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| 1 | 华人、马来人及印度人的白介素4基因多态性与哮喘的关系显示文摘【目的】调查华人、马来人及印度人的白介素 4 基因多态性与哮喘和哮喘严重度是否有相关性。【方法】研究人群包括315名哮喘患者(华人 152,马来人 76,印度人 87) 和 360 名无哮喘病史的健康献血者(华人157,马来人100,印度人103) 。患者组进一步分为轻、中度哮喘组(FEV1>=60%预计值) 和重度哮喘组(FEV1<60%预计值) 。白介素4基因启动子(C 590T) 通过 PCR限制性扩增片段长度多态性(PCR RFLP)方法检测。统计学分析应用多元回归法检测白介素基因与哮喘的关系。【结果】在三种族人群中,白介素4(C 590T)基因型及等位基因与哮喘、哮喘严重度无相关性(P>0.05)。然而,华人的白介素 4(T590)等位基因(98.3%)显著高于马来人(84%)及印度人(35.9%)(P<0.01)。【结论】华人、马来人及印度人的白介素4(C 590T) 基因多态性与哮喘无关。然而,此基因多态性存在种族差异。 | 张卫东 张萧竹 邱迪文 Tan WC | 2005 | 医学临床研究2005，22，3： | 5 |
| 2 | Endocrine complications in transfusion dependent thalassaemia in Penang Hospital显示文摘 | Ong CK Lira sL Tan WC | 2008 | Med J Malaysia2008，63，： | 1 |
| 3 | Steroidal Alkaloids from Veratrum taliense 显示文摘 | Zhou CX Tan RX Ye WC | 2000 | Indian J Chem2000，39，： | 1 |
| 4 | Why we do caesars : a comparison of the trends in caesarean sectiondelivery over a decade 显示文摘 | Wang CP Tan WC Kanagalingam D | 2013 | Ann Acad Med Singapore2013，42，8： | 1 |
| 5 | Diabetes as a risk factor for periodontal disease: current status and future considerations显示文摘 | Tan WC Tay FB Lim LP | 2006 | Ann Acad Med Singapore2006，35，8： | 1 |
| 6 | Mitotic deregulation by survivin in ErbB2-overexpressing breast cancer ceils contributes to Taxol resistance 显示文摘 | Lu J Tan M Huang WC | 2009 | Clin Cancer Res2009，15，4： | 1 |
| 7 | Prevalence and determinants of excessive daytime sleepiness in an Asian multi-ethnic population显示文摘 | Ng TP Tan WC | | 0，，： | 1 |
| 8 | Allergic rhinitis and non-al- lergic rhinitis in children in the tropics:prevalence and risk assia- tions显示文摘 | Chiang WC Chen YM Tan HK | 2012 | Pediatr Pulmonol2012，47，10： | 1 |
| 9 | Balloon kyphoplasty versus vertebroplasty for treatment of osteoporotic vertebral compres- sion fracture :a prospective, comparative,and randomized clinical study显示文摘 | Liu JT Liao W J Tan WC et a/ | 2010 | Osteoporos Int2010，21，2： | 1 |
| 10 | IL -4 receptor genetic polymorphisms and asthma in Asian populations 显示文摘 | Zhang W Zhang X Qia D Sandford A Tan WC | 2007 | Respir Med2007，101，1： | 1 |
| 11 | Balloon kyphoplasty versus vertebroplasty for treatment of osteoporotic vertebral com- pression fracture : a prospective, comparative, and random- ized clinical study 显示文摘 | Liu JT Liao WJ Tan WC | 2010 | Osteoporos Int2010，21，2： | 1 |
| 12 | Depressive symptoms and chronic obstructive pulmonary disease:effect on mortalily, hospital readmission, symptom burden, functional status, and quality of life 显示文摘 | Ng TP Niti M Tan WC | 2010 | Arch Intern Med2010，167，1： | 1 |
| 13 | CanadianCohort Obstructive Lung Disease (CanCOLD) : fulfilling theneed for longitudinal observational studies in COPD 显示文摘 | BOURBEAU J TAN WC BENEDETTI A | 2014 | COPD2014，11，2： | 1 |
| 14 | Depressive symptoms and chronic obstructive pulmonary disease:effect on mortality,hospital readmission,symptom burden,functional status,and quality of life显示文摘 | Ng TP Niti M Tan WC | 2007 | Arch Intern Med2007，167，1： | 1 |
| 15 | The role of climatic conditions and histamine release in exercise induced bronchoconstriction 显示文摘 | Tan WC Tan CH Teoh PC | 1985 | Ann Acad Med Singapore1985，14，46： | 1 |
| 16 | Trends in chronic obstructive pulmonary disease in the Asia-Pacific regions显示文摘 | Tan WC | 2011 | Current Opinion in Pulmonary Medicine2011，17，2： | 1 |
| 17 | Mitotic deregulation by survivin in ErbB2-overexpressing breast cancer cells contributes to Taxol resistance显示文摘 | Lu J Tan M Huang WC | 2009 | Clin Cancer Res2009，15，4： | 1 |
| 18 | Allergic rhinitis and non-allergic rhinitis in children in the tropics: prevalence and risk assiations显示文摘 | CHIANG WC CHEN YM TAN HK | 2012 | Pediatr Pulmonol2012，47，10： | 1 |
| 19 | Balloon kyphoplasty versusvertebroplasty for treatment of osteoporotic vertebral compressionfracture:a prospective,comparative,and randomized clinical study显示文摘 | Liu JT Liao WJ Tan WC | 2010 | Osteoporos Int2010，21，2： | 1 |
| 20 | A systematic review of the effects of full - mouth debridement with and without antiseptics in patients with chronic periodontitis 显示文摘 | Lang NP Tan WC Krhenmann MA | 2008 | J Clin Periodonto12008，35，8： | 1 |
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