rhythm may disrupt the growth of tumors,it is generally unclear whether the circadian rhythm controls the release of CTCs.In clinical examinations,the current in vitro methods for detecting CTCs in blood samples are based on a fundamental assumption that CTC counts in the peripheral blood do not change significantly over time,which is being challenged by recent studies.Since it is not practical to draw blood from patients repeatedly,a feasible strategy to investigate the circadian rhythm of CTCs is to monitor them by in vivo detection methods.Fluoresce nee in vivo flow cytometry(IVFC)is a powerful optical technique that is able to detect fluoresce nt circulating cells directly in living animals in a noninvasive manner over a long period of time.In this study,we applied fluorescence IVFC to monitor CTCs noninvasively in an orthotopic mouse model of human prostate cancer.We observed that CTCs exhibited stochastic bursts over cancer progression.The probability of the bursting activity was higher at early stages than at late stages.We longitudinally monitored CTCs over a 24-h period,and our results revealed striking daily oscillations in CTC counts that peaked at the onset of the night(active phase for rodents),suggesting that the release of CTCs might be regulated by the circadian rhythm. | Xi Zhu Yuanzhen Suo Yuting Fu Fuli Zhang Nan Ding Kai Pang Chengying Xie Xiaofu Weng Meilu Tian Hao He Xunbin Wei | 2021 | Light(Science & Applications)2021，10，6： | 6 |
| 5 | Primary effect of dual growing rod technique for the treatment of severe scoliosis in young children显示文摘在小孩子的很快进行的脊柱侧凸的背景处理是为脊骨外科医生的挑战。一些外科医生开始了在小孩子为很快进行的脊柱侧凸的处理使用双成长的杆技术并且完成了可接受的结果。这研究的目的是在中国决定这种新技术的主要结果和复杂并发症。受不了很快进行的脊柱侧凸的十一个孩子在北京联合医学院医院(PUMCH ) 与在 2004 年 11 月和 2009 年 3 月之间的双成长的杆技术被对待的方法。在有 0 等级的 Risser 符号的组有 10 女性和 1 男性。在起始的外科的吝啬的年龄是 6.1 年(范围, 2.1-10.9 年) 。十个病人作为先天的脊柱侧凸和 1 耐心的神经与肌的脊柱侧凸被诊断。所有病人有 1-4 变长过程(平均数, 1.8 过程) 在起始的手术以后。所有病人的 X 光线照相术的结果被调查。脊柱侧凸的花冠 Cobb 角度改善了从的结果(67.64 数?? | LI Qi-yi ZHANG Jian-guo QIU Gui-xing WANG Yi-peng SHEN Jian-xiong ZHAO Yu LI Shu-gang YU Bin WANG Xi WENG Xi-sheng | 2010 | Chinese Medical Journal2010，，2： | 6 |
| 6 | Efficient oxidation of benzyl alcohol with heteropolytungstate as reaction-controlled phase-transfer catalyst显示文摘一系列 heteropolytungstates 被综合了并且作为催化剂利用了与水的过氧化氢催化本甲基酒精的氧化。结果显示三这些催化剂显示出控制反应的阶段转移催化作用的性质,并且他们有优秀催化能力到本甲基酒精的氧化。没有另外的副产品被气相色谱检测。一旦过氧化氢完全被消费,催化剂从催化剂的溶剂,和结果猛抛再循环证明催化剂有高稳定性。 | Zhi Huan Weng Jin Yan Wang Xi Gao Jian | 2007 | Chinese Chemical Letters2007，18，8： | 5 |
| 7 | SDICN: A Software Defined Deployable Framework of Information Centric Networking显示文摘the Information-Centric Networking(ICN) paradigm is proved to have the advantages of decreasing data delivery latency, enhancing user mobility, etc. However, current implementations of ICN require changing the infrastructure of Internet, which hinders its deployment and development. Meanwhile, Software Defined Networking(SDN) emerges as a viable solution to facilitate the deployment of new network paradigm without disrupting production traffic by decoupling the control plane from data forwarding plane. In this paper, the essential properties which reflect ICN working principles are summarized, and a framework called SDICN is designed in accordance to the SDN philosophy. The algorithmic frameworks of SDICN which can satisfy the essential properties are designed based on the programmability and virtualization functions of SDN. Based on Open Flow and data center technology, a prototype of SDICN is implemented. By comparing the performance with the CCNx, the SDICN is proved to be feasibility and availability. | WANG Xiulei CHEN Ming HU Chao WENG Xi XING Changyou | 2016 | China Communications2016，13，3： | 4 |
| 8 | Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model显示文摘Photobiomodulation,by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in cells and tissues,has been considered as a possible therapeutic strategy for Alzheimer’s disease(AD),while its specific mechanisms have remained elusive.Here,we demonstrate that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebralβ-amyloid(Aβ)burden,the hallmark of AD.The glial cells,including microglia and astrocytes,play important roles in Aβclearance.Our results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD mice.The 1070-nm lightinduced microglia responses with alteration in morphology and increased colocalization with Aβare sufficient to reduce Aβload in AD mice.Moreover,1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further enhance Aβclearance.Our study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic approach for AD. | Lechan Tao Qi Liu Fuli Zhang Yuting Fu Xi Zhu Xiaofu Weng Hongbin Han Yong Huang Yuanzhen Suo Liang Chen Xiaoling Gao Xunbin Wei | 2021 | Light(Science & Applications)2021，10，10： | 4 |
| 9 | A new member of the topological semimetals family显示文摘In topological semimetals(TSMs),the quasi-particle excitations of electrons can be described by the Dirac or Weyl equation,mimicking the elusive massless Dirac or Weyl fermions in the low-frequency regime as emergent phenomena.The realization of elementary excitations,with and even | Hongming Weng Chen Fang Zhong Fang Xi Dai | 2017 | National Science Review2017，4，6： | 3 |
| 10 | Topological nodal line semimetals predicted from first-principles calculations显示文摘拓扑的半金属是量物质的最新发现的状态,它从绝缘体扩大了拓扑的状态的概念到金属并且在最近的年里吸引了大研究兴趣。一般来说,有三种拓扑的半金属,也就是迪拉克半金属, Weyl 半金属,和节的线半金属。节的线半金属能为另外的拓扑的状态被看作先锋状态。例如,从如此的节的线开始说,节的线结构可能演变为 Weyl 点,把点变换成迪拉克,或由介绍联合的纺纱轨道(SOC ) 或集体术语成为拓扑的绝缘体。在这篇评论论文,我们介绍显示出节的线半金属状态的理论材料,包括所有碳 Mackay-Terrones 水晶( MTC ), anti-perovskite Cu 3 PdN ,压的黑磷,和材料的帽子3家庭,并且我们在场为获得物质的如此的新奇状态的设计原则。 | Rui Yu Zhong Fang Xi Dai Hongming Weng | 2017 | Frontiers of physics2017，12，3： | 3 |
| 11 | SAR image despeckling based on edge detection and nonsubsampled second generation bandelets显示文摘To preserve the sharp features and details of the synthetic aperture radar(SAR)image effectively when despeckling,a despeckling algorithm with edge detection in nonsubsampled second generation bandelet transform (NSBT)domain is proposed.First,the Canny operator is utilized to detect and remove edges from the SAR image. Then the NSBT which has an optimal approximation to the edges of images and a hard thresholding rule are used to approximate the details while despeckling the edge-removed image.Finally,the removed edges are added to the reconstructed image.As the edges are detected and protected,and the NSBT is used,the proposed algorithm reaches the state-of-the-art effect which realizes both despeckling and preserving edges and details simultaneously. Experimental results show that both the subjective visual effect and the mainly objective performance indexes of the proposed algorithm outperform that of both Bayesian wavelet shrinkage with edge detection and Bayesian least square-Gaussian scale mixture(BLS-GSM). | Zhang Wenge~(1,2),Liu Fang~(1,2),Jiao Licheng~(2,3)& Gao Xinbo~(2,3) 1.School of Computer Science and Technology,Xidian Univ.,Xi’an 710071,P.R.China 2.Key Lab.of Intelligent Perception and Image Understanding of Ministry of Education of China,Xi’an 710071,P.R.China 3.Inst,of Intelligent Information Processing,Xidian Univ.,Xi’an 710071,P.R.China | 2009 | Journal of Systems Engineering and Electronics2009，20，3： | 3 |
| 12 | Data monitoring system of technical diagnosis system for EAST显示文摘Technical diagnosis system(TDS)is an important subsystem to monitor status parameters of EAST (experimental advanced superconducting tokamak).The upgraded TDS data monitoring system is comprised of management floor,monitoring floor and field floor.Security protection,malfunction record and analysis are designed to make the system stable,robust and friendly.During the past EAST campaigns,the data monitoring system has been operated reliably and stably.The signal conditioning system and software architecture are described. | QIAN Jing WENG Peide LUO Jiarong CHEN Zhuomin WU Yu XI Weibin | 2010 | Nuclear Science and Techniques2010，21，3： | 3 |
| 13 | Genetic diversity and association analyses of fruit traits with microsatellite ISSRs in Sapindus显示文摘Sapindus mukorossi Gaertn. and S. delavayi Franchet are among the most valuable species in the genus Sapindus for their commercially exploitable plant oils and chemicals. However, few studies have addressed genetic variation and improvement for either species. We evaluated the genetic diversity of germplasm from selected plus trees within a wide region and established the relationship between fruit traits and molecular markers. An association analysis based on inter-simple sequence repeats(ISSRs)provided a genetic basis for studies of fruit traits. A total of 247 loci were detected by scanning 61 trees of S. mukorossi and S. delavayi using 16 ISSR markers. Genetic diversity parameters were estimated for selected superior trees(or germplasm) and S. mukorossi and S. delavayi were categorized into two main groups, as well as into four groups within S. mukorossi. An association analysis between the ISSR markers and 14 fruit traits used the TASSEL MLM model. A genetic structure analysis differentiated S.mukorossi and S. delavayi. Eighteen ISSR loci associated with 13 fruit traits(P<0.005) were identified, with 13, 1,and 4 loci associated with seed oil production, fruit saponin production, and fruit quality, respectively. Using this information, a core collection was selected with adequate genetic diversity and good seed oil characters. Our results demonstrate the feasibility of effectively estimating fruit trait associations in Sapindus using ISSR markers, and the method is applicable and valuable for select germplasm conservation. The markers obtained in this study are potentially useful for molecular-assisted breeding of Sapindus spp. | Caowen Sun Liming Jia Benye Xi Jiming Liu Lianchun Wang Xuehuang Weng | 2019 | Journal of Forestry Research2019，30，1： | 2 |
| 14 | Reply to Comment on “In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells”显示文摘Dear Editor,We thank Niedre et al.for their correspondence regarding our recent paper1.They proposed a point that the temporal distribution of circulating tumor cells(CTCs)monitored by diffuse in vivo flow cytometry in a multiple myeloma mouse model in their previous work2 might be different from our results.Niedre et al.claimed that CTC detection statistics deviated from Poisson but did not found circadian variations in CTC numbers in a multiple myeloma mouse model.They also cite another literature by Juratli.et al.3,in which the authors reported that CTC numbers did not always correlate with tumor size during cancer progression.However,by establishing an orthotopic mouse model of prostate cancer and utilizing the technology in vivo flow cytometry(IVFC),we found CTCs exhibited bursting activity and daily oscillation in an orthotopic model of prostate cancer. | Xi Zhu Yuanzhen Suo Yuting Fu Fuli Zhang Nan Ding Kai Pang Chengying Xie Xiaofu Weng Meilu Tian Hao He Xunbin Wei | 2021 | Light(Science & Applications)2021，10，10： | 2 |
| 15 | High-pressing preparation of rock glasses and their elastic properties显示文摘Melt glasses for seven types of rock ranging from acid to basic were prepared under 1.0 GPa on a multi-anvil pressure apparatus, YJ-3000 ton press. Densities and elastic properties of the melt glasses were compared with those described in previous studies. It was found that the glasses melted under 1.0 GPa were consistent in density with both naturally-occurring glassy rocks and artificially prepared glasses melted at ambient pressure. The densities of glasses are negatively correlated with the SiO2 contents and positively correlated with the (MgO+FeO) contents. The compressive velocity (Vp) of glass tends to increase with decreasing SiO2 contents and increasing (MgO+FeO) contents. The shear velocity (Vs) of glass tends to increase slightly with increasing SiO2 contents, which has little connection with the (MgO+FeO) contents. It was calculated from densities and velocities that the elastic moduli of glasses are negatively correlated with the SiO2 contents and positively correlated with the (MgO+FeO) contents. | JIANG Xi ZHOU Wenge XIE Hongsen LIU Yonggang FAN Dawei WAN Fang | 2008 | Chinese Journal Of Geochemistry2008，27，2： | 2 |
| 16 | Effects of mesh loop modes on performance of unstructured finite volume GPU simulations显示文摘In unstructured finite volume method,loop on different mesh components such as cells,faces,nodes,etc is used widely for the traversal of data.Mesh loop results in direct or indirect data access that affects data locality significantly.By loop on mesh,many threads accessing the same data lead to data dependence.Both data locality and data dependence play an important part in the performance of GPU simulations.For optimizing a GPU-accelerated unstructured finite volume Computational Fluid Dynamics(CFD)program,the performance of hot spots under different loops on cells,faces,and nodes is evaluated on Nvidia Tesla V100 and K80.Numerical tests under different mesh scales show that the effects of mesh loop modes are different on data locality and data dependence.Specifically,face loop makes the best data locality,so long as access to face data exists in kernels.Cell loop brings the smallest overheads due to non-coalescing data access,when both cell and node data are used in computing without face data.Cell loop owns the best performance in the condition that only indirect access of cell data exists in kernels.Atomic operations reduced the performance of kernels largely in K80,which is not obvious on V100.With the suitable mesh loop mode in all kernels,the overall performance of GPU simulations can be increased by 15%-20%.Finally,the program on a single GPU V100 can achieve maximum 21.7 and average 14.1 speed up compared with 28 MPI tasks on two Intel CPUs Xeon Gold 6132. | Yue Weng Xi Zhang Xiaohu Guo Xianwei Zhang Yutong Lu Yang Liu | 2021 | Advances in Aerodynamics2021，3，1： | 2 |
| 17 | Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomized clinical trial显示文摘We aimed to evaluate the effectiveness and safety of single-course initial regimens in patients with low-risk gestational trophoblastic neoplasia(GTN).In this trial (NCT01823315),276 patients were analyzed.Patients were allocated to three initiated regimens:single-course methotrexate(MTX),single-course MTX+dactinomycin(ACTD),and multi-course MTX(control arm).The primary endpoint was the complete remission(CR)rate by initial drug(s).The primary CR rate was 64.4%with multi-course MTX in the control arm.For the single-course MTX arm,the CR rate was 35.8%by one course;it increased to 59.3%after subsequent multi-course MTX,with non-inferiority to the control(difference-5.1%,95%confidence interval(CI)-19.4%to 9.2%,P=0.014).After further treatment with multi-course ACTD,the CR rate(93.3%)was similar to that of the control(95.2%,P=0.577).For the single-course MTX+ACTD arm,the CR rate was 46.7%by one course,which increased to 89.1%after subsequent multi-course,with non-inferiority(difference 24.7%,95%CI 12.8%-36.6%,P<0.001)to the control.It was similar to the CR rate by MTX and further ACTD in the control arm(89.1%vs.95.2%,P=0.135).Four patients experienced recurrence,with no death,during the 2-year follow-up.We demonstrated that chemotherapy initiation with single-course MTX may be an alternative regimen for patients with low-risk GTN. | Lili Chen Ling Xi Jie Jiang Rutie Yin Pengpeng Qu Xiuqin Li Xiaoyun Wan Yaxia Chen Dongxiao Hu Yuyan Mao Zimin Pan Xiaodong Cheng Xinyu Wang Qingli Li Danhui Weng Xi Zhang Hong Zhang Quanhong Ping Xiaomei Liu Xing Xie Beihua Kong Ding Ma Weiguo Lu | 2022 | Frontiers of Medicine2022，16，2： | 2 |
| 18 | A study of microemulsion systems for transdermal delivery of triptolide 显示文摘 | CHEN HB CHANG XI WENG T | 2004 | J Control Release2004，98，3： | 1 |
| 19 | Use of biogas fluid-soaked water hyacinth for cultivating Pleurotus geesteranus显示文摘 | Xiuxia Chen Zhihe Jiang Xi Chen Jingui Lei Boqi Weng Qin Huang | 2009 | Bioresource Technology2009，，7： | 1 |
| 20 | Application of Energy Dissipation Technology to C-category Frame Structure of School Buildings for Seismic Retrofit of Increasing Precautionary Intensity显示文摘 | Weng Da Gen Zhang Chao Lu Xi Lin | 2011 | Advanced Materials Research2011，，163： | 1 |
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