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| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | Non-steroidal anti-inflammatory drugs and statins in relation to colorectal cancer risk显示文摘AIM:To investigate the association between individual or combined use of non-steroidal anti-inflammatory drugs(NSAIDs) or statins and colorectal cancer risk.METHODS:In a population-based case-control study in women,we examined the association between NSAIDs and statin use and the risk of colorectal cancers.We further investigated whether the use of statins modifies the protective effect of NSAIDs.Female cases(n = 669) of colorectal cancer aged 50-74 years were identified from a statewide registry in Wisconsin during 1999-2001.Community control women(n = 1375) were randomly selected from lists of licensed drivers and Medicare beneficiaries.Medication use and risk factor information were gathered during a structured telephone interview.A multivariable logistic regression model was used to calculate odds ratio(OR) and 95% conf idence interval(CI) .RESULTS:Overall,NSAIDs users had a 30% reduction in risk of colorectal cancer(95% CI:0.56-0.88) .Statin use was not associated with colorectal cancer risk(OR = 1.17,95% CI:0.74-1.85) ,regardless of structural type(lipophilic or hydrophilic) ,duration of use,or recency.There was no evidence of an interaction between NSAIDs and statins and colorectal cancer risk(P-interaction = 0.28) .CONCLUSION:Although our results confirm the inverse association between NSAIDs use and colorectal cancer risk,they do not support a risk reduction in statin users,or an interaction effect of combined NSAIDs and statin use. | Mazyar Shadman Polly A Newcomb John M Hampton Karen J Wernli Amy Trentham-Dietz | 2009 | World Journal of Gastroenterology2009，15，19： | 5 |
| 3 | A new perspective of stratosphere troposphere exchange显示文摘 | Stohl A Wernli H James P | 2003 | Bulletin of the American Meteorological Society2003，84，： | 1 |
| 4 | Role of apoptosis in basal cell and squamous cell carcinoma formation显示文摘 | Erb P Ji J Wernli M | 2005 | Immunol Lett2005，100，1： | 1 |
| 5 | Measurement of isotope ratios on transient signals by MC-ICP-MS 显示文摘 | GUNTHER-LEOPOLD I WERNLI B KOPAJTIC | 2004 | Anal Bioanal Chem2004，378，： | 1 |
| 6 | SAL-a novel quality measure for the verification of quantitative precipitation forecasts显示文摘 | WERNLI H PAULAT M HAGEN M | 2008 | Mon Wea Rev2008，136，11： | 1 |
| 7 | A new perspective of stratosphere-troposphere exchange显示文摘 | STOHL A WERNLI H JAMES P | 2003 | Bulletin of the American Meteorological Society2003，84，11： | 1 |
| 8 | Comparison of fluconazole with oral polyenes in the prevention of fungal infections in neutropenic patients显示文摘 | Thomas Egger Alois Gratwohl André Tichelli Mario Uhr Christine Stebler Gysi Jakob Passweg Miklos Pless Martin Wernli Ulrich Buser Jürg Wuhrmann R.N. Reno Frei Catherine Nissen Bruno Speck | 1995 | Supportive Care in Cancer1995，，2： | 1 |
| 9 | Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial ceils of human adipose tissue 显示文摘 | Zeyda M Wernly B Demyanets S | 2013 | Int J Obes (Lond)2013，37，5： | 1 |
| 10 | Successful treatment of paraneoplastic pemphigus in follicular NHL with rituximab:report of a case and review of treatment for paraneoplastic pemphigus in NHL and CLL显示文摘 | Heizmann M Itin P Wernli M | 2001 | Am J Hematol2001，66，2： | 1 |
| 11 | Structure and evolution of an isolated semi-geostrophic cyclone显示文摘 | Schar C H Wernli | 1993 | Quart J Roy Meteor Soc1993，119，509： | 1 |
| 12 | Successful treatment of paraneoplastic pemphigus in follicular NHL with rituximab: report of a case and review of treatment for paraneoplastic pemphigus in NHL and CLL 显示文摘 | Heizmann M hin P Wernli M | 2001 | Am J Hematol2001，66，2： | 1 |
| 13 | A 15-year climatology of warm conveyor belts显示文摘 | Eckhardt S Stohl A Wernli H | 2004 | Journal of Climate2004，17，1： | 1 |
| 14 | Occupational exposures and ovarian cancer in textile workers 显示文摘 | Wernli KJ Ray RM Gao DL | 2008 | Epidemiology2008，19，： | 1 |
| 15 | Computering a three-dimensional electronic energy manifold for the LiH+H→Li+H2chemical reaction显示文摘 | Wernli M Caruso D Bodo E | 2009 | J Phys Chem2009，113，： | 1 |
| 16 | Macmphage depletion suppresses sympathetic hypefinnervation following myocardi- al infarction显示文摘 | WERNLI G HASAN W BHATYACHERJEE A | 2009 | Basic Res Cardiol2009，104，6： | 1 |
| 17 | Evaluation of eight cases of confirmed Bordetella bronchiseptica infection and colonization over a 15-year period显示文摘 | Wernli D Emonet S Schrenzel J | | 0，，02： | 1 |
| 18 | Short remission durations in therapy-related leukemia despite cytogenetic complete responses to high-dose cytarabine显示文摘 | Larson RA Wernli M Le Beau MM | 1988 | Blood1988，72，4： | 1 |
| 19 | Menstrual and reproductive factors in relation to risk of endometrial cancer in Chinese women显示文摘 | Wernli KJ Ray RM Gao DL | 2006 | Cancer Causes Control2006，17，7： | 1 |
| 20 | Processes governing the chemical composition of the extra-tropical UTLS 显示文摘 | Law K Pan L Wernli H | 2005 | IGAC Newsletter2005，，32： | 1 |
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