|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nonalcoholic fatty liver disease:A comprehensive review of a growing epidemic显示文摘Nonalcoholic fatty liver disease(NAFLD)is quickly becoming one of the most prominent causes of liver disease worldwide.The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it.Current efforts to elucidate the mechanism and causes of the disease have answered some questions,but much remains unknown about NAFLD.The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease,as well as the current and future diagnostic,preventative,and therapeutic options available to clinicians for the management of NAFLD. | Kareem Hassan Varun Bhalla Mohammed Ezz El Regal H Hesham A-Kader | 2014 | World Journal of Gastroenterology2014，20，34： | 36 |
| 2 | Bilirubin in coronary artery disease:Cytotoxic or protective?显示文摘Bilirubin has traditionally been considered a cytotoxic waste product.However,recent studies have shown bilirubin to have anti-oxidant,anti-inflammatory,vasodilatory,anti-apoptotic and anti-proliferative functions.These properties potentially confer bilirubin a new role of protection especially in coronary artery disease(CAD),which is a low grade inflammatory process exacerbated by oxidative stress.In fact,recent literature reports an inverse relationship between serum concentration of bilirubin and the presence of CAD.In this article,we review the current literature exploring the association between levels of bilirubin and risk of CAD.We conclude that current evidence is inconclusive regarding the protective effect of bilirubin on CAD.A causal relationship between low serum bilirubin level and increased risk of CAD is not currently established. | Nancy Gupta Tavankit Singh Rahul Chaudhary Sushil K Garg Gurprataap Singh Sandhu Varun Mittal Rahul Gupta Roxana Bodin Sachin Sule | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 14 |
| 3 | Spectrum of biliary complications following live donor liver transplantation显示文摘Liver transplantation is the optimal treatment for many patients with advanced liver disease, including decompensated cirrhosis, hepatocellular carcinoma and acute liver failure. Organ shortage is the maindeterminant of death on the waiting list and hence living donor liver transplantation(LDLT) assumes importance. Biliary complications are the most common post operative morbidity after LDLT and occur due to anatomical and technical reasons. They include biliary leaks, strictures and cast formation and occur in the recipient as well as the donor. The types of biliary complications after LDLT along with their etiology, presenting features, diagnosis and endoscopic and surgical management are discussed. | Priya Simoes Varun Kesar Jawad Ahmad | 2015 | World Journal of Hepatology2015，7，14： | 7 |
| 4 | Colorectal cancers in ulcerative colitis from a low-prevalence area for colon cancer显示文摘AIM: To determine the incidence and risk factors for colorectal cancer(CRC) in patients with ulcerative colitis from a low prevalence region for CRC.METHODS: Our prospective database yielded a cohort of 430 patients [age: 44 ± 14.6 years; 248 men(57.7%)] with ulcerative colitis(median disease duration 6, range: 1-39 years) for analysis. Of these, 131(30.5%) had left-sided colitis and 159(37%) extensive colitis. Patients with histologically confirmed CRC within the segment with colitis were compared with those without CRC, to determine the risk factors for the development of CRC.RESULTS: Twelve patients(2.8%) developed CRC. The overall incidence density was 3.56/1000 patient-years of disease- 3/1000 in the first 10 years, 3.3/1000 at 10 to 20 years, and 7/1000 at > 20 years. Three of our 12 patients developed CRC within 8 years of disease onset. On univariate analysis, extensive colitis, longer duration of disease, and poor control of disease were associated with development of CRC. On multivariate analysis, duration of disease and extent of colitis remained significant.CONCLUSION: CRC occurred in 2.8% of patients with ulcerative colitis in our population- an incidence density similar to that in Western countries in spite of a low overall prevalence of colon cancer in our population.The risk increased with extent and duration of disease. | Devendra Desai Sudeep Shah Abhijit Deshmukh Philip Abraham Anand Joshi Tarun Gupta Ramesh Deshpande Varun Khandagale Siji George | 2015 | World Journal of Gastroenterology2015，21，12： | 7 |
| 5 | Techniques and accuracy of thoracolumbar pedicle screw placement显示文摘Pedicle screw instrumentation has been used to stabilize the thoracolumbar spine for several decades. Although pedicle screws were originally placed via a freehand technique, there has been a movement in favor of pedicle screw placement with the aid of imaging. Such assistive techniques include fluoroscopy guidance and stereotactic navigation. Imaging has the benefit of increased visualization of a pedicle's trajectory, but can result in increased morbidity associated with radiation exposure, increased time expenditure, and possible workflow interruption. Many institutions have reported high accuracies with each of these three core techniques. However, due to differing definitions of accuracy and varying radiographic analyses, it is extremely difficult to compare studies side-by-side to determine which techniques are superior. From the literature, it can be concluded that pedicles of vertebrae within the mid-thoracic spine and vertebrae that have altered morphology due to scoliosis or other deformities are the most difficult to cannulate. Thus, spine surgeons would benefit the most from using assistive technologies in these circumstances. All other pedicles in thethoracolumbar spine should theoretically be cannulated with ease via a free-hand technique, given appropriate training and experience. Despite these global recommendations, appropriate techniques must be chosen at the surgeon's discretion. Such determinations should be based on the surgeon's experience and the specific pathology that will be treated. | Varun Puvanesarajah Jason A Liauw Sheng-fu Lo Ioan A Lina Timothy F Witham | 2014 | World Journal of Orthopedics2014，5，2： | 7 |
| 6 | Current state of renal transplant immunosuppression:Present and future显示文摘For kidney transplant recipients, immunosuppression commonly consists of combination treatment with a calcineurin inhibitor, an antiproliferative agent and a corticosteroid. Many medical centers use a sequential immunosuppression regimen where an induction agent, either an anti-thymocyte globulin or interleukin-2 receptor antibody, is given at the time of transplantation to prevent early acute rejection which is then followed by a triple immunosuppressive maintenance regimen. Very low rejection rates have been achieved at many transplant centers using combinations of these agents in a variety of protocols. Yet, a large number of recipients suffer chronic allograft injury and adverse events associated with drug therapy. Regimens designed to limit or eliminate calcineurin inhibitors and/or corticosteroid use are actively being pursued. An ideal immunosuppressive regimen limits toxicity and prolongs the functional life of the graft. This article contains a critical analysis of clinical data on currently available immuno-suppressive strategies and an overview of therapeutic moieties in development. | Hari Varun Kalluri Karen L Hardinger | 2012 | World Journal of Transplantation2012，2，4： | 5 |
| 7 | Locus coeruleus-norepinephrine: basic functions and insights into Parkinson’s disease显示文摘The locus coeruleus is a pontine nucleus that produces much of the brain's norepinephrine.Despite its small size,the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders.In this review,we discuss the physiology and anatomy of the locus coeruleus system and focus on norepinephrine's role in synaptic plasticity.We highlight Parkinson's disease as a disorder with motor and neuropsychiatric symptoms that may be understood as aberrations in the normal functions of locus coeruleus. | Bilal Abdul Bari Varun Chokshi Katharina Schmidt | 2020 | Neural Regeneration Research2020，15，6： | 4 |
| 8 | A Multi-Threaded Semantic Focused Crawler显示文摘The Web comprises of voluminous rich learning content.The volume of ever growing learning resources however leads to the problem of information overload.A large number of irrelevant search results generated from search engines based on keyword matching techniques further augment the problem.A learner in such a scenario needs semantically matched learning resources as the search results.Keeping in view the volume of content and significance of semantic knowledge,our paper proposes a multi-threaded semantic focused crawler(SFC) specially designed and implemented to crawl on the WWW for educational learning content.The proposed SFC utilizes domain ontology to expand a topic term and a set of seed URLs to initiate the crawl.The results obtained by multiple iterations of the crawl on various topics are shown and compared with the results obtained by executing an open source crawler on the similar dataset.The results are evaluated using Semantic Similarity,a vector space model based metric,and the harvest ratio. | Punam Bedi Anjali Thukral Hema Banati Abhishek Behl Varun Mendiratta | 2012 | Journal of Computer Science & Technology2012，27，6： | 4 |
| 9 | 索拉非尼抑制肝癌细胞增殖中自噬的作用及其机制显示文摘目的:研究分子靶向药物索拉非尼在体外对人肝癌细胞株HepG_2增殖抑制过程中自噬的表达及作用,并探讨其可能机制。方法:以吖啶橙染色荧光显微镜对自噬进行定性观察;cell counting kit-8检测活性氧(reactiveoxygen species,ROS)抑制前后HepG_2细胞成活率的变化;RT-PCR检测自噬基因Beclin-1表达的变化。Western印迹检测自噬相关蛋白Beclin-1的变化:荧光分光光度计检测胞内二氯荧光素DCF的荧光强度。结果:索拉非尼对肝癌细胞HepG_2具有显著的抑制作用;索拉非尼可诱导肝癌细胞HepG_2产生自噬及ROS,自噬在基因及蛋白水平表达均增加;抑制ROS的产生可减少索拉非尼诱导的肝癌细胞HepG_2自噬的表达量,自噬的抑制增强了索拉非尼对肝癌细胞的抑制作用。结论:ROS参与索拉非尼诱导肝癌细胞HepG_2的自噬表达,索拉非尼在抑制肝癌细胞自噬过程中自噬可能起到保护作用,抑制自噬可能为提高进展期肝癌病人索拉非尼分子靶向治疗敏感性提供新的思路。 | 杜海磊 杨卫平 陈聆 施敏敏 汪洋 李军 刘卓然 陈拥军 严佶祺 匡洁 李勤裕 Seewoo Varun 邱伟华 | 2011 | 外科理论与实践2011，16，3： | 4 |
| 10 | Extreme Rainfall Events and Associated Natural Hazards in Alaknanda Valley, Indian Himalayan Region显示文摘Entire Himalayan region is vulnerable to rain-induced (torrential rainfall) hazards in the form of flash flood, cloudburst or glacial lake outburst flood.Flash floods and cloudburst are generally caused by high intensity rainfall followed by debris flow or landslide often resulting into blockade of river channels. The examples of some major disasters caused by torrential rainfall events in last fifty years are the flash floods of 1968 in Teesta valley, in 1993 and 2000 in Sutlej valley, in 1978 in Bhagirathi and in 1970 in Alaknanda river valleys. The formation of landslide dams and subsequent breaching is also associated with such rainfall events. These dams may persist for years or may burst within a short span of its formation. Due to sudden surge of water level in the river valleys, havoc and panic are created in the down stream. In Alaknanda valley, frequencies of such extreme rainfall events are found to be increasing in last two decades. However, the monthly trend of extreme rainfall events has partly indicated this increase. In most of the years extreme rainfall events and cloudburst disaster were reported inAugust during the later part of the monsoon season. | JOSHI Varun KUMAR Kireet | 2006 | Journal of Mountain Science2006，3，3： | 4 |
| 11 | Anomaly detection显示文摘 | Varun Chandola Arindam Banerjee Vipin Kumar | 2009 | ACM Computing Surveys (CSUR)2009，，3： | 4 |
| 12 | Graphene-based bipolar plates for polymer electrolyte membrane fuel cells显示文摘Bipolar plates(BPs)are a major component of polymer electrolyte membrane fuel cells(PEMFCs).BPs play a multifunctional character within a PEMFC stack.It is one of the most costly and critical part of the fuel cell,and hence the development of efficient and cost-effective BPs is of much interest for the fabrication of next-generation PEMFCs in future.Owing to high electrical conductivity and chemical inertness,graphene is an ideal candidate to be utilized in BPs.This paper reviews recent advances in the area of graphene-based BPs for PEMFC applications.Various aspects including the momentous functions of BPs in the PEMFC,favorable features of graphene.based BPs,performance evaluation of various reported BPs with their advantages and disadvantages,challenges at commercial level products and future prospects of frontier research in this direction are extensively documented. | Ram Sevak SINGH(El) Anurag GAUTAM Varun RAI | 2019 | Frontiers of Materials Science2019，13，3： | 3 |
| 13 | Transanal rectosigmoid resection via natural orifice translumenal endoscopic surgery (NOTES) with total mesorectal excision in a large human cadaver series显示文摘 | Dana A. Telem Kyung Su Han Min-Chan Kim Ifode Ajari Dae Kyung Sohn Kevin Woods Varun Kapur Mohammad A. Sbeih Silvana Perretta David W. Rattner Patricia Sylla | 2013 | Surgical Endoscopy2013，，1： | 3 |
| 14 | A Context Sensitive Multilevel Thresholding Using Swarm Based Algorithms显示文摘In this paper, a comprehensive energy function is used to formulate the three most popular objective functions:Kapur's, Otsu and Tsalli's functions for performing effective multilevel color image thresholding. These new energy based objective criterions are further combined with the proficient search capability of swarm based algorithms to improve the efficiency and robustness. The proposed multilevel thresholding approach accurately determines the optimal threshold values by using generated energy curve, and acutely distinguishes different objects within the multi-channel complex images. The performance evaluation indices and experiments on different test images illustrate that Kapur's entropy aided with differential evolution and bacterial foraging optimization algorithm generates the most accurate and visually pleasing segmented images. | Shreya Pare Anil Kumar Varun Bajaj Girish Kumar Singh | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，6： | 3 |
| 15 | Bioactive compounds and probiotics-a ray of hope in COVID-19 management显示文摘The use of bioactive compounds and probiotic bacteria against the viral diseases in human is known for a long time.Anti-viral,anti-inflammatory and anti-allergic properties of bioactive compounds and bacteria with probiotic properties in respiratory viral diseases may have significance to enhance immunity.This review highlights some of the important bioactive compounds and probiotic bacteria,suggesting them as a ray of hope in the milieu of the COVID-19 management. | Indu Bhushan Mahima Sharma Malvika Mehta Shivi Badyal Varun Sharma Indu Sharma Hemender Singh Srinivas Sistla | 2021 | Food Science and Human Wellness2021，10，2： | 3 |
| 16 | Telaprevir- and Boceprevir-based Triple Therapy for Hepatitis C in Liver Transplant Recipients With Advanced Recurrent Disease: A Multicenter Study显示文摘 | Elizabeth C. Verna Varun Saxena James R. Burton Jacqueline G. O’Leary Jennifer L. Dodge Richard T. Stravitz Josh Levitsky James F. Trotter Gregory T. Everson Robert S. Brown Norah A. Terrault | 2015 | Transplantation2015，，8： | 2 |
| 17 | Experimental Investigation of Centrifugal Pump Working as Turbine for Small Hydropower Systems显示文摘 | Himanshu Nautiyal Varun Varun Anoop Kumar Sanjay Yadav Sanjay Yadav | 2011 | Energy Science and Technology2011，，1： | 2 |
| 18 | Evaluation of interface shear strength of composite liner system and stability analysis for a landfill lining system in Thailand显示文摘 | D.T. Bergado G.V. Ramana H.I. Sia Varun | 2006 | Geotextiles and Geomembranes2006，，6： | 2 |
| 19 | mpaired regulatory T cell function in autoimmune Jiseases: are microRNAs the culprits?显示文摘 | Varun K Sharma Srini V Kaveri Jagadeesh Bayry | 2016 | Cellular & Molecular Immunology2016，13，2： | 2 |
| 20 | Effectiveness and Safety of Indomethacin versus Ibuprofen for the Treatment of Patent Ductus Arteriosus in Preterm Infants显示文摘 | Sindhu Sivanandan Varun Bali Amuchou Soraisham Andrei Harabor Majeeda Kamaluddeen | 2013 | Amer J Perinatol2013，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员