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| 1 | Aging and menopause reprogram osteoclast precursors for aggressive bone resorption显示文摘Women gradually lose bone from the age of〜35 years,but around menopause,the rate of bone loss escalates due to increasing bone resorption and decreasing bone formation levels,rendering these individuals more prone to developing osteoporosis.The increased osteoclast activity has been linked to a reduced estrogen level and other hormonal changes.However,it is unclear whether intrinsic changes in osteoclast precursors around menopause can also explain the increased osteoclast activity.Therefore,we set up a protocol in which CD14f blood monocytes were isolated from 49 female donors(40-66 years old).Cells were differentiated into osteoclasts,and data on differentiation and resorption activity were collected.Using multiple linear regression analyses combining in vitro and in vivo data,we found the following:(1)age and menopausal status correlate with aggressive osteoclastic bone resorption in vitro;(2)the type I procollagen N-terminal propeptide level in vivo inversely correlates with osteoclast resorption activity in vitro;(3)the protein level of mature cathepsin K in osteoclasts in vitro increases with age and menopause;and(4)the promoter of the gene encoding the dendritic cell-specific transmembrane protein is less methylated with age.We conclude that monocytes are'reprogrammed'in vivo,allowing them to'remember'age,the menopausal status,and the bone formation status in vitro,resulting in more aggressive osteoclasts.Our discovery suggests that this may be mediated through DNA methylation.We suggest that this may have clinical implications and could contribute to understanding individual differences in age-and menopause-induced bone loss. | Anais Marie Julie Moller Jean-Marie Delaisse Jacob Bastholm Olesen Jonna Skov Madsen Luisa Matos Canto Troels Bechmann Silvia Regina Rogatto Kent Soe | 2020 | Bone Research2020，8，3： | 4 |
| 2 | Persistent postsurgical pain: risk factors and prevention显示文摘 | Henrik Kehlet Troels S Jensen Clifford J Woolf | 2006 | The Lancet . 2006 (9522)2006，，9522： | 2 |
| 3 | prolonged hypobaric hypoxemia attenuates vasopressin secretion and renal response to osmostimu - lation in men显示文摘 | MORTEN H BESTLE NIELS V OLSEN TROELS D POULSEN | 2002 | J Appl Physiol2002，92，： | 1 |
| 4 | Differential Efficacy of Protease Inhibitors Against HCV Genotypes 2a, 3a, 5a, and 6a NS3/4A Protease Recombinant Viruses显示文摘 | Judith M. Gottwein Troels K.H. Scheel Tanja B. Jensen Lubna Ghanem Jens Bukh | 2011 | Gastroenterology2011，，3： | 1 |
| 5 | Systemic intermittent parathyroid hormone treatment improves osseointegration of press-fit inserted implants in cancellous bone显示文摘 | Henrik Daugaard Brian Elmengaard Troels Torp Andreassen Anders Lamberg Joan Elisabeth Bechtold Kjeld Soballe | 2012 | Acta Orthopaedica2012，，4： | 1 |
| 6 | Diagnostic and prog-nostic microRNAs in stageⅡcolon cancer显示文摘 | Troels S Jrgen TR Marie SO | 2008 | CancerRes2008，68，15： | 1 |
| 7 | Estimation of Body Weight from Size Meamirements and Body Condition Scores in Dairy Cows显示文摘 | Carsten Enevoldaen and Troels Kristenaen | 1997 | J Dairy Sci1997，80，： | 1 |
| 8 | Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: assessment of correlation between clinical response and vaccine parameters显示文摘 | Lotte Engell-Noerregaard Troels Holz Hansen Mads Hald Andersen Per thor Straten Inge Marie Svane | 2009 | Cancer Immunology Immunotherapy2009，，1： | 1 |
| 9 | Accumulation and seepages of biogenic gas in Northern Denmark 显示文摘 | Troels Laier Niels Qluf Jorgensen Bjorn Buchardt | 1992 | Continental Shelf Research1992，12，10： | 1 |
| 10 | The role of the mannose-binding lecin in innate immunity显示文摘 | Troels KH Schwartz G | 2005 | Clin Infect Dis2005，41，7： | 1 |
| 11 | Risk Factors for Chronic Pain after Hysterectomy: A Nationwide Questionnaire and Database Study显示文摘 | Birgitte Brandsborg Lone Nikolajsen Charlotte T. Hansen Henrik Kehlet Troels S. Jensen | 2007 | Anesthesiology2007，，5： | 1 |
| 12 | The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysis显示文摘 | Christina Therkildsen Troels K. Bergmann Tine Henrichsen-Schnack Steen Ladelund Mef Nilbert | 2014 | Acta Oncologica2014，，7： | 1 |
| 13 | Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: assessment of correlation between clinical response and vaccine parameters显示文摘 | Lotte Engell-Noerregaard Troels Holz Hansen Mads Hald Andersen Per thor Straten Inge Marie Svane | 2009 | Cancer Immunology, Immunotherapy2009，，： | 1 |
| 14 | Central post-stroke pain: clinical characteristics, pathophysiology, and management显示文摘 | Henriette Klit Nanna B Finnerup Troels S Jensen | 2009 | Lancet Neurology2009，，： | 1 |
| 15 | Integrated marine cultivation of Gracialria chilensis(Gracilariales, Rhodophyta) and salmon cages for reduced environmental impact and increased economic output 显示文摘 | Troel M Hallin G C Nilsson A | 1997 | A quaculture1997，156，： | 1 |
| 16 | Breakthrough pain in malignant and non-malignant diseases: a review of prevalence, characteristics and mechanisms显示文摘 | Kristina B. Svendsen Steen Andersen Sigurdur Arnason Staffan Arnér Harald Breivik Tarja Heiskanen Eija Kalso Ulf E. Kongsgaard Per Sjogren Peter Strang Flemming W. Bach Troels S. Jensen | 2004 | European Journal of Pain2004，，2： | 1 |
| 17 | Prediction of postoperative pain by preoperative pain response to heat stimulation in total knee arthroplasty显示文摘 | Troels H. Lunn Lissi Gaarn-Larsen Henrik Kehlet | 2013 | Pain2013，，： | 1 |
| 18 | Persistent high incidence of tuberculosis in immigrants in low-incidence country 显示文摘 | Troels L Ase B A Asger D | 2002 | Emerging Infectious Diseases J2002，8，： | 1 |
| 19 | Prolonged hypobaric hypoxemia attenuates vasopressin secretion and renal response to osmostimu-lation in men显示文摘 | Morten H B Niels V O Troels D P | | 0，，： | 1 |
| 20 | Breakthrough pain in malignant and non-malignant diseases: a review of prevalence, characteristics and mechanisms显示文摘 | Kristina B. Svendsen Steen Andersen Sigurdur Arnason Staffan Arnér Harald Breivik Tarja Heiskanen Eija Kalso Ulf E. Kongsgaard Per Sjogren Peter Strang Flemming W. Bach Troels S. Jensen | 2004 | European Journal of Pain2004，，2： | 1 |
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