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| 1 | SEMS vs cSEMS in duodenal and small bowel obstruction:High risk of migration in the covered stent group显示文摘AIM:To compare clinical success and complications of uncovered self-expanding metal stents(SEMS)vs covered SEMS(cSEMS)in obstruction of the small bowel.METHODS:Technical success,complications and outcome of endoscopic SEMS or cSEMS placement in tumor related obstruction of the duodenum or jejunum were retrospectively assessed.The primary end points were rates of stent migration and overgrowth.Secondary end points were the effect of concomitant biliary drainage on migration rate and overall survival.The data was analyzed according to the Strengthening the Reporting of Observational Studies in Epidemiology guidelines.RESULTS:Thirty-two SEMS were implanted in 20 patients.In all patients,endoscopic stent implantation was successful.Stent migration was observed in 9 of16 cSEMS(56%)in comparison to 0/16 SEMS(0%)implantations(P=0.002).Stent overgrowth did not significantly differ between the two stent types(SEMS:3/16,19%;cSEMS:2/16,13%).One cSEMS dislodged and had to be recovered from the jejunum by way of laparotomy.Time until migration between SEMS and cSEMS in patients with and without concomitant biliary stents did not significantly differ(HR=1.530,95%CI0.731-6.306;P=0.556).The mean follow-up was 57±71 d(range:1-275 d).CONCLUSION:SEMS and cSEMS placement is safe in small bowel tumor obstruction.However,cSEMS is accompanied with a high rate of migration in comparison to uncovered SEMS. | Oliver Waidmann Jrg Trojan Mireen Friedrich-Rust Christoph Sarrazin Wolf Otto Bechstein Frank Ulrich Stefan Zeuzem Jrg Gerhard Albert | 2013 | World Journal of Gastroenterology2013，19，37： | 4 |
| 2 | Vertebroplasty and Kyphoplasty: A Systematic Review of 69 Clinical Studies显示文摘 | Paul A. Hulme J?rg Krebs Stephen J. Ferguson Ulrich Berlemann | 2006 | Spine2006，，17： | 2 |
| 3 | Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine. | Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 4 | Voxel-based analyses of magnetization transfer imaging of the brain in hepatic encephalopathy显示文摘AIM: To evaluate the spatial distribution of cerebral abnormalities in cirrhotic subjects with and without hepatic encephalopathy (HE) found with magnetization transfer imaging (MTI).METHODS: Nineteen cirrhotic patients graded from neurologically normal to HE grade 2 and 18 healthy control subjects underwent magnetic resonance imaging. They gave institutional-review-board-approved written consent. Magnetization transfer ratio (MTR) maps were generated from MTI. We tested for significant differences compared to the control group using statistical non-parametric mapping (SnPM) for a voxelbased evaluation.RESULTS: The MTR of grey and white matter was lower in subjects with more severe HE. Changes were found in patients with cirrhosis without neurological defi cits in the basal ganglia and bilateral white matter. The loss in magnetization transfer increased in severity and spatial extent in patients with overt HE. Patients with HE grade 2 showed an MTR decrease in white and grey matter: the maximum loss of magnetization transfer effect was located in the basal ganglia [SnPM (pseudo-)t = 17.98, P = 0.0001].CONCLUSION: The distribution of MTR changes in HE points to an early involvement of basal ganglia and white matter in HE. | Falk R Miese Hans-Jrg Wittsack Gerald Kircheis Arne Holstein Christian Mathys Ulrich Mdder Mathias Cohnen | 2009 | World Journal of Gastroenterology2009，15，41： | 2 |
| 5 | An- thrax,toxins and vaccines : a 125-year journey targeting Bacillus anthracis 显示文摘 | Tournier JN Ulrich RG Quesnel-Hellmann A | 2009 | Expert Rev Anti Infect Ther2009，7，2： | 1 |
| 6 | Intrahepatic IL-8 producing Foxp3 + CD4 + regulatory T cells and fibrogenesis in chronic hepatitis C<!-- Doctopic: VH -->显示文摘 | Bettina Langhans Benjamin Kr?mer Marcell Louis Hans Dieter Nischalke Robert Hüneburg Andrea Staratschek-Jox Margarethe Odenthal Steffen Manekeller Michael Schepke J?rg Kalff Hans-Peter Fischer Joachim L. Schultze Ulrich Spengler | 2013 | Journal of Hepatology2013，，2： | 1 |
| 7 | Changes of soil chemistry, stand nutrition, and stand growth at two Scots pine (Pinus sylvestris L.) sites in Central Europe during 40?years after fertilization, liming, and lupine introduction显示文摘 | J?rg Prietzel Karl Eugen Rehfuess Ulrich Stetter Hans Pretzsch | 2008 | European Journal of Forest Research2008，，1： | 1 |
| 8 | Comparison of fluconazole with oral polyenes in the prevention of fungal infections in neutropenic patients显示文摘 | Thomas Egger Alois Gratwohl André Tichelli Mario Uhr Christine Stebler Gysi Jakob Passweg Miklos Pless Martin Wernli Ulrich Buser Jürg Wuhrmann R.N. Reno Frei Catherine Nissen Bruno Speck | 1995 | Supportive Care in Cancer1995，，2： | 1 |
| 9 | The toxicogenomics of nuclear receptor agonists显示文摘 | Ulrich RG | 2003 | Curr Opi Chem Biol2003，7，4： | 1 |
| 10 | Profiling the hepatic effects of flutamide in rats:a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers 显示文摘 | Coe KJ Nelson SD Ulrich RG | 2006 | Drug Metab Dispos2006，34，7： | 1 |
| 11 | Contractile hyporesponsiveness of hepatic arteries in humans with cirrhosis: Evidence for a receptor-specific mechanism显示文摘 | Michael Schepke J?rg Heller Sebastian Paschke Julia Thomas Martin Wolff Markus Neef Max Malago Gerhard J. Molderings Ulrich Spengler Tilman Sauerbruch | 2001 | Hepatology2001，，5： | 1 |
| 12 | Metabolic,idiosyncratic toxicity of drugs:overview of the hepatic toxicity induced by the anxiolytic,panadiplon显示文摘 | ULRICH RG BACON JA BRASS EP | 2001 | Chem Biol Interact2001，134，3： | 1 |
| 13 | An- thrax,toxins and vaccines: a 125-year journey targeting Bacillus anthracis显示文摘 | Tournier JN Ulrich RG Quesnel-Hellmann A | 2009 | Expert Rev Anti Infect Ther2009，7，2： | 1 |
| 14 | Structural basis for abrogated binding between staphylococcal enterotoxin A superantigen vaccine and MHC-Ⅱ alpha 显示文摘 | Krupka HI Segelke BW Ulrich RG | 2002 | Protein Sci2002，11，： | 1 |
| 15 | Protection against Staphylococcus aureus sepsis by vaccination with recombinant Staphylococcal enterotoxin A devoid of superantigenicity显示文摘 | Nilsson IM Verdrengh M Ulrich RG | 1999 | J Infect Dis1999，180，4： | 1 |
| 16 | Mucosal vaccination with recombinantly attenuated Staphylococcal enterotoxin B and protection in a Murine Model 显示文摘 | Stiles BG Garza AR Ulrich RG | 2001 | Infect Immun2001，69，4： | 1 |
| 17 | Mid- to Late Holocene climate change: an overview显示文摘 | Heinz Wanner Jürg Beer Jonathan Bütikofer Thomas J. Crowley Ulrich Cubasch Jacqueline Flückiger Hugues Goosse Martin Grosjean Fortunat Joos Jed O. Kaplan Marcel Küttel Simon A. Müller I. Colin Prentice Olga Solomina Thomas F. Stocker Pavel Tarasov Mayke W | 2008 | Quaternary Science Reviews2008，，19： | 1 |
| 18 | Fulminant Toxoplasmosis in a Heart Transplant Recipient显示文摘 | Benita Hermanns Anne Brunn Ernst R. Schwarz J?rg S. Sachweh Ingrid Seipelt J. Michael Schr?der Ulrich Vogel Friedrich A. Schoendube Reinhard Buettner | 2001 | Pathology - Research and Practice2001，，3： | 1 |
| 19 | Vaccine based on a ubiquitous cysteinyl protease and streptococcal pyrogenic exotoxin A protects against Streptococcus pyogenes sepsis and toxic shock显示文摘 | Ulrich RG | 2008 | J Immune Based Ther Vaccines2008，6，： | 1 |
| 20 | Vertebroplasty and Kyphoplasty: A Systematic Review of 69 Clinical Studies显示文摘 | Paul A. Hulme J?rg Krebs Stephen J. Ferguson Ulrich Berlemann | | Spine0，，： | 1 |
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