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516篇 您的检索式:作者名="WATKINS H"
    题名 作者 年代 出处 被引量
1胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
2Epigenetic inactivation of SFRP gene allows constitutive WNT signaling in colorectal cancer 显示文摘Suzuki H Watkins DN Jair KW 2004Nat Genet2004,36,4:1
3Reducing external chiliing industry in stored 'Hass' with dry heat treatments显示文摘WOOLF A B WATKINS C B BOWEN J H 1995J Amer Soc Hort Sci1995,120,6:1
4Identification of novel, functional genetic variants in the human matrix metalloproteinase - 2 gene:role of Spl in allele - specific transcriptional regulation显示文摘Price SJ Greaves DR Watkins H 2001J Biol Chem2001,276,10:1
5Characterization of PdJgamma-Alumina catalysts containing ceria 显示文摘Shyu J Z Otto K Watkins W L H 1988J Catal1988,,114:1
6Microbial population dynamics of in- oculated low-grade chalcopyrite bioleaching columns 显示文摘Mutch L Watling H Watkin E 2010Hydrometal- lurgy2010,104,34:1
7Hydrodynamic cellular volume changes enable glioma cell invasion 显示文摘Watkins S Sontheimer H 2011J Neurosci2011,31,17:1
8Antioxidant and antiproliferative activities of strawberries显示文摘MEYERS K J WATKINS C B RITTS M P LIU R H 2003Journal of Agricultural and Food Chemistry2003,51,23:1
9Dynarrfic EMG analysis of torque transfer in professional baseball pitchers显示文摘WATKINS R G DENNIS S DILLIN W H 1989Spine1989,14,4:1
10Stromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer显示文摘Kang H Watkins G Parr C 2005Breast Cancer Res2005,7,4:1
11Altered regulatory properties of human cardiac troponin in mntants that cause hypertrophic cardiomyopathy显示文摘Elliott K Watkins H Redwood CS 2000J Biol Chem2000,275,22:1
12Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin显示文摘Jessop C E Tavender T J Watkins R H 2009Journal of Biological Chemistry2009,284,4:1
13Physical and mechanical changes in strawberry fruit after high carbondioxide treatments显示文摘Harker F R Elgar H J Watkins C B 2000Postharvest Biology and Technology2000,19,2:1
14The antiwear mechanisms of ZDDPs-Part Ⅰ 显示文摘Spedding H Watkins R C 1982Tribology International1982,15,1:1
15Physical and mechanical changes in strawberry fruit after high carbondioxide treatments显示文摘HARKER F R ELGAR H J WATKINS C B 2000Postharvest Biology and Technology2000,19,2:1
16Technical Note: Q-learning显示文摘Watkins C J C H Dayan P 1992Machine Learning1992,8,34:1
172001 Identification of novel,functional genetic variants in the human matrix metalloproteinase-2 gene:role of Sp1 in allele specific tanscriptional regulation显示文摘PRICE S J GREAVES D R WATKINS H 2001J Biol Chem2001,276,:1
18Calcitonin and ealcitonin receptor-like receptors: common themes with family B GPCRsV 显示文摘Barwell J Gingell J J Watkins H A 2012Brit J Pharmacol2012,166,1:1
19α-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: A disease of the sarcomere 显示文摘Thierfelder L Watkins H MacRae C 1994Cell1994,77,:1
20Q-learning显示文摘Watkins J C H Dayan Peter 1992Machine Learning1992,8,:1
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