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| 1 | Advances in radiotherapy and targeted therapies for rectal cancer显示文摘The last decade witnessed a significant progress in understanding the biology and immunology of colorectal cancer alongside with the technical innovations in radiotherapy.The stepwise implementation of intensitymodulated and image-guided radiation therapy by means of megavolt computed tomography and helical tomotherapy enabled us to anatomically sculpt dose delivery,reducing treatment related toxicity.In addition,the administration of a simultaneous integrated boost offers excellent local control rates.The novel challenge is the development of treatment strategies for medically inoperable patient and organ preserving approaches.However,distant control remains unsatisfactory and indicates an urgent need for biomarkers that predict the risk of tumor spread.The expected benefit of target?ed therapies that exploit the tumor genome alone is so far hindered by high cost techniques and pharmaceuticals,hence hardly justifying rather modest improvements in patient outcomes.On the other hand,the immune landscape of colorectal cancer is now better clarified with regard to the immunosuppressive network that promotes immune escape.Both N2 neutrophils and myeloid-derived suppressor cells(MDSC)emerge as useful clinical biomarkers of poor prognosis,while the growing list of anti-MDSC agents shows promising ability to boost antitumor T-cell immunity in preclinical settings.Therefore,integration of genetic and immune biomarkers is the next logical step towards effective targeted therapies in the context of personalized cancer treatment. | Alexandra Sermeus Wim Leonard Benedikt Engels Mark De Ridder | 2014 | World Journal of Gastroenterology2014，20，1： | 3 |
| 2 | 超声辅助下切割针吸活检诊断头颈部淋巴瘤:是否可以取代淋巴结摘取活检?显示文摘Sonography-assisted cutting needle biopsy in the head and neck for the diagnosis of lymphoma: can it replace lymph node extirpation? Pfeiffer J, Kayser G, Ridder GJ. Laryngoscope, 2009, 119(4):689-695. | Pfeiffer J Kayser G Ridder GJ | 2009 | 中国口腔颌面外科杂志2009，7，4： | 3 |
| 3 | Diagnostic value of ultrasound-guided core needle biopsy in patients with salivary gland masses显示文摘 | J. Pfeiffer G.J. Ridder | 2011 | International Journal of Oral & Maxillofacial Surgery2011，，： | 2 |
| 4 | Knowledge sharing in context: the influence of organizational commitment, communication climate and CMC use on knowledge sharing显示文摘 | Bart van den Hooff Jan A. de Ridder | 2004 | Journal of Knowledge Management2004，，6： | 2 |
| 5 | Efficacy of neurofeedback treatment in ADHD:the effects on inattention,impulsivity and hyperactivity:a meta-analysis显示文摘 | Arns M de Ridder S Strehl U | 2009 | Clin EEG Neurosci2009，40，3： | 1 |
| 6 | Image processing with neural networks - a review 显示文摘 | EGMONT-PETERSEN M DE RIDDER D HANDELS H | 2002 | Pattern Recogn2002，35，10： | 1 |
| 7 | Priming the cow for mo-bilization in the periparturient period:effects of supplemen-ting the dry cow with saturated fat or linseed显示文摘 | Andersen J B Ridder C Larsen T | 2008 | J Dairy Sci2008，91，3： | 1 |
| 8 | Image processing using neural networks-a review显示文摘 | Egmont P M Ridder D Handels H | 2002 | Pattern Recognition2002，，： | 1 |
| 9 | International small business survey:a picture of entrepreneurial climate显示文摘 | HUISMAN D DE RIDDER W J | 1984 | SKIM Industrial Market Research1984，，10： | 1 |
| 10 | Transient alcohol craving suppression by rTMS of dorsal anterior cingulate: an fMRI and LORETA EEG study显示文摘 | De Ridder D Vanneste S Kovaes S | 2011 | Neurosci Lett2011，496，： | 1 |
| 11 | Suicidalbehaviour in adolescence and subsequent mental health outcomes inyoung adulthood显示文摘 | FERGUSSON DM HORWOOD U RIDDER EM | 2005 | Psychol Med2005，35，7： | 1 |
| 12 | An International Urogynecological Association (IUGA)/International Continence Society (ICS)joint report on the terminology for female pelvic floor dysfunction显示文摘 | Haylen BT de Ridder D Freeman RM | 2010 | Int Urogynecol J2010，21，： | 1 |
| 13 | DNA methylation of the allergy regulatory gene interferon gamma varies by age, sex, and tissue type in asthmatics 显示文摘 | Stephanie Lovinsky-Desir Robert Ridder David Tor- rone | 2014 | Clinical Epigenetics2014，6，9： | 1 |
| 14 | Preoperative Helical Tomotherapy and Megavoltage Computed Tomography for Rectal Cancer: Impact on the Irradiated Volume of Small Bowel显示文摘 | Benedikt Engels Mark De Ridder Koen Tournel Alexandra Sermeus Peter De Coninck Dirk Verellen Guy A. Storme | 2009 | International Journal of Radiation Oncology, Biology, Physics2009，，5： | 1 |
| 15 | Functional anatomy of the human cochlear nerve and its role in microvascular decompressions for tinnitus显示文摘 | De Ridder D Ryu H MФfller AR | 2004 | Neurosurgery2004，54，： | 1 |
| 16 | Determination of tetracycline an- tibiotics in cow's milk by liquid chromatography/tandem mass spectrometry显示文摘 | H De Ruyck H De Ridder | 2007 | Rapid Communications in Mass Spectrome- try2007，21，9： | 1 |
| 17 | Infliximab dependency in pediatric Crohn's disease: long-term follow-up of an unselected cohort显示文摘 | de Ridder L Rings EH Damen GM | 2008 | Inflamm Bowel Dis2008，14，3： | 1 |
| 18 | Water in the stems of sessile oak( Quercns petraca) assessed by computer tomography with concurrent measurements of sap velocity and ultrasound emission显示文摘 | Raschi A Tognetti R Ridder H W | 1995 | Plant Cell and Environment1995，18，5： | 1 |
| 19 | Knowledge sharing in context: the influence of organizational commitment, communication climate and CMC use on knowledge sharing 显示文摘 | VAN DEN HOOFF B DE RIDDER J | 2004 | Journal of Knowledge Management2004，8，6： | 1 |
| 20 | Prognostic factors after resection of ampullary carcinoma: multivariate survival analysis in comparison with duetal cancer of the pancreatic head显示文摘 | Klempnauer J Ridder | 1995 | Br J Surg1995，82，： | 1 |
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