|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 2 | SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice显示文摘Establishment of the primordial follicle(PF)pool is pivotal for the female reproductive lifespan;however,the mechanism of primordial folliculogenesis is poorly understood.Here,the transcription factor SP1 was shown to be essential for PF formation in mice.Our results showed that SP1 is present in both oocytes and somatic cells during PF formation in the ovary.Knockdown of Sp1 expression,especially in pregranulosa cells,significantly suppressed nest breakdown,oocyte apoptosis,and PF formation,suggesting that SP1 expressed by somatic cells functions in the process of primordial folliculogenesis.We further demonstrated that SP1 governs the recruitment and maintenance of Forkhead box L2-positive(FOXL2^+)pregranulosa cells using an Lgr5-EGFP-IRES-CreER^T2(Lgr5-KI)reporter mouse model and a FOXL2^+ cell-specific knockdown model.At the molecular level,SP1 functioned mainly through manipulation of NOTCH2 expression by binding directly to the promoter of the Notch2 gene.Finally,consistent with the critical role of granulosa cells in follicle survival in vitro,massive loss of oocytes in SP1 knockdown ovaries was evidenced before puberty after the ovaries were tranSP1anted under the renal capsules.Conclusively,our results reveal that SP1 controls the establishment of the ovarian reserve by regulating pregranulosa cell development in the mammalian ovary. | Han Cai Bingying Liu Huarong Wang Guanghong Sun Lizhao Feng Ziqi Chen Jiaqi Zhou Jiawei Zhang Tuo Zhang Meina He Tingting Yang Qirui Guo Zhen Teng Qiliang Xin Bo Zhou Hua Zhang Guoliang Xia Chao Wang | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 3 | Ecological Environment Conservation and Restoration and Sustainable Development of Minqin Oasis显示文摘Minqin oasis in the lower reaches of the Shiyang River is a main natural barrier for the Wuwei Basin. Due to the combined influence of human activities and natural factors in the past half a century, water quality in the lower reaches of the Shiyang River decreased and ecological environment deteriorated, which influenced sustainable development of this area and surrounding area seriously. This paper analyzed current situation and reasons of the deteriorated ecological environment in the lower reaches of the Shiyang River, and proposed that water environment regulation was the primary task in the eco-environment control of Minqin area, specifically,(a) By using existing policies, accelerating the construction of water-saving agriculture in the middle reaches of the Shiyang River, water quantity in the lower reaches would be guanranted, water shortage for agricultural production and ecological use in Minqin oasis would be relieved;(b) Unreasonable human activities such as overexploitation of underground water should be controlled strictly;(c) Water conservancy project should be developed vigorously to ensure rate of flow. It was expected that the above schemes would contribute to the benign circulation of ecological environment in Minqin oasis. | WANG Lide YAO Tuo XU Feng HAN Fugui GUO Chunxiu WANG Fangling Li Faming | 2016 | Journal of Landscape Research2016，8，1： | 2 |
| 4 | Clinical Study of Autologous Cytokine-Induced Killer Cells for the Treatment of Elderly Patients with Diffuse Large B-Cell Lymphoma显示文摘 | Xue-chun Lu Bo Yang Rui-li Yu Xiao-hua Chi Shuai Tuo Chao-wei Tuo Hong-li Zhu Yao Wang Chao-guang Jiang Xiao-bing Fu Yang Yang Yang Liu Shan-qian Yao Han-ren Dai Li-li Cai Bing-jun Li Wei-dong Han | 2012 | Cell Biochemistry and Biophysics2012，，1： | 2 |
| 5 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 6 | Seed traits and rodent community interact to determine seed fate:evidence from both enclosure and field experiments显示文摘Animal-mediated seed dispersal is an important ecological process in which a strong mutualism between animals and plants can arise.However,few studies have examined how a community of potential seed dispersers interacts with sympatric seed trees.We employed a series of experiments in the Qinling Mountains in both semi-natural enclosure and the field to assess the interactions among 3 sympatric rodent species and 3 Fagaceae tree seeds.Seed traits all showed similar tannin levels but markedly different physical traits and nutritional contents.We found that seeds with heavy weight,thick coat,and high nutritional contents were less likely to be eaten in situ but more often to be eaten after dispersal or hoarded by rodents.These results support both the handling time hypothesis and the high nutrition hypothesis.Surprisingly,we also found that rodents,maybe,preferred to consume seeds with low levels of crude fiber in situ,and to harvest and hoard those with high levels of crude fiber for later consumption.The sympatric rodent species,Cansumys canus,the largest rodent in our study,harvested and hoarded more Quercus variabilis seeds with high physical and nutritional traits,while Apodemus draco,the smallest rodent,harvested more Q.serrata seeds with low physical and nutritional traits,and Niviventer confucianus harvested and hoarded more Q.aliena seeds with medium physical and nutritional traits.Our study demonstrates that different seed traits play different roles in influencing the seed fate and the shaping of mutualism and predation interactions within a community of rodent species. | Xiang HOU Bo ZHANG Michael A.STEELE Ning HAN Tuo FENG Jing WANG Xiaoning CHEN Xiaolei AN Gang CHANG | 2021 | Integrative Zoology2021，16，6： | 1 |
| 7 | In vitro assessment of immunomodulating activity of the two Lactobacillus strains isolated from traditional fermented milk显示文摘 | TUO Y ZHANG HAN X | | 0，，： | 1 |
| 8 | Antimicrobial activity against Shigella sonnei and probiotic properties of wild lactobacilli from fermented food显示文摘 | Yingchun Zhang Lanwei Zhang Ming Du Huaxi Yi Chunfeng Guo Yanfeng Tuo Xue Han Jingyan Li Lili Zhang Lin Yang | 2011 | Microbiological Research2011，，1： | 1 |
| 9 | Laminar-flow immediate-overlay hepatocyte sandwich perfusion system for drug hepatotoxicity testing 显示文摘 | Xia L Ng S Han R Tuo X Xiao G Leo HL | 2009 | Biomaterials2009，30，30： | 1 |
| 10 | In vitro as- sessment of immunomodulating activity of the two Lactobacillus strains isolated from traditional fermented milk显示文摘 | Tuo Y F Zhang L W Han X | 2011 | World Journal of Microbiol- ogy & Biotechnology2011，27，： | 1 |
| 11 | Compounding effects of human activities and climatic changes on coexistence of oasis-desert ecosystems:Prioritizing resilient decision-making for a riskier world显示文摘Water-salt balance is critical for the stable coexistence of salt-affected and groundwater-fed oasis-desert ecosystems. Yet, a comprehensive investigation of how soil salinization and groundwater degradation threaten the coexistence of oasis-desert ecosystems is still scarce, especially under the compounding effects of human activities and climatic changes. Here, we assessed the impacts of irrigated agriculture on hydrological regimes in oasisdesert systems, investigated the spatio-temporal variations of soil salinization in irrigated cropland, and evaluated the implications of the interplays of soil salinization and groundwater degradation on the coexistence of oasis-desert ecosystems in northwestern China, based on meaningful modelling approaches and comprehensive measurements over 1995–2020. The results showed that the irrigation return flow coefficient decreased sharply from 0.21 ± 0.09 in the traditional irrigation period to 0.09 ± 0.01 in the water-saving irrigation period. The continuous drop in groundwater tables and significant degradation of groundwater quality are occurring throughout this watershed. The eco-environmental flows are reaching to their limit with watershed closures(i.e.,the drainage from the oasis region into the desert region is being weakened or even eliminated), although these progressions were largely hidden by regional precipitation and streamflow variability. The process of salt migration and accumulation across different landscapes in oasis-desert system is being reshaped, and soil salinization in water-saving agricultural irrigated lands is accelerating with a regional average annual growth rate of18%. The vegetation in this watershed is degrading, and anthropogenic disturbance accelerates this trend. Our results highlight that environmental stress adaptation strategies must account for resilience maintenance to avoid accelerating catastrophic transitions in oasis-desert ecosystems. Determining the optimal oasis scales and formulating the best irrigation management plans are effective and resilient decision-making ways to maintain the coexistence relationship of oasis-desert ecosystem in drylands. | XinWei Yin Wei Liu Meng Zhu JuTao Zhang Qi Feng HaiYang Xi LinShan Yang Tuo Han WenJu Cheng YingQing Su BaiTing Zhang YuanYuan Xue ZeXia Chen LingGe Wang | 2023 | Research in Cold and Arid Regions2023，15，5： | 0 |
| 12 | Prediction of cognitive scores by joint use of movie-watching fMRI connectivity and eye tracking via Attention-CensNet显示文摘Background:Brain functional connectivity under the naturalistic paradigm has been shown to be better at predicting individual behaviors than other brain states,such as rest and doing tasks.Nevertheless,the state-of-the-art methods have found it difcult to achieve desirable results from movie watching paradigm functional magnetic resonance imaging(mfMRI)-induced brain functional connectivity,especially when there are fewer datasets.Incorporating other physical measurements into the prediction method may enhance accuracy.Eye tracking,becoming popular due to its portability and lower expense,can provide abundant behavioral features related to the output of human's cognition,and thus might supplement the mfMRI in observing participants'subconscious behaviors.However,there are very few studies on how to effectively integrate the multimodal information to strengthen the performance by a unified framework.objective:A fusion approach with mfMRI and eye tracking,based on convolution with edge-node switching in graph neural networks(CensNet),is proposed in this article.Methods:In this graph model,participants are designated as nodes,mfMRI derived functional connectivity as node features,and different eye-tracking features are used to compute similarity between participants to construct heterogeneous graph edges.By taking multiple graphs as different channels,we introduce squeeze-and-excitation attention module to CensNet(A-CensNet)to integrate graph embeddings from multiple channels into one.Results:The proposed model outperforms those using a single modality and single channel,and state-of-the-art methods.Conclusions:The results indicate that brain functional activities and eye behaviors might complement each other in interpreting trait-like phenotypes. | Jiaxing Gao Lin Zhao Tianyang Zhong Changhe Li Zhibin He Yaonei Wei Shu Zhang Lei Guo Tianming Liu Junwei Han Xi Jiang Tuo Zhang | 2023 | Psychoradiology2023，3，1： | 0 |
| 13 | Atypical double right coronary artery:a case report and literature review显示文摘Coronary artery anomalies are a kind of rare congenital coronary disease most of which are nonmalignant and asymptomatic,while some could lead to severe clinical manifestations and even sudden cardiac death.Here,we reported an atypical anomaly of a double right coronary artery with no obvious atherosclerosis on angiograms,in a 51-year-old woman who showed mild symptoms and had ischemic signs on electrocardiogram.This anomaly is neither similar to the typical appearances of a split right coronary artery nor a large right ventricle branch,is probably account for the potential risk of myocardial ischemia and highly likely to be missed during coronary angiography. | Tuo Han Hao-Yu Wu Yan-Chao Hu Yan Zhang Cong-Xia Wang | 2021 | Life Research2021，4，3： | 0 |
| 14 | Reconfigurable memristor based on SrTiO_(3) thin-film for neuromorphic computing显示文摘Neuromorphic computing aims to achieve artificial intelligence by mimicking the mechanisms of biological neurons and synapses that make up the human brain.However,the possibility of using one reconfigurable memristor as both artificial neuron and synapse still requires intensive research in detail.In this work,Ag/SrTiO_(3)(STO)/Pt memristor with low operating voltage is manufactured and reconfigurable as both neuron and synapse for neuromorphic computing chip.By modulating the compliance current,two types of resistance switching,volatile and nonvolatile,can be obtained in amorphous STO thin film.This is attributed to the manipulation of the Ag conductive filament.Furthermore,through regulating electrical pulses and designing bionic circuits,the neuronal functions of leaky integrate and fire,as well as synaptic biomimicry with spike-timing-dependent plasticity and paired-pulse facilitation neural regulation,are successfully realized.This study shows that the reconfigurable devices based on STO thin film are promising for the application of neuromorphic computing systems. | Xiaobing Yan Xu Han Ziliang Fang Zhen Zhao Zixuan Zhang Jiameng Sun Yiduo Shao Yinxing Zhang Lulu Wang Shiqing Sun Zhenqiang Guo Xiaotong Jia Yupeng Zhang Zhiyuan Guan Tuo Shi | 2023 | Frontiers of physics2023，18，6： | 0 |
| 15 | Parameter sensitivity analysis for a biochemically-based photosynthesis model显示文摘A challenge for the development of Land Surface Models(LSMs) is improving transpiration of water exchange and photosynthesis of carbon exchange between terrestrial plants and the atmosphere, both of which are governed by stoma in leaves. In the photosynthesis module of these LSMs, variations of parameters arising from diversity in plant functional types(PFTs) and climate remain unclear. Identifying sensitive parameters among all photosynthetic parameters before parameter estimation can not only reduce operation cost, but also improve the usability of photosynthesis models worldwide. Here, we analyzed 13 parameters of a biochemically-based photosynthesis model(FvCB), implemented in many LSMs, using two sensitivity analysis(SA) methods(i.e., the Sobol’ method and the Morris method) for setting up the parameter ensemble. Three different model performance metrics, i.e.,Root Mean Squared Error(RMSE), Nash Sutcliffe efficiency(NSE), and Standard Deviation(STDEV) were introduced for model assessment and sensitive parameters identification. The results showed that among all photosynthetic parameters only a small portion of parameters were sensitive, and the sensitive parameters were different across plant functional types: maximum rate of Rubisco activity(Vcmax25), maximum electron transport rate(Jmax25), triose phosphate use rate(TPU) and dark respiration in light(Rd) were sensitive in broad leafevergreen trees(BET), broad leaf-deciduous trees(BDT) and needle leaf-evergreen trees(NET), while only Vcmax25and TPU are sensitive in short vegetation(SV), dwarf trees and shrubs(DTS), and agriculture and grassland(AG). The two sensitivity analysis methods suggested a strong SA coherence;in contrast, different model performance metrics led to different SA results. This misfit suggests that more accurate values of sensitive parameters, specifically, species specific and seasonal variable parameters, are required to improve the performance of the FvCB model. | Tuo Han Qi Feng TengFei Yu | 2023 | Research in Cold and Arid Regions2023，15，2： | 0 |
| 16 | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers显示文摘Nicotinamide adenine dinucleotide(NAD+)is a central metabolite in cellular processes.Depletion of NAD+has been demonstrated to be a prevalent theme in both prokaryotic and eukaryotic immune responses.Short prokaryotic Argonaute proteins(Agos)are associated with NADase domain-containing proteins(TIR-APAZ or SIR2-APAZ)encoded in the same operon.They confer immunity against mobile genetic elements,such as bacteriophages and plasmids,by inducing NAD+depletion upon recognition of target nucleic acids.However,the molecular mechanisms underlying the activation of such prokaryotic NADase/Ago immune systems remain unknown.Here,we report multiple cryo-EM structures of NADase/Ago complexes from two distinct systems(TIR-APAZ/Ago and SIR2-APAZ/Ago).Target DNA binding triggers tetramerization of the TIR-APAZ/Ago complex by a cooperative self-assembly mechanism,while the heterodimeric SIR2-APAZ/Ago complex does not assemble into higher-order oligomers upon target DNA binding.However,the NADase activities of these two systems are unleashed via a similar closed-to-open transition of the catalytic pocket,albeit by different mechanisms.Furthermore,a functionally conserved sensor loop is employed to inspect the guide RNA–target DNA base pairing and facilitate the conformational rearrangement of Ago proteins required for the activation of these two systems.Overall,our study reveals the mechanistic diversity and similarity of Ago protein-associated NADase systems in prokaryotic immune response. | Xinwei Wang Mu Wang Tuo Xu Ye Feng Qiang Shao Shuo Han Xiaojing Chu Yechun Xu Shuling Lin Qiang Zhao Beili Wu | 2023 | Cell Research2023，33，10： | 0 |
| 17 | Anti-fertility effect of levonorgestrel and/or quinestrol on striped field mouse(Apodemus agrarius):evidence from both laboratory and field experiments显示文摘The effect of combined levonorgestrel(P)and quinestrol(E)on the fertility of stripedfield mouse(Apodemus agrarius)has not been evaluated.We performed a series of experiments in both the laboratory andfield to assess the effect of P and/or E on the fertility of A.agrarius.In the laboratory,to test the time-dependent anti-fertility ef-fects of P and E,as well as their mixtures,90 male stripedfield mice were randomly assigned to 6 treatment groups(n=60),and a control group(n=30).Mice in 3 treatment groups were administered 1 of the 3 compounds(1 mg�kg–1[body weight]EP-1,0.34 mg�kg–1 E,0.66 mg�kg–1 P)for 3 successive days(another half for 7 suc-cessive days)via oral gavage;mice were then sacrificed 15 and 45 days after initiating the gavage treatment.Ourfindings indicated that E and EP-1 treatment,but not P or control treatment,significantly decreased the sperm count in the caudal epididymis,as well as the weight of the testes,epididymides,and seminal vesicles.Additionally,fer-tile female mice mated with E-and EP-1-treated males produced smaller pups.These data indicate that E and EP-1 can induce infertility in male A.agrarius.In thefield,the population density of A.agrarius was significantly influ-enced by EP-1,and the rodent density in the treatment group was lower than that in the control group.Overall,our results indicate that EP-1 is an effective contraceptive in A.agrarius,a dominant rodent species in the farmland. | Xiaoning CHEN Xiang HOU Tuo FENG Ning HAN Jing WANG Gang CHANG | 2022 | Integrative Zoology2022，17，6： | 0 |
| 18 | Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)显示文摘The incre asing interest in RNA modifications has signifcantly advanced epigenomic and epitranscriptomic technologies.This study focuses on the immuno oncological impact of ALYREF in human cancer through a pan-cancer analysis,enhancing understanding of this gene's role in cancer.We observed differential ALYREF expression between tumor and normal samples,correl ating strongly with prognosis in various cancers,particularly kidney renal papillary cell carcinoma(KIRP)and liver hepatocellular carcinoma(LIHC).ALYREF showed a negative correlation with most tumor-infitrating cells in lung squamous cell carcinoma(LUSC)and lymphoid neoplasm difuse large B-cell lymphoma(DLBC),while positive correlations were noted in IIHC,kidney chromophobe(KICH),mesothelioma(MESO),KIRP,pheochromocytoma and paraganglioma(PARD),and glioma(GBMLGG).Aditionally,ALYREF expression was closely associated with tumor heterogeneity,stemness indices,and a high mutation rate in TP53 across these cancers.In conclusion,ALYREF may serve as an oncogenic biomarker in numerous cancers,meriting further research attention. | XING YE ZHOUTING TUO KAI CHEN RUICHENG WU JIE WANG QINGXIN YU LUXIA YE AKIRA MIYAMOTO KOO HAN YOO CHI ZHANG WURAN WEI DENGXIONG LI DECHAO FENG | 2024 | Oncology Research2024，32，3： | 0 |
| 19 | Preparation of FePt magnetic nanodot arrays by nanosphere lithography显示文摘Magnetic FePt nanodot arrays are promising candidates for making quantum magnetic recording disk. Here we introduce a hybrid method of FePt nanodot array fabrication through nanosphere lithography. This method combines the advantages of both top-down and bottom-up approaches and does not re- quire expensive equipment nor complicated processing steps.The size of magnetic FePt nanodots prepared can be as small as 40 nm. | wu PeiWen FANG YiKun TUO XinLin WANG XiaoGong HAN BaoShan YUAN Jun | 2007 | Chinese Science Bulletin2007，52，8： | 0 |
| 20 | Tamoxifen does not d eteriorate cardiac function in female alphaMHC-MerCreMer transgenic mice显示文摘Cre-loxP recombination system is widely used in gene function research to realize specific gene knockout or knockin through DNA editing.TheαMHC-MerCreMer transgenic mouse line can achieve conditional cardiomyocyte-specific gene editing and make itself be of high value in cardiovascular research.However,there is an ongoing controversy on cardiomyopathy caused by unspecific Cre activity or related to tamoxifen overload,and the majority of studies only focused on male mice.Here,we investigated in femaleαMHC-MerCreMer mice the effect of tamoxifen on myocardia at a conventional dose of 20 mg/kg for five consecutive days by intraperitoneal injection.Our results confirmed that the conventional dose of tamoxifen administration effectively knock down myocardial MED1 expression within one week,without any changes in body weight or heart and liver mass after a 2-week washout period.Serological examination showed that tamoxifen did not deteriorate hepatic or renal function.Hematoxylin-eosin and Sirius red staining revealed no difference in the structure or fibrosis deposition in the heart upon tamoxifen treatment.F4/80 immunohistochemistry staining showed no signs of increased macrophage infiltration in myocardia.The results of RT-qPCR also confirmed the histological observations.Furthermore,differences in energy metabolism and inflammatory response were observed in femaleαMHC-MerCreMer mice,and the underlying mechanism still needs to be clarified. | Tuo Han Jie Gao Mehreen Fatima Yi-Wen Wang Li-Xia Wang Cong-Xia Wang | 2021 | Life Research2021，4，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员