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| 1 | Phenylpropanoid Biosynthesis显示文摘一般 phenylpropanoid 新陈代谢作为核心单位基于 shikimate 小径的很少中介产生第二等的代谢物的一个庞大的数组。产生 hydroxycinnamic 酸和酉旨被导致一个机关和代谢物的发展地特定的模式的 reductases, oxygenases,和 transferases 的联合在几串联放大,为每植物种特征。在最后十年期间,驾驶的方法论指向了,在几植物种的非指向的途径启用了这复杂 biosynthetic 机械的参与的酶的鉴定,并且为规定和分隔揭示了众多的基因,酶,和代谢物必需品。在结构、计算的生物学的可观的成功,与分析敏感结合了在代谢物,抄本,或酶模式检测甚至踪迹混合物和 smallest changes,向对它的关於生命、不能生活的环境的植物反应的一个全面看法便于进步。转基因的途径被用来揭示卓见进为各种各样的 phenylpropanoid biosynthetic 小径的功能的正直和粘性要求的显然冗余的基因和酶模式。不过,一个基因家庭的所有成员的功能和影响尚待完全被证实。这评论试图在一般 phenylpropanoid 小径的各种各样的方面上给更改,它是不仅限制了为普通木质素或 flavonoid 生合成,但是喂进许多另外的芳香的代谢物喜欢香豆素,酉分的 volatiles,或 hydrolyzable 丹宁。 | Thomas Vogt | 2010 | Molecular Plant2010，3，1： | 158 |
| 2 | Evaluation of acoustic radiation force impulse imaging for determination of liver stiffness using transient elastography as a reference显示文摘AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan■ (FS)] as a reference. METHODS: Six hundred and six patients were enrolled in this study.All patients underwent liver stiffness measurement with FS (FS-LS) and ARFI (with shear wave velocity quantification; ARFI-SWV) and the performance of ARFI in comparison to FS was determined. Sixtyeight patients underwent liver biopsy. RESULTS: Significantly higher success rates for the determination of liver stiffness were found using ARFI as compared to FS [604/606 (99.7%) vs 482/606 (79.5%); P < 0.001]. ARFI-SWV correlated significantly with FS-LS (r = 0.920, P < 0.001). ARFI-SWV increased significantly with the stage of fibrosis (1.09 ± 0.13 m/s for patients with no significant fibrosis (FS-LS < 7.6 kPa); 1.46 ± 0.27 m/s for patients with significant liver fibrosis (7.6 < FS-LS ≤ 13.0 kPa); and 2.55 ± 0.77 m/s for patients with liver cirrhosis (FS-LS > 13.0 kPa)). ARFI-SWV cut-off values were identified for no significant fibrosis (1.29 m/s; sensitivity 91.4% and specificity 92.6%) and for liver cirrhosis (1.60 m/s; sensitivity 92.3% and specificity 96.5%). The optimal cut-off value for predicting liver fibrosis (F ≥ 2) was 1.32 m/s (sensitivity 87.0% and specificity 80.0%) and for liver cirrhosis (F4) 1.62 m/s (sensitivity 100% and specificity 85.7%), for patients who underwent liver biopsy. An excellent inter-and intraobserver reproducibility was observed for ARFI-SWV determinations. CONCLUSION: An ARFI-SWV cut-off value of 1.29 m/s seems to be optimal for patients with no significant liver fibrosis and 1.60 m/s for patients with liver cirrhosis. | Gerald Kircheis Abdurrahman Sagir Christoph Vogt Stephan vom Dahl Ralf Kubitz Dieter Hussinger | 2012 | World Journal of Gastroenterology2012，18，10： | 30 |
| 3 | Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro显示文摘AIM: Eph receptor tyrosine kinases and their membrane bound receptor-like ligands, the ephrins, represent a bi-directional cell-cell contact signaling system that directs epithelial movements in development. The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD).METHODS: mRNA expression profiles of all Eph/ephrin family members in normal small intestine and colon were established by real-time RT-PCR. In addition, differential expression in IBD was investigated by cDNA array technology, and validated by both real-time RT-PCR and immunohistochemistry. Potential effects of enhanced EphB/ephrin-B signaling were analyzed in an in vitro IEC-6 cell scratch wound model.RESULTS: Human adult intestinal mucosa exhibits a complex pattern of Eph receptors and ephrins. Beside the known prominent co-expression of EphA2 and ephrinA1,we found abundantly co-expressed EphB2 and ephrin-B1/2.Interestingly, cDNA array data, validated by real-time PCR and immunohistochemistry, showed upregulation of ephrin-B2 in both perilesional and lesional intestinal epithelial cells of IBD patients, suggesting a role in epithelial homeostasis. Stimulation of ephrin-B signaling in ephrinB1/2 expressing rat IEC-6-cells with recombinant EphB1Fc resulted in a significant dose-dependent acceleration of wound closure. Furthermore, fluorescence microscopy showed that EphB1-Fc induced coordinated migration of wound edge cells is associated with enhanced formation of lamellipodial protrusions into the wound, increased actin stress fiber assembly and production of laminin at the wound edge.CONCLUSION: EphB/ephrin-B signaling might represent a novel protective mechanism that promotes intestinal epithelial wound healing, with potential impact on epithelial restitution in IBD. | Christian Hafner Stefanie Meyer Thomas Langmann Gerd Schmitz Frauke Bataille Ilja Hagen Bernd Becker Alexander Roesch Gerhard Rogler Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 4 | 酸性森林土壤中Ca-H-Al交换过程与铝的溶解机制研究显示文摘华南酸性森林土壤分别在pH值为3.46、4.24和4.84条件下用含不同浓度盐基离子(Ca2+)的酸性浸提液浸提,以查明降水中盐基离子对土壤水中Al和H+的影响。实验结果表明:随着Ca2+浓度的增加,土壤浸出液中H+和Al都有增加的趋势。随着Ca2+浓度的变化,H+和Al有不同的来源:当Ca2+<0.5mmol L-1时,土壤主要通过Ca-H交换机制释放H+,浸出液中Al主要来源于土壤活性铝的溶解;当Ca2+>0.5mmol L-1时,由于Ca-Al交换反应,浸出液中Al随Ca2+浓度增加而显著增加,此时H+主要来源于Al的水解反应。浸出液中pH-pAl关系也随pH值(或Ca2+浓度)的变化有显著不同:当浸出液pH>3.7(Ca2+<0.5 mmol L-1)时,浸出液中Al3+活度随pH的变化幅度较小,这可能是酸性土壤中活性铝已显著流失的缘故;当pH<3.7(Ca2+>0.5 mmol L-1)时H+对于Al浓度具有较强的依赖性,故pH随Al3+活度增加而显著降低。因此,降水中盐基离子的增加能够引起土壤水乃至地表水中酸性阳离子(特别是Al)的迅速增加,可能造成对水生生物的突发性影响。 | 郭景恒 张晓山 张逸 Rolf David Vogt | 2006 | 土壤学报2006，43，1： | 9 |
| 5 | Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: a prospective study显示文摘AIM: To prospectively analyze the impact of increased intestinal permeability(IP) on mortality and the occurrence of infections in patients with cirrhosis.METHODS: IP was quantified using the lactulose/mannitol(L/M) test in 46 hospitalized patients with cirrhosis(25 Child-Pugh A/B, 21 Child-Pugh C) and in 16 healthy controls. Markers of inflammation [LPSbinding protein, Interleukin-6(IL-6)] and enterocyte death [intestinal fatty-acid binding protein(I-FABP)] were determined in serum using enzyme-linked immunosorbent assays. Patients were followed for one year and assessed for survival, liver transplantation, the necessity of hospitalization and the occurrence of bacterial infections. The primary endpoint of the study was defined as differences in survival between patients with pathological and without pathological lactulose/mannitol test.RESULTS: Thirty-nine(85%) patients with cirrhosis had a pathologically increased IP index(L/M ratio > 0.07) compared to 4(25%) healthy controls(P < 0.0001). The IP index correlated with the ChildPugh score(r = 0.484, P = 0.001) and with serum IL-6(r = 0.342, P = 0.02). Within one year, nineteen(41%) patients developed a total of 33 episodes of hospitalization with bacterial or fungal infections. Although patients who developed spontaneous bacterial peritonitis(SBP)(n = 7) had a higher IP index than patients who did not(0.27 vs 0.14, P = 0.018), the baseline IP index did not predict time to infection, infection-free survival or overall survival, neither when assessed as linear variable, as tertiles, nor dichotomized using an established cut-off. In contrast, model for end-stage liver disease score, Child-Pugh score, the presence of ascites, serum IL-6 and I-FABP were univariate predictors of infection-free survival.CONCLUSION: Although increased IP is a frequent phenomenon in advanced cirrhosis and may predispose to SBP, it failed to predict infection-free and overall survival in this prospective cohort study. | Anika Vogt Philipp A Reuken Sven Stengel Andreas Stallmach Tony Bruns | 2016 | World Journal of Gastroenterology2016，22，11： | 8 |
| 6 | A dual positional specific lipoxygenase functions in the generation of flavor compounds during climacteric ripening of apple显示文摘Lipoxygenase(LOX)is an important contributor to the formation of aroma-active C6 aldehydes in apple(Malus×domestica)fruit upon tissue disruption but little is known about its role in autonomously produced aroma volatiles from intact tissue.We explored the expression of 22 putative LOX genes in apple throughout ripening,but only six LOXs were expressed in a ripening-dependent manner.Recombinant LOX1:Md:1a,LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b proteins showed 13/9-LOX,9-LOX,13/9-LOX and 13-LOX activity with linoleic acid,respectively.While products of LOX1:Md:1c and LOX2:Md:2b were S-configured,LOX1:Md:1a and LOX2:Md:2a formed 13(R)-hydroperoxides as major products.Site-directed mutagenesis of Gly567 to an alanine converted the dual positional specific LOX1:Md:1a to an enzyme with a high specificity for 9(S)-hydroperoxide formation.The high expression level of the corresponding MdLOX1a gene in stored apple fruit,the genetic association with a quantitative trait locus for fruit ester and the remarkable agreement in regio-and stereoselectivity of the LOX1:Md:1a reaction with the overall LOX activity found in mature apple fruits,suggest a major physiological function of LOX1:Md:1a during climacteric ripening of apples.While LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b may contribute to aldehyde production in immature fruit upon cell disruption our results furnish additional evidence that LOX1:Md:1a probably regulates the availability of precursors for ester production in intact fruit tissue. | Doreen Schiller Carolina Contreras Jörg Vogt Frank Dunemann Bruno G Defilippi Randolph Beaudry Wilfried Schwab | 2015 | Horticulture Research2015，2，1： | 6 |
| 7 | Utility of different glycemic control metrics for optimizing management of diabetes显示文摘The benchmark for assessing quality of long-term glycemic control and adjustment of therapy is currently glycated hemoglobin(Hb A1c). Despite its importance as an indicator for the development of diabeticcomplications, recent studies have revealed that this metric has some limitations; it conveys a rather complex message, which has to be taken into consideration for diabetes screening and treatment. On the basis of recent clinical trials, the relationship between Hb A1 c and cardiovascular outcomes in long-standing diabetes has been called into question. It becomes obvious that other surrogate and biomarkers are needed to better predict cardiovascular diabetes complications and assess efficiency of therapy. Glycated albumin, fructosamin, and 1,5-anhydroglucitol have received growing interest as alternative markers of glycemic control. In addition to measures of hyperglycemia, advanced glucose monitoring methods became available. An indispensible adjunct to Hb A1 c in routine diabetes care is selfmonitoring of blood glucose. This monitoring method is now widely used, as it provides immediate feedback to patients on short-term changes, involving fasting, preprandial, and postprandial glucose levels. Beyond the traditional metrics, glycemic variability has been identified as a predictor of hypoglycemia, and it might also be implicated in the pathogenesis of vascular diabetes complications. Assessment of glycemic variability is thus important, but exact quantification requires frequently sampled glucose measurements. In order to optimize diabetes treatment, there is a need for both key metrics of glycemic control on a day-to-day basis and for more advanced, user-friendly monitoring methods. In addition to traditional discontinuous glucose testing, continuous glucose sensing has become a useful tool to reveal insufficient glycemic management. This new technology is particularly effective in patients with complicated diabetes and provides the opportunity to characterize glucose dynamics. Several continuous glucose monitoring(CGM) systems, which have shown usefulness in clinical practice, are presently on the market. They can broadly be divided into systems providing retrospective or real-time information on glucose patterns. The widespread clinical application of CGM is still hampered by the lack of generallyaccepted measures for assessment of glucose profiles and standardized reporting of glucose data. In this article, we will discuss advantages and limitations of various metrics for glycemic control as well as possibilities for evaluation of glucose data with the special focus on glycemic variability and application of CGM to improve individual diabetes management. | Klaus-Dieter Kohnert Peter Heinke Lutz Vogt Eckhard Salzsieder | 2015 | World Journal of Diabetes2015，6，1： | 6 |
| 8 | 中国的酸化问题——一项基于重庆—广州森林监测点研究结果的评估显示文摘中国经济的快速增长一直伴随着污染的加剧。本文在现场观测和文献研究的基础上讨论了酸性降水及其先兆的范围和影响。目前酸性降水的主要原因是二氧化硫的排放,但氮氧化物的排放也在增加。中国污染最严重地区的硫化合物沉降比东欧和中欧经受严重污染的地区要高。中国南部很多地区的土壤和土壤水看来已经被酸化。这些地区的污染已经影响了森林和其他植物的生命力,特别是在位于和靠近城市地区的地方。地表水的酸化似乎在近期不会成为主要的区域性问题,但一些地区的河流,目前虽仅接受少量的酸沉降,却对酸化显得较敏感。 | Hans M. Seip Per Aagaard Valter Angell Odd Eilertsen ThorjφrnLarssen Espen Lydersen Jan Mulder Ivar P. Muniz Arne Semb 汤大钢 Rolf D. Vogt 肖劲松 赵大为 孔国辉 岳欣 | 1999 | AMBIO-人类环境杂志1999，28，6： | 5 |
| 9 | The quasiparticle band dispersion in epitaxial multilayer silicene显示文摘 | Paola De Padova Jose Avila Andrea Resta Ivy Razado-Colambo Claudio Quaresima Carlo Ottaviani Bruno Olivieri Thomas Bruhn Patrick Vogt Maria Carmen Asensio Guy Le Lay | 2013 | Journal of Physics: Condensed Matter2013，，： | 4 |
| 10 | In Inland China, Rice, Rather than Fish, Is the Major Pathway for Methylmercury Exposure显示文摘 | Zhang Hua Feng Xinbin Larssen Thorj?rn Qiu Guangle Vogt Rolf D | 2010 | Environmental Health Perspectives2010，，9： | 3 |
| 11 | Degradable biomaterials based on magnesium corrosion显示文摘 | Frank Witte Norbert Hort Carla Vogt Smadar Cohen Karl Ulrich Kainer Regine Willumeit Frank Feyerabend | 2009 | Current Opinion in Solid State & Materials Science2009，，5： | 3 |
| 12 | 强化降压治疗期间估算的肾小球滤过率初始降低与长期肾功能:收缩压干预试验与控制糖尿病患者心血管病风险行动研究-血压随机对照试验的事后分析显示文摘血压降低可导致估算的肾小球滤过率(estimated glomerular filtration rate,eGFR)的初始下降,但eGFR降低多少可以接受仍存在争议。研究人员对控制糖尿病心血管病风险行动(action to control cardiovascular risk in diabetes,ACCORD)-血压研究及收缩压干预试验(systolic blood pressure intervention trial,SPRINT)进行事后分析,两项研究均随机将患者分为强化或标准收缩压靶目标治疗。 | 赵狄(译) 刘莉(校) Collard D Brouwer TF Engberink RHGO Zwinderman AH Vogt L Born BJH | 2020 | 中华高血压杂志2020，28，5： | 3 |
| 13 | Various atomic structures of monolayer silicene fabricated on Ag(111)显示文摘 | Zhi-Long Liu Mei-Xiao Wang Jin-Peng Xu Jian-Feng Ge Guy Le Lay Patrick Vogt Dong Qian Chun-Lei Gao Canhua Liu Jin-Feng Jia | 2014 | New Journal of Physics2014，，： | 3 |
| 14 | Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C显示文摘 | Michael T. Dill Francois H.T. Duong Julia E. Vogt Stéphanie Bibert Pierre–Yves Bochud Luigi Terracciano Andreas Papassotiropoulos Volker Roth Markus H. Heim | 2011 | Gastroenterology2011，，3： | 2 |
| 15 | Dual-energy CT of the heart—Principles and protocols显示文摘 | Florian Schwarz Balazs Ruzsics U. Joseph Schoepf Gorka Bastarrika Salvatore A. Chiaramida Joseph A. Abro Robin L. Brothers Sebastian Vogt Bernhard Schmidt Philip Costello Peter L. Zwerner | 2008 | European Journal of Radiology2008，，3： | 2 |
| 16 | Arthropod prey of imported fire ants (Hymenoptera: Formicidae) in Mississippi sweetpotato fields显示文摘红进口的火蚂蚁, Solenopsis invicta (Buren ) ,通常被认为害虫。他们也被看作了在各种各样的 agroecosystems 的另外的昆虫害虫上喂的有益的食肉动物。这研究在密西西比在一块 sweetpotato 地里记录火蚂蚁的 foraging 习惯。与一个 sweetpotato 领域在殖民地外面连接的火蚂蚁 foraging 小道被暴露, foraging 蚂蚁向殖民地的方向从这个领域移动与固体一起是镇定的他们正在带的食物粒子。食物材料在起源作为节肢动物或植物被分类。节肢动物粒子被识别到订单。火蚂蚁 foragers 比植物材料带了更多的节肢动物。翘目和 Homoptera 是最丰富的组 preyed 在之上。这些昆虫订单包含 sweetpotato 的各种各样的经济地重要的害虫。另外的主要昆虫组包括了订单半翅类,双翅目并且 Collembola。foraged 材料的数量在季节变化了。sweetpotato 根的损坏都不能被归因开除蚂蚁喂。进口的火蚂蚁 foraging 可以在 sweetpotato 地里减少昆虫害虫的数字。 | Tahir Rashid Jian Chen James T. Vogt Paul J. McLeod | 2013 | Insect Science2013，20，4： | 2 |
| 17 | Association between conventional risk factors and different ultrasound-based markers of atherosclerosis at carotid and femoral levels in a middle-aged population显示文摘 | Patrick Yerly Nicolas Rodondi Barathi Viswanathan Walter Riesen Pierre Vogt Pascal Bovet | 2013 | The International Journal of Cardiovascular Imaging2013，，3： | 2 |
| 18 | Wnt/β-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells显示文摘 | Katrin Hoffmeyer Angelo Raggioli Stefan Rudloff Roman Anton Andreas Hierholzer Ignacio Del Valle Kerstin Hein Riana Vogt Rolf Kemler | 2012 | 2012 (6088)2012，，6088： | 2 |
| 19 | Ephrin-B reverse signaling induces expression of wound healing associated genes in IEC-6 intestinal epithelial cells显示文摘AIM: Eph receptors and ephrin ligands play a pivotal role in development and tissue maintenance. Since previous data have indicated an involvement of ephrin-B2 in epithelial healing, we investigated the gene expression and downstream signaling pathways induced by ephrin-B mediated cell-cell signaling in intestinal epithelial cells.METHODS: Upon stimulation of ephrin-B pathways in IFC-6 cells with recombinant rat EphB1-Fc, gene expression was analyzed by Affymetrix(R) rat genome 230 high density arrays at different time points. Differentially expressed genes were confirmed by real-time RT-PCR. In addition, MAP kinase pathways and focal adhesion kinase (FAK) activation downstream of ephrin-B were investigated by immunoblotting and fluorescence microscopy.RESULTS: Stimulation of the ephrin-B reverse signaling pathway in IEC-6 cells induces predominant expression of genes known to be involved into wound healing/cell migration, antiapoptotic pathways, host defense and inflammation. Cox-2, c-Fos, Egr-1, Egr-2, and MCP-1 were found among the most significantly regulated genes.Furthermore, we show that the expression of repairrelated genes is also accompanied by activation of the ERK1/2 MAP kinase pathway and FAK, two key regulators of epithelial restitution.CONCLUSION: Stimulation of the ephrin-B reverse signaling pathway induces a phenotype characterized by upregulation of repair-related genes, which may partially be mediated by ERK1/2 pathways. | Christian Hafner Stefanie Meyer Ilja Hagen Bernd Becker Alexander Roesch Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，29： | 2 |
| 20 | The Metallic Nature of Epitaxial Silicene Monolayers on Ag(111)显示文摘 | Neil W. Johnson Patrick Vogt Andrea Resta Paola De Padova Israel Perez David Muir Ernst Z. Kurmaev Guy Le Lay Alexander Moewes | 2014 | Adv. Funct. Mater2014，，： | 2 |
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