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| 1 | CBCT的基本原理及在口腔各科的应用进展显示文摘目的锥形束CT(cone beam computer tomography,CBCT)应用于口腔科进行三维立体成像,具有广泛的临床应用前景。本文主要综述CBCT成像的基本原理,以及在口腔种植科、正畸科、颌面外科和内科等口腔临床科室应用的最新进展。 | 鞠昊 朱红华 段涛 李志民 孙宏晨 Farman AG Scarfe WC | 2015 | 医学影像学杂志2015,25,5: | 37 |
| 2 | 中国丽江内陆降水背景值研究显示文摘 | 刘嘉麒 Keen.,WC | 1993 | 中国环境科学1993,13,4: | 20 |
| 3 | 确立RBRVS为目的的医生劳动的估算显示文摘本文研制出按资源投入为基准的相对价值费用率(RBRVS),藉以替代基于医生服务收费的支付制度。医生资源投入包括:1.每项服务中医生的劳动投入总量;2.医疗成本(含治疗失当保险费);3.专科训练成本。综合这三种因素,制定出非货币单位的相对价值费用率。在此,我们对定义、估算医生劳动的过程进行了描述。本项研究提出两个问题:何为每项服务中的医生劳动?能否可靠、有效地对医生劳动进行估算?结论是:医生劳动包含四个部分,即时间、脑力劳动和判断、专业技能和体力劳动、以及心理压力。通过对四个部分加以全面考虑,医生在其专科范围内可直接估算其服务的相对劳动量,而且此种估算值具有高度的再现性、一致性,并因此可能具备有效性。 | Hsiao WC 施荣根 | 1992 | 国外医学(卫生经济分册)1992,9,2: | 16 |
| 4 | Inhibition of angiogenesis and HCT-116 xenograft tumor growth in mice by kallistatin显示文摘AIM: To investigate the inhibitory effect of kallistatin (KAL) on angiogenesis and HCT-116 xenograft tumor growth. METHODS: Heterotopic tumors were induced by subcutaneous injection of 2 × 106 HCT-11 cells in mice. Seven days later, 2 × 1011 rAAV-GFP or rAAV-KAL was injected intratumorally (n = 5 for each group). The mice were sacrificed at d 28, by which time the tumors in the rAAV-GFP group had grown to beyond 5% of the total body weight. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density (MVD) by immunohistology. Tumor cell proliferation was assessed by Ki-67 staining. RESULTS: Intratumor injection of rAAV-KAL inhibited tumor growth in the treatment group by 78% (171 ± 52 mm3) at d 21 after virus infection compared to the control group (776 ± 241 mm3). Microvessel density was significantly inhibited in tumor tissues treated with rAAV-KAL. rAAV-KAL also decreased the proportion of proliferating cells (Ki-67 positive cells) in tumors compared with the control group.CONCLUSION: rAAV-mediated expression of KAL inhibits the growth of colon cancer by reducing angiogenesis and proliferation of tumor cells, and may provide a promising anti-angiogenesis-based approach to the treatment of metastatic colorectal cancer. | Yong Diao Jian Ma Wei-Dong Xiao Jia Luo Xin-Yan Li Kin-Wah Chu Peter WC Fung Nagy Habib Farzin Farzaneh Rui-An Xu | 2007 | World Journal of Gastroenterology2007,13,34: | 15 |
| 5 | 静脉注射奥美拉唑可辅助内镜肾上腺素注射治疗消化性溃疡出血显示文摘 | Lo WC | 2006 | 中国处方药2006,5,5: | 11 |
| 6 | 长期食用含糖和人工甜味剂的饮料与美国成年人死亡风险的关系显示文摘摄入含糖饮料(sugar-sweetened beverages,SSB)或含人工甜味剂饮料(artificially sweetened beverages,ASB)是否与死亡风险相关,这关乎公共卫生利益。研究者分析了卫生专业人员随访研究(1986-2014年)中男性37 716人和护士健康研究(1980-2014年)中女性80 647人(基线无慢性病)的SSB和ASB的消费与总死亡率和病因特异性死亡率之间的关系。应用Cox比例风险回归估计风险比和95%CI。结果显示,在随访3415564人年期间,研究者记录了36436例死亡,其中心血管病死亡7896例,癌症死亡12380例。 | 刘青(译) 叶鹏(摘、审校) Malik VS Li Y Pan A De Koning L Schernhammer E Willett WC Hu FB | 2019 | 中华高血压杂志2019,27,5: | 9 |
| 7 | 电动牙刷与手动牙刷对口腔卫生的效果比较显示文摘目的对电动牙刷和手动牙刷在去除菌斑、维护牙龈健康、对色素和牙结石的作用、可靠性、不良作用和成本等进行比较.方法计算机检索Cochrane口腔健康协作组临床试验资料库(截至2004年6月17日)、Cochran临床对照试验中心资料库(Cochrane图书馆2004第2期)、MEDLINE(1966~2004)、EMBASE(1980~2004第2周)和CINAHL(1982~2004第2周),并与制造商联系以获取更多资料.根据下列标准纳入随机对照试验:随机分配研究对象;参加者为手运动无障碍的普通人群;干预措施为无监督的手动或电动牙刷刷牙,至少4周;主要结局指标为试验期间菌斑和牙龈炎的变化.由6个作者独立评价并纳入研究资料.用随机效应模型进行Meta分析,用标准化均数差(SMD)及其95%CI测量效果.检查可能的异质性来源,并针对研究质量和发表偏倚进行敏感性分析.为便于讨论,将SMD转换为百分率.结果对包含3 855例研究对象的42个试验进行系统评价,结果显示,旋转振动型电动牙刷去除菌斑和减低牙龈炎的效果在短期内明显优于手动牙刷,并在3个月以上的研究中显示降低了牙龈炎指数.在1~3个月的研究中,菌斑SMD为-0.43 [95%CI (-0.72, 0.14)],牙龈炎SMD为-0.62 [95%CI (-0.90, 0.34)],Quigley Hein菌斑指数降低11%,Loe and Silness龈炎指数降低6%.在3个月以上的研究中,菌斑指数SMD为-1.29 [95%CI (-2.67, 0.08)], 龈炎指数为-0.51 [95%CI (-1.76, 0.25)],Ainamo Bay探诊出血指数降低17%.短期研究之间有异质性,敏感性分析显示当选择高质量的研究时结果是肯定的,没有证据表明有发表偏倚.采取其他设计的电动牙刷并不比手动牙刷更优.对成本、可靠性和不良作用的报道不一致,已报道的不良作用都是局限的、暂时的.结论旋转振动型电动牙刷去除牙菌斑、减少牙龈炎的效果优于手动牙刷.遵守方法学指南和更标准化的设计有益于将来的研究和Meta分析. | Robinson PG Deacon SA Deery C Heanue M Walmsley AD Worthington HV Glenny AM Shaw WC 陈娥 史宗道 | 2005 | 中国循证医学杂志2005,5,11: | 8 |
| 8 | 地西泮-聚羟基丁酸酯-羟基戊酸酯共聚物缓释微球制备与性质显示文摘目的 :探索以新型生物可降解材料聚羟基丁酸酯 羟基戊酸酯共聚物 (PHBV)为载体的地西泮药物中长期缓释微球制备工艺 ;方法 :以溶剂蒸发法制备微球 ,用扫描电镜SEM观察微球表面及内部横断面形态结构 ;结果 :微球的平均粒径为 3 0 .5μm ,平均载药量 (1 8.66± 0 .2 3 ) % ,包封率 (80 .85± 1 .0 1 ) %。体外释放第一天呈突释效应 ,而后药物释放基本符合零级动力学过程 .其释放曲线方程为 Q =2 0 .55+ 2 .3 99t,r=0 .9569;结论 :开发与研制PHBV为载体的中长期缓释微球具有较好应用前景。 | 陈建海 Washinton WC 陈志良 许重远 | 2000 | 中国药学杂志2000,35,4: | 8 |
| 9 | Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia显示文摘 | Wang HK Fung HC Hsu WC Wu YR Lin JC Ro LS Chang KH Hwu FJ Hsu Y Huang SY Lee-Chen GJ Chen CM | 2006 | 中国生物学文摘2006,20,8: | 8 |
| 10 | Validation of the Physical Activity Questionnaire for Older Children(PAQ-C) among Chinese Children显示文摘Objective This study initially validates the Chinese version of the Physical Activity Questionnaire for Older Children(PAQ-C), which has been identified as a potentially valid instrument to assess moderate-to-vigorous physical activity(MVPA) in children among diverse racial groups. Methods The psychometric properties of the PAQ-C with 742 Hong Kong Chinese children were assessed with the scale's internal consistency, reliability, test-retest reliability, confirmatory factory analysis(CFA) in the overall sample, and multistep invariance tests across gender groups as well as convergent validity with body mass index(BMI), and an accelerometry-based MVPA. Results The Cronbach alpha coefficient(α=0.79), composite reliability value(ρ=0.81), and the intraclass correlation coefficient(α=0.82) indicate the satisfactory reliability of the PAQ-C score. The CFA indicated data fit a single factor model, suggesting that the PAQ-C measures only one construct, on MVPA over the previous 7 days. The multiple-group CFAs suggested that the factor loadings and variances and covariances of the PAQ-C measurement model were invariant across gender groups. The PAQ-C score was related to accelerometry-based MVPA(r=0.33) and inversely related to BMI(r=-0.18). Conclusion This study demonstrates the reliability and validity of the PAQ-C in Chinese children. | WANG Jing Jing BARANOWSKI Tom LAU WC Patrick CHEN Tzu An PITKETHLY Amanda Jane | 2016 | Biomedical and Environmental Sciences2016,29,3: | 7 |
| 11 | Lean techniques for the improvement of patients' flow in emergency department显示文摘BACKGROUND: Emergency departments(EDs) face problems with overcrowding, access block, cost containment, and increasing demand from patients. In order to resolve these problems, there is rising interest to an approach called 'lean' management. This study aims to(1) evaluate the current patient flow in ED,(2) to identify and eliminate the non-valued added process, and(3) to modify the existing process.METHODS: It was a quantitative, pre- and post-lean design study with a series of lean management work implemented to improve the admission and blood result waiting time. These included structured re-design process, priority admission triage(PAT) program, enhanced communication with medical department, and use of new high sensitivity troponin-T(hsTnT) blood test. Triage waiting time, consultation waiting time, blood result time, admission waiting time, total processing time and ED length of stay were compared.RESULTS: Among all the processes carried out in ED, the most time consuming processes were to wait for an admission bed(38.24 minutes; SD 66.35) and blood testing result(mean 52.73 minutes, SD 24.03). The triage waiting time and end waiting time for consultation were significantly decreased. The admission waiting time of emergency medical ward(EMW) was significantly decreased from 54.76 minutes to 24.45 minutes after implementation of PAT program(P<0.05).CONCLUSION: The application of lean management can improve the patient flow in ED. Acquiescence to the principle of lean is crucial to enhance high quality emergency care and patient satisfaction. | HY Chan SM Lo LLY Lee WYL Lo WC Yu YF Wu ST Ho RSD Yeung JTS Chan | 2014 | World Journal of Emergency Medicine2014,5,1: | 6 |
| 12 | 一种基于二进制小波变换的无损图像编码算法显示文摘该文提出了一种基于二进制小波变换的嵌入式无损图像编码算法——渐进式分裂二进制小波树编码器(PPBWC)。PPBWC采用混合系数扫描方法按模值大小排序小波系数得到中间符号序列,通过非因果的自适应上下文条件编码考虑了不同频带小波系数的自相似特性,并利用待编码系数的'未来'信息提高了PPBWC的压缩编码性能。混合系数扫描和非因果的自适应上下文条件编码是PPBWC高效编码的主要因素。实验结果表明,与其它嵌入式无损算法相比,PPBWC具有最优的无损编码性能。 | 潘泓 WC Siu 夏良正 | 2008 | 电子与信息学报2008,30,7: | 5 |
| 13 | 华人、马来人及印度人的白介素4基因多态性与哮喘的关系显示文摘【目的】调查华人、马来人及印度人的白介素 4 基因多态性与哮喘和哮喘严重度是否有相关性。【方法】研究人群包括315名哮喘患者(华人 152,马来人 76,印度人 87) 和 360 名无哮喘病史的健康献血者(华人157,马来人100,印度人103) 。患者组进一步分为轻、中度哮喘组(FEV1>=60%预计值) 和重度哮喘组(FEV1<60%预计值) 。白介素4基因启动子(C 590T) 通过 PCR限制性扩增片段长度多态性(PCR RFLP)方法检测。统计学分析应用多元回归法检测白介素基因与哮喘的关系。【结果】在三种族人群中,白介素4(C 590T)基因型及等位基因与哮喘、哮喘严重度无相关性(P>0.05)。然而,华人的白介素 4(T590)等位基因(98.3%)显著高于马来人(84%)及印度人(35.9%)(P<0.01)。【结论】华人、马来人及印度人的白介素4(C 590T) 基因多态性与哮喘无关。然而,此基因多态性存在种族差异。 | 张卫东 张萧竹 邱迪文 Tan WC | 2005 | 医学临床研究2005,22,3: | 5 |
| 14 | Derivation of hypermethylated pluripotent embryonic stem cells with high potency显示文摘天真的 hypomethylated 胚胎的 pluripotent 干细胞(转换字符) 离胚囊的 preimplantation epiblast 发展地最靠近,与潜力到贡献所有胚胎的纸巾和 germline,除了在妄想的胚胎的胚胎外的纸巾。由对比,类似于 postimplantation epiblast 的 epiblast 干细胞(EpiSCs ) 是相对更多的 methylated 和表演为 chimerism 的一个有限潜力。第一次,这里,我们在 pluripotent 房间以外发展地揭示先进 pluripotent 干细胞(ASC ) ,它是在内部房间团中,但是与更高的力量比 EpiSCs。因此,单个 ASC 在怪物很高效地作出贡献到胎儿, germline,蛋黄囊和胎盘的迷宫。因为他们是,发展地,更多进展了, ASC 不贡献 trophoblast。ASC 在与 Activin A 和基本成纤维细胞生长因素补充的化学上定义的媒介在二个步骤从胚囊被导出,在包含 ActA, BMP4, CHIR99021 和白血病的 ABCL 媒介由 culturing 列在后面禁止的因素。尤其是, ASC 与天真的 pluripotency 基因,以及 mesodermal 的表示展出不同 transcriptome 体的基因;Eomes,时代, Tdgf1, Evx1, hand1, Wnt5a 和不同重复元素。到 ASC 的确定的转换字符的变换也是可完成的。重要地, ASC 作为与 hypomethylated 相比展出稳定的 hypermethylated epigenome 和主要未经触动的印记胚囊和天真的转换字符的内部房间质量。ASC 的性质建议他们以在 pluripotency 的天真、告知的状态之间的一个中间的细胞的状态代表房间。 | Siqin Bao Walfred WC Tang Baojiang Wu Shinseog Kim Jingyun Li Lin Li Toshihiro Kobayashi Caroline Lee Yanglin Chen Mengyi Wei Shudong Li Sabine Dietmann Fuchou Tang Xihe Li | 2018 | Cell Research2018,28,1: | 4 |
| 15 | Tamoxifen对真皮成纤维细胞种植胶原网格的抑制效应显示文摘目的 探索Tamoxifen用于治疗皮肤瘢痕挛缩的可能性。方法 将人真皮成纤维细胞种植于Ⅰ型胶原构成的胶原网格内培养 ,加入 1~ 5 0 μmol L的Tamoxifen ,测定网格收缩率 ;采用MTT染色法原位观察网格内的细胞形态及活力变化。结果 Tamoxifen对胶原网格收缩具有抑制效应 ,其浓度低于 5 μmol L时对网格收缩无影响 ,高于 30 μmol L时网格收缩被不可逆性完全抑制 ,处于 10~ 2 0 μmol L时对网格收缩作用呈现剂量及时间依赖性抑制。MTT染色后观察显示网格收缩变化与处于三维培养的细胞突起伸展状态相关 ;Tamoxifen并不直接导致网格内的细胞死亡 ,而是通过抑制细胞功能发挥作用。结论 Tamoxifen可对真皮成纤维细胞体外模拟的瘢痕挛缩产生抑制效应 。 | 胡大海 朱雄翔 徐明达 陈璧 Margaret AH George WC | 2002 | 中华整形外科杂志2002,18,3: | 4 |
| 16 | 雄激素剥夺治疗时间对前列腺癌根治术后放疗的预后影响显示文摘为了明确持续的雄激素剥夺治疗是否影响前列腺癌根治术后患者接受放疗的临床预后,对1986年至2010年间某三级医疗机构收治的680例接受辅助放疗或接受挽救性放疗的患者的临床资料进行回顾性分析并进行随访。 | Jackson WC 陆金金 | 2016 | 现代泌尿生殖肿瘤杂志2016,8,3: | 4 |
| 17 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘 | John Burn Anne-Marie Gerdes Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diane Eccles D Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm G Dunlop Judy WC Ho Shirley V Hodgson Annika Lindblom Jan Lubinski Pa | 2011 | The Lancet2011,,9809: | 3 |
| 18 | 6 儿童血管瘤的流行病学、影像学特征及治疗效果显示文摘对1998—2007年间收治的58例血管瘤患者进行回顾性研究,分析患者人口学资料、影像学特点、治疗方法及其结果。结果:男19例,女39例,64%的患者病变位于头颈部.3例合并卡-梅综合征.21例无影像学资料.37例行B超和(或)MRI检查,85%的患者B超为混合性回声。 | Rasalkar DD Chu WC Cheng FW | 2010 | 中国口腔颌面外科杂志2010,8,6: | 2 |
| 19 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007,21,11: | 2 |
| 20 | Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin显示文摘 | Knowler WC Barrett-Connor E Fowler SE | | 0,,: | 2 |