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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 3 | Prognostic impact of the Bismuth-Corlette classification:Higher rates of local unresectability in stageⅢb hilar cholangiocarcinoma显示文摘Background:The Bismuth-Corlette(BC)classification is used to categorize hilar cholangiocarcinoma by proximal extension along the biliary tree.As the right hepatic artery crosses just behind the left bile duct,we hypothesized that BCⅢb tumors would have a higher likelihood of local unresectability due to involvement of the contralateral artery.Methods:A retrospective review of a prospectively maintained database identified patients with hilar cholangiocarcinoma taken to the operating room for intended curative resection between April 2008 and September 2016.Cases were assigned BC stages based on preoperative imaging.Results:Sixty-eight patients were included in the study.All underwent staging laparoscopy after which 16 cases were aborted for metastatic disease.Of the remaining 52 cases,14 cases were explored and aborted for locally advanced disease.Thirty-eight underwent attempt at curative resection.After exclud-ing cases aborted for metastatic disease,the chance of proceeding with resection was 55.6%for BCⅢb staged lesions compared to 80.0%of BCⅢa lesions and to 82.4%for BCⅠ-Ⅲa staged lesions(P<0.05).About 44.4%of BCⅢb lesions were aborted for locally advanced disease versus 17.6%of remaining BC stages.Conclusions:When hilar cholangiocarcinoma is preoperatively staged as BCⅢb,surgeons should antici-pate higher rates of locally unresectable disease,likely involving the right hepatic artery. | Michael J Passeri Maria R Baimas-George Jesse K Sulzer David A Iannitti John B Martinie Erin H Baker Lee M Ocuin Dionisios Vrochides | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 3 |
| 4 | Annual growth banding in a cave stalagmite显示文摘 | Baker A Smart P Edwards R | 1993 | Nature1993，364，： | 2 |
| 5 | Assessment of the Progress of the Back-Pain Patient显示文摘 | R MILLION W HALL K HAAVIK NILSEN R D BAKER M I V JAYSON | 1982 | Spine1982，，3： | 2 |
| 6 | Subtype-selective antagonists of lysophosphatidic acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques显示文摘 | ROTHER E BRANDL R BAKER D L | 2003 | Circulation2003，108，6： | 2 |
| 7 | A global perspective on cadmium pollution and toxicity in non-occupationally exposed population显示文摘 | Soisungwan Satarug Jason R Baker Supanee Urbenjapol Melissa Haswell-Elkins Paul E.B Reilly David J Williams Michael R Moore | 2002 | Toxicology Letters2002，，1： | 2 |
| 8 | The relationship between the quantum yield of photosynthetic electron transport and quenching of chlorophyll fluorescence显示文摘 | Genty B Briantails J M Baker N R | 1989 | Biochim Biophys Acta1989，990，： | 1 |
| 9 | Geomorphological understanding of floods 显示文摘 | Baker V R | 1994 | Geomorphology1994，10，14： | 1 |
| 10 | Comparison of reaction mechanism of epoxy resins undergoing thermal and microwave cure from insitu measurements of microwave dieltric properxties and infrared spectroscopy显示文摘 | Marand E Baker K R Graybeal J D | 1992 | Macromolecules1992，25，8： | 1 |
| 11 | Global perspective on cadmium and toxicity in nonoccupationally exposed pollution显示文摘 | Baker J R Urbenjapol S | 2003 | Toxicology Letters2003，137，： | 1 |
| 12 | A framework for designing efficient value chain networks显示文摘 | Taulluri S Baker R C and Sarikis J | 1999 | International Journal of Pro duction Economics1999，62，12： | 1 |
| 13 | Mycoplasma infections in growing cattle 显示文摘 | NICHOLAS R A J BAKER S AYLING R D | 2000 | Cattle Practice2000，，8： | 1 |
| 14 | The effect of strength envelope nonlinearity on slope stability calculations显示文摘 | JIANG J C BAKER R YAMAGAMI T | 2003 | Can Geotech2003，40，2： | 1 |
| 15 | Commonality in the deter- minants of expected stock returns显示文摘 | Haugen R A Baker N L | 1996 | Journal of Fi- nancial Economics1996，41，3： | 1 |
| 16 | The role of the family in the treatment of anorexia nervosa显示文摘 | Liebman R Minuehin S Baker L | 1974 | J Am Acad Child Psychiatry1974，13，2： | 1 |
| 17 | Applications of chlorophyll fluorescence can improve crop production strategies: an examination of future possibilities 显示文摘 | Baker N R Rosenqvist E | 2004 | Journal of Experimental Botany2004，55，403： | 1 |
| 18 | Psychological adjustment of cancer caregivers with multiple roles显示文摘 | Kim Y Baker F Spillers R L | 2006 | Psycho-Oncol2006，15，9： | 1 |
| 19 | 1α-hydroxylat-edchole-calciferol compounds act additively with microbial phytaseto improve phosphorus,zinc andmanganese utilization inchicks fed soy-based diets显示文摘 | Biehl R R Baker D H Deluca H F | 1995 | Journal of Nutrition1995，125，9： | 1 |
| 20 | Accuracy of devices used for self-monitoring of blood glucose显示文摘 | Johnson R N Baker J R | 1998 | Ann Clin Biochem1998，35，1： | 1 |
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