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| 1 | Determinant-Based Classification of Acute Pancreatitis Severity: An International Multidisciplinary Consultation显示文摘 | E. Patchen Dellinger Christopher E. Forsmark Peter Layer Philippe Lévy Enrique Maraví-Poma Maxim S. Petrov Tooru Shimosegawa Ajith K. Siriwardena Generoso Uomo David C. Whitcomb John A. Windsor | 2012 | Annals of Surgery2012，，6： | 7 |
| 2 | FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts显示文摘AIM: To evaluate the efficacy and safety of the FOLFIRI regimen in patients with metastatic pancreatic adenocarcinoma (PAC) after the failure of gemcitabine and platinum salts. METHODS: All consecutive patients with histologically confirmed, metastatic PAC and World Health Organiza-tion performance status (PS) ≤ 2 received FOLFIRI-1 [irinotecan 180 mg/m2 on day 1 and leucovorin 400 mg/m2 followed by 5-fluorouracil (5-FU) 400 mg/m2 bolus, then 5-FU 2400 mg/m2 as a 46-h infusion, biweekly] or FOLFIRI-3 (irinotecan 100 mg/m2 on day 1 and leucovorin 400 mg/m2, then 5-FU 2400 mg/m2 as a 46-h infusion and irinotecan 100 mg/m2 repeated on day 3, biweekly) after failure of gemcitabine and platinum-based chemotherapies as a systematic policy in two institutions between January 2005 and May 2010. Tumor response, time to progression (TTP), overall survival rate (OS) and grade 3-4 toxicities were retrospectively studied. Subgroup analyses were performed to search for prognostic factors. RESULTS: Sixty-three patients (52.4% male, median age 59 years) were analyzed. Among them, 42.9% were PS 0, 38.1% were PS 1 and 19.0% were PS 2. Fifty one patients (81.0%) had liver metastases. Before the FOLFIRI regimen, patients had received 1 line (n = 19), 2 lines (n = 39) or 3 lines (n = 5) of chemotherapy. Median TTP obtained with the line before FOLFIRI was 3.9 mo (95% CI: 3.4-5.3 mo). A total of 480 cycles was completed (median: 6 cycles, range: 1-51 cycles). The main reason for discontinuing FOLFIRI was tumor progression (90.3%). Tumor control was achieved in 25 patients (39.7%) (partial response: n = 5, stable disease: n = 20) with FOLFIRI. Median TTP was 3.0 mo (95% CI: 2.1-3.9 mo) and median OS was 6.6 mo (95% CI: 5.3-8.1 mo). Dose adaptation was required in 36 patients (57.1%). Fifteen patients (23.8%) had grade 3-4 toxicities, mainly hematological (n = 11) or digestive (n = 4). Febrile neutropenia occurred in 3 patients. There was no toxic death. PS 2 was significantly associated with poor TTP [hazard ratio (HR): 16.036, P < 0.0001] and OS (HR: 4.003, P = 0.004). CONCLUSION: The FOLFIRI regimen had an acceptable toxicity and an interesting efficacy in our study, limited to patients in good condition (PS 0-1). | Cindy Neuzillet Olivia Hentic Benot Rousseau Vinciane Rebours Léla Bengrine-Lefèvre Franck Bonnetain Philippe Lévy Eric Raymond Philippe Ruszniewski Christophe Louvet Pascal Hammel | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 3 | Natural History of Intraductal Papillary Mucinous Tumors of the Pancreas: Actuarial Risk of Malignancy显示文摘 | Philippe Lévy Vincent Jouannaud Dermot O’Toole Anne Couvelard Marie Pierre Vullierme Laurent Palazzo Alain Aubert Philippe Ponsot Alain Sauvanet Frédérique Maire Olivia Hentic Pascal Hammel Philippe Ruszniewski | 2006 | Clinical Gastroenterology and Hepatology2006，，4： | 2 |
| 4 | Splenic and portal venous obstruction in chronic pancreatitis显示文摘 | Pr. Pierre Bernades André Baetz Philippe Lévy Jacques Belghiti Yves Menu Fran?ois Fékété | 1992 | Digestive Diseases and Sciences1992，，3： | 2 |
| 5 | Role of endoscopic ultrasound in the screening and follow-up of high-risk individuals for familial pancreatic cancer显示文摘Managing familial pancreatic cancer(FPC)is challenging for gastroenterologists,surgeons and oncologists.High-risk individuals(HRI)for pancreatic cancer(PC)(FPC or with germline mutations)are a heterogeneous group of subjects with a theoretical lifetime cumulative risk of PC over 5%.Screening is mainly based on annual magnetic resonance imaging(MRI)and endoscopic ultrasound(EUS).The goal of screening is to identify early-stage operable cancers or high-risk precancerous lesions(pancreatic intraepithelial neoplasia or intraductal papillary mucinous neoplasms with high-grade dysplasia).In the literature,target lesions are identified in 2%-5%of HRI who undergo screening.EUS appears to provide better identification of small solid lesions(0%-46%of HRI)and chronicpancreatitis-like parenchymal changes(14%-77%of HRI),while MRI is probably the best modality to identify small cystic lesions(13%-49%of HRI).There are no specific studies in HRI on the use of contrast-enhanced harmonic EUS.EUS can also be used to obtain tissue samples.Nevertheless,there is still limited evidence on the accuracy of imaging procedures used for screening or agreement on which patients to treat.The cost-effectiveness of screening is also unclear.Certain new EUS-related techniques,such as searching for DNA abnormalities or protein markers in pancreatic fluid,appear to be promising. | Diane Lorenzo Vinciane Rebours Frédérique Maire Maxime Palazzo Jean-Michel Gonzalez Marie-Pierre Vullierme Alain Aubert Pascal Hammel Philippe Lévy Louis de Mestier | 2019 | World Journal of Gastroenterology2019，25，34： | 2 |
| 6 | Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese显示文摘 | Judith Aron-Wisnewsky Caroline Minville Joan Tordjman Patrick Lévy Jean-Luc Bouillot Arnaud Basdevant Pierre Bedossa Karine Clément Jean-Louis Pépin | 2011 | Journal of Hepatology2011，，1： | 2 |
| 7 | Efficacyandtolerabilityof eseitalopram versus citalopram in major depressive disorder: a 6-week, multicenter, prospective, randomized, double-blind, active-controlled study in adult outpatients显示文摘 | YEVTUSHENKO VY BELOUS AI YEVTUSHENKO YG et ol | 2007 | Clin Ther2007，29，11： | 1 |
| 8 | Regeneration of intervertebral disc by mesenchymal stem ceils : potentials, limitations, and future direction 显示文摘 | Leung VY Chan D Cheung KM | 2006 | Eur Spine J2006，3，： | 1 |
| 9 | Removal of ossified ligamentum flavum via a minimally invasive surgical approach显示文摘 | Wang VY Kanter AS Mummaneni PV | 2008 | Neurosurg Focus2008，25，2： | 1 |
| 10 | Setting times of Resilon and other sealers in aerobic and anaerobic environments 显示文摘 | Nielsen BA Beeler WJ Vy C | 2006 | J Endod2006，32，2： | 1 |
| 11 | Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003 显示文摘 | Dombrovskiy VY Martin AA Sunderram J | 2007 | Crit Care Med2007，35，5： | 1 |
| 12 | CT Fluoroscopic Guidance for Percutaneous Needle Placement into Abdominopelvic Lesions with Difficult Access Routes显示文摘 | Schweiger GD Yip VY Brown BP | 2000 | Abdom Imaging2000，25，6： | 1 |
| 13 | Proteins of the Rpf Family:Immune Cell Reactivity and Vaccination Efficacy against Tuberculosis in Mice显示文摘 | Vladimir VY Tatiana KK Elvira IR | 2003 | Infection and Immunity2003，71，8： | 1 |
| 14 | Identification of an autoinhibitory domain ofp21-activated protein kinase 5显示文摘 | Ching YP Leong VY Wong CM | 2003 | J Biol Chem2003，278，33： | 1 |
| 15 | Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse显示文摘 | Yang F Leung VY Luk KD | 2009 | J Pathol2009，218，： | 1 |
| 16 | Chromatofocusing fails to separate hFSH isoforms on the basis of glycan structure显示文摘 | Bousfield GR Butnev VY Bidart JM | 2008 | Biochemistry2008，47，6： | 1 |
| 17 | Current perspective of pathophysiological and interventional effects on endothelial progenitor cell biology:Focus on Pi3K/AKT/eNOS pathway显示文摘 | Everaert BR Van Craenenbroeck EM Hoymans VY | | 0，，03： | 1 |
| 18 | Low-density lipoprotein and noncalcified coronary plaque composition in patients with newly diagnosed coronary artery disease on computed tomographic angiography显示文摘 | Cheng VY Wolak A Gutstein A | | 0，，： | 1 |
| 19 | Atrial fibrillation ablation using a robotic catheter remote control system:initial human experience and long-term follow-up results显示文摘 | Saliba W Reddy VY Wazni O Cummings JE Burkhardt JD Haissaguerre M | | 0，，25： | 1 |
| 20 | Percutaneous closure of the left atrial ap- pendage versus warfarin therapy for prevention of stroke in patients with atrial fi- brillation:a randomized non-inferiority trial显示文摘 | Holmes DR Reddy VY Turi ZG | 2009 | Lanc-et2009，374，： | 1 |
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